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Rabbit Anti-LSM10 antibody

SL18434R

Product Name: LSM10 Chinese Name: LSM10相关蛋白抗体 LSM 10; LSM10 U7 small nuclear RNA associated; MGC15749; MST074; Alias: LSM10_HUMAN; MSTP074; U7 snRNA associated Sm like protein LSm10; U7 snRNP specific Sm like protein LSM10. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Cow,Horse,Rabbit, ELISA=1:500-1000IHC-P=1:400-800IHC-F=1:400-800ICC=1:100-500IF=1:100- 500（Paraffin sections need antigen repair） Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 14kDa Cellular localization: The nucleus Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human LSM10:1-80/123 Lsotype: IgGwww.sunlongbiotech.com Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed: PubMed LSM10 is a 14 kDa polypeptide that is a member of the Sm/Lsm protein family. Like U7 snRNA, LSM10 is enriched in Cajal or coiled bodies (CBs) in the nucleus. LSM10 Product Detail: associates with the U7 snRNP and this interaction is dictated by the special Sm binding site of U7 snRNA. Function: Appears to function in the U7 snRNP complex that is involved in 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.

Subunit: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with CLNS1A and SMN.

Subcellular Location: Nuclear

Post-translational modifications: Not methylated. Methylation is not necessary for interaction with SMN.

Similarity: Belongs to the snRNP Sm proteins family.

SWISS: Q969L4

Gene ID: 84967

Database links: Entrezwww.sunlongbiotech.com : 84967 Human Entrez Gene: 116748 Mouse

Entrez Gene: 366468 Rat

SwissProt: Q969L4 Human

SwissProt: Q8QZX5 Mouse

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. www.sunlongbiotech.com