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Therapeutic Hypothermia: Where Do We Stand?
5/29/2015 Therapeutic Hypothermia: Where Do We Stand? Melina Aguinaga-Meza, MD Assistant Professor of Medicine Gill Heart Institute University of Kentucky Disclosure Information Melina Aguinaga-Meza, MD “Therapeutic Hypothermia: Where Do We Stand?” • FINANCIAL DISCLOSURE: – No relevant financial relationship exists • UNLABELED/UNAPPROVED USES DISCLOSURE: – No relevant relationship exists 1 5/29/2015 The Clinical Problem • Out-of-hospital cardiac arrest (OHCA) is a leading cause of death among adults in the US • Approx. 300,000 OHCA events occur each year in the US • Resuscitation is attempted in 100,000 of these arrests • Less than 40 000 survive to hospital admission MMWR / July 29, 2011 / Vol. 60 / No. 8 2 5/29/2015 Consequences From Cardiac Arrest Myocardial Brain injury dysfunction Post-Cardiac Arrest Syndrome Systemic ischemia Disorder that + reperfusion caused the cardiac responses arrest • The effects of this syndrome are severe and pervasive MMWR / July 29, 2011 / Vol. 60 / No. 8 Survival and Neurological Outcomes after OHCA • Only one third of patients admitted to the hospital survive to hospital discharge • Approx. one out of ten people who experience OHCA survive to hospital discharge • Only 2 out of 3 of them have a good/moderate neurologic recovery MMWR / July 29, 2011 / Vol. 60 / No. 8: CARES 3 5/29/2015 “Chain of Survival” • Actions needed to improve chances of survival from out-of-hospital cardiac arrest Circulation 2010; 122:S676-84 • Try to identify and treat the precipitating causes of the arrest and prevent recurrent -
Alterations in the Specific Gravity of the Blood Plasma with Onset of Diuresis in Heart Failure
MECHANISM OF DIURESIS: ALTERATIONS IN THE SPECIFIC GRAVITY OF THE BLOOD PLASMA WITH ONSET OF DIURESIS IN HEART FAILURE Harold J. Stewart J Clin Invest. 1941;20(1):1-6. https://doi.org/10.1172/JCI101189. Research Article Find the latest version: https://jci.me/101189/pdf MECHANISM OF DIURESIS: ALTERATIONS IN THE SPECIFIC GRAVITY OF THE BLOOD PLASMA WITH ONSET OF DIURESIS IN HEART FAILURE By HAROLD J. STEWART (From the Department of Medicine of.the New York Hospital and Cornell University Medical College and the Hospital of the Rockefeller Institute for Medical Research, New York) (Received for publication July 3, 1940) There are divergent views concerning the Moreover, its duration may be brief before res- mechanism by which diuresis is initiated. Many toration is attempted, or it may be long enough of the observations on this subject relate to mer- and of such magnitude that it can be detected. curial drugs. Crawford and McIntosh (1) con- On the other hand, if diuresis is initiated at cluded that novasurol induced primary dilution, the tissue side of the system so that fluid enters followed by concentration of the blood in edema- the blood stream first, dilution of the blood would tous patients. Bryan, Evans, Fulton, and Stead occur. Equilibrium would be disturbed until the (2) thought that salyrgan resulted in concentra- kidneys began to excrete the surplus fluid. If di- tion of the blood, since sustained rise in its spe- lution of the blood was of sufficient duration and cific gravity occurred coincident with diuresis in magnitude, it might be detected. -
Critical Care in the Monoplace Hyperbaric Chamber
Critical Care in the Monoplace Hyperbaric Critical Care - Monoplace Chamber • 30 minutes, so only key points • Highly suggest critical care medicine is involved • Pitfalls Lindell K. Weaver, MD Intermountain Medical Center Murray, Utah, and • Ventilator and IV issues LDS Hospital Salt Lake City, Utah Key points Critical Care in the Monoplace Chamber • Weaver LK. Operational Use and Patient Care in the Monoplace Chamber. In: • Staff must be certified and experienced Resp Care Clinics of N Am-Hyperbaric Medicine, Part I. Moon R, McIntyre N, eds. Philadelphia, W.B. Saunders Company, March, 1999: 51-92 in CCM • Weaver LK. The treatment of critically ill patients with hyperbaric oxygen therapy. In: Brent J, Wallace KL, Burkhart KK, Phillips SD, and Donovan JW, • Proximity to CCM services (ed). Critical care toxicology: diagnosis and management of the critically poisoned patient. Philadelphia: