Performance Enhancing Drugs: History, Medical Effects & Policy
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Impact of GH Administration on Athletic Performance in Healthy Young Adults: a Systematic Review and Meta-Analysis of Placebo-Controlled Trials MARK
Growth Hormone & IGF Research 34 (2017) 38–44 Contents lists available at ScienceDirect Growth Hormone & IGF Research journal homepage: www.elsevier.com/locate/ghir Review Article Impact of GH administration on athletic performance in healthy young adults: A systematic review and meta-analysis of placebo-controlled trials MARK ⁎ Kasper Hermansena, , Mads Bengtsena, Michael Kjærb, Peter Vestergaardc,d, Jens Otto Lunde Jørgensena a Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark b Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Centre for Healthy Aging, Faculty of Health and Medical Science, University of Copenhagen, Denmark c Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark d Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark ARTICLE INFO ABSTRACT Keywords: Objective: Illicit use of growth hormone (GH) as a performance-enhancing drug among athletes is prevalent, GH although the evidence of such effects in healthy, young subjects is sparse. We therefore performed a meta- Athletic performance analysis of published studies on the effect of GH administration on body composition, substrate metabolism, and Doping athletic performance in healthy, young subjects. Design: The English-language based databases PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched, and eligible articles were reviewed in accordance with the PRISMA guidelines. Fifty-four potentially relevant articles were retrieved of which 11 were included in this analysis comprising 254 subjects. Results: Administration of GH significantly increased lean body mass (p < 0.01) and decreased fat mass (p < 0.01). In addition, GH increased the exercising levels of glycerol (p = 0.01) and free fatty acids (p < 0.01), but did not alter the respiratory quotient during exercise (p = 0.30). -
Hormone Abuse in Sports: the Antidoping Perspective
Asian J Androl 2008; 10 (3): 391–402 DOI: 10.1111/j.1745-7262.2008.00402.x .Review . Hormone abuse in sports: the antidoping perspective Osquel Barroso, Irene Mazzoni, Olivier Rabin Science Department, World Anti-Doping Agency (WADA), Montreal, Quebec H4Z 1B7, Canada Abstract Since ancient times, unethical athletes have attempted to gain an unfair competitive advantage through the use of doping substances. A list of doping substances and methods banned in sports is published yearly by the World Anti- Doping Agency (WADA). A substance or method might be included in the List if it fulfills at least two of the following criteria: enhances sports performance; represents a risk to the athlete’s health; or violates the spirit of sports. This list, constantly updated to reflect new developments in the pharmaceutical industry as well as doping trends, enume- rates the drug types and methods prohibited in and out of competition. Among the substances included are steroidal and peptide hormones and their modulators, stimulants, glucocorticosteroids, β2-agonists, diuretics and masking agents, narcotics, and cannabinoids. Blood doping, tampering, infusions, and gene doping are examples of prohibited methods indicated on the List. From all these, hormones constitute by far the highest number of adverse analytical findings reported by antidoping laboratories. Although to date most are due to anabolic steroids, the advent of molecular biology techniques has made recombinant peptide hormones readily available. These substances are gradu- ally changing the landscape of doping trends. Peptide hormones like erythropoietin (EPO), human growth hormone (hGH), insulin, and insulin-like growth factor I (IGF-I) are presumed to be widely abused for performance enhancement. -
Sportsletter Interview: Shaun Assael
