Medical to Lay Terminology (Version November 2011)
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Diagnosis, Treatment, and Prognosis of Glioma Five New Things
Diagnosis, treatment, and prognosis of glioma Five new things s the profession of neurology becomes in- creasingly subspecialized, it becomes more A and more difficult for general neurologists to feel comfortable with every category of disease. At no time is this felt more keenly than when an imaging procedure has been performed on a pa- tient for a seizure, headache, or focal neurologic complaint and a brain tumor is discovered. In con- trast to consulting with a patient with a movement disorder or neuromuscular disease, there is no time to craft the discussion and discuss a differential diag- nosis. As with demyelinating disease or stroke, the scan result dictates an immediate conversation with the patient, but in contrast to those disorders this takes place from the perspective of a provider who understands that the eventual outcome for the pa- tient is likely to be guarded. How to give that message with tact, candor, and some optimism could be the sole topic of this article but, instead, we focus on 5 new ideas that are changing the management of brain tumor patients in the hopes that these points might prove useful during those times. Lynne P. Taylor, MD PROGNOSIS AND GLIOMA SUBTYPES In his pioneering work “Death Foretold,” Dr. Nicholas Chris- takis1 says “prognosis gives diagnosis its affective component, striking fear in patients and physicians Address correspondence and alike.” There has traditionally been a lot of therapeutic nihilism about the treatment of glioblastoma, but reprint requests to Dr. Lynne P. that is now changing. Previously believed to be one homogeneous group of tumors based on clinicopath- Taylor, X7NEU, Virginia Mason Medical Center, 1100 9th ologic and histologic assessments, we are now finding that subgroups exist within these tumors that one Avenue, Seattle, WA 98101 day may allow us to better predict which chemotherapy option is best for each individual patient. -
Evaluation of Artery Visualizations for Heart Disease Diagnosis
Evaluation of Artery Visualizations for Heart Disease Diagnosis Michelle A. Borkin, Student Member, IEEE, Krzysztof Z. Gajos, Amanda Peters, Dimitrios Mitsouras, Simone Melchionna, Frank J. Rybicki, Charles L. Feldman, and Hanspeter Pfister, Senior Member, IEEE Fig. 1. Left: Traditional 2D projection (A) of a single artery, and 3D representation (C) of a right coronary artery tree with a rainbow color map. Right: 2D tree diagram representation (B) and equivalent 3D representation (D) of a left coronary artery tree with a diverging color map. Abstract—Heart disease is the number one killer in the United States, and finding indicators of the disease at an early stage is critical for treatment and prevention. In this paper we evaluate visualization techniques that enable the diagnosis of coronary artery disease. A key physical quantity of medical interest is endothelial shear stress (ESS). Low ESS has been associated with sites of lesion formation and rapid progression of disease in the coronary arteries. Having effective visualizations of a patient’s ESS data is vital for the quick and thorough non-invasive evaluation by a cardiologist. We present a task taxonomy for hemodynamics based on a formative user study with domain experts. Based on the results of this study we developed HemoVis, an interactive visualization application for heart disease diagnosis that uses a novel 2D tree diagram representation of coronary artery trees. We present the results of a formal quantitative user study with domain experts that evaluates the effect of 2D versus 3D artery representations and of color maps on identifying regions of low ESS. We show statistically significant results demonstrating that our 2D visualizations are more accurate and efficient than 3D representations, and that a perceptually appropriate color map leads to fewer diagnostic mistakes than a rainbow color map. -
A Revised Computational Neuroanatomy for Motor Control