Elsevier Mosby; 2005:181-187. • Must have study patient in chamber • Weaver, LK. Critical care of patients needing hyperbaric oxygen. In: Thom SR and Neuman T, (ed). The physiology and medicine of hyperbaric oxygen therapy. quickly Philadelphia: Saunders/Elsevier, 2008:117-129. • Weaver LK. Management of critically ill patients in the monoplace hyperbaric chamber. In: Whelan HT, Kindwall E., Hyperbaric Medicine Practice, 4th ed.. • CCM equipment North Palm Beach, Florida: Best, Inc. 2017; 65-95. • Without certain modifications, treating • Gossett WA, Rockswold GL, Rockswold SB, Adkinson CD, Bergman TA, Quickel RR. The safe treatment, monitoring and management -
ASBS Newsletter Will Recall That the Collaboration and Integration
Newsletter No. 174 March 2018 Price: $5.00 AUSTRALASIAN SYSTEMATIC BOTANY SOCIETY INCORPORATED Council President Vice President Darren Crayn Daniel Murphy Australian Tropical Herbarium (ATH) Royal Botanic Gardens Victoria James Cook University, Cairns Campus Birdwood Avenue PO Box 6811, Cairns Qld 4870 Melbourne, Vic. 3004 Australia Australia Tel: (+617)/(07) 4232 1859 Tel: (+613)/(03) 9252 2377 Email: [email protected] Email: [email protected] Secretary Treasurer Jennifer Tate Matt Renner Institute of Fundamental Sciences Royal Botanic Garden Sydney Massey University Mrs Macquaries Road Private Bag 11222, Palmerston North 4442 Sydney NSW 2000 New Zealand Australia Tel: (+646)/(6) 356- 099 ext. 84718 Tel: (+61)/(0) 415 343 508 Email: [email protected] Email: [email protected] Councillor Councillor Ryonen Butcher Heidi Meudt Western Australian Herbarium Museum of New Zealand Te Papa Tongarewa Locked Bag 104 PO Box 467, Cable St Bentley Delivery Centre WA 6983 Wellington 6140, New Zealand Australia Tel: (+644)/(4) 381 7127 Tel: (+618)/(08) 9219 9136 Email: [email protected] Email: [email protected] Other constitutional bodies Hansjörg Eichler Research Committee Affiliate Society David Glenny Papua New Guinea Botanical Society Sarah Mathews Heidi Meudt Joanne Birch Advisory Standing Committees Katharina Schulte Financial Murray Henwood Patrick Brownsey Chair: Dan Murphy, Vice President, ex officio David Cantrill Grant application closing dates Bob Hill Hansjörg Eichler Research Fund: th th Ad hoc -
A Rare Complication of Carbon Monoxide Poisoning
International Clinical Pathology Journal Case Report Open Access Compartment syndrome of the lower limb: a rare complication of carbon monoxide poisoning Abstract Volume 6 Issue 5 - 2018 Carbon monoxide poisoning (CO) nicknamed “Silent killer” remains the leading cause Ghassen Drissi, Mohamed Khaled, Houssem of poisoning deaths in most countries. In Tunisia, an estimated number of 2000 to 4000 cases of poisoning was noted per a year with an estimated percentage of death up Kraiem, Khaled Zitouna, Mohamed lassed to 90% at the site of intoxication. This intoxication is very exceptionally complicated kanoun by a compartment syndrome that can aggravate the functional and vital prognosis Department of Orthopaedics and Traumatology, La Rabta Hospital of Tunis, Tunisia when it is dominated by other symptoms, particularly neurological ones. We report the case of a patient who presented a compartment syndrome during CO intoxication Correspondence: Ghassen Drissi, Department of that evolved favorably. Orthopaedics and Traumatology, La Rabta Hospital of Tunis, Tunisia, Email Received: October 08, 2018 | Published: November 15, 2018 Introduction an inhalation syndrome causing acute respiratory failure associated with a compartmental syndrome of the left lower limb syndrome Carbon monoxide is a colorless, odourless, non-irritating gas. It is causing acute kidney failure (tubular necrosis) with rhabdomyolysis particularly toxic to mammals but undetectable by them giving it an requiring intubation associated to mechanical ventilation with insidious “Silent killer” character. In humans, it is the cause of much emergency hemodialysis sessions. With regard to the compartmental domestic intoxication, often fatal. Its causes are most often accidental, syndrome, two fasciotomies in emergency were made in our service. -
THE EFFECT of CONTINUOUS NEGATIVE PRESSURE BREATH- ING on WATER and ELECTROLYTE EXCRETION by the HUMAN KIDNEY by HERBERT 0
