Annual Report 2013

ANNUAL REPORT 2013

www.aasld.org CONTENTS

American Association for the Study of Liver Diseases 2013 Annual Report

AWARD RECIPIENTS: 2013 Research and Career Development Awards...... 2 2013 AASLD Abstract Awards...... 5 VISION: 2013 Distinguished Award Recipients...... 8 2013 AASLD Emerging Liver Scholar Resident Travel Award Program...... 10 To Prevent and Cure Liver Disease TRAIN/EDUCATE: New Developments in Transplant Hepatology Training...... 11 MISSION: American Board of Internal Medicine (ABIM)...... 11 The Liver Meeting®...... 11 To advance and disseminate Special Interest Groups (SIGs)...... 14 Single Topic Conferences...... 14 the science and practice of Digestive Disease Week...... 15 LiverLearning®...... 15 hepatology, and to promote liver AASLD Curriculum & Training (ACT)...... 15 ACT-on-HCV...... 15 health and quality patient care. Collaboration...... 16 Journals...... 17 Clinical Practice Guidelines...... 17 Online Expert Advice for Clinicians Treating Hepatitis C...... 18

EFFECT: Public Policy...... 19

FINANCIALS Financials...... 22

GOVERNANCE: Governing Board...... 24 Past Presidents...... 25 AASLD Staff...... 26

A ASLD 2013 Annual Report 1 2013 RESEARCH AND CAREER DEVELOPMENT AWARDS AWARD RECIPIENTS

The AASLD Research, Career Development, and Abstract Awards are the preeminent AASLD/Alpha-1 Foundation AASLD Sheila Sherlock Clinical awards for liver research and advanced hepatology training. In 2013, AASLD and The Liver Scholar Award and Translational Research AASLD Liver Research Fund committed over $2.4 million in funding for awards and A three-year basic science award of $225,000 Award in Liver Diseases

AWARD RECIPIENTS AWARD fellowships. This level of funding represents the largest single commitment in support ($75,000/year) with a focus on alpha-1-antitrypsin This two-year clinical research and/or translational of liver research and advanced hepatology training by any professional organization. deficiency-associated liver disease. research award of $150,000 ($75,000/year) is intended This award was established in recognition of to foster career development for young investigators AASLD and the AASLD Liver Research Fund are able to provide funding at a critical the 50th anniversary of the discovery of Alpha-1 performing clinical and/or translational research in time in the careers of young investigators and other healthcare providers, which may Antitrypsin Deficiency. a liver-related area who have shown commitment to encourage them to pursue careers in hepatology. We support three types of Awards: excellence at an early stage in their research study. Andrew Chu, MD This award is named in honor of Dame Sheila Sherlock • Multi-Year Research Awards in Basic, Clinical, and Translational Research Children’s Hospital of Pittsburgh of UPMC Pittsburgh, PA for her pioneering research and dedication to young MENTOR: David Perlmutter, MD research fellows which helped elevate hepatology to • One-Year Career Development Awards to encourage front- RESEARCH PROJECT: Mechanisms of action the discipline it is today. line providers to pursue specialized training in hepatology for autophagy enhancer drugs on alpha-1- antitrypsin deficiency-associated liver disease Monika A. Sarkar, MD, MAS • Abstract Awards which allow young investigators the opportunity to present AASLD gratefully acknowledges funding for the 2013 AASLD/ University of California, San Francisco their outstanding research to an international audience at The Liver Meeting® Alpha-1 Liver Scholar Award from Alpha-1 Foundation, and donors San Francisco, CA to the New Challenges-New Solutions Campaign and The AASLD MENTOR: Marion Peters, MD Liver Research Fund. RESEARCH PROJECT: Racial/ethnic Differences in The AASLD awards program has a proven track record of success. Fibrosis Progression in HIV/HCV Co-Infected Women Since 2000, AASLD has funded over $32 million in awards. AASLD Career Development AASLD gratefully acknowledges funding for the 2013 Sheila in Liver Transplantation Sherlock Clinical and Translational Research Award from Genentech and donors to the New Challenges-New Solutions AASLD Liver Scholar Award Leela L. Paris, PhD In Memory of the University of Michigan Campaign and The AASLD Liver Research Fund. A three-year basic science award of $225,000 Indiana University Transplant Team Indianapolis, IN ($75,000/year) that is designed to bridge the gap AASLD Clinical and Translational MENTOR: A. Joseph Tector, PhD A two-year award of $90,000 ($45,000/year) designed between completion of research training and attaining RESEARCH PROJECT: The study of SIRP and ASGR1 to foster career development for an individual Research Award in Liver Diseases status as an independent research scientist and in platelet phagocytosis by the porcine liver performing clinical and/or translational research in This two-year clinical research and/or translational encourage young investigators to pursue a career the field of liver transplantation and who has shown research award of $150,000 ($75,000/year) is intended in liver-related research. The additional research Wei Qiu, PhD commitment to excellence in the field at an early stage to foster career development for young investigators experience provided by this award enables young Loyola University Chicago in their career. performing clinical and/or translational research in Chicago, IL researchers to successfully compete for research a liver-related area who have shown commitment to MENTOR: Tarun Patel, PhD This award was established to honor the Transplant grants from national sources, particularly the National excellence at an early stage in their research study. RESEARCH PROJECT: Repress HCC Survival Flight Team whose transport crashed over Institutes of Health (NIH). development by inhibiting PUMA Lake Michigan on June 4, 2007 on the return leg of an Brittany N. Bohinc, MD Baran A. Ersoy, PhD AASLD gratefully acknowledges funding for the 2013 Liver organ procurement mission. This award honors those Scholars from AbbVie, Genentech, Merck, and donors to the Duke University Brigham and Women’s Hospital New Challenges-New Solutions Campaign and The AASLD Liver dedicated to life-saving organ transplantation. Durham, NC Boston, MA Research Fund. MENTORS: Anna Mae Diehl, MD, and MENTOR: David Cohen, MD, PhD Michael G. Hughes, Jr., MD Manal Abdelmalek, MD, MPH RESEARCH PROJECT: Molecular control of hepatic insulin University of Louisville School of Medicine RESEARCH PROJECT: Non-Alcoholic Fatty Liver Disease Is signaling by phosphatidylcholine transfer protein Louisville, KY Associated With Systemic and Hepatic Hypothyroidism MENTOR: Craig J. McClain, MD AASLD gratefully acknowledges funding for the 2013 Clinical Cara T. Pager, PhD RESEARCH PROJECT: Role of Envelope and Translational Research Award from Merck and donors to the Protein Glycosylation Sites in Hepatitis University at Albany, State University of New York New Challenges-New Solutions Campaign and The AASLD Liver C Viral Infection of Liver Allografts Research Fund. Albany, NY MENTOR: Peter Ells, MD AASLD gratefully acknowledges funding for the 2013 Clinical and Translational Research Award from Astellas USA Foundation and RESEARCH PROJECT: The Role of RCK/p54 donors to the New Challenges-New Solutions Campaign and The in hepatitis C virus gene expression AASLD Liver Research Fund.

2013 Liver Scholar Awards Recipients

2 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 3 AWARD RECIPIENTS

AASLD Advanced/Transplant 2013 AASLD Abstract Awards Hepatology Fellowship Provides $60,000 in salary and benefit support for Fellow Research Award Student Research Award

