NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method A Location : Canada LC-MS/MS Human 1 Acetaminophen 0.1 to 13 µg / mL K EDTA - (API 300 or 3000) Plasma 2 LC-MS/MS Human 2 Acetaminophen 0.1 to 13 µg / mL K EDTA 320 mg (Waters QPXE) Plasma 2 Human 3 Acyclovir HPLC-UV 5 to 1280 ng / mL Heparin - Plasma HPLC Human Sodium 4 Acyclovir 10 to 2560 ng / mL - - Flurosence Plasma heparin HPLC Human Sodium 5 Acyclovir 20 to 2560 ng / mL - Flurosence Plasma heparin LC-MS/MS Human 6 Acyclovir 5 to 1600 ng / mL K EDTA 200 mg (Thermo) Plasma 2 LC-MS/MS Human 7 Alverine 0.05 to 10 ng / mL K EDTA 120 mg (Thermo) Plasma 2 LC-MS/MS Human 8 Allopurinol 10 to 5000 ng/mL K EDTA 200 mg (Thermo) Plasma 2 LC-MS/MS Human 9 2 to 1500 ng / mL K EDTA 300mg (Waters QPXE) Plasma 2 LC-MS/MS Human Not 10 Amantadine 20 to 3000 ng / mL 160 mg (Thermo) Urine applicable LC-MS/MS Human 0.4 to 51 ng / mL K EDTA - (API 3000) Plasma 2 11 LC-MS/MS Human 0.4 to 51 ng / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Human 12 Amlodipine 0.1 to 13 ng / mL K EDTA 10 mg (API 3000) Plasma 3 LC-MS/MS Human D- 0.5 to 100 ng / mL K EDTA (API 6500) Plasma 2 13 30 mg LC-MS/MS Human L-Amphetamine 0.15 to 30 ng/mL K EDTA (API 6500) Plasma 2 LC-MS/MS Human 14 Amphotericin B 5 to 5000 ng / mL K EDTA 200 to 400 mg (Waters QPXE) Plasma 2 LC-MS/MS Human 15 Alectinib 1 to 600 ng/mL K EDTA 50mg (Thermo) Plasma 2 LC-MS/MS Human 16 Alectinib 1 to 600 ng/mL K EDTA 150 mg (Thermo) Plasma 2 LC-MS/MS Human Not 17 Alendronate 1 to 256 ng / mL - (API 3000) Urine applicable LC-MS/MS Human 18 Anastrozole 0.1 to 26 ng / mL K EDTA 1 mg (API 3000) Plasma 2 LC-MS/MS 19 Apixaban Human Plasma 0.251 to 301.631 ng/mL K2EDTA 5 mg New (API 6500) LC-MS/MS Human 20 0.500 to 500 ng/mL K EDTA 10 mg (Thermo) Plasma 2 LC-MS/MS Human 21 Atomoxetine 2.5 to 2500 ng/mL K EDTA 60 mg (Thermo) Plasma 2 LC-MS/MS Human Atomoxetine 2 to 512 ng / mL K EDTA 40 mg (Thermo) Plasma 2 LC-MS/MS Human 22 4-Hydroxyatomoxetine 2 to 512 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human N-Desmethylatomoxetine 2 to 512 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Sodium 23 Atorvastatin 0.3 to 300 ng/mL 80 mg (Thermo) Plasma heparin LC-MS/MS Human Atorvastatin 0.4 to 102 ng / mL K EDTA 80 mg (Thermo) Plasma 2 LC-MS/MS Human 24 o-hydroxyatorvastatin 0.4 to 102.5 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human p-hydroxyatorvastatin 0.04 to 10 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Dog Atorvastatin 0.25 to 2500 ng / mL K EDTA 5 mg to 80 mg (Thermo) Plasma 2 LC-MS/MS Dog o-hydroxyatorvastatin 0.25 to 500 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Dog p-hydroxyatorvastatin 0.25 to 500 ng / mL K EDTA - (Thermo) Plasma 2 25 LC-MS/MS Dog Atorvastatin Lactone 0.5 to 2500 ng / mL K EDTA - (Thermo) Plasma 2 o-Hydroxy Atorvastatin LC-MS/MS Dog 0.5 to 250 ng / mL K EDTA - Lactone (Thermo) Plasma 2 p-Hydroxy Atorvastatin LC-MS/MS Dog 0.5 to 250 ng / mL K EDTA - Lactone (Thermo) Plasma 2 LC-MS/MS Dog Atorvastatin 10 to 2500 ng / mL K EDTA 5 mg to 80 mg (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Dog o-hydroxyatorvastatin 1 to 250 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Dog p-hydroxyatorvastatin 1 to 250 ng / mL K EDTA - (Thermo) Plasma 2 26 LC-MS/MS Dog Atorvastatin Lactone 10 to 2500 ng / mL K EDTA - (Thermo) Plasma 2 o-Hydroxy Atorvastatin LC-MS/MS Dog 1 to 250 ng / mL K EDTA - Lactone (Thermo) Plasma 2 p-Hydroxy Atorvastatin LC-MS/MS Dog 1 to 250 ng / mL K EDTA - Lactone (Thermo) Plasma 2 LC-MS/MS Human Atorvastatin 10 to 15000 pg / mL K EDTA 10 mg (Thermo) Plasma 2 LC-MS/MS Human 27 o-Hydroxy Atorvastatin 10 to 10000 pg / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human p-Hydroxy Atorvastatin 10 to 5000 pg / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Atorvastatin 0.1 to 40 ng / mL K EDTA 20 mg (Thermo) Plasma 2 LC-MS/MS Human o-Hydroxy Atorvastatin 0.1 to 40 ng / mL K EDTA - (Thermo) Plasma 2 28 LC-MS/MS Human p-Hydroxy Atorvastatin 0.05 to 20 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Glimepiride 0.5 to 200 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 29 Atazanavir 20 to 8000 ng/mL K EDTA 300 mg (Thermo) Plasma 2 LC-MS/MS Human 30 Axitinib 0.1 to 100 ng/mL K EDTA 5 mg (Thermo) Plasma 2 LC-MS Human Sodium 31 Azithromycin 5 to 1280 ng / mL 600 mg (API 150) Plasma heparin B LC-MS/MS Human 32 Barnidipine 50 to 10000 ng/mL K EDTA 20 mg (Thermo) Plasma 2