THE EFFECT OF CONTINUOUS NEGATIVE PRESSURE BREATH- ING ON WATER AND ELECTROLYTE EXCRETION BY THE HUMAN KIDNEY By HERBERT 0. SIEKER,1 OTTO H. GAUER,2 AND JAMES P. HENRY (From the Aero-Medical Laboratory, Wright-Patterson Air Force Base, Ohio) (Submitted for publication September 4, 1953; accepted December 30, 1953) The effects of decreased intrathoracic pressure ment. Negative pressure breathing during both inspiration on arterial blood pressure (1), venous pressure and expiration was applied through a standard U. S. Air (2, 3), cardiac output (4), and pres- Force pressure breathing oxygen mask attached by a pulmonary short tubing to a 40 liter cylinder. This cylinder was sure and volume (5) have been investigated in the ventilated by a suction pump with fresh air at the rate of past. The present study was prompted by the as- 100 to 160 liters per minute and rebreathing was pre- sociation of marked diuresis with continuous nega- vented by means of a two-way valve in the face mask. tive pressure breathing in anesthetized animals (6) The desired negative pressure, which in these experiments and the observation that in unanesthetized man was a mean pressure of 15 to 18 centimeters of water, was obtained by varying the air inlet to the container. continuous positive pressure breathing leads to an Control studies duplicated the procedure exactly except oliguria (7). The purpose of this investigation that the negative pressure breathing was omitted. Re- was to demonstrate that human subjects like an- peat studies were done in all but two subjects. esthetized animals have an increased urine flow in The urine volume for each 15-minute interval was noted response to continuous negative pressure breathing. -
Renal Function in Hyperbaric Environment
APPLIED HUMAN SCIENCE Journal of Physiological Anthropology Renal Function in Hyperbaric Environment Yang Saeng Park1), John R. Claybaugh2), Keizo Shiraki3) and Motohiko Mohri4) 1) Kosin Medical College, Korea 2) Tripler Army Medical Center, USA 3) University of Occupational and Environmental Health 4) Japan Marine Science and Technology Center Abstract. During mixed gas saturation diving (to 3– diuresis. This topic has been reviewed previously by Hong 49.5 ATA) daily urine flow increases by about 500 ml/ (1975), Hong et al. (1983; 1995), Hong and Claybaugh day, with no changes in fluid intake and glomerular (1989), Shiraki (1987), and Sagawa et al. (1996). filtration rate. The diuresis is accompanied by a significant decrease in urine osmolality and increase in excretion Characteristics of Hyperbaric Diuresis of such solutes as urea, K+, Na+, Ca2+ and inorganic phosphate (Pi). The fall in urine osmolality is mainly Fig. 1 depicts time courses of urine flow in subjects due to a reduction of free water reabsorption which is exposed to 31 ATA He-O2 atmosphere determined in associated with a suppression of insensible water loss three saturation dives, Seadragon IV (Nakayama et al., and the attendant inhibition of antidiuretic hormone 1981), Seadragon VI (Shiraki et al., 1987), and New (ADH) system. The increase in urea excretion may be Seatopia (Sagawa et al., 1990), conducted in Japan associated with a reduction of urea reabsorption at the Marine Science and Technology Center (JAMSTEC). The collecting duct as a consequence of ADH suppression. daily urine flow increased rapidly upon compression to a The rise in K+ excretion is due to a facilitated K+ secretion value 700–1000 ml/day above the predive level, then it at the distal tubule as a result of increased aldosterone, dropped off slightly to a steady level of approximately 500 urine flow and excretion of impermeable anions such ml/day above the predive level. -
Hyperthermia & Heat Stroke: Heat-Related Conditions