This is the author’s final version; this article has been accepted for publication in the Journal of Cognitive Neuroscience 1 A Revised Computational Neuroanatomy for Motor Control 2 Shlomi Haar1, Opher Donchin2,3 3 1. Department of BioEngineering, Imperial College London, UK 4 2. Department of Biomedical Engineering, Ben-Gurion University of the Negev, Israel 5 3. Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Israel 6 7 Corresponding author: Shlomi Haar ([email protected]) 8 Imperial College London, London, SW7 2AZ, UK 9 10 Acknowledgements: We would like to thank Ilan Dinstein, Liad Mudrik, Daniel Glaser, Alex Gail, and 11 Reza Shadmehr for helpful discussions about the manuscript. Shlomi Haar is supported by the Royal 12 Society – Kohn International Fellowship (NF170650). Work on this review was partially supported by 13 DFG grant TI-239/16-1. 14 15 Abstract 16 We discuss a new framework for understanding the structure of motor control. Our approach 17 integrates existing models of motor control with the reality of hierarchical cortical processing and the 18 parallel segregated loops that characterize cortical-subcortical connections. We also incorporate the recent 19 claim that cortex functions via predictive representation and optimal information utilization. Our 20 framework assumes each cortical area engaged in motor control generates a predictive model of a different 21 aspect of motor behavior. In maintaining these predictive models, each area interacts with a different part 22 of the cerebellum and basal ganglia. These subcortical areas are thus engaged in domain appropriate 23 system identification and optimization. This refocuses the question of division of function among different 24 cortical areas. -
Molecular Signatures of Tissue-Specific
Developmental Cell Resource Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration Daniel J. Nolan,1,6 Michael Ginsberg,1,6 Edo Israely,1 Brisa Palikuqi,1 Michael G. Poulos,1 Daylon James,1 Bi-Sen Ding,1 William Schachterle,1 Ying Liu,1 Zev Rosenwaks,2 Jason M. Butler,1 Jenny Xiang,4 Arash Rafii,1,7 Koji Shido,1 Sina Y. Rabbany,1,8 Olivier Elemento,3 and Shahin Rafii1,5,* 1Department of Genetic Medicine, Howard Hughes Medical Institute 2Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine 3HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine 4Genomics Resource Core Facility Weill Cornell Medical College, New York, NY 10065, USA 5Ansary Stem Cell Institute, New York, NY 10065, USA 6Angiocrine Bioscience, New York, NY 10065, USA 7Weill Cornell Medical College-Qatar, Stem Cell and Microenvironment Laboratory, Education City, Qatar Foundation, Doha 24144, Qatar 8Bioengineering Program, Hofstra University, Hempstead, NY 11549, USA *Correspondence: srafi[email protected] http://dx.doi.org/10.1016/j.devcel.2013.06.017 SUMMARY been appreciated. Capillary ECs of the blood brain barrier (BBB) form a restrictive environment for passage between the Microvascular endothelial cells (ECs) within different brain tissue and the circulating blood. Many of the trafficking pro- tissues are endowed with distinct but as yet unrecog- cesses that are passive in other vascular beds are tightly nized structural, phenotypic, and functional attri- controlled in the brain (Rubin and Staddon, 1999). As opposed butes. We devised EC purification, cultivation, to the BBB, the capillary ECs of the kidney glomeruli are fenes- profiling, and transplantation models that establish trated for the filtration of the blood (Churg and Grishman, tissue-specific molecular libraries of ECs devoid of 1975). -
Motor Control: a Sense of Movement
RESEARCH HIGHLIGHTS MOTOR CONTROL A sense of movement Neuroscience textbooks tell us that with a shorter latency after S1 stimu- whisker protraction, and that M1retract the motor cortex controls move- lation than after M1 stimulation. only induces whisker retraction ment. But now, Carl Petersen and Thus, S1 and M1 are both involved in indirectly, through S1 activation. colleagues show that sensory cortex whisker motor and sensory process- By mapping the neural pathways may have an equally important role ing. The M1 area that induced C2 involved in C2 whisker retraction in motor control. retraction was termed M1retract; a and protraction, the authors found The authors showed that a single, more medial M1 region that induced that M1C2 and S1C2 have reciprocal brief deflection of the C2 whisker C2 protraction under microstimula- connections and project to adjacent induced activity in the correspond- tion was termed M1protract. regions in subcortical areas. In the ing barrel column of the primary The authors next investigated the brain stem, this includes the reticular somatosensory cortex (S1), followed functional relevance of this finding. formation