AWARD RECIPIENTS AWARD gastroenterology (GI) fellows pursuing an additional full-year of training focused on patient care in 2013 NP/PA Recipients A $1,000 award presented for the best abstract A $1,000 award presented for research conducted by a ® advanced/transplant hepatology. The intent of the submitted to The Liver Meeting by a fellow. graduate or undergraduate student. The recipient must Jennifer M. Vittorio, MD be a primary contributor on the project. program is to prepare the trainees to be eligible for Columbia University Alexandra Menchise, MD certification in transplant hepatology by the American New York, NY Cincinnati Children’s Hospital Medical Center Camilla Pilati, PhD MENTOR: Joel Lavine, MD, PhD Board of Internal Medicine (ABIM) and/or the American Cincinnati, OH INSERM U674 Board of Pediatrics (ABP). AASLD gratefully acknowledges funding for the 2013 Advanced/ ABSTRACT TITLE: Heterozygosity for deleterious Paris, France Transplant Hepatology Fellowship Program from AbbVie, Astellas mutations in Abcb4 is associated with a ABSTRACT TITLE: Integrative genomic profiling Monique L. Choquette, MD USA Foundation, Gilead Sciences, Merck, Janssen Pharmaceutical pro-inflammatory hepatic transcriptome predisposing of hepatocellular adenomas identify mutational Companies, Salix Pharmaceuticals, and donors to the New neonatal mice to cholestatic liver injury processes involved in malignant transformation Cincinnati Children’s Hospital Medical Center Challenges-New Solutions Campaign and The AASLD Liver Research Fund. Cincinnati, OH AASLD gratefully acknowledges funding for the 2013 Fellow AASLD gratefully acknowledges funding for the 2013 Student MENTOR: John Bucuvalas, MD Research Award is made possible through a grant from the Research Award is made possible through a grant from the SunTrust Foundation. AASLD NP/PA Clinical SunTrust Foundation. Matthew G. Deneke, MD Mayo Clinic in Rochester Hepatology Fellowship Pediatric Research Award PSC Partners Seeking a Cure Award Rochester, MN Provides $78,000 in salary and benefit support for A $1,000 award presented for the best abstract A $3,000 award presented to the investigator MENTOR: Kymberly Watt, MD certified and licensed physician assistants (PA) or nurse ® submitted to The Liver Meeting by a physician/ presenting the most promising PSC research at The practitioners (NP) pursuing a full year of training focused Chanda K. Ho, MD, MPH scientist with a primary appointment affiliation in a Liver Meeting®. University of California, San Francisco on clinical care in hepatology. This award is designed to department of pediatrics. San Francisco, CA increase the number of associate practitioners in clinical James H. Tabibian, MD MENTOR: Norah Terrault, MD, MPH hepatology; thereby increasing access for liver disease Alexander Wree, MD Mayo Clinic in Rochester patients to well-trained clinicians. University of California, San Diego Rochester, MN San Diego, CA ABSTRACT TITLE: Cholangiocyte senescence ABSTRACT TITLE: NLRP3 inflammasome activation results via N-Ras activation is a characteristic Danielle E. Cardona, PA-C in hepatocyte pyroptosis, liver inflammation and fibrosis of primary sclerosing cholangitis The University of North Carolina at Chapel Hill Chapel Hill, NC AASLD gratefully acknowledges funding for the 2013 Pediatric AASLD gratefully acknowledges funding for the 2013 PSC Partners MENTOR: Jama M. Darling, MD Research Award is made possible through a grant from the Seeking a Cure Award from PSC Partners. SunTrust Foundation. Melissa Ferrari, PA-C Hospital of the University of Pennsylvania Resident Research Award Philadelphia, PA The purpose of this $1,000 award is to recognize high MENTOR: K. Rajender Reddy, MD 2013 Advanced Hepatology Awards Recipients quality research undertaken by a resident in training. Christine C. Hsu, MD Ann E. (Hagan) Burke, CRNP, FNP-BC The recipient must be a primary contributor on the Columbia University Thomas Jefferson University project and committed to a career in liver disease. New York, NY Philadelphia, PA MENTOR: Robert Brown, MD, MPH MENTOR: Steven K. Herrine, MD Phillip Levine, MDCM Scott & White Hospital, Texas A&M Brian Kim, MD Melissa R. Laycock, APRN, FNP-BC HSC College of Medicine Mount Sinai School of Medicine Kansas University Medical Center Temple, TX New York, NY Kansas City, KS ABSTRACT TITLE: The role of stem cell MENTOR: Thomas Schiano, MD MENTOR: Richard K. Gilroy, MD derived microvesicles and microRNAs during alcoholic liver injury 2013 AASLD Abstract Awards Recipients Ming Valerie Lin, MD Jordan Mayberry, PA-C Massachusetts General Hospital UT Southwestern Medical Center Boston, MA Dallas, TX MENTOR: Raymond T. Chung, MD MENTOR: William Lee, MD

AASLD gratefully acknowledges funding for the 2013 NP/PA Clinical Marina Serper, MD Hepatology Fellowship Program from Janssen Pharmaceuticals, Hospital of the University of Pennsylvania Salix Pharmaceuticals, Vertex Pharmaceuticals, and donors to the Philadelphia, PA New Challenges-New Solutions Campaign and The AASLD Liver Research Fund. MENTOR: K. Rajender Reddy, MD

4 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 5 AWARD RECIPIENTS

Liver Transplant and/or Professor Margit Hamosh Cristina Cudalbu, PhD Irina Tikhanovich, PhD École Polytechnique Fédérale De Lausanne (EPFL) Kansas University Medical Center Hepatobiliary Surgery Award Travel Award Lausanne, Switzerland Kansas City, KS These $1,000 travel awards enable liver transplant This $2,500 memorial travel award was established ABSTRACT TITLE: In vivo brain energy ABSTRACT TITLE: Hepatitis C induced inhibition metabolism in a rat model of chronic Hepatic of arginine methylation activates antioxidant

AWARD RECIPIENTS AWARD and/or hepatobiliary surgery fellows submitting to honor the memory of Dr. Margit Hamosh’s life ® Encephalopathy using 31P MRS functions of the FOXO3 transcription factor abstracts for The Liver Meeting to receive and legacy. The award is presented to a fellow or through the ubiquitin hydrolase USP7 travel support. junior investigator who submits the most outstanding Ramy El-Diwany abstract on hepatocellular carcinoma research for The Johns Hopkins School of Medicine Laura Wozniak, MD, MS Christoph Tschuor, MD ® Liver Meeting . Baltimore, MD University of California, Los Angeles University Hospital Zurich ABSTRACT TITLE: Acute Hepatitis C Los Angeles, CA Zurich, Switzerland Tsunekazu Oikawa, MD, PhD Infection is Associated with an Increase ABSTRACT TITLE: Complement Binding Donor ABSTRACT TITLE: Activation of the Constitutive in Circulating microRNA-122 Specific Antibodies are Associated with Late Graft Androstane Receptor (CAR) reverses deficient liver UNC Lineberger Comprehensive Cancer Center of the Dysfunction Following Pediatric Liver Transplantation regeneration in the Small-For-Size Syndrome via University of North Carolina School of Medicine Chapel Hill, NC Foxm1b and miR375/YAP-dependent pathways AASLD acknowledges funding for the 2013 Young Investigator ABSTRACT TITLE: Human Fibrolamellar Hepatocellular Gene Im, MD Mount Sinai School of Medicine Travel Awards is made possible through an independent grant Carcinomas: Evidence for their Derivation from from Merck. Federico Piñero Fernandez Casares, MD Biliary Tree Stem Cell Subpopulations New York, NY ABSTRACT TITLE: Initial Single-Center Hospital Universitario Austral AASLD gratefully acknowledges the donors to the AASLD Liver Experience in the United States with Early Liver Buenos Aires, Argentina Midlevel Professional Awards Research Fund whose gifts support funding for the 2013 Professor Transplantation for Severe Alcoholic Hepatitis ABSTRACT TITLE: Risk Factors of Neurologic Margit Hamosh Travel Award. These $500 awards are presented for the best Events after Liver Transplantation: Towards abstracts submitted to The Liver Meeting® by an a Prognostic Risk Score Assessment Davide Povero, PhD associate member. AASLD gratefully acknowledges funding for the 2013 Liver University of California, San Diego Transplant and/or Hepatobiliary Surgery Award is made San Diego, CA Geri Hirsch, NP possible through a grant from Ikaria. ABSTRACT TITLE: Hepatocytes-derived microparticles released during lipotoxicity induce hepatic Capital District Health Authority stellate cells activation and migration Halifax, Canada Edmund J. Bini, MD Travel Award ABSTRACT TITLE: Canadian Experience Developing Viral This $2,500 memorial travel award was established Hepatitis Nursing Standards and Competencies Yoon Seok Roh, DVM, PhD to honor Dr. Edmund Bini’s outstanding career as a University of California, San Diego clinician and researcher. The award is presented to San Diego, CA Amy Nelson, BSN, RN, ACRN a fellow or junior investigator who submits the most ABSTRACT TITLE: Hepatocyte gp130-mediated National Institute of Allergy and Infectious Diseases/ National Institutes of Health outstanding abstract on clinical hepatitis C research Signaling promotes hepatocellular carcinogenesis through activation of mTORC1 and Stat3 Bethesda, MD for The Liver Meeting®. ABSTRACT TITLE: Impact of Pre-existing Mental Health Disorders on Adherence and Sustained Partha Chandra, PhD 2013 Young Investigator Travel Awards Recipients Barry Schlansky, MD, MPH Virologic Response with an Interferon-Free Trial of Tulane University Health Sciences Center Oregon Health & Science University Sofosbuvir and Ribavirin for Chronic Hepatitis C New Orleans, LA Portland, OR ABSTRACT TITLE: Persistently Infected Young Investigator Travel Awards ABSTRACT TITLE: Wait List Time Predicts Survival Hepatitis C Virus Cell Culture Impairs Type after Liver Transplantation for Hepatocellular I But Not The Type III IFN Signaling These $500 travel awards enable young investigators Carcinoma: A Cohort Study in the UNOS Registry ® AASLD gratefully acknowledges the donors to the AASLD Liver submitting abstracts for The Liver Meeting to receive Research Fund whose gifts support funding for the 2013 Dr. travel support. Soona Shin, PhD, MS Edmund J. Bini Travel Award. University of Pennsylvania Hawwa Alao, MD Philadelphia, PA National Institutes of Health Bethesda, MD ABSTRACT TITLE: The Role of Keap1/Nrf2 in Modulating ABSTRACT TITLE: Global microRNA profiling Redox Status of Hepatic Progenitor Cells reveals complex interactions among hepatic microRNA regulation, hepatitis C virus infection and interferon response

2013 AASLD Midlevel Professional Awards Recipients

6 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 7 DISTINGUISHED AWARD RECIPIENTS 2013 DISTINGUISHED AWARD RECIPIENTS