LC-MS/MS Human 33 Barnidipine 15 to 7000 pg/mL K EDTA 20mg (Thermo) Plasma 2

LC-MS/MS Human 34 R-Baclofen 1 to 500 ng / mL K EDTA 10 mg (Thermo) Plasma 2

LC-MS/MS Human R-Baclofen 1 to 500 ng / mL K EDTA 20 mg (Thermo) Plasma 2 35 LC-MS/MS Human S-Baclofen 1 to 500 ng / mL K EDTA 20 mg (Thermo) Plasma 2

LC-MS/MS Human Not R-Baclofen 2 to 2000 ng / mL 20 mg (Thermo) Urine applicable 36 LC-MS/MS Human Not S-Baclofen 2 to 2000 ng / mL 20 mg (Thermo) Urine applicable

LC-MS/MS Human Betamethasone 0.5 to 128 ng / mL K EDTA - (Thermo) Plasma 2

Betamethasone LC-MS/MS Human 37 0.5 to 128 ng / mL K EDTA - Acetate (Thermo) Plasma 2 Betamethasone LC-MS/MS Human 2 to 512 ng / mL K EDTA - Phosphate (Thermo) Plasma 2

LC-MS/MS Human Sodium 38 Budesonide 20 to 10000 pg/mL 3 x 3 mg (API 6500) Plasma heparin

LC-MS/MS Human or Sodium 1 to 1023 ng / mL 348 mg (API 3000) Rat Plasma heparin

Bupropion Erythroamino LC-MS/MS Human or Sodium 1 to 1024 ng / mL - Alcohol (API 3000) Rat Plasma heparin 39 Bupropion Threoamino LC-MS/MS Human or Sodium 1 to 1024 ng / mL - Alcohol (API 3000) Rat Plasma heparin

LC-MS/MS Human or Sodium 3 to 4000 ng / mL - (API 3000) Rat Plasma heparin

LC-MS/MS Human Sodium Bupropion 1 to 512 ng / mL 174 mg (API 3000) Plasma heparin

Bupropion Erythroamino LC-MS/MS Human Sodium 1 to 512 ng / mL - Alcohol (API 3000) Plasma heparin 40 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method 40 Bupropion Threoamino LC-MS/MS Human Sodium 1 to 512 ng / mL - Alcohol (API 3000) Plasma heparin

LC-MS/MS Human Sodium Hydroxybupropion 4 to 2000 ng / mL - (API 3000) Plasma heparin

LC-MS/MS Human Not Bupropion 16 to 1024 ng / mL 174 mg (API 3000) Urine applicable

Bupropion Erythroamino LC-MS/MS Human Not 16 to 1024 ng / mL - Alcohol (API 3000) Urine applicable 41 Bupropion Threoamino LC-MS/MS Human Not 16 to 1024 ng / mL - Alcohol (API 3000) Urine applicable

LC-MS/MS Human Not Hydroxybupropion 62.5 to 4000 ng / mL - (API 3000) Urine applicable