Hyperthermia & Heat Stroke: Heat-Related Conditions Joseph Rampulla, MS, APRN,BC eat-related conditions occur when excess heat taxes or overwhelms the body’s thermoregulatory mechanisms. Heat illness is preventable and occurs more Hcommonly than most clinicians realize. Heat illness most seriously affects the poor, urban-dwellers, young children, those with chronic physical and mental illnesses, substance abusers, the elderly, and people who engage in excessive physical The exposure to activity under harsh conditions. While considerable overlap occurs, the important the heat and the concrete during the syndromes are: heat stroke, heat exhaustion, and heat cramps. Heat stroke is a life- hot summer months places many rough threatening emergency and occurs when the loss of thermoregulatory control results sleepers at great risk in hyperpyrexia (very high fever) and severe damage to many internal organs. for heat stroke and hyperthermia. Photo by Epidemiology Sharon Morrison RN Heat illness is generally underreported, and the deaths than all other natural disasters combined in true incidence is unknown. Death rates from other the USA. The elderly, the very poor, and socially causes (e.g. cardiovascular, respiratory) increase isolated individuals are disproportionately affected during heat waves but are generally not reflected in by heat waves. For example, death records during the morbidity and mortality statistics related to heat heat waves invariably include many elders who died illness. Nonetheless, heat waves account for more alone in hot apartments. Age 65 years, chronic The Health Care of Homeless Persons - Part II - Hyperthermia and Heat Stroke 199 illness, and residence in a poor neighborhood are greater than 65. -
Hyperbaric Diuresis at a Thermoneutral 31 ATA He-O2 Environment
〔日 生 気 誌 、20(1)38-15,1983〕 Original Hyperbaric Diuresis at a Thermoneutral 31 ATA He-O2 Environment K. SHIRAKI*, S. SAGAWA*, N. KONDA* and H. NAKAYAMA** * Department of Physiology , University of Occupational and Environmental Health, Japan School of Medicine ** Department of Hyperbaric Medicine , University of Occupational and Environmental Health, Japan School of Medicine (Yahatanishi-ku, kitakyushu-shi, 807 JAPAN) Abstract The basic pattern of body water exchange was studied in four Japanese male divers during exposure to a thermoneutral 31 ATA (He-O2) environment for 3 days (Seadragon V). The hyperbaric chamber temperature was raised from 25•}0.5•Ž at 1 ATA (air) pre-dive to 31.5 f 0.3•Ž at 31 ATA. Both rectal and mean skin temperatures were measured every hour (including during sleep) and were maintained at the same level at both pressures. The exposure to 31 ATA induced an increase in the daily urine flow, and a corresponding reduction in the insensible (and evaporative) water loss without changing the total daily water output. However, the daily fluid intake decreased by 600 ml at 31 ATA, and hence the divers developed a state of negative fluid balance, as reflected by a reduction in body weight and an increase in hematocrit. All changes in the pattern of body water exchange observed at 31 ATA were gradually reversed during subsequent decompression. As observed in a previous dive to 31 ATA (Seadragon IV) in which there was a subtle cold stress (as indicated by the 1•Ž reduction in mean skin temperature at 31 ATA), the increase in daily urine flow at pressure was almost entirely due to the increase in overnight urine flow. -
Diuretics and Chronic Lung Disease of Prematurity
Editorial &&&&&&&&&&&&&& Diuretics and Chronic Lung Disease of Prematurity Luc P. Brion, MD supplementation, mortality, oxygen dependency at 28 days or 36 Sin Chuen Yong weeks, length of stay, and number of hospitalizations during the first Iris A. Perez year of life. The complete list of eligible randomized trials and details Robert Primhak of selection criteria and methods of analyses are all available at {http:/ /www.nichd.nih.gov/cochraneneonatal}. Despite the widespread use of diuretics in CLD, there have Babies leaving today’s neonatal nurseries with chronic lung been surprisingly few randomised clinical trials of their clinical disease of prematurity (CLD) are very different to those initial safety or efficacy. The 20 eligible studies used very variable survivors followed by Northway et al.1 The definition of the disease outcome measures, and most concentrated on short-term has changed; most now consider an oxygen requirement beyond physiological measures such as pulmonary mechanics. Only three 36 weeks post conceptional age to be a more important defining of the studies extended beyond 8 days duration: two compared criterion than the 28 days of oxygen dependency used initially for thiazide and spironolactone to placebo,7,8 and a third evaluated bronchopulmonary