SportsLetter Interviews December 2007 Volume 18, No. 6 Shaun Assael With the recent release of the Mitchell Report, the story of steroids in Major League Baseball has dominated sports coverage. The report states, “Everyone involved in baseball over the past two decades — Commissioners, club officials, the Players Association, and the players — shares to some extent in the responsibility for the steroids era. There was a collective failure to recognize the problem as it emerged and deal with it early on.” For all the hand-wringing about Major League Baseball’s mea culpa, the use of anabolic steroids and other performance- enhancing drugs has been sports’ dirty little not-so-secret for decades. In his book, “Steroid Nation: Juiced Home Run Totals, Anti-aging Miracles, and a Hercules in Every High School: The Secret History of America’s True Drug Addiction” (ESPN Books), ESPN staff writer Shaun Assael traces the culture of steroids in sports. The tale is about as long as the sub-title of the book, and Assael chronicles the many twists of this complex story. He writes about the long-forgotten “visionaries” (like Dan Duchaine, author of the “Underground Steroid Handbook”), the athletes who became caught in cycles of steroid abuse (NFL star Lyle Alzado) and the research scientists charged to nab them (UCLA’s Dr. Don Catlin). The result is a panoramic view of steroids in America — a view that echoes the Mitchell Report in placing responsibility for the spread of performance-enhancing drugs on just about everyone including the media 1 ©1996-2008 LA84 Foundation. Reproduction of SportsLetter is encouraged with credit to the LA84 Foundation. -
Final County Votes Give Obama Local Win Mccain Easily Wins with by BEN BROWN and County’S Vote Left to Be Counted, Reporting on Wednesday Morning, Percent
Potter Valley Weekend FORUM girls basketball entertainment Our readers write tops Geyserville .............Page 6 ..............Page 3 ..................................Page 4 INSIDE Mendocino County’s World briefly The Ukiah local newspaper ..........Page 2 Tomorrow: Partly sunny; H 64º L 38º 7 58551 69301 0 THURSDAY Feb. 7, 2008 50 cents tax included DAILY JOURNAL ukiahdailyjournal.com 16 pages, Volume 149 Number 304 email: [email protected] Final county votes give Obama local win McCain easily wins with By BEN BROWN and County’s vote left to be counted, reporting on Wednesday morning, percent. county’s GOP voters; ROB BURGESS New York Sen. Hillary Clinton Illinois Sen. Barack Obama appeared As of 11:30 p.m. Tuesday, Clinton The Daily Journal appeared to have the county in the to have won in Mendocino County, was leading Obama 44.08 percent to those who voted outside At 11:30 p.m. Tuesday night, with bag. What a difference a day makes. with 44.12 percent of the vote, fol- 40.13 percent. party invalidated ballots less than 8 percent of Mendocino With 100 percent of precincts lowed closely by Clinton with 42.34 See ELECTION, Page 15 PREPARATIONS UNDER WAY FOR THIS WEEKEND’S EVENT OF THE HEART RV man accused of threatening with knife Jailed on charges of attempted murder The Daily Journal A Redwood Valley man was arrested on charges of attempted murder Tuesday night after he allegedly threat- ened a woman with a kitchen knife over the weekend. According to reports from the Mendocino County Sheriff’s Office, the woman, a 64-year-old Redwood Valley resident, called sheriff’s deputies and told them she had been attacked by her roommate, John Ayotte, 66, of Redwood Valley. -
Spring 2009 Issue of the University of Denver Sports and Entertainment
UNIVERSITY OF DENVER SPORTS AND ENTERTAINMENT LAW JOURNAL VOLUME 6 Spring 2009 CONTENTS LETTER FROM THE EDITOR …………………………………………………………………………………………………..2 ARTICLES MAJOR LEAGUE BASEBALL AND THE ANTITRUST RULE: WHERE ARE WE NOW? ………………………..3 Harvey Gilmore GREAT EXPECTATIONS: CONTENT REGULATION IN FILM, RADIO, AND TELEVISION…………………….31 Alexandra Gil “FROM RUSSIA” WITHOUT LOVE: CAN THE SHCHUKIN HEIRS RECOVER THEIR ANCESTOR’S ART COLLECTION?………………………………………………..…………………………………...65 Jane Graham OPPORTUNISM, UNCERTAINTY AND RELATIONAL CONTRACTING – ANTITRUST IN THE FILM INDUSTRY………………………………………………………………………………………107 Ryan M. Riegg SHOULD THE GOVERNMENT FLEX ITS MUSCLES AND REGULATE STEROIDS N BASEBALL? WEAKNESSES IN THE PUBLIC HEALTH ARGUMENT......………………………………………………………………151 Connor Williams SOUTH BY SOUTHWEST 2009 CLE CONFERENCE – WHERE TRENDY ENTERTAINMENT MEETS TRENDS IN ENTERTAINMENT LAW……………………...…………………………………………………..