AASLD Distinguished AASLD Distinguished Service Award Dr. Suchy’s research has been funded by the National He returned to Cleveland in 1980 and became a Institutes of Health for over three decades. The focus of Professor of Medicine at Case Western Reserve School Achievement Award The AASLD Distinguished Service Award is given to an his work has been on the biology and pathobiology of of Medicine and a gastroenterologist at MetroHealth The AASLD Distinguished Achievement Award is individual in honor of his or her sustained service to liver transport systems that contribute to bile formation. Medical Center, where he became Division Chief in given to an individual in honor of his or her sustained AASLD or the liver disease community in general. The He has also had a long-standing clinical focus on 1991. In 2006, he took the position of Chairman of the scientific contributions to the field of liver disease and award recognizes service provided to the community pediatric liver disease, and in addition to publication of Cleveland Clinic Department of Gastroenterology and the scientific foundations of hepatology. The award of hepatology researchers and clinicians over an many reviews, case reports, and book chapters, he is Hepatology and Professor of the Lerner College of honors a sustained contribution rather than a single extended period; service that is well above and beyond an editor of a comprehensive textbook entitled “Liver Medicine of Case Western Reserve and Vice Chairman discovery or major achievement. The awardee need that provided by many members who serve on the Disease in Children” which is now in its 4th edition. for research and education for the Digestive Disease not be a member of AASLD and may be a non-scientist Governing Board and Committees of AASLD. The

DISTINGUISHED AWARD RECIPIENTS DISTINGUISHED AWARD Institute. He is currently the director of research for the but the contribution should be solidly in the area of liver awardee need not be a member of AASLD. Dr. Suchy is currently Chief Research Officer, Director Digestive Disease Institute at the Cleveland Clinic. disease, physiology, anatomy or pathology. of The Children’s Hospital Colorado Research Institute, Frederick J. Suchy, MD Professor of Pediatrics and Associate Dean for Child Over his career, Dr. McCullough has received multiple Professor Roger Williams, CBE, MD, University of Colorado School of Medicine Health Research, University of Colorado School of institutional teaching awards, motivated numerous FRCP, FRCS, FRCPE, FRACP, Aurora, CO Medicine, Aurora, CO. young physicians, and maintained a clinical excellence enthusiastically endorsed by his patients. He has been Frederick J. Suchy, MD graduated FMedSci, FRCPI (Hon), FACP (Hon) named one of the Best Doctors in America and one of from the University of Cincinnati AASLD Distinguished Clinician Foundation for Liver Research the top 75 gastroenterologists in the country, co-authored London, United Kingdom College of Medicine in 1974. He Educator/Mentor Award two books on nonalcoholic fatty liver disease and completed pediatric residency and The Distinguished Clinician Educator/Mentor Award Prof. Williams’ career in hepatology chaired NIH-funded research on fatty liver disease. Dr. fellowship training in pediatric is given in honor of the sustained service of clinician began in 1959 when he was McCullough has received research and achievement gastroenterology and hepatology at educators to AASLD or the liver community in general. appointed as Lecturer in Medicine awards from the American Diabetes Association, Cincinnati Children’s Hospital The award recognizes the skills of outstanding clinicians at the Royal Free Hospital by the the Cleveland Foundation and the American Liver Medical Center with Drs. William K. and educators who have made momentous contributions late Professor Dame Sheila Foundation, and served as president of the American Schubert and William F. Balistreri. He subsequently was to hepatology over an extended period. The awardee Sherlock. He worked at King’s Association for the Study of Liver Diseases in 2008. Chief of Pediatric Gastroenterology and Hepatology at need not be a member of AASLD. College London from 1966 to Yale University (1988-1996) and Chair of Pediatrics at Dr. McCullough’s primary research interests include 1996 where he established the Mount Sinai School of Medicine (1996-2009). Arthur J. McCullough, MD the study of non-alcoholic steatohepatitis and alcoholic Institute of Liver Studies and served as its first Director. steatohepatitis, abnormal energy and protein metabolism Dr. Suchy has contributed to the AASLD and the Digestive Disease Institute at the Cleveland Clinic In 1968 he was involved in the first liver transplant in in cirrhosis, and nutritional and pharmacologic strategies hepatology community in many capacities including Cleveland, OH the United Kingdom. to address malnutrition in chronic liver disease. He is a memberships on the Research Committee, the Education Arthur J. McCullough, MD, received leader in research of nonalcoholic fatty liver disease, a In 1973 he created the Foundation for Liver Research Committee, several Strategic Planning Committees, and his MD degree from the State disease that affects nearly all fields of clinical medicine which has become the United Kingdom’s leading search committees for the AASLD executive director and University of New York (SUNY) at and is the most common form of chronic liver disease in gastroenterological charity. In 1996 he moved to an editor for HEPATOLOGY. He was elected to the AASLD Syracuse in 1974. After his internal the United States. University College London where he established and governing board (1999–2004), and served as President in medicine and chief medical directed the Institute of Hepatology. 2003. He has chaired the Scientific Advisory Committee residency at the Cleveland Clinic in He has published over 2,500 papers, journals and books for Pediatric Liver Diseases of the American Liver Cleveland, OH, Dr. McCullough and served on over 20 editorial boards. He is a Fellow of Foundation, and was the Vice Chair for Scientific Affairs, briefly considered a career in the Academy of Medical Sciences and is the recipient of National Board of Directors, American Liver Foundation cardiology before becoming a G.I. fellow at the Mayo numerous honorary fellowships and awards including the (2006–2010). Clinic in Rochester, MN. While there, he earned the Gold Medal of the Canadian Liver Foundation (1992), the prestigious J. Arnold Bargen Award for clinical, research, American Society of Transplantation Senior Achievement and teaching excellence. Award (2004), the Hans Popper Lifetime Achievement Award (2008) and the Distinguished Service Award of the International Liver Transplant Society (2011). His main clinical and research interests are in acute liver failure and liver transplantation.

8 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 9 TRAIN/EDUCATE TRAIN/EDUCATE 2013 AASLD Emerging Liver Scholar New Developments in Transplant Hepatology Training: Milestones, EPAs and the In-training Examination Resident Travel Award Program 2013 marked many important changes in graduate medical education. The Accreditation Council

AWARD RECIPIENTS AWARD for Graduate Medical Education (ACGME) introduced the next phase of competency-based training Ahmed Akhter, MD Neha R. Jakhete, MD Joshua R. Peck, MD for residency and fellowship programs, called the Next Accreditation System (NAS). Of the key University of Wisconsin Johns Hopkins Hospital Wexner Medical Center at The Ohio Hospital and Clinics MENTOR: Ayman Koteish, MD State University NAS performance indicators, much of the current focus is on milestones. AASLD participated in the MENTOR: Adnan Said, MD MENTOR: Jim Hanje, MD Daniel Joyce, MD development of the subspecialty reporting milestones, which are modeled closely on the Internal Pranab M. Barman, MD Cleveland Clinic Joseph Roberts, MD Medicine reporting milestones. AASLD was a key participant in the development of Entrustable University of Michigan Health System MENTOR: John J. Fung, MD University of Colorado Anschutz MENTOR: Grace Su, MD Medical Campus Professional Activities (EPAs) for Gastroenterology training, which includes the necessary Rachel Kohn, MD MENTOR: Kiran Bambha, MD development of competency in general hepatology. Jihane N. Benhammou, MD Massachusetts General Hospital University of California, Los Angeles MENTOR: Parsia A. Vagefi, MD Nitzan C. Roth, MD MENTOR: Simon Beaven, MD University of California Los Angeles Jeffrey P. LaFond, MD MENTOR: Neil Kaplowitz, MD American Board of Internal Medicine (ABIM) Ruchi Bhatia, MA University of Virginia AASLD collaborated with ABIM in 2012 to create a three-year competency-based pilot program Saint Louis University Hospital MENTOR: Neeral Shah, MD Suzanne R. Sharpton, MD MENTOR: Brent Tetri, MD University of California San Francisco in gastroenterology-transplant hepatology training. Now in its second year, the pilot program is a Christina C. Lindenmeyer, MD MENTOR: Oren Fix, MD qualitative success in the use of competency-based training concepts, while also effectively reducing Kristin E. Burke, MD Thomas Jefferson University Hospital Beth Israel Deaconess Medical Center MENTOR: Jonathan M. Fenkel, MD Shazia M. Siddique, MD the length of training required to become a board-certified Transplant Hepatologist. MENTOR: Simon Robson, MD Johns Hopkins Hospital Lisa M. McElroy, MD MENTOR: James Hamilton, MD David T. Chao, MD Northwestern University The Liver Meeting® 2013—Science, Technology and Collaboration University of Pittsburgh Medical Center MENTOR: Daniela P. Ladner, MD Amber L. Tierney, MD MENTOR: Mindie Nguyen, MD Washington University/ The Liver Meeting® was designed specifically to educate researchers and clinicians on the dynamic Adam Mikolajczyk, MD Barnes-Jewish Hospital Cynthia E. Cherfane, MD The University of Chicago MENTOR: Kevin Korenblat, MD changes in the field of hepatology, to connect leading scientists from around the world, and to University of Iowa Hospitals and Clinics MENTOR: Andrew Aronsohn, MD incorporate technological solutions to enhance the attendee experience. MENTOR: Michael Voigt, MD Nicole M. Welch, MD John T. Miura, MD University of Chicago Jacqueline J. Choi, MD MENTOR: Nancy Reau, MD Medical College of Wisconsin During our first ever meeting in Washington, DC, Debrief. ePosters allow an attendee to interact with University of Illinois at Chicago MENTOR: T. Clark Gamblin, MD Medical Center Ju Dong Yang, MD more than 8,800 health professionals from 96 the poster presenters virtually to extend the poster MENTOR: Grace Guzman, MD Omar Y. Mousa, MD University of Arkansas for Medical countries met to exchange groundbreaking research hall experience. LiverLearning®—available to all SUNY—Upstate Medical University Sciences/Mayo Clinic Doan Y. Dao, MD and progressive clinical treatments in liver disease. registrants of the meeting and AASLD members— MENTOR: Victor Ankoma-Sey, MD MENTOR: Lewis R. Roberts, MD The University of Texas Southwestern In addition to the educational sessions, the exhibit hosts a number of sessions captured during the Elizabeth X. Zheng, MD Medical Center Nirah S. Patel, MD hall provided attendees the opportunity to further meeting for on-demand viewing. Our Twitter feed was MENTOR: William M. Lee, MD University of California at San Diego Albert Einstein College of Medicine/ Medical Center Montefiore Medical Center their awareness of products and services available also streamed into the general session room keeping Nicholas J. Day, MD MENTOR: Rohit Loomba, MD MENTOR: Allan Wolkoff, MD to them. More than 1,000 exhibit staff representing attendees in the loop on the meeting chatter. University of Michigan 83 companies including industry, publishing, non- MENTOR: Anna Suk-Fong Lok, MD The Liver Meeting® 2013 attendance, scores, profit organizations and more were on hand to evaluations and comments reflect a meeting that is Albert Do, MD interact with attendees. Yale-New Haven Hospital maintaining its credibility and increasing its popularity MENTOR: Guadalupe Garcia-Tsao, MD Expanding on the in-person experience, AASLD within the hepatology community. The Liver Meeting® Mohannad F. Dugum, MD offered a meeting app which included all accepted 2014 will be in Boston, Massachusetts. Cleveland Clinic Foundation abstracts, ePosters, LiverLearning®, and, for the MENTOR: Nizar Zein, MD first time, a livestream webcast of the Hepatitis Moria B. Hilscher, MD Mayo School of Graduate Medical Education MENTOR: Vijay Shah, MD 2013 Emerging Liver Scholar Resident Travel Award Recipients