LC-MS/MS Rat Sodium Bupropion 5 to 5120 ng / mL - (Thermo) Plasma heparin

Bupropion Erythroamino LC-MS/MS Rat Sodium 1 to 1024 ng / mL - Alcohol (Thermo) Plasma heparin 42 Bupropion Threoamino LC-MS/MS Rat Sodium 1 to 1024 ng / mL - Alcohol (Thermo) Plasma heparin LC-MS/MS Rat Sodium Hydroxybupropion 2 to 2048 ng / mL - (Thermo) Plasma heparin Human LC-MS/MS Plasma Sodium Buprenorphine 0.1 to 25 ng / mL - (API 3000) or Dog heparin Plasma 43 Human LC-MS/MS Plasma Sodium Norbuprenorphine 0.1 to 25 ng / mL - (API 3000) or Dog heparin Plasma LC-MS/MS Human Sodium Buprenorphine 25 to 10000 pg / mL 8 mg (API 6500) Plasma heparin 44 LC-MS/MS Human Sodium Norbuprenorphine 50 to 10000 pg / mL - (API 6500) Plasma heparin LC-MS/MS Human Sodium Buspirone (API 300 0.02 to 10 ng / mL - Plasma heparin 45 or 3000) LC-MS/MS Human Sodium 1-(2-Pyrimidyl)Piperazine (API 300 0.2 to 25 ng / mL - Plasma heparin or 3000) Human LC-MS/MS Plasma Buspirone 0.4 to 77 ng / mL K EDTA - (API 3000) or Mouse 3 Plasma 46 Human LC-MS/MS Plasma 1-(2-Pyrimidyl)Piperazine 1.6 to 307.2 ng / mL K EDTA - (API 3000) or Mouse 3 Plasma Human Plasma or Mouse LC-MS/MS Plasma Sodium Buspirone 0.05 to 10 ng / mL - (API 3000) or Rat heparin Plasma or Dog 47 Plasma Human Plasma or Mouse LC-MS/MS Plasma Sodium 1-(2-Pyrimidyl)Piperazine 0.2 to 38 ng / mL - (API 3000) or Rat heparin Plasma or Dog Plasma Human Plasma LC-MS/MS or Rat Buspirone (API 300 0.4 to 50 ng / mL Heparin - Plasma or 3000) or Dog 48 Plasma Human Plasma LC-MS/MS or Rat 1-(2-Pyrimidyl) Piperazine (API 300 0.4 to 50 ng / mL Heparin - Plasma or 3000) or Dog Plasma NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human Sodium Buspirone 0.04 to 10 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium 49 1-(2-Pyrimidyl)Piperazine 0.15 to 40 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium 6-Hydroxybuspirone 0.625 to 160 ng / mL - (API 3000) Plasma heparin C LC-MS/MS Human Cannabidiol 5-1000 ng/mL K2EDTA - New (API 6500) Plasma 50 LC-MS/MS Human Tetrahydro Cannabinol 5-1000 ng/mL K2EDTA - New (API 6500) Plasma Human Sodium Carbamazepine HPLC-UV 48 to 25000 ng / mL 400 mg Plasma heparin 51 Human Sodium Carbamazepine-10,11-epoxide HPLC-UV 10 to 5000 ng / mL - Plasma heparin LC-MS/MS Human Carvedilol 1 to 128 ng / mL K EDTA 40 mg (Thermo) Plasma 2 LC-MS/MS Human O-Desmethylcarvedilol 0.2 to 25 ng / mL K EDTA - (Thermo) Plasma 2 52 LC-MS/MS Human 4'-Hydroxyphenyl carvedilol 0.2 to 25 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 5'-Hydroxyphenyl carvedilol 0.2 to 25 ng / mL K EDTA - (Thermo) Plasma 2 Human Lithium 53 Cefaclor HPLC-UV 0.2 to 25 µg / mL 500 mg Plasma heparin Human Sodium 54 Cefixime HPLC-UV 0.1 to 13 µg / mL 400 mg Plasma heparin Human 55 Cefuroxime HPLC-UV 0.2 to 27 µg / mL K EDTA 500 mg Plasma 2 LC-MS/MS Human 56 Cefuroxime 100 to 20135 ng / mL K EDTA 500 mg (Thermo) Plasma 2 HPLC Human Sodium 57 Celecoxib 20 to 2560 ng / mL 200 mg - Flurosence