…186 Paul Tigan 1 LETTER FROM THE EDITOR Dear Reader, Welcome to the Spring 2009 issue of the University of Denver Sports and Entertainment Law Journal. With this issue, we are excited to bring you insightful analysis and commentary focusing on a variety of legal topics within sports and entertainment law. Our goal is to provide compelling legal commentary on these industries, and with the hard work of our authors and editing staff, we are delighted to publish 6 articles presenting a variety of issues and perspectives. Anti-trust issues in Major League Baseball, government regulation of media content, and performance enhancing drugs in professional sports are among the topics our authors address in this edition of the Sports and Entertainment Law Journal. Additionally, a fellow law student from the University of Denver has written a review of the 2009 South-by-Southwest music and film conference. The students, professors, and practitioners of law that produce this commentary offer a valuable resource to our legal community. -
What Doctors and Scientists Are Saying About Human Growth Hormone in the Year 2003
What Doctors and Scientists Are Saying About Human Growth Hormone in the Year 2003. TABLE OF CONTENTS H1 Disclaimer H2 Introduction H3 A String of Successes H3_1 A simple description of the growth hormone system. H3_2 Growth hormone treatment of growth hormone deficiency in children. H3_3 Growth hormone treatment of growth hormone deficiency in adults. H3_4 Growth hormone treatment of children and adults with kidney failure. H3_5 Growth hormone and Prader-Willi syndrome. H3_6 Growth hormone and cystic fibrosis. H3_7 Human growth hormone and Turner Syndrome. H3_8 Growth hormone and severe burns. H3_8_1 The metabolic consequences of severe burns. H3_8_2 The benefits of growth hormone therapy for burns H3_8_3 The disadvantages of growth hormone treatment for burns. H3_8_4 Drug combinations may bring burn therapy progress. H3_9 Growth hormone can reduce wasting in critically ill patients. H3_10 The effects of axis hormones on skin and wound healing. H3_11 Growth hormone therapy in HIV-infected patients. H3_12 Conclusions about hGH-responsive medical conditions. H4 A Promising Disappointment: Growth Hormone and Ageing. H4_1 Ageing, bone strength and growth hormone. H4_2 Age, muscle loss (sarcopenia) and growth hormone. H4_2_1 A description of age-related sarcopenia H4_2_2 The causes of age-related sarcopenia. H4_2_3 Exercise is the best antidote to sarcopenia. H4_2_4 Growth hormone may modestly increase muscular strength in the elderly. H4_2_5 Growth hormone increases lean mass, but the benefit is uncertain. H4_2_6 Innervation changes may enhance muscle strength. H4_2_7 Growth hormone resistance. H4_2_8 Exercise induces growth hormone. H4_2_9 Obesity decreases growth hormone secretion. H4_2_10 Locally produced IGF-I may dominate age-related sarcopenia H4_2_11 GH inducers can strengthen muscles in the elderly. -
Proefschrift Door
STRIKING THE RIGHT BALANCE Effectiveness of Anti-Doping Policies ZOEKEN NAAR HET JUISTE EVENWICHT Effectiviteit van het anti-dopingbeleid (met een samenvatting in het Nederlands) Proefschrift ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de rector magnificus, prof.dr. G.J. van der Zwaan, ingevolge het besluit van het college voor promoties in het openbaar te verdedigen op vrijdag 18 november 2016 des middags te 2.30 uur door Olivier Matthijs de Hon geboren op 3 september 1972 te Amsterdam Promotor: Prof.dr. M. van Bottenburg Dit proefschrift werd mede mogelijk gemaakt met financiële steun van het Ministerie van Volksgezondheid, Welzijn en Sport. In mooie herinnering aan Julie, die altijd overal bij zal zijn In loving memory of Julie, who will always be present at all occasions Assessment Committee: Prof.dr. F.J.G. Backx (Utrecht University) Prof.dr. J.P.P.E.F. Boselie (Utrecht University) Prof.dr. J. Hoberman (University of Texas at Austin) Prof.dr. M.J. McNamee (Swansea University) Prof.dr. V. Møller (Aarhus University) On the day of thesis defence the Doctoral Examination Committee will also include: Prof.dr. M. van den Berg (Utrecht University) Prof.dr. M. Olfers (VU University Amsterdam) Prof.dr. S.H. Backhouse (Leeds Beckett University) The time to write this thesis was partially made available by means of a grant from the Dutch Ministry of Health, Welfare, and Sports. Printing this thesis has been financially enabled by Anti-Doping Authority Netherlands, also known as ‘Dopingautoriteit’. All views presented in this thesis are solely the individual views of the author and are by no means official policy statements of any organisation. -