10 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 11 TRAIN/EDUCATE

Postgraduate Course of hepatology’s growing importance as a medical Leon Schiff State-of-the-Art Lecture to one that saves thousands of lives annually. A specialty by providing participants the opportunity to HCV Therapeutics in the Post-Interferon Era: More restricted fund has been established to support The AASLD Postgraduate Course on New exchange research, discuss outcomes, and interact than the Sum of its Parts? delivered by Robert the lecture in perpetuity and AASLD gratefully Treatments in Liver Disease: A New Era of

TRAIN/EDUCATE with colleagues focused on liver and biliary diseases. Schooley, MD, discussed the role of innate immune acknowledges the donors to this fund, which Diagnostics, Therapeutics and Intervention in evasion mechanisms of HCV in establishing includes Astellas USA, for their support. Hepatology; Course Directors: Adrian M. Di ® and maintaining chronic infection in the liver, Bisceglie, MD and Paul Martin, MD highlighted Invited Lectures at The Liver Meeting Hyman J. Zimmerman Hepatotoxicity and identified the potential implications of viral significant issues of liver research facing physicians State-of-the-Art Lecture The offering of groundbreaking research by top dynamics and replication fidelity as barriers to the today. This course provided 3,200 learners with William Lee, MD, delivered a lecture titled scientists in their specific areas of hepatobiliary research pharmacologic cure of HCV infection. Acetaminophen and the Liver: Poison or Panacea? a comprehensive overview of the state-of-the-art continued to be a priority. The lectures featured: advances in the management of chronic liver This annual lecture recognizes Dr. Schiff’s work that focused on possible reasons for this diseases based on the latest in both basic and Global Forum to elevate the study and practice of hepatology persistent challenge and areas to explore for future clinical research. The global forum focused on the world-wide to the discipline it is today. A restricted fund remediation of the problem. public health epidemic of liver diseases caused by has been established to support the lecture in The annual presentation of this lecture continues excessive alcohol use or obesity and the metabolic perpetuity and AASLD gratefully acknowledges the Scientific and Educational Activities to recognize Dr. Zimmerman’s contributions to the syndrome. The aim of this program was to develop a National Genetics Institute for their generous support at The Liver Meeting® field by providing valuable insights on liver toxicity discussion on this topic among the five major regions of this program. and injury. A restricted fund has been established AASLD offers scientific educational activities that of the world, North America, Europe, Latin America, Thomas E. Starzl Transplant Surgery to support the lecture in perpetuity and AASLD are developed by leading hepatologists. Each Asia, and Africa. The discussion addressed the most State-of-the-Art Lecture gratefully acknowledges Eli Lilly and Company for activity features expert speakers presenting the important public health problems regarding fatty liver Anthony Atala, MD, delivered his lecture on their generous support of this program. finest data in the most current and critical topics diseases in each of these regions. Regenerative Medicine: New Approaches to of liver disease. President’s Choice Lecture Hepatitis Debrief Healthcare that described the field of tissue The President’s Choice lecture, Random Germline More than 3,100 abstracts were submitted. 72% This session provided a synthesis of new data on engineering and regenerative medicine, and Mutagenesis in the Analysis of Immunity, delivered by were accepted for oral and poster presentation with the treatment of viral hepatitis presented at The explained current research and clinical applications Nobel Laureate Bruce Beutler, MD, described how a 203 receiving recognition as a Poster of Distinction. Liver Meeting® 2013. Attendees left this session with in regenerative medicine. classical genetic approach can be used to provide Thirty-nine scientific sessions were conducted to practical knowledge of cutting-edge therapies for This annual lecture recognizes the pioneering a list of the causes of inherited disease and how it present the most up-to-date research available in chronic hepatitis C. Additionally, for the first time, this work that Dr. Starzl has done to elevate liver has become practical to saturate the genome of the the field. The oral sessions were complemented program was live streamed to allow participation by transplantation from an experimental procedure mouse with mutations and assign cause and effect. by more than 40 interactive posters sessions. those who could not attend in person.

AASLD activities meet the increasing demand Hans Popper Basic Science State-of-the-Art Lecture In his lecture titled Alpha-1 Antitrypsin Deficiency: Novel Treatment Strategies Fifty Years After Discovery, David Perlmutter, MD, described the history of the disease, what we have learned about its unique clinical sequellae and novel treatment strategies that originated from understanding the unique pathobiology.

This annual lecture recognizes Dr. Popper, the founder of the American Association for the Study of Liver Diseases (AASLD), for his role in the establishment of HEPATOLOGY and his promotion of the intellectual spirit of the Association.

12 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 13 TRAIN/EDUCATE

Special Interest Groups (SIGs) Digestive Disease Week LiverLearning® Expanding on the existing 12 SIGs, the Governing Board approved the creation of a Clinical Practice DDW is sponsored through the partnership of four As AASLD’s official eLearning portal, LiverLearning® leading medical societies focused on the digestive has continued to grow in both content and reputation. SIG in 2013 to address the needs of AASLD members in the clinical community. Their mission is in ® TRAIN/EDUCATE system: AASLD, American Gastroenterological In 2013, AASLD launched the LiverLearning mobile development with full formation of the group expected by the end of 2014. Association (AGA), American Society for application for Apple and Android, allowing the user to Gastrointestinal Endoscopy (ASGE), and The Society view all webcasts and ePosters available on the portal At The Liver Meeting® 2013, two of the six programs developed and presented by SIGs were for Surgery of the Alimentary Tract (SSAT). As a in a mobile format. LiverLearning® now has hundreds collaborations by multiple SIGs and the Liver Transplantation and Surgery SIG introduced a poster tour sponsoring society with a strong presence and an of hours of webcasts, over 6,000 abstracts, and over mentorship program. There are currently 2,755 SIG members that participate in the following groups: excellent liver and biliary tract education program, 2,300 ePosters. AASLD’s successful liver-specific sessions include state-of-the-art presentations, clinical symposia, • Acute on Chronic Liver Failure • Liver Cell Biology in Hepatic Disease presidential plenaries, research fora, poster CHAIR: Jasmohan Bajaj, MD CHAIR: Mark A. McNiven, PhD presentations, and a Research Highlights session • Cholestatic Liver Disorders • Liver Fibrosis devoted to Hepatology: The Year in Review. CHAIR: Saul J. Karpen, MD, PhD CHAIR: Natalie Torok, MD • Hepatitis B • Liver Transplantation and Surgery CHAIR: Brian J. McMahon, MD CHAIR: David C. Mulligan, MD • Hepatitis C • Pediatric Liver Disorders CHAIR: Michael W. Fried, MD CHAIR: Regino Gonzalez-Peralta, MD • Hepatobiliary Neoplasia • Portal Hypertension CHAIR: Gregory J. Gores, MD CHAIR: Guadalupe Garcia-Tsao, MD • Hepatotoxicity • Steatosis and Steatohepatitis CHAIR: Robert J. Fontana, MD CHAIR: Naga P. Chalasani, MD