Plasma heparin LC-MS/MS Human 58 Celecoxib 20 to 2560 ng / mL K EDTA 200 mg (API 3000) Plasma 2 Human 59 Cephalexin HPLC-UV 0.2 to 25 µg / mL K EDTA - Plasma 3 LC-MS/MS Human 60 Cetirizine 2 to 512 ng / mL K EDTA 10 mg (API 3000) Plasma 2 LC-MS/MS Human Cetirizine 1 to 250 ng / mL K EDTA 5 mg (Waters QPXE) Plasma 2 61 LC-MS/MS Human Pseudoephedrine 5 to 1500 ng / mL K EDTA 120 mg (Waters QPXE) Plasma 2 LC-MS/MS Human 62 Chlorpheniramine 0.1 to 51 ng / mL K EDTA 8 mg / 5 mL (API 3000) Plasma 2 LC-MS/MS Human 63 Chlorthalidone 2 to 1000 ng/mL K EDTA 50 mg (Thermo) Plasma 2 LC-MS/MS Human 64 Chlorzoxazone 0.1 to 50 µg/mL K EDTA 750mg (Thermo) Plasma 2 LC-MS/MS Human Cilazapril 1 to 256 ng / mL K EDTA 1 mg (API 3000) Plasma 3 65 LC-MS/MS Human Cilazaprilat 0.25 to 64 ng / mL K EDTA 1 mg (API 3000) Plasma 3 LC-MS/MS Human Cilazapril 4 to 1024 ng / mL K EDTA 2.5 mg (API 3000) Plasma 3 66 LC-MS/MS Human Cilazaprilat 1 to 256 ng / mL K EDTA 2.5 mg (API 3000) Plasma 3 HPLC Human 67 Ciprofloxacin 25 to 6400 ng / mL K EDTA - - Flurosence Plasma 3 HPLC Human 68 Ciprofloxacin 20 to 2561 ng / mL K EDTA - - Flurosence Plasma 3 Human Not Ciprofloxacin HPLC-UV 1.5 to 15 µg / mL - Urine applicable Human Not Desethyleneciprofloxacin HPLC-UV 0.5 to 5 µg / mL - Urine applicable Human Not 69 Sulfociprofloxacin HPLC-UV 0.5 to 5 µg / mL - Urine applicable Human Not Oxociprofloxacin HPLC-UV 0.5 to 5 µg / mL - Urine applicable Human Not Formylciprofloxacin HPLC-UV 0.5 to 5 µg / mL - Urine applicable HPLC Human 70 0.25 to 32 ng / mL Heparin - - Flurosence Plasma HPLC Human Sodium 71 Citalopram 0.25 to 64 ng / mL - - Flurosence Plasma heparin LC-MS/MS Human Sodium Citalopram 0.25 to 32 ng / mL 20 mg (API 3000) Plasma heparin NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human Sodium 72 Demethylcitalopram 0.05 to 6 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium Didemethylcitalopram 0.05 to 6 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium Citalopram 0.25 to 64 ng / mL 40 mg (API 3000) Plasma heparin LC-MS/MS Human Sodium 73 Demethylcitalopram 0.05 to 12 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium Didemethylcitalopram 0.05 to 13 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium S-Citalopram 0.25 to 64 ng / mL 40 mg (API 3000) Plasma heparin 74 LC-MS/MS Human Sodium S-Demethylcitalopram 0.05 to 13 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium Citalopram 0.251 to 128 ng / mL 40 mg (Thermo) Plasma heparin LC-MS/MS Human Sodium 75 Demethylcitalopram 0.126 to 64 ng / mL - (Thermo) Plasma heparin LC-MS/MS Human Sodium Didemethylcitalopram 0.025 to 13 ng / mL - (Thermo) Plasma heparin LC-MS/MS Human Sodium Citalopram Chiral (R and S) 0.25 to 64 ng / mL 40 mg (API 3000) Plasma heparin LC-MS/MS Human Sodium 76 Demethylcitalopram (R and S) 0.2 to 51 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium Didemethylcitalopram (S) 0.2 to 51 ng / mL - (API 3000) Plasma heparin