A History of Media Influence on Major League Baseball Steroid Policies
Media Influence on MLB Steroid Policies Page 3 UNDER MOUNTING PRESSURE: A HISTORY OF MEDIA INFLUENCE ON MAJOR LEAGUE BASEBALL STEROID POLICIES Dan DeIuliis & David DeIuliis Dan DeIuliis studied Abstract military terminology in sports coverage in This research is interested in the relationships among media coverage, governmental the Department of legislation and Major League Baseball’s anabolic steroids testing policies. An analysis of Film/Video and patterns of media coverage, legislation, and adoption of tougher penalties are explored, Media Studies at Penn State followed by an analysis of specific legislation in an attempt to identify its specific goals and University. target populations. The paper first analyzes recent Supreme Court cases and current federal David DeIuliis is a legislation to determine if Congress acted legally in investigating Major League Baseball. Ph.D. student in the Beginning in the mid-1980s with the surfacing of these media reports and ending with Department of baseball’s toughest policy implementation in 2005, it then tracks the pattern of media Communication and Rhetorical Studies at coverage influencing the enactment of tougher penalties in baseball. Finally, it will examine Duquesne the goals and justifications of a specific piece of legislation, the Clean Sports Act of 2005. University. Because anabolic steroids remain a problem among teenage and amateur athletes, this revisitation of the issue from a communications perspective will allow administrators to more efficiently combat the problem and media professionals to more effectively cover it. Keywords: Major League Baseball, anabolic steroids, Congress, Clean Sports Act DeIuliis, D., & DeIuliis, D. (2012) Under mounting pressure: A history of media influence on Major League Baseball steroid policies. -
Peptides from Natural Or Rationally Designed Sources Can Be Used in Overweight, Obesity, and Type 2 Diabetes Therapies
molecules Review Peptides from Natural or Rationally Designed Sources Can Be Used in Overweight, Obesity, and Type 2 Diabetes Therapies Mayara C. F. Gewehr 1, Renata Silverio 2, José Cesar Rosa-Neto 3 , Fabio S. Lira 4, Patrícia Reckziegel 5 and Emer S. Ferro 1,* 1 Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, Brazil; [email protected] 2 Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis 88040-900, Brazil; [email protected] 3 Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, Brazil; [email protected] 4 Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente 19060-900, Brazil; [email protected] 5 Department of Pharmacology, National Institute of Pharmacology and Molecular Biology (INFAR), Federal University of São Paulo (UNIFESP), São Paulo 05508-000, Brazil; [email protected] * Correspondence: [email protected]; Tel.: +55-11-3091-7310 Received: 15 January 2020; Accepted: 25 February 2020; Published: 29 February 2020 Abstract: Overweight and obesity are among the most prominent health problems in the modern world, mostly because they are either associated with or increase the risk of other diseases such as type 2 diabetes, hypertension, and/or cancer. Most professional organizations define overweight and obesity according to individual body–mass index (BMI, weight in kilograms divided by height squared in meters). Overweight is defined as individuals with BMI from 25 to 29, and obesity as individuals with BMI 30. Obesity is the result of genetic, behavioral, environmental, physiological, ≥ social, and cultural factors that result in energy imbalance and promote excessive fat deposition. -
A Behavioral Law and Economics Approach to Legal Regulation of Doping in Sports Shayna M
Marquette Sports Law Review Volume 19 Article 7 Issue 1 Fall Are We All Dopes? A Behavioral Law and Economics Approach to Legal Regulation of Doping in Sports Shayna M. Sigman Follow this and additional works at: http://scholarship.law.marquette.edu/sportslaw Part of the Entertainment and Sports Law Commons Repository Citation Shayna M. Sigman, Are We All Dopes? A Behavioral Law and Economics Approach to Legal Regulation of Doping in Sports, 19 Marq. Sports L. Rev. 125 (2008) Available at: http://scholarship.law.marquette.edu/sportslaw/vol19/iss1/7 This Symposium is brought to you for free and open access by the Journals at Marquette Law Scholarly