AASLD Curriculum & Training (ACT) ACT-on-HCV Single Topic Conferences Attendee evaluations suggested these conferences meet their objectives, provide excellent interactions ACT-FIRST This interactive program provides strategies and In 2013, three Single Topic Conferences (STC) ,one and produce new research collaborations. mentoring for managing HCV and is designed Emerging Trends Conference (ETC) and the AASLD/ AASLD in collaboration with the American College FDA Workshop were conducted. Of special note, the ETC on Reactivation of Hepatitis of Physicians (ACP), Centers for Disease Control to increase the confidence and competence of B was a cross-disciplinary clinical course featuring 1. Clinical Research STC: Portal Hypertension (CDC), U.S. Department of Veterans Affairs healthcare professionals new to providing care speakers and panelists from the American Academy and Variceal Hemorrhage (VA), and Project ECHO began development of for patients with HCV. It includes interactive of Dermatology (AAD), American Society of Clinical 2. Basic Research STC: Portal Hypertension online CME/CE-certified modules and experiential Oncology (ASCO), American College of Rheumatology a hepatology curriculum in 2013. The program and Vascular Biology of the Liver (ACR), and National Cancer Institute (NCI). Our joint will provide training (didactic) in Hepatology component which includes logging direct clinical 3. Hepatitis STC: Hepatitis C Treatment in efforts and persistence as an organization in this area to front-line providers, with the ultimate goal of experiences. The five modules were reviewed and Special Populations was instrumental in the Food and Drug Administrations improving the care of patients with liver disease. monthly webinars with case-based discussions 4. ETC: Reactivation of Hepatitis B (FDA) announcement of the requirement of a Boxed were offered to participants. 5. AASLD/FDA Workshop: Trial Designs and Warning for the anti-cancer immunosuppressive drugs The first two modules being developed are on Endpoints for Liver Disease Secondary to Arzerra (ofatumumab) and Rituxan (rituximab). Hepatitis B and C and will launch at the ACP Nonalcoholic Fatty Liver Disease Annual Meeting.

14 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 15 TRAIN/EDUCATE

Collaboration Journals CLINICAL PRACTICE GUIDELINES To expand our impact on education, research, training and therapy of liver disease AASLD AASLD develops clinical practice guidelines supported HEPATOLOGY by a high level of scientific evidence to assist collaborates with related societies and organizations. AASLD actively seeks cooperative ventures with TRAIN/EDUCATE The premier publication in practitioner and patient decisions about appropriate appropriate national, regional and international organizations in order to pursue projects of mutual the field of liver disease, health care for specific clinical circumstances. Where interest. These interactions are meant to be mutually beneficial and increase our ability to fulfill our HEPATOLOGY publishes published information is insufficient to make strongly vision and mission of treating and curing liver disease. original, peer-reviewed evidence-based recommendations, the state of the articles concerning art of current practice based on descriptive reports all aspects of liver 2013 collaborative efforts included: and expert opinions are published as position papers. structure, function, and AASLD has published 18 practice guidelines and disease. Each month, the Alpha-1 Foundation American Subspecialty Professors International Liver Transplantation two position papers which are updated regularly at AASLD/Alpha-1 Foundation Liver (ASP) Society (ILTS) distinguished editorial www.aasld.org and rewritten and published in the Scholar Award The Liver Meeting® board monitors and Centers for Disease Control (CDC) society’s journals every five years. Liver Transplantation Journal selects only the best ACT-First American Board of Internal Medicine articles on subjects such as immunology, In recent years, AASLD has partnered with several (ABIM) National Institutes of Health (NIH) chronic hepatitis, viral hepatitis, cirrhosis, genetic and Competency-based Curriculum Centers for Medicare & Medicaid societies to develop practice guidelines under the Services (CMS) metabolic liver diseases and their complications, liver The Liver Meeting® North American Society for Pediatric oversight of the Practice Guidelines Committee. Letters Competency cancer, and drug metabolism. Workshop Gastroenterology, Hepatology and of Agreement define the terms of collaboration which EASL Nutrition (NASPGHAN) 2013 EDITOR: Co-sponsored the AASLD/EASL Clinical ® Michael H. Nathanson, MD include representation on the writing group, review American College of Gastroenterology The Liver Meeting Research Single Topic Conference of each draft, and concurrent publication in each (ACG) on Portal Hypertension and Variceal Digestive Disease Week—Clinical LIVER Practice Guidelines Hemorrhage Symposium on Liver Manifestations of society’s journal. Related societies expressing interest Intestinal Disease in Children TRANSPLANTATION Training Directors Workshop in endorsing AASLD guidelines are provided early Food and Drug Administration (FDA) Since the first application drafts for review and approval. Project ECHO American College of Physicians (ACP) Endorsed the FDA Drug Induced of liver transplantation ACT-First Subspecialty Advisory Group on Liver Injury program on Detecting and in a clinical situation Evaluating Drug-Induced Liver Injury and PUBLISHED Socioeconomic Affairs was reported more than Dysfunction: What’s Normal ? What’s PSC Partners Seeking a Cure Council of Subspecialty Societies • Long-Term Management of the Successful Adult Liver Not? What Should We Do About It? PSC Abstract Award twenty years ago, there Transplant (in collaboration with the American Society ACT-First Co-sponsored the AASLD/ FDA has been a great deal of The Liver Meeting® Workshop on Trial Designs and Society for Surgery of the Alimentary growth in this field and of Transplantation) Endpoints for Liver Disease Secondary Tract (SSAT) more is anticipated. This • Long Term Medical Management of the to Nonalcoholic Fatty Liver Disease American Gastroenterological Digestive Disease Week journal delivers current, Pediatric Patient following Liver Transplantation Association (AGA) peer-reviewed articles on (in collaboration with the American Society of Digestive Disease Week International Association for the Study United Network for Organ Sharing of the Liver (UNOS) surgical techniques, clinical investigations Transplantation and endorsement by the North Training Directors Workshop Co-sponsored the AASLD/IASL and drug research—the information necessary to American Society for Pediatric Gastroenterology, Symposium Veterans Administration (VA) keep abreast of this evolving specialty. Hepatology and Nutrition) American Liver Foundation (ALF) ACT-First Combined awards selection committee International Liver Disease Associations 2013 EDITORS: John R. Lake, MD • Update of Management of Adult Patients with Ascites African Association for the Study of John P. Roberts, MD due to Cirrhosis American Medical Association Liver Disease • Evaluation of the Adult Patient for Liver Physicians Consortium for Practice Asian-Pacific Association for the Study CLINICAL LIVER Improvement (PCPI) Transplantation (in collaboration with the American of the Liver DISEASE (CLD) Society of Transplantation) American Society of Clinical Oncology European Association for the Study of CLD is the latest online the Liver (ASCO) learning resource of IN DEVELOPMENT GI Cancers Symposium, content advisor International Liver Cancer Association AASLD. Clinical in • Evaluation of the Pediatric Patient for Liver International Association for the Study focus, CLD blends text, audio, video, webinars, and American Society of Gastrointestinal of the Liver Transplantation (in collaboration with the North Endoscopy (ASGE) other interactive content into education interventions Latin-American Association for the American Society for Pediatric Gastroenterology, Digestive Disease Week launched every two months. These interventions are Study of the Liver designed for any physician or healthcare provider Hepatology and Nutrition and the American Society The Liver Meeting® World Gastroenterology Association caring for a patient with liver disease. of Transplantation) • Diagnosis and Management of Hepatic 2013 EDITOR: Michael R. Lucey, MD Encephalopathy (in collaboration with the European Association for the Study of Liver)

16 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 17 EFFECT EFFECT

Online Expert Advice for The initial guidance includes: The public policy agenda of the American Association for the Study of Liver Diseases Clinicians Treating Hepatitis C • HCV Testing and Linkage To Care (AASLD) in 2013 continued to grow and evolve. AASLD’s growth reflects the growth • Recommendations for Initial Treatment of HCV AASLD and the Infectious Diseases Society of America in the role of the government in the fields of medical practice and medical research.