LC-MS/MS Human Sodium 77 Clarithromycin 20 to 5120 ng / mL - (API 300 or 3000) Plasma heparin

LC-MS/MS Human Sodium 78 Clavulanic Acid 25 to 1600 ng / mL 125 mg (API 300 or 3000) Plasma heparin

LC-MS/MS Human Clobazam 5 to 600 ng/mL K EDTA 20mg (Thermo) Plasma 2 79 LC-MS/MS Human N-Desmethyl Clobazam 5 to 500 ng/mL K EDTA 20mg (Thermo) Plasma 2

LC-MS/MS Human 80 Clobazam 1 to 400 ng / mL K EDTA 2 mg / mL (Waters QPXE) Plasma 2

LC-MS/MS Human Sodium 81 Clonazepam 0.1 to 51 ng / mL - (API 300 or 3000) Plasma heparin

LC-MS/MS Human 82 Clonidine 0.03 to 2 ng / mL K EDTA 0.3 mg (Thermo) Plasma 2 LC-MS/MS Human Sodium 83 Clopidogrel 0.05 to 51 ng / mL 300 mg (Thermo) Plasma heparin LC-MS/MS Human 300 mg of 84 Clopidogrel Carboxylic Acid 0.049 to 25 µg / mL K EDTA (Thermo) Plasma 2 Clopidogrel LC-MS/MS Human 300 mg of 85 Clopidgorel Thiol 0.1 to 100 ng / mL K EDTA (Thermo) Plasma 2 Clopidogrel LC-MS/MS Human 86 Codeine 0.7 to 400 ng / mL K EDTA 30 mg (Thermo) Plasma 2 LC-MS/MS Human 2% Ointment(50 87 Crisaborole 0.05 to 100 ng/ mL K EDTA (Thermo) Plasma 2 mg & 100 mg) LC-MS/MS Human Lithium Cyproterone Acetate 0.3 to 25 ng / mL - (API 3000) Plasma heparin 88 LC-MS/MS Human Lithium Ethinyl Estradiol 15 to 1280 pg / mL - (API 3000) Plasma heparin D LC-MS/MS Human 89 Darunavir 10 to 6400 ng / mL K EDTA 600 mg (API 3000) Plasma 2 LC-MS/MS Human 90 Dapsone 0.025 to 10.0 ng/mL K EDTA New (API 6500) Plasma 2 LC-MS/MS Dabigartan Free Human Plasma 1.018 to 300.221 ng/mL Sodium Citrate 150 mg New (Thermo) LC-MS/MS Dabigartan Total Human Plasma 1.004 to 501.3471 ng/mL Sodium Citrate 150 mg New (Thermo) LC-MS/MS Human 91 Dexamethasone 0.2 to 60 ng / mL K EDTA 0.5 mg (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS 92 Human plasma 0.2 to 40 ng/mL NaF & KOx 40 mg (Thermo) LC-MS/MS Human 93 Dextroamphetamine 0.2 to 51 ng / mL K EDTA 30 mg (API 3000) Plasma 2 LC-MS/MS Human Dextromethrophan 0.1 to 100 ng/mL K EDTA 60 mg (Thermo) Plasma 2 94 LC-MS/MS Human Detrorphan 0.1 to 50 ng/mL K EDTA NA (Thermo) Plasma 2 LC-MS/MS Human Sodium 0.1 to 51 ng / mL 30 mg (API 3000) Plasma heparin LC-MS/MS Human Sodium 95 1 to 512 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium Pseudoephedrine 1 to 512 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Dextromethorphan 0.05 to 12 ng / mL K EDTA 10mg (Thermo) Plasma 2 LC-MS/MS Human 96 Pseudoephedrine 1 to 300 ng / mL K EDTA 30mg (Thermo) Plasma 2 LC-MS/MS Human 0.05 to 12 ng / mL K EDTA 2mg (Thermo) Plasma 2 LC-MS/MS Human 97 Diclofenac 0.05 to 25 ng / mL K EDTA 1 % gel (Thermo) Plasma 2 LC-MS/MS Human Sodium 98 Didanosine 10 to 1280 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human 99 Dienogest 3 to 120 ng / mL K EDTA 2 mg (Thermo) Plasma 2 Human Diltiazem HPLC-UV 3 to 385 ng / mL K EDTA - Plasma 3 Human 100 Desacetyldiltiazem HPLC-UV 1 to 128 ng / mL K EDTA - Plasma 3 Human N-Desmethyldiltiazem HPLC-UV 3 to 385 ng / mL K EDTA - Plasma 3 Human Diltiazem HPLC-UV 3 to 770 ng / mL K EDTA - Plasma 3 Human 101 Desacetyldiltiazem HPLC-UV 1 to 255 ng / mL K EDTA - Plasma 3 Human N-Desmethyldiltiazem HPLC-UV 3 to 780 ng / mL K EDTA - Plasma 3 LC-MS/MS Human Diltiazem 1 to 256 ng / mL K EDTA - (API 3000) Plasma 3 LC-MS/MS Human 102 Desacetyldiltiazem 0.125 to 32 ng / mL K EDTA - (API 3000) Plasma 3 LC-MS/MS Human N-Desmethyldiltiazem 0.25 to 64 ng / mL K EDTA - (API 3000) Plasma 3 LC-MS/MS Human Diltiazem 0.8 to 800 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 103 Desacetyldiltiazem 0.2 to 200 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human N-Desmethyldiltiazem 0.4 to 400 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Diltiazem 2.5 to 750 ng / mL K EDTA 420 mg (Thermo) Plasma 2 LC-MS/MS Human 104 Desacetyldiltiazem 0.2 to 75 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human N-Desmethyldiltiazem 2 to 150 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Sodium 105 0.5 to 128 ng / mL 25 to 38 mg (API 3000) Plasma heparin LC-MS/MS Human 106 Donepezil 0.25 to 64 ng / mL K EDTA 10 mg (Thermo) Plasma 2 HPLC Human 107 Doxazosin 0.5 to 128 ng / mL Heparin - - Flurosence Plasma LC-MS/MS Human Doxepine 0.1 to 100 ng/mL K EDTA 100 mg (Thermo) Plasma 2 108 LC-MS/MS Human Nordoxepine 0.101 to 50.476 ng/mL K EDTA - (Thermo) Plasma 2 Human 109 Doxycycline HPLC-UV 80 to 5120 ng / mL Heparin - Plasma NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human 110 0.5 to 128 ng / mL K EDTA 60 mg (API 3000) Plasma 2 LC-MS/MS Human 111 Duloxetine 0.5 to 128 ng / mL K EDTA 60 mg New (Thermo) Plasma 2 LC-MS/MS Human Sodium 112 Duloxetine 0.5 to 400 ng/mL 120 mg (Thermo) Plasma heparin LC-MS/MS Human 113 Dutasteride 60 to 5120 pg / mL K EDTA 0.5 mg (Thermo) Plasma 2 E