as a projection area of M1, by a response in a small area in the By attaching metal particles to the C2 and the spinal trigeminal nuclei as primary motor cortex (M1). Direct whisker and applying a pulsed mag- a projection area of S1. Both areas microstimulation or optogenetic netic field, the authors could evoke project to the facial nucleus, which stimulation of either area induced C2 whisker deflections. The whisker contains whisker motor neurons. a brief retraction of the C2 whisker, retracted in response to this stimulus, Indeed, direct electrical stimula- and this response was abolished when tion of the reticular formation and S1 was inactivated — but not spinal trigeminal nuclei induced when M1 was inactivated — with whisker protraction and retraction, tetrodoxin (TTX). -
Mouth Esophagus Stomach Rectum and Anus Large Intestine Small
1 Liver The liver produces bile, which aids in digestion of fats through a dissolving process known as emulsification. In this process, bile secreted into the small intestine 4 combines with large drops of liquid fat to form Healthy tiny molecular-sized spheres. Within these spheres (micelles), pancreatic enzymes can break down fat (triglycerides) into free fatty acids. Pancreas Digestion The pancreas not only regulates blood glucose 2 levels through production of insulin, but it also manufactures enzymes necessary to break complex The digestive system consists of a long tube (alimen- 5 carbohydrates down into simple sugars (sucrases), tary canal) that varies in shape and purpose as it winds proteins into individual amino acids (proteases), and its way through the body from the mouth to the anus fats into free fatty acids (lipase). These enzymes are (see diagram). The size and shape of the digestive tract secreted into the small intestine. varies in each individual (e.g., age, size, gender, and disease state). The upper part of the GI tract includes the mouth, throat (pharynx), esophagus, and stomach. The lower Gallbladder part includes the small intestine, large intestine, The gallbladder stores bile produced in the liver appendix, and rectum. While not part of the alimentary 6 and releases it into the duodenum in varying canal, the liver, pancreas, and gallbladder are all organs concentrations. that are vital to healthy digestion. 3 Small Intestine Mouth Within the small intestine, millions of tiny finger-like When food enters the mouth, chewing breaks it 4 protrusions called villi, which are covered in hair-like down and mixes it with saliva, thus beginning the first 5 protrusions called microvilli, aid in absorption of of many steps in the digestive process. -
Salivary Gland Infections and Salivary Stones (Sialadentis and Sialithiasis)
Salivary Gland Infections and Salivary Stones (Sialadentis and Sialithiasis) What is Sialadenitis and Sialithiasis? Sialdenitis is an infection of the salivary glands that causes painful swelling of the glands that produce saliva, or spit. Bacterial infections, diabetes, tumors or stones in the salivary glands, and tooth problems (poor oral hygiene) may cause a salivary gland infection. The symptoms include pain, swelling, pus in the mouth, neck skin infection. These infections and affect the submandibular gland (below the jaw) or the parotid glands (in front of the ears). The symptoms can be minor and just be a small swelling after meals (symptoms tend to be worse after times of high saliva flow). Rarely, the swelling in the mouth will progress and can cut off your airway and cause you to stop breathing. What Causes Sialadenitis and Sialithiasis When the flow of saliva is blocked by a small stone (salilithiasis) in a salivary gland or when a person is dehydrated, bacteria can build up and cause an infection. A viral infection, such as the mumps, also can cause a salivary gland to get infected and swell. These infections can also be caused by a spread from rotten or decaying teeth. Sometimes there can be a buildup of calcium in the saliva ducts that form into stones. These can easily stop the flow of saliva and cause problems How are these infections and stones treated? Treatment depends on what caused your salivary gland infection. If the infection is caused by bacteria, your doctor may prescribe antibiotics. Home treatment such as drinking fluids, applying warm compresses, and sucking on lemon wedges or sour candy to increase saliva may help to clear the infection quicker. -