TRAIN/EDUCATE Infection in Patients Starting Treatment (IDSA), in collaboration with the International Antiviral Gone are the days of AASLD members focused on their labs, or teaching or practice • Retreatment in Persons in Whom Prior Therapy Society-USA (IAS-USA), established the framework Has Failed solely. AASLD has been a significant and growing participant as key decisions and writing panel to offer up-to-date guidance for the • Unique Patient Populations are made at in both the legislative and executive branches of the government. treatment of hepatitis C virus (HCV) infection. The initial Additional sections, including Who Should Be Treated recommendations were completed following Food and and Monitoring Patients on HCV Therapy, will be A number of seminal events in recent years—the passage of the Affordable Care Act Drug Administration (FDA) approval of two direct- included in subsequent updates. and the Budget Control Act, for example—have greatly enhanced the focus on health acting antivirals for the treatment of hepatitis C in late 2013. The Recommendations for Testing, Managing It is estimated that between 3 and 4 million Americans care issues in Washington, in general. And, as AASLD members know, the impact and Treating HCV were published on a new website, are infected with HCV and have chronic liver disease of liver disease on the health of Americans has never been greater. Fortunately, the www.HCVguidelines.org, in January 2014. as a result. The most recent generation of direct-acting quality of treatments has been improving steadily, particularly with regard to viral antivirals has the potential to cure most patients with In contrast with traditional Practice Guidelines, this hepatitis. AASLD’s mission in this area is to ensure that public policies keep pace HCV. However, the rapid pace of drug development web-based guidance was developed rapidly and with the rapid scientific advancements and understanding that is occurring. has left medical providers and insurance companies will be revised regularly to keep pace with improved unsure what the optimal treatments are. The guidance diagnostic tools and new drug options as they provided through www.HCVguidelines.org will assist meet FDA approval. Recent changes in HCV testing clinicians in using these and other treatments in the guidelines have led to the diagnosis of increasing care of their patients. numbers of patients who were previously unaware RESEARCH The goals associated with AASLD’s public policy mission in research are too numerous to detail here. of their infection. The guidance provided through Funding for the project is provided by AASLD and IDSA. Strong advocacy for increased funding for research is We continue to pursue these, and all of our public www.HCVguidelines.org comes at a critical time as always one of the primary foci of AASLD during Liver policy priorities, in a reasonable and measured way more and more of these patients seek treatment that Capitol Hill Day (see below), as well as throughout the based upon promoting the strongest science we are has the potential to effectively ‘cure’ them. year. The level of appropriated funds for the National able to provide. The website is accessible to all practitioners who treat Institutes of Health (NIH), the Department of Veteran patients with liver disease and provides expert advice Affairs (DVA) and the Agency for Healthcare Research about how to best use the next generation of direct- and Quality (AHRQ) research is critically important to PATIENT CARE acting antivirals and other treatment options. A panel AASLD members—and to their patients. The Centers for Disease Control and Prevention (CDC) of 26 hepatologists and infectious diseases specialists 2013 proved to be an incredibly challenging year in Atlanta is the home of the Division of Viral Hepatitis. and a patient advocate developed the evidence- on the research funding side, as liver research Funding for this important agency—the only element based, consensus recommendations. became “collateral damage” in the budget wars that of CDC that currently addresses liver disease in any we afflicting the Congress at the time. As a result way—has been consistently inadequate. AASLD has of provision in the Budget Control Act of 2012 and worked with Congress and the administration and Congress’s inability to reach agreement on funding continues to seek additional funding to assure that levels, a process known as sequestration took CDC is able to bring its prevention and treatment effect which resulted in a 5.1 percent reduction of messages about viral hepatitis to all fifty states. all domestic discretionary spending on March 1, Hepatitis C screening for persons born between 1945 2013. Fortunately, after the government shutdown on and 1965 is a strong recommendation of the CDC. October 1 was resolved, cooler heads prevailed and However, the US Preventive Services Task Force in the FY14 appropriations bill fully 2/3 of the reduction (USPSTF) reviewed the evidence and gave such was restored. screening a C rating, which is critical because an A or B rating would mandate that it be considered an “essential health benefit” and would prohibit charging

18 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 19 Thank You for Your Support co-pays to public and private insurance beneficiaries. organizations return to Capitol Hill for the Sixth 100% OF YOUR DONATION IS USED TO SUPPORT LIVER RESEARCH AASLD, along with our partners in the patient advocacy Annual LCHD. The Association has made a strong EFFECT INDIVIDUAL Marco A. Olivera- In Honor of Florence & In Memory of Annie In Memory of In Memory of community, presented reams of evidence to prove the commitment to keeping liver front and center as DONORS Martinez, MD Jack Levin Edward Gorny Endriulaitis Cindy Raiford J.R. Wilkins value of the screening. In an almost unprecedented Congress faces tough budget and policy decisions. Anonymous (10) George Ostapowicz, Michael L. Schilsky, MD Bev & Dick Hagen Irene Harbuziuk DeWolf Kathleen M. Meskill Kim, Patty & Joan Manal F. Abdelmalek, Bmed, MD, FRACP In Honor of Andrea & John Ben Skvirblys Shirley Nasoff In Memory of J. MD, MPH move, USPSTF reversed itself and gave the screening A significant part of this mission is to explain the Stephen Chris Libia Lopez Hockridge In Memory of Robert C. Raiford Richard (Dickie) Joseph M. Alcorn, MD Pappas, MD a B rating, greatly enhancing the potential for long-term cost avoidance associated with diagnosing Danny & Trisha Rey Meagan Hockridge John Lee Gibbons In Memory of Williams Mohammed S. Anwer, Alexandra E. Read, MD and Family Sandra & Robert Jones Anonymous Victor Rothstein Jackie & Al Meyers PhD, DMVH identifying hepatitis C patients earlier in their disease. and treating all liver diseases—including viral Ricardo Rebuffi In Honor of James S. Kavannah In Memory of Maria & Kenneth D. In Memory of Shahid Aziz, DO Gautham Reddy, MD Rothstein, MD hepatitis—at the earliest possible time. And the success Franklin Rogers The Keyo Family James Edward Wanda Wentworth In addition, with the implementation of the Affordable Jasmohan Bajaj, MD Mary Rinella, MD Anonymous Mr. & Mrs. Jack (Bud) Goodman In Memory of Catharine & James Bell of that effort depends on investing in research now. Graham F. Barnard, Philip Rosenthal, MD In Honor of McCarthy Carol Rae & Paul Moore Teresa Savo Peg Lloyd & Cindy Healthcare Act (ACA) continuing to move ahead, MD, PhD Gladhill Richard A. Schreiber, MD Ramaraju Arlene & Stephen In Memory of Susan Blomster Oscar Alfredo David Shapiro, MD Vijayakrishna O’Brien Tedine Greenwald John & Betse Charleen Griemsman AASLD has increased its involvement substantially in Beltran, MD & Glenn Luedtke Seal Financial Group Gopal A. Ramaraju, MD Emma O’Leary Celeste Nugent Dolan Courtmanche Paul D Berk, MD Janet & Harry Faust the development of quality measures for physicians FEDERAL AGENCY DAY Leonard B. Seeff, MD In Memory of Steven & Jennifer In Memory of Geri Diorio & Thomas Boyer, MD Mark Edwards Terry and Clay Kotara treating patients with liver disease. This complex Benjamin L. Steven Amelotte Pratt Family Gina Heindl For the last six years, AASLD has undertaken a Carol L. Brosgart, MD Shneider, MD Marilyn & George Miller Linda & James Rogers Howard & Iris Helis Ann & Ron Petrillo Patti Quinn and Sheila Charleston Melinda Wright process will have an important and growing role in significant effort to expand its involvement with a William Sloan, MD In Memory of The Sarnowitz Family In Memory of In Memory of Chuhan Chung, MD Louis Wong Kee William Trenton Priscilla Saucier Michael Kirt Kimberly Skadan On Behalf of the future in assuring access to care for patients and broader spectrum of government agencies. Again Stanley Martin Song, MD Bradley, Jr. Shelley J. Shuman Henderson Donna Norsen James Browning Cohen, MD Linda & Steve Kish Thomas Kraynak adequate reimbursement for providers. in 2013, more than a dozen members of the AASLD Frederick J. Suchy, MD Dana & Michael Silveira Judy Henderson In Memory of Scott Cotler, MD Yasukiyo Sumino, In Memory of Ann & Lyle Staab In Memory of Mark J. Vierling On Behalf of We have also continued to work closely with some Governing Board and committee leadership came to Son T. Do, MD MD, PhD Mike Browne Joanne & William Paul Jarman Jr. Drs. Donna & Dr. Ana Corregidor Adrian M. Di Bisceglie, Anthony S. Tavill, MD Anonymous T. Sweeney Frank & Sharon Dowhan John Vierling Anonymous Washington DC to conduct meetings throughout the MD, FACP of the leading officials at the U.S. Food and Drug Brent A Tetri, MD In Memory of Doreen & Richard In Memory of In Memory of On Behalf of Kimberly Farrell Administration to assure that this important regulatory greater Washington DC area. Emmanuel Thomas, Phyllis Casey Tremaine Marshall Kaplan, MD Michael Vieau Patricia Magreta J. Gregory Fitz, MD MD, PhD Barbara Carmack Bryan, Lindsay, Lawrence S. Rita Mae Marsh Anonymous agency is actively engaged in the latest advances in Kristen Gengaro Natalie Torok, MD Irene & Ralph Cameron & Cali Weber Friedman, MD Mary Lou McGarry In Support of the One team of AASLD leaders went to the NIH and met Darbyshire Regino Gonzalez- Kymberly Watt, MD Scott Weber In Memory of Anna & Donald Dr. Edmund J. Bini treating liver disease. Meetings have occurred on a with the leadership of four different institutes which Peralta, MD Francis R. Weiner, MD Tom & Sharon Teri & Bob Weber Emmet Keeffe, MD Turtenwald Travel Award McGillivray Ken & Sue Wagner Naga Chalasani, MD variety of topics including, most prominently this year, Stuart C Gordon, MD Vincent Wong, MD In Memory of Walid Ayoub, MD have significant liver research portfolios. The other Norman D Grace, MD Michele Hope & Donna & Charles Wood Kyong-Mi Chang, MD Kentaro Yoshioka, Harry Rosenfeld William J. Curry In Memory of Allison dealing with reactivation of hepatitis B. team of leaders met with officials from the Office of Joseph Hoffman, MD MD, PhD Russ & Jane Anderson Copeland King Jody & David Ramsey Cheung, MD Nadeem Hussain, MD Brunhilde & Phyllis & PD Nicaise Rymaszewski Samuel B. Ho, MD Samir Zakhari, PhD Lewis O’Brien Marcia & Bruce Basarab the Assistant Secretary for Health in the Department Ravi Jhaveri, MD In Memory of Timothy R. Morgan, MD Joe Louis Loquinario Irene & Jerry O’Brien Diana & Douglas In Memory of of Health and Human Services; the Veterans Health Tsunehisa Kawasaki, Zimmerman A. Berthiaume Patricia Kowanick Cecilia Vitale Saray Stancic, MD LIVER CAPITOL HILL DAY MD, PhD Nancy Swanton & Teresa Battiata Stephen D. Zucker, MD Brent Petrie Marie & Paul Broderick Alexander T. Lalos, MD Andrew Talal, MD, MPH Administration in the VA; and the Food and Drug Andrew Keaveny, MD Mary & Eugene Cassis Mr. & Mrs. Peter Craig T. Tenner, MD In 2013, AASLD sponsored its Fifth Annual Liver In Honor of Bureau of Ocean In Memory of Bongiorno Administration (FDA). In 2014, we plan to build on this M. Farooq Khokhar, MD Laurie Blendis Energy Management Bev & Dick Hagen Ronald Krieger Teresa L. Wright, MD Capitol Hill Day (LCHD) bringing together AASLD W Ray Kim, MD Dirk J. Van Leeuwen, Barbara & E. Neil Tim Krieger Mr. & Mrs. Nino Peiying Xiao, MD In Memory of Domingo effort visiting agencies that will be most beneficial to Ayman A. Koteish, MD MD, PhD Hodgerney member-physicians, some of their patients, and Judith Ann Cash In Memory of Mr. & Mrs. Peter In Support of Edward L. Krawitt, MD In Honor of Anonymous Steven & Jennifer James Laurie the Professor AASLD members and where the greatest opportunities Pratt Family Domingo representatives of six patient advocacy organizations Gerd Kullak-Ublick, MD Anne Borhart Kathleen & Mr. & Mrs. Peter Margit Hamosh Debra Diedrick In Memory of Daniel Joy Robinson Lawrence Wisinski Travel Award for advancement exist. Anne M. Larson, MD C. Cockren Domingo in a day of meetings with Senate and House members The Sarnowitz Family Tamar H. Taddei, MD Patricia S. Latham, MD Karen & Mark Ostrander Julia & Ryan Merrill In Memory of Matilda & Angelo Illuzzi and staff. The roughly 60 participants involved in Jay Lefkowitch, MD Trudy Ann Jurs Frank & Pattie Dr. Eric Lemmer LEGACY SOCIETY In Memory of Sorrentino Mr. & Mrs. Salvatore Zhiping Li, MD In Honor of Anonymous Sereno The Estate of John the day advocated for increased research funding Kathleen M. Curry Ann & Lyle Staab Hunter Anna Suk-Fong Lok, MD Sherrie Cathcart Anonymous In Memory of Matilda & Ernest Tarmin Phil & Kathie Taymor and better patient care. They conducted more than Rohit Loomba, MD David J. Reich, MD, Russ & Jane Anderson Edward S. Levine Josephine Valenti FACS Doreen & Richard The Beach Bowlers Michael R. Lucey, MD Nancy Camfora Tremaine Dino A. Vitale 85 meetings on Capitol Hill, working in teams that Jorge Marrero, MD In Honor of Ruth & William Carroll In Memory of Tren Duevel Terri Ann Yaz In Memory of Julie Mack C. Mitchell, MD John Cohen, MD and John Mangialetto Ann Drayer Whyte combined patients and physicians to relate both the Sarah Catherine MFS—GIS Jack & Sandra Omar Massoud, MD the Staff of Newton Anonymous (3) personal impact of liver diseases and the scientific Beasley Wellesley Pediatrics The SEC Institute, Inc. Mackston Nahum Méndez Hannah E. Schlei Kumar Bala Sánchez, MD, PhD Susan M. Curley In Memory of In Memory of Bonny Bender opportunities to address it. Christopher Clara Newton Ethan D. Miller, MD In Honor of Roberta M. Dee Francis Ann Cummings Tanner Hickman DiNoto, Jr. Cara Nina Newton Timothy Morgan, MD Jane Dufault Monica DiCorpo We anticipate that our program will be continued and Anonymous Baker Mechanical In Memory of Jane & David Courtney Ellard & Systems Troy Gibson Jason & Myriah Shaun Wason Kenichi Okabe expanded in March of 2014, when AASLD members, Novick, MD Baker and Family Monroe Plan for Sally Kruger Janice & Robert Femino Yumiko & Scott Residor Lisa Marie Nyberg, Eric Walker Medical Care Sarah Mueller their patients and our partners from patient advocacy MD, MPH Karen Gibson In Memory of In Memory of Ian Robbins Joseph Odin, MD, PhD In Honor of Carlos Y. Ortiz Tiffany & Rob Giglio Alain M. Duwaerts Fede & Brad Rodriguez Robert K. Ockner, MD Marshall Jacobson and Girls Mia Estella Anonymous Caroline C. Duwaerts Amy Stagl WWW.AASLD.ORG/DONATE