LC-MS Human Sodium 114 0.02 to 5 µg / mL - (API 150) Plasma heparin LC-MS/MS Human 115 Eliglustat 0.1 to 50 ng/mL K EDTA 84mg (Thermo) Plasma 2 LC-MS/MS Human Enalapril 0.25 to 80 ng / mL Heparin - (API 3000) Plasma LC-MS/MS Human 116 Enalaprilat 0.25 to 80 ng / mL Heparin - (API 3000) Plasma LC-MS/MS Human Hydrochlorthiazide 2.5 to 800 ng / mL Heparin - (API 3000) Plasma LC-MS/MS Human Enalapril 0.25 to 256 ng / mL K EDTA - (API 3000) Plasma 2 117 LC-MS/MS Human Enalaprilat 0.25 to 256 ng / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Mice plasma 118 Endoxifen 0.1 to 100 ng/mL K EDTA 0.2 mg/mL New (Thermo) Extract 2 LC-MS/MS Beagle Dog 119 Enrofloxacin 10 to 5000 ng/mL K EDTA 150 mg (Thermo) plasma 2 LC-MS/MS Human 120 Eprosartan 5 to 3840 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 121 Esomeprazole 1 to 2000 ng / mL K EDTA 20 mg (Thermo) Plasma 2 LC-MS/MS Human 122 Epinephrine 11 to 1500 pg/mL K EDTA 10 mg New (API 6500) Plasma 2 LC-MS/MS Human 123 17 β‐Estradiol 1 to 100 pg/mL K EDTA 0.1 % Gel New (API 6500) Plasma 2 Human 124 Etodolac HPLC-UV 0.25 to 32 µg / mL Heparin - Plasma LC-MS/MS Human 125 Ethinyl Estradiol 3 to 128 pg / mL K EDTA 0.03 mg (Thermo) Plasma 2 LC-MS/MS Human 126 Ethinyl Estradiol 0.5 to 125 pg / mL K EDTA 20 mcg (API 6500) Plasma 2 LC-MS/MS Human 127 Exemestane 0.2 to 25 ng / mL K EDTA 25 mg (API 3000) Plasma 2 LC-MS/MS Human 128 Exemestane 0.05 to 25 ng / mL K EDTA 25 mg (Thermo) Plasma 2 LC-MS/MS Human Sodium Ezetimibe 0.05 to 15 ng/mL 10 mg (API 6500) Plasma heparin 129 Ezetimibe Phenoxy LC-MS/MS Human Sodium 0.5 to 300 ng/mL 10 mg Glucuronide (API 6500) Plasma heparin F Human 130 Famotidine HPLC-UV 5 to 640 ng / mL Heparin - Plasma LC-MS/MS Human 131 Felodipine 0.05 to 13 ng / mL K EDTA 10 mg (Thermo) Plasma 2 LC-MS/MS Human 132 Fenofibric acid 50 to 19200 ng / mL K EDTA 135 mg (API 3000) Plasma 2 Human K EDTA/Sodium 133 Fenofibric acid HPLC-UV 50 to 12800 ng / mL 2 - Plasma heparin Human Sodium 134 Fenofibric acid HPLC-UV 10 to 5120 ng / mL - Plasma heparin LC-MS/MS Human 135 Fenofibric acid 0.05 to 25 µg / mL K EDTA 215 mg (Thermo) Plasma 2 LC-MS/MS Human Sodium 136 Fentanyl 0.02 to 20 ng / mL - (API 3000) Plasma heparin NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method Human plasma LC-MS/MS Fesoterodine (Bufferized) 0.45 to 100 pg/mL K EDTA 3.1 mg (API 6500) 2 137 Human plasma LC-MS/MS 5-Hydroxy Tolterodine (Bufferized) 30 to 11000 pg/mL K EDTA 6.2 mg (API 6500) 2

HPLC Human Sodium 138 Fexofenadine 5 to 640 ng / mL - - Flurosence Plasma heparin LC-MS/MS Human 139 Fexofenadine 1 to 1000 ng / mL K EDTA 180 mg (Waters QPXE) Plasma 2 LC-MS/MS Human 140 Fexofenadine 3 to 3500 ng/mL K EDTA 180mg (Thermo) Plasma 2 LC-MS/MS Human 141 Fingolimod 25 to 500 pg / mL K EDTA 3 X 0.5 mg (Thermo) Blood 2 LC-MS/MS Human 3 X 0.5 mg of 142 Fingolimod Phosphate 75 to 4000 pg / mL K EDTA (Waters QPXE) Blood 2 fingolimod Human Sodium 143 Fluconazole HPLC-UV 0.1 to 13 µg / mL 150 mg Plasma heparin LC-MS Human 0.15 to 37.5 ng / mL Heparin 20 mg (API 150) Plasma 144 LC-MS Human Norfluoxetine 0.15 to 37.5 ng / mL Heparin - (API 150) Plasma LC-MS Human Sodium Fluoxetine 0.5 to 64 ng / mL - (API 150) Plasma heparin 145 LC-MS Human Sodium Norfluoxetine 0.5 to 64 ng / mL - (API 150) Plasma heparin LC-MS/MS Human 146 Flupenthixol 0.1 to 13 ng / mL K EDTA 10 mg (API 3000) Plasma 2 Fluticasone LC-MS/MS Human 147 1 to 32 pg / mL K EDTA - Propionate (Thermo) Plasma 2 Fluticasone LC-MS/MS Human 148 5 to 640 pg / mL K EDTA - Propionate (Thermo) Plasma 2 LC-MS/MS Human 149 Fluvastatin 2 to 512 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Sodium 150 0.5 to 64 ng / mL - (API 3000) Plasma heparin LC-MS/MS Dog Sodium 151 Fulvestrant 0.5 to 40 ng / mL 50 mg (Thermo) Plasma heparin LC-MS/MS Human 152 Fulvestrant 0.05 to 40 ng / mL K EDTA 50 mg (Thermo) Plasma 2 G LC-MS/MS Human 153 Gabapentin 75 to 9600 ng / mL K EDTA 600 mg (API 3000) Plasma 2

LC-MS/MS Human 154 Galantamine 0.5 to 63 ng / mL K EDTA 8 mg (API 3000) Plasma 2

HPLC Human 155 Ganciclovir 30 to 1920 ng / mL K EDTA - - Flurosence Plasma 3

HPLC Human 156 Gatifloxacin 25 to 6400 ng / mL K EDTA - - Flurosence Plasma 3

LC-MS/MS Human 157 Glimepiride 2 to 1024 ng / mL K EDTA 4 mg (API 300 or 3000) Plasma 3

Human 158 Glipizide HPLC-UV 10 to 640 ng / mL K EDTA - Plasma 2

LC-MS Human 159 Glipizide 10 to 640 ng / mL K EDTA - (API 150) Plasma 2

LC-MS/MS Human 160 Glipizide 10 to 1280 ng / mL K EDTA - (API 300 or 3000) Plasma 2