Esophago-Pulmonary Fistula Caused by Lung Cancer Treated with a Covered Self-Expandable Metallic Stent
Abe et al. J Clin Gastroenterol Treat 2016, 2:038 Volume 2 | Issue 4 Journal of ISSN: 2469-584X Clinical Gastroenterology and Treatment Clinical Image: Open Access Esophago-Pulmonary Fistula Caused by Lung Cancer Treated with a Covered Self-Expandable Metallic Stent Takashi Abe1, Takayuki Nagai1 and Kazunari Murakami2 1Department of Gastroenterology, Oita Kouseiren Tsurumi Hospital, Japan 2Department of Gastroenterology, Oita University, Japan *Corresponding author: Takashi Abe M.D., Ph.D., Department of Gastroenterology, Oita Kouseiren Tsurumi Hospital, Tsurumi 4333, Beppu City, Oita 874-8585, Japan, Tel: +81-977-23-7111 Fax: +81-977-23-7884, E-mail: [email protected] Keywords Esophagus, Pulmonary parenchyma, Fistula, lung cancer, Self- expandable metallic stent A 71-year-old man was diagnosed with squamous cell lung cancer in the right lower lobe. He was treated with chemotherapy (first line: TS-1/CDDP; second line: carboplatin/nab-paclitaxel) and radiation therapy (41.4 Gy), but his disease continued to progress. The patient complained of relatively sudden-onset chest pain and high-grade fever. Computed tomography (CT) showed a small volume of air in the lung cancer of the right lower lobe, so the patient was suspected of fistula between the esophagus and the lung parenchyma. Upper gastrointestinal endoscopy revealed an esophageal fistula (Figure 1), which esophagography using water- soluble contrast medium showed overlying the right lower lobe Figure 2: Esophagography findings. Contrast medium is shown overlying the right lower lobe (arrow). (Figure 2). The distance from the incisor teeth to this fistula was 28 cm endoscopically. CT, which was done after esophagography, showed fistulous communication between the esophagus and Figure 1: Endoscopy showing esophageal fistula (arrow). -
Are You Ready for ICD-10-PCS? Expert Tips, Tools, and Guidance to Make the Transition Simple
Are You Ready for ICD-10-PCS? Expert Tips, Tools, and Guidance to Make the Transition Simple By Amy Crenshaw Pritchett February 19, 2014 1 Agenda In this webinar: Expand your understanding of ICD-10-PCS with can’t miss ICD-10-PCS coding conventions & guidelines. Understand the basic differences between ICD-9-CM Volume 3 and ICD-10-PCS. Learn code structure, organization, & characters: Step 1 to coding section “0” ICD-10-PCS? Pinpoint the body system. To build your ICD-10-PCS code, you must identify the root operation. Study 7 options when assigning your PCS code’s 5th character. Master how to determine the device value for your PCS code’s character. Raise your awareness of unique ICD-10-PCS challenges pertaining to documentation and specificity: Prepare physicians now for more detailed transfusion notes under ICD- 10-PCS. Discover why writing “Right Carotid Endarterectomy” won’t be enough. Know where to find ICD-10-PCS tools, techniques, and best practices. 2 Understanding ICD-10-PCS ICD-10-PCS is a major departure from ICD-9-CM procedure coding, requiring you to know which root word applies. Effective October 1, 2014, this procedure coding system will be used to collect data, determine payment, and support the electronic health record for all inpatient procedures performed in the US. 3 Gear Up for ICD-10-PCS This procedure coding system is starkly different from ICD-9-CM procedure coding: Every ICD-10-PCS code has seven characters, each character defining one aspect of the procedure performed. For instance, not correctly identifying your physician’s approach – the fifth character – and not being able to distinguish between similar root operations can throw off your claims accuracy! 4 Converting to ICD-10-PCS Have your inpatient coders and clinical documentation specialists begun preparing for ICD-10-PCS yet? That’s why we’re here today … to ease your transition from ICD-9-CM procedure coding to ICD-10-PCS. -
1 Fluid and Elect. Disorders of Serum Sodium Concentration