Commons. For more information, please contact [email protected]. ARE WE ALL DOPES? A BEHAVIORAL LAW & ECONOMICS APPROACH TO LEGAL REGULATION OF DOPING IN SPORTS SHAYNA M. SIGMAN* INTRODUCTION You should care about the prevalence of performance-enhancing drugs (PEDs) and doping methods currently being used and abused within elite sports. You should care, not because teenagers and youth are harmed by this, even though they most likely are. 1 You should care, not because elite athletes or those attempting to become elite athletes are harmed by this, even though they most likely are. 2 Whether you are a recreational athlete or a couch potato, whether you are a serious sports fan, a casual fan, or not a fan at all, you should care about the fact that it is highly likely that you have been harmed by doping in sports. Associate Professor of Law, Jacob D. Fuchsberg Touro Law Center. -
Growth Hormone, IGF-I and Insulin and Their Abuse in Sport
British Journal of Pharmacology (2008) 154, 542–556 & 2008 Nature Publishing Group All rights reserved 0007– 1188/08 $30.00 www.brjpharmacol.org REVIEW Growth hormone, IGF-I and insulin and their abuse in sport RIG Holt and PH So¨nksen Principal Investigators GH-2004 Project, Endocrinology and Metabolism Sub-Division, Developmental Origins of Adult Health and Disease Division, School of Medicine, University of Southampton, Southampton, UK There is widespread anecdotal evidence that growth hormone (GH) is used by athletes for its anabolic and lipolytic properties. Although there is little evidence that GH improves performance in young healthy adults, randomized controlled studies carried out so far are inadequately designed to demonstrate this, not least because GH is often abused in combination with anabolic steroids and insulin. Some of the anabolic actions of GH are mediated through the generation of insulin-like growth factor-I (IGF-I), and it is believed that this is also being abused. Athletes are exposing themselves to potential harm by self- administering large doses of GH, IGF-I and insulin. The effects of excess GH are exemplified by acromegaly. IGF-I may mediate and cause some of these changes, but in addition, IGF-I may lead to profound hypoglycaemia, as indeed can insulin. Although GH is on the World Anti-doping Agency list of banned substances, the detection of abuse with GH is challenging. Two approaches have been developed to detect GH abuse. The first is based on an assessment of the effect of exogenous recombinant human GH on pituitary GH isoforms and the second is based on the measurement of markers of GH action. -
Deanna Rusch* —Baseball Must Ascend and Aspire to the Highest Principles Œ of Integrity, of Professionalism, of Performance
MAJOR LEAGUE BASEBALL & DRUG TESTING: A LEGAL CRITIQUE OF THE CURRENT POLICY AND A LOOK AT THE FUTURE OF DRUG TESTING IN THE MLB Deanna Rusch* I. INTRODUCTION “Baseball must ascend and aspire to the highest principles – of integrity, of professionalism, of performance, of fair play within its rules.”1 Spoken by Bart Giamatti, former Commissioner of Major League Baseball (hereinafter “MLB”), that sentiment seems consistent with most public comments made by the MLB administration, team owners, union representatives and players. More specifically, the integrity issue often arises in public efforts to justify and/or promote drug testing within baseball. In a 1997 memorandum on drug policy, prevention and testing, addressed to all MLB clubs, current MLB Commissioner (then chairman) Bud Selig wrote, “[a]s in the past, the health and welfare of those who work in baseball will continue to be our paramount concern. No less compelling, however, is the need to maintain the integrity of the game.”2 Drug testing in baseball has been established in order to protect and promote the health and welfare of the players, to guard the integrity of the game, and to encourage professionalism in a sport that is a career for many. But does the current MLB drug testing policy actually address these concerns? Does the policy, along with its consequences, act as enough of a deterrent in order to achieve the goals it was implemented to accomplish? As Commissioner Selig and others push for a drug testing *Deanna Rusch, Gonzaga University School of Law, Juris Doctorate Candidate – May 2006. The author would like to thank Professor Vickie J.