LC-MS/MS Human 161 Glipizide 2.5 to 640 ng / mL K EDTA 10 mg (API 3000) Plasma 2 LC-MS Human 162 Glyburide 2 to 128 ng / mL K EDTA - (API 150) Plasma 3 LC-MS/MS 163 Glycopyrrolate Human plasma 1 to 400 pg/mL K EDTA 44 µg New (Thermo) 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS 164 Glycopyrrolate Human plasma 2 to 800 pg/mL K EDTA New (Thermo) 2 LC-MS/MS Human 161 Griseofulvin 15 to 3840 ng / mL K EDTA - (API 300 or 3000) Plasma 3

LC-MS/MS Human 162 Granisetron 0.02 to 10 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 163 Guaifenesin 10 to 1280 ng / mL K EDTA - (Thermo) Plasma 2

LC-MS/MS Human 164 Guaifenesin 10 to 5000 ng/mL K EDTA 1200 mg (Thermo) Plasma 2 H LC-MS/MS Human 7.5 mg / 165 Hydrocodone 0.4 to 51 ng / mL K EDTA (Thermo) Plasma 2 5 mL LC-MS/MS Human Sodium Hydrocodone 1 to 128 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium 166 Hydromorphone 1 to 128 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human 100 to Sodium Ibuprofen - (API 3000) Plasma 12800 ng / mL heparin LC-MS/MS Human Hydralazine 0.25 to 128 ng/mL K EDTA 50 mg (Thermo) Plasma 2 167 hydralazine pyruvic acid LC-MS/MS Human 1.2 to 1250 ng/mL K EDTA - hydrazone (HPH) (Thermo) Plasma 2 LC-MS Human 168 Hydrochlorthiazide 5 to 1280 ng / mL K EDTA 12.5 mg to 25 mg (API 150) Plasma 2 LC-MS/MS Human 169 Hydromorphone 50 to 15000 pg / mL K EDTA 32 mg (Thermo) Plasma 2 LC-MS/MS Human 170 Hydromorphone 0.05 to 6 ng / mL K EDTA 16 mg (Thermo) Plasma 2 I Human Sodium 171 Ibuprofen HPLC-UV 0.4 to 512 µg / mL 200 mg Plasma heparin LC-MS/MS Human 172 Ibuprofen 0.1 to 40 µg/mL Sodium Heparin 200mg New (API 6500) Plasma LC-MS/MS Human 173 Ibuprofen 0.2 to 50 µg / mL K EDTA 600 mg (Waters QPXE) Plasma 2 LC-MS/MS Human Ibuprofen 0.2 to 51 µg/mL K EDTA 200 mg (Thermo) Plasma 2 174 LC-MS/MS Human Methocarbamol 0.06 to 15 µg/mL K EDTA 500 mg (Thermo) Plasma 2

LC-MS/MS Human 175 Imatinib 5 to 3500 ng / mL K EDTA 400 mg (Thermo) Plasma 2

Human 176 Indapamide HPLC-UV Whole 10 to 1280 ng / mL Heparin - Blood

LC-MS/MS Human 177 Ipratropium 1 to 150 pg/mL K EDTA New (Thermo Altis) Plasma 2

LC-MS/MS Human Itraconazole 1 to 320 ng / mL Heparin - (API 300 or 3000) Plasma 178 LC-MS/MS Human Hydroxy Itraconazole 1 to 320 ng / mL Heparin - (API 300or 3000) Plasma LC-MS/MS Human Itraconazole 2 to 512 ng / mL K EDTA 100 mg (API 3000) Plasma 2 179 LC-MS/MS Human Hydroxy Itraconazole 2 to 512 ng / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Human Ivabradine 20 to 20000 ng / mL K EDTA 15mg (Waters QPXE) Plasma 2 180 N-desmethyl LC-MS/MS Human 15 mg of 20 to 2480 ng / mL K EDTA Ivabradine (Waters QPXE) Plasma 2 Ivabradine LC-MS/MS Ivermectin B1a Human plasma 0.25 to 50 ng/mL K EDTA 3 mg New (API 6500) 2 181 LC-MS/MS Ivermectin B1b Human plasma 40 to 8000 pg/mL K EDTA 3 mg New (API 6500) 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS 182 Ivermectin Human plasma 0.25 to 50 ng/mL K EDTA 3 mg New (API 6500) 2 L LC-MS/MS Human 183 Labetalol 5 to 1500 ng/mL K EDTA 200 mg (Thermo) Plasma 2 LC-MS/MS Human Sodium 184 Lamotrigine 10 to 1280 ng / mL 50 mg (Thermo) Plasma heparin

LC-MS/MS Human Sodium 185 Lansoprazole 2 to 4096 ng / mL 30 mg (API 300 or 3000) Plasma heparin