DISORDERS OF SERUM SODIUM CONCENTRATION Bruce M. Tune, M.D. Stanford, California Regulation of Sodium and Water Excretion Sodium: glomerular filtration, aldosterone, atrial natriuretic factors, in response to the following stimuli. 1. Reabsorption: hypovolemia, decreased cardiac output, decreased renal blood flow. 2. Excretion: hypervolemia (Also caused by adrenal insufficiency, renal tubular disease, and diuretic drugs.) Water: antidiuretic honnone (serum osmolality, effective vascular volume), renal solute excretion. 1. Antidiuresis: hyperosmolality, hypovolemia, decreased cardiac output. 2. Diuresis: hypoosmolality, hypervolemia ~ natriuresis. Physiologic changes in renal salt and water excretion are more likely to favor conservation of normal vascular volume than nonnal osmolality, and may therefore lead to abnormalities of serum sodium concentration. Most commonly, 1. Hypovolemia -7 salt and water retention. 2. Hypervolemia -7 salt and water excretion. • HYFERNATREMIA Clinical Senini:: Sodium excess: salt-poisoning, hypertonic saline enemas Primary water deficit: chronic dehydration (as in diabetes insipidus) Mechanism: Dehydration ~ renal sodium retention, even during hypernatremia Rapid correction of hypernatremia can cause brain swelling - Management: Slow correction -- without rapid administration of free water (except in nephrogenic or untreated central diabetes insipidus) HYPONA1REMIAS Isosmolar A. Factitious: hyperlipidemia (lriglyceride-plus-plasma water volume). B. Other solutes: hyperglycemia, radiocontrast agents,. mannitol. -
Study Guide Medical Terminology by Thea Liza Batan About the Author
Study Guide Medical Terminology By Thea Liza Batan About the Author Thea Liza Batan earned a Master of Science in Nursing Administration in 2007 from Xavier University in Cincinnati, Ohio. She has worked as a staff nurse, nurse instructor, and level department head. She currently works as a simulation coordinator and a free- lance writer specializing in nursing and healthcare. All terms mentioned in this text that are known to be trademarks or service marks have been appropriately capitalized. Use of a term in this text shouldn’t be regarded as affecting the validity of any trademark or service mark. Copyright © 2017 by Penn Foster, Inc. All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the copyright owner. Requests for permission to make copies of any part of the work should be mailed to Copyright Permissions, Penn Foster, 925 Oak Street, Scranton, Pennsylvania 18515. Printed in the United States of America CONTENTS INSTRUCTIONS 1 READING ASSIGNMENTS 3 LESSON 1: THE FUNDAMENTALS OF MEDICAL TERMINOLOGY 5 LESSON 2: DIAGNOSIS, INTERVENTION, AND HUMAN BODY TERMS 28 LESSON 3: MUSCULOSKELETAL, CIRCULATORY, AND RESPIRATORY SYSTEM TERMS 44 LESSON 4: DIGESTIVE, URINARY, AND REPRODUCTIVE SYSTEM TERMS 69 LESSON 5: INTEGUMENTARY, NERVOUS, AND ENDOCRINE S YSTEM TERMS 96 SELF-CHECK ANSWERS 134 © PENN FOSTER, INC. 2017 MEDICAL TERMINOLOGY PAGE III Contents INSTRUCTIONS INTRODUCTION Welcome to your course on medical terminology. You’re taking this course because you’re most likely interested in pursuing a health and science career, which entails proficiencyincommunicatingwithhealthcareprofessionalssuchasphysicians,nurses, or dentists. -
Overview of Gastrointestinal Function
Overview of Gastrointestinal Function George N. DeMartino, Ph.D. Department of Physiology University of Texas Southwestern Medical Center Dallas, TX 75390 The gastrointestinal system Functions of the gastrointestinal system • Digestion • Absorption • Secretion • Motility • Immune surveillance and tolerance GI-OP-13 Histology of the GI tract Blood or Lumenal Serosal Side or Mucosal Side Structure of a villus Villus Lamina propria Movement of substances across the epithelial layer Tight junctions X Lumen Blood Apical membrane Basolateral membrane X X transcellular X X paracellular GI-OP-19 Histology of the GI tract Blood or Lumenal Serosal Side or Mucosal Side Motility in the gastrointestinal system Propulsion net movement by peristalsis Mixing for digestion and absorption Separation sphincters Storage decreased pressure GI-OP-42 Intercellular signaling in the gastrointestinal system • Neural • Hormonal • Paracrine GI-OP-10 Neural control of the GI system • Extrinsic nervous system autonomic central nervous system • Intrinsic (enteric) nervous system entirely with the GI system GI-OP-14 The extrinsic nervous system The intrinsic nervous system forms complete functional circuits Sensory neurons Interneurons Motor neurons (excitatory and inhibitory) Parasympathetic nerves regulate functions of the intrinsic nervous system Y Reflex control of gastrointestinal functions Vago-vagal Afferent reflex Salivary Glands Composition of Saliva O Proteins α−amylase lactoferrin lipase RNase lysozyme et al mucus O Electrolyte solution water Na+ , K + - HCO3