CORPORATE DONORS

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20 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES Donor List as of December 31, 2013 Statement of Activities and Change in Net Assets 2012 2011 Temporarily Permanently Unrestricted Total Total for the Year Ended December 31, 2012 Restricted Restricted With Summarized Financial Information For 2011 Revenue FINANCIALS Annual Meeting $6,456,077 $212,500 - $6,668,577 $6,703,768 Meetings and Education 608,148 - - 608,148 716,515 Revenue 2012 Expenses 2012 Membership Dues 1,172,238 - - 1,172,238 1,137,657 Professional Relations 35,000 10,000 - 45,000 26,530 FINANCIALS Annual Meeting ...... $ 6,668,577 Annual Meeting ...... $ 3,042,586. Publications, Hepatology and Liver Transplantation Journals 2,329,996 - - 2,329,996 2,265,291 Awards & Grants...... $ 1,196,975 Awards & Grants...... $ 2,319,234. Research and Fellowship Awards 150,000 1,046,975 - 1,196,975 1,834,231 Professional Relations, Fundraising, & Other...... $ 104,587 Communications...... $ 528,631 Rental income 225,678 - - 225,678 188,970 Meetings & Education...... $ 608,148 Meetings & Education...... $ 1,623,760. In kind contribution 14,500 - - 14,500 6,900 Publications...... $ 2,329,996 Professional Relations...... $ 219,278 Communications - - - - 50,000 Rental Income...... $ 225,678 Publications...... $ 1,499,507. Membership...... $ 1,172,238 Leadership, IT & F&A...... $ 1,672,856. Fundraising Campaign/Liver Research 44,611 - - 44,611 56,916 FR/Liver Research Fund...... $ 226,148 Other 476 - - 476 900 Membership...... $ 921,921 Net assets released from donor restrictions 2,092,259 (2,092,259) - - - Total revenue 13,128,983 (822,784) - 12,306,199 12,987,678 2% 2% 9% 8% 25% Expenses 19% 14% Program Services: 54% 12% Annual Meeting 3,042,586 - - 3,042,586 3,051,942 19% Professional Relations 219,278 - - 219,278 202,498 10% 14% 5% Publication Journals 1,499,507 - - 1,499,507 1,600,360 1% 2% Communications 263,206 - - 263,206 299,205 4% Research and Fellowship Awards 2,319,234 - - 2,319,234 2,080,464 Assets Liabilities and net assets Meetings and Education 1,623,760 - - 1,623,760 1,359,221 Clinical and Public Policies 265,425 - 265,425 248,592 Membership Development and Website 921,921 - 921,921 794,913 CURRENT ASSETS 2012 2011 CURRENT LIABILITIES 2012 2011 Total program services 10,154,917 - - 10,154,917 9,637,195 Cash and cash equivalents $6,480,934 $ 7,424,778 Current portion of notes payable $161,299 $163,346 Supporting Services: Investments—Reserve and Endowments 24,535,745 20,550,452 Current portion of bonds payable 100,000 100,000 Governance, Executive and Administration 1,672,856 - - 1,672,856 1,375,362 Investments—Liver Research Fund 6,721,312 5,751,327 Accounts payable and accrued expenses 1,089,304 1,658,960 Fundraising 226,148 - - 226,148 205,113 Contributions receivable, current portion 829,405 1,153,575 Deferred revenue: Total supporting services 1,899,004 - - 1,899,004 1,580,475 Accounts receivable 785,510 610,288 Membership dues 552,040 718,058 Total expenses 12,053,921 - - 12,053,921 11,217,670 Prepaid expenses 212,821 95,913 Meeting registrations and exhibits 6,480 37,705 Change in net assets before other items 1,075,062 (822,784) - 252,278 1,770,008 Total current assets 39,565,727 35,586,333 Grants and awards payable 1,433,045 1,226,657 Total current liabilities 3,342,168 3,904,726 Other Items FIXED ASSETS Investment (loss) income 3,207,372 565,844 - 3,773,256 (281,553)