dysplasia.2 Early stages of the disease are the addition of spironolactone to thiazide treatment.9 The studies associated with alveolar and interstitial edema,1,3 which could spanned a 16-year period, during which the pattern of disease reduce lung compliance as well as increase airway resistance by and survival in preterm infants have changed, and the narrowing terminal airways.3 Diuretic administration could assumptions made to calculate summary statistics from the often improve pulmonary mechanics by three mechanisms: (1) limited data available may have underestimated real differences immediate diuresis-independent reabsorption of lung fluid, (2) between treatments. -
Malignant Hyperthermia.Pdf
Malignant Hyperthermia Matthew Alcusky PharmD, MS Student University of Rhode Island July, 2013 Financial Disclosure I have no financial obligations to disclose. Outline • Introduce malignant hyperthermia including its causes and implications • Describe the underlying pathophysiology • Detail the clinical presentation of MH • Summarize the necessary pharmacological and non-pharmacological treatment of MH • Highlight necessary considerations with the use of dantrolene • Discuss recrudescence Malignant Hyperthermia • A life threatening reaction that is most often triggered by the use of inhalational anesthetics • Estimated incidence of 1 in 5,000 to 1 in 100,000 anesthesia inductions • Early recognition and treatment is essential in reducing morbidity and mortality • Screening patients for past anesthesia history and family history, as well as conducting testing on at risk individuals is necessary to reduce MH occurrence Rosenberg H, Davis M, James D, Pollock N, Stowell K. Malignant hyperthermia. Orphanet J Rare Dis. 2007 Apr 24;2:21. Review. Drugs Triggering Malignant Hyperthermia • Desflurane • Succinylcholine- • Enflurane only non-inhalational • Halothane anesthetic that triggers MH • Isoflurane • Nitrous Oxide- only • Methoxyflurane inhalational anesthetic • Sevoflurane that does not cause MH Hopkins PM. Malignant hyperthermia: pharmacology of triggering. Br J Anaesth. 2011 Jul;107(1):48-56. doi: 10.1093/bja/aer132. Epub 2011 May 30. Review. Pathophysiology • MH partially attributed to a dominant mutation in the ryanodine receptror 1 (RYR1) – Ryanodine receptors are activated by elevated Ca2+ levels, known as store overload induced calcium release (SOICR) – Mutant receptors are activated by lower Ca2+ levels – Volatile anesthetics further lower the SOICR threshold MacLennan DH, Chen SR. Store overload-induced Ca2mutations + release as a triggering mechanism for CPVT and MH episodes caused by in RYR and CASQ genes. -
Maritime Archaeology—Discovering and Exploring Shipwrecks
Monitor National Marine Sanctuary: Maritime Archaeology—Discovering and Exploring Shipwrecks Educational Product Maritime Archaeology Educators Grades 6-12 Discovering and Exploring Shipwrecks http://monitor.noaa.gov Monitor National Marine Sanctuary: Maritime Archaeology—Discovering and Exploring Shipwrecks Acknowledgement This educator guide was developed by NOAA’s Monitor National Marine Sanctuary. This guide is in the public domain and cannot be used for commercial purposes. Permission is hereby granted for the reproduction, without alteration, of this guide on the condition its source is acknowledged. When reproducing this guide or any portion of it, please cite NOAA’s Monitor National Marine Sanctuary as the source, and provide the following URL for more information: http://monitor.noaa.gov/education. If you have any questions or need additional information, email [email protected]. Cover Photo: All photos were taken off North Carolina’s coast as maritime archaeologists surveyed World War II shipwrecks during NOAA’s Battle of the Atlantic Expeditions. Clockwise: E.M. Clark, Photo: Joseph Hoyt, NOAA; Dixie Arrow, Photo: Greg McFall, NOAA; Manuela, Photo: Joseph Hoyt, NOAA; Keshena, Photo: NOAA Inside Cover Photo: USS Monitor drawing, Courtesy Joe Hines http://monitor.noaa.gov Monitor National Marine Sanctuary: Maritime Archaeology—Discovering and Exploring Shipwrecks Monitor National Marine Sanctuary Maritime Archaeology—Discovering and exploring Shipwrecks _____________________________________________________________________ An Educator