Office condominium 8,081,872 8,081,872 LONG-TERM LIABILITIES Unrealized gain (loss) on interest rate swap obligation 15,144 - - 15,144 (1,019,544) Furniture and equipment 444,167 412,145 Notes payable, net of current portion 3,425,907 3,587,205 Change in net assets 4,297,578 (256,900) - 4,040,678 468,911 Less: Accumulated depreciation 8,526,039 8,494,017 Bonds payable, net of current portion 3,300,000 3,400,000 Net assets at beginning of year 21,971,951 4,180,295 4,061,850 30,214,096 29,745,185 and amortization (1,650,653) (1,371,757) Interest rate swap obligation 2,446,042 2,461,185 Net fixed assets 6,875,386 7,122,260 Deferred compensation liability 159,673 103,362 Net assets at end of year $26,269,529 $3,923,395 $4,061,850 $34,254,774 $30,214,096 Total long term liabilities 9,331,622 9,551,752 OTHER ASSETS Total liabilities 12,673,790 13,456,478 Contributions receivable, 132,225 652,640 net of current portion NET ASSETS Deferred financing cost, Unrestricted net of accumulated amortization 111,575 116,306 of $30,358 Undesignated 18,033,601 16,084,209 Deferred compensation investments 159,673 103,362 Board designated 8,235,928 5,887,742 Deposits 83,978 89,673 Total unrestricted 26,269,529 21,971,951 Total other assets 487,451 961,981 Temporarily restricted 3,923,395 4,180,295 Permanently restricted 4,061,850 4,061,850 Total assets $46,928,564 $43,670,574 Total net assets 34,254,774 30,214,096

Total liabilities and net assets $46,928,564 $43,670,574 1001 North Fairfax Street, Suite 400 | Alexandria, VA 22314 Phone: 703-299-9766 | Fax: 703-299-9622 | www.aasld.org

22 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 23 Governing Board Past Presidents GOVERNANCE

2014 AASLD 2013 AASLD 2013 AASLD 2013 1996 1979 1962 Governing Board Governing Board Committee Chairs J. Gregory Fitz, MD Anthony S. Tavill, MD Harold J. Fallon, MD Hugh R. Butt, MD, MS President President Annual Meeting Practice Guidelines 2012 1995 1978 1961 GOVERNANCE Adrian M. Di Bisceglie, J. Gregory Fitz, MD Education Committee Committee Guadalupe Garcia-Tsao, MD D. Montgomery Bissell, MD Robert Zeppa, MD Stanley Hartroft, MD MD, FACP University of Texas Rebecca G. Wells, MD Jayant A. Talwalkar, MD, MPH Saint Louis University Southwestern 2011 1994 1977 1960 St. Louis, MO Dallas, TX Basic Research Program Evaluation T. Jake Liang, MD John L. Gollan, MD, PhD Fenton Schaffner, MD George J. Gabuzda, MD Committee Committee President-Elect President-Elect Mark J. Czaja, MD Mary E. Rinella, MD 2010 1993 1976 1959 Gyongyi Szabo, MD, PhD Adrian M. Di Bisceglie, Arun J. Sanyal, MD Esteban Mezey, MD Irwin M. Arias, MD Richard B. Capps, MD University of Massachusetts MD, FACP Clinical Research Public and Clinical Policy Worcester, MA Saint Louis University Committee Committee 2009 1992 1975 1958 St. Louis, MO Past-President Marc G. Ghany, MD Nancy Reau, MD Scott L. Friedman, MD Jay H. Hoofnagle, MD William H. J. Summerskill, MD Thomas C. Chalmers, MD J. Gregory Fitz, MD Past-President Development Committee Research Awards 2008 1991 1974 1957 Guadalupe Garcia-Tsao, MD University of Texas W. Ray Kim, MD Committee Arthur J. McCullough, MD Michael F. Sorrell, MD John R. Senior, MD Gerald Klatskin, MD Southwestern Yale University Steven Lidofsky, MD, PhD Dallas, TX New Haven, CT Education Oversight 2007 1990 1973 1956 Secretary Secretary Committee Research Awards Gregory J. Gores, MD Roger Lester, MD Harold O. Conn, MD Wade Volwiler, MD Gary L. Davis, MD Committee Gary L. Davis, MD Gary L. Davis, MD Linda Greenbaum, MD 2006 1989 1972 1955 Baylor University Baylor University Ethics Commmittee John M. Vierling, MD, FACP Paul D. Berk, MD Burton Combes, MD Robert M. Kark, MD Medical Center Medical Center Adrian Reuben, MBBS, Scientific Program Dallas, TX Dallas, TX FRCP, FACG Committee 2005 1988 1971 1954 Treasurer Treasurer CHAIR Teresa L. Wright, MD David H. Van Thiel, MD Allan G. Redeker, MD Franklin Hanger, MD W. Ray Kim, MD Donald M. Jensen, MD Federal Agencies Liaison J. Gregory Fitz, MD Committee 2004 1987 1970 1953 Stanford University University of Chicago Bruce R. Bacon, MD J. Donald Ostrow, MD Richard C. Britton, MD Jesse L. Bollman, PhD Stanford, CA Chicago, IL CHAIR Surgery and Liver Laurie D. DeLeve, MD, PhD Transplantation Councilors Councilors Committee 2003 1986 1969 1952 Frederick J. Suchy, MD Marcus A. Rothschild, MD Archie H. Baggenstoss, MD Paul Gyorgy, MD Keith D. Lindor, MD Gyongyi Szabo, MD, PhD Finance Committee Kenneth D. Chavin, MD, PhD Arizona State University University of Massachusetts CHAIR 2002 1985 1968 1951 Phoenix, AZ Worcester, MA Lynt B. Johnson, MD, MBA Training and Workforce Thomas D. Boyer, MD Alan F. Hofmann, MD Carroll M. Leevy, MD Frederick W. Hoffbauer, MD Anna Suk-Fong Lok, MD Keith D. Lindor, MD Committee Hepatology Associates University of Michigan Arizona State University Bruce A. Luxon, MD, PhD 2001 1984 1967 1950 Ann Arbor, MI Committee Phoenix, AZ Eugene R. Schiff, MD Robert K. Ockner, MD Kurt J. Isselbacher, MD Leon Schiff, MD CHAIR Ronald J. Sokol, MD Anna Suk-Fong Lok, MD Joy A. Peter, RN, BSN University of Colorado University of Michigan 2000 1983 1966 Aurora, CO Ann Arbor, MI Journals Publication William F. Balistreri, MD E. Lee Forker, MD Robert E. Shank, MD Councilors-at-Large Councilors-at-Large Committee 1999 1982 1965 Raymond T. Chung, MD Norah Terrault, MD, MPH CHAIR Joseph R. Bloomer, MD Willis C. Maddrey, MD Rudi Schmid, MD, PhD Theo Heller, MD Massachusetts General Hospital University of California, Boston, MA San Francisco 1998 1981 1964 San Francisco, CA Membership & Neil Kaplowitz, MD Steven Schenker, MD Telfer B. Reynolds, MD Susan Orloff, MD Mentorship Committee Raymond T. Chung, MD Oregon Health and CHAIR 1997 1980 1963 Science University Massachusetts General Hospital Steven K. Herrine, MD Nicholas F. LaRusso, MD James L. Boyer, MD Hans Popper, MD Portland, OR Boston, MA K. Rajender Reddy, MD Susan Orloff, MD Nominating Committee University of Pennsylvania Oregon Health and CHAIR Science University Philadelphia, PA Guadalupe Garcia-Tsao, MD Portland, OR

24 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES A ASLD 2013 Annual Report 25 AASLD Staff

Executive Division Communications Education and Meetings IT/Web Services Sherrie Cathcart, CAE and Public Policy Julie Deal Paula McGraw

GOVERNANCE Executive Director Gregory Bologna, CAE Deputy Executive Director Chief Technology Officer Heidi Bruce, MBA Chief Communications Officer Janeil Klett Chris Dugmore Director, Development Martha Sauchuk Senior Director, Education Director, Data Integrity Audrey Davis-Owino Director, Marketing Melissa Parrish, CMP Wick Davis Director, Governance and Ann Haran Director, Meetings and Senior Manager, Website Practice Guidelines Conferences Senior Manager, Publications Roger Riddell Kristin Hutcherson Kristin Howard Denise Seise Manager, Website Coordinator, Governance Manager, Marketing Director, Programs and Professional Services Member Services Julia Merrill Karey Martinez Bette Anne Preston Coordinator, Development Manager, Publications Edward Pramuk Director, Online Learning Senior Director, Member Erica Taylor Megan Webster Services Executive Administrative Coordinator, Marketing Akena Better, CMP Mary Kostelc Assistant Senior Manager, Kara Cheatham Meetings and Conferences Manager, Member Services Administration Editorial Assistant, Publications Allyson Petty Erica Lowe and Finance Tazeen Shirazi Manager, CME Programs Representative, Member Nellie Sarkissian Editorial Assistant, Publications Services Anne Wrobel Chief Operations Officer Manager, CME Programs Mark Islam Crystal Novas Controller Coordinator, Meetings and Catherine Celestino Conferences Staff Accountant Aaron Batla Junior Accountant

26 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES 1001 North Fairfax Street, Suite 400 | Alexandria, VA 22314 Phone: 703-299-9766 | Fax: 703-299-9622 | www.aasld.org