LC-MS/MS Human 186 Leuprolide 0.025 to 13 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 187 Letrozole 0.5 to 128 ng / mL K EDTA 2.5 mg (API 3000) Plasma 2 LC-MS Human 188 Levetiracetam 0.5 to 24 µg / mL K EDTA - (API 150) Plasma 3 LC-MS/MS Human 189 Levetiracetam 0.375 to 48 µg / mL K EDTA 1 gm (API 3000) Plasma 2 LC-MS/MS 190 Human plasma 20 to 10000 pg/mL K EDTA 2 mg New (Thermo) 2 LC-MS/MS 191 Levothyroxine(T4) Human Serum 5 to 300 ng/mL Human Serum New (API 6500) LC-MS/MS Human Lithium 192 Lisinopril 0.25 to 64 ng / mL - (API 300 or 3000) Plasma heparin LC-MS/MS Human 193 Lisinopril 0.25 to 128 ng / mL Heparin - (API 300 or 3000) Plasma LC-MS/MS Human Lithium 194 Lisinopril 1 to 256 ng / mL - (API 300 or 3000) Plasma heparin LC-MS/MS Human 195 Loperamide 0.05 to 6 ng / mL K EDTA 2 mg (Thermo) Plasma 2 LC-MS/MS Human Loratadine 0.1 to 51 ng / mL Heparin - (API 3000) Plasma LC-MS/MS Human 196 Descarboethoxyloratadine 0.1 to 51 ng / mL Heparin - (API 3000) Plasma LC-MS/MS Human Pseudoephedrine 2.5 to 1280 ng / mL Heparin - (API 3000) Plasma LC-MS/MS Human Loratadine 0.1 to 51 ng / mL Heparin - (API 300 or 3000) Plasma 197 LC-MS/MS Human Descarboethoxyloratadine 0.1 to 25 ng / mL Heparin - (API 300 or 3000) Plasma Human Loratadine LC-MS/MS (API 6500) 5 to 5000 pg / mL K EDTA 5mg Plasma 2 LC-MS/MS Human 198 Descarboethoxyloratadine 10 to 10000 pg / mL K EDTA - (API 6500) Plasma 2 LC-MS/MS Human Pseudoephedrine 2.5 to 1250 ng / mL K EDTA 120 mg (API 6500) Plasma 2 LC-MS/MS Human Loratadine 40 to 12000 pg/mL K EDTA 10 mg (API 6500) Plasma 2 LC-MS/MS Human 199 Desloratadine 40 to 12000 pg/mL K EDTA N/AP (API 6500) Plasma 2 LC-MS/MS Human Pseudoephedrine 5 to 1600 ng/mL K EDTA 240 mg (API 6500) Plasma 2 LC-MS/MS Human 200 Lormetazepam 0.06 to 8 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Losartan 4 to 1027 ng / mL K EDTA 100 mg (API 3000) Plasma 2 201 LC-MS/MS Human Losartan Hydroxy Acid 4 to 1024 ng / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Human Lovastatin 0.1 to 25 ng / mL Heparin - (API 300 or 3000) Plasma 202 LC-MS/MS Human Lovastatin Hydroxy Acid 0.2 to 51 ng / mL Heparin - (API 300 or 3000) Plasma M LC-MS/MS Human 203 Meclizine 1.01 to 256 ng / mL K EDTA 25 mg (API 3000) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method Human 204 Mefanamic Acid HPLC-UV 50 to 6400 ng / mL K EDTA - Plasma 2 LC-MS/MS Human 205 Mefanamic Acid 50 to 12800 ng / mL K EDTA 250 mg (API 3000) Plasma 2 LC-MS/MS Human Sodium 206 Medroxyprogesterone Acetate 0.02 to 10 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium 207 Medroxyprogesterone Acetate 50 to 10000 pg/mL 150 mg (Thermo) Plasma heparin LC-MS/MS Human 208 Megestrol Acetate 0.3 to 153.6 ng/mL K EDTA 40 mg / mL (Thermo) Plasma 2 LC-MS/MS Human 209 Megestrol Acetate 1 to 300 ng/mL K EDTA New (Thermo) Plasma 2 Human Plasma or 210 Meloxicam HPLC-UV 0.03 to 1.92 µg / mL K EDTA - Dog 2 Plasma LC-MS/MS Human Not 211 Meloxicam 1 to 128 ng / mL - (API 3000) Urine applicable LC-MS/MS Human 212 Meloxicam 10 to 2560 ng / mL K EDTA 15 mg (API 3000) Plasma 2 LC-MS/MS Human 213 Mesalamine 5 to 3000 ng/mL K EDTA 500 mg (API 6500) Plasma 2 Human 214 Metaxalone HPLC-UV 1 to 256 µg / mL Heparin - Plasma Human 215 Metaxalone HPLC-UV 1 to 256 µg / mL K EDTA - Plasma 3 Human 216 Metaxalone LC-MS (API 150) 5 to 2560 ng / mL K EDTA - Plasma 3 LC-MS/MS Human 217 Metaxalone 20 to 6000 ng / mL K EDTA 400 mg (API 6500) Plasma 2 LC-MS/MS Human 218 0.1 to 50 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Sodium Fluoride & 219 Methylphenidate 0.1 to 50 ng/mL 54mg (Thermo) Plasma Potassium Oxalate LC-MS/MS Human 220 Methylphenidate 0.026 to 15 ng/mL K EDTA 20 mg (Thermo) Plasma 2 L-Threo- Human LC‐MS/MS (API 6500) 1 to 195 pg/mL K EDTA 18 mg Methylphenidate Plasma 2 221 D-Threo- Human LC‐MS/MS (API 6500) 25 to 9800 pg/mL K EDTA NA Methylphenidate Plasma 2 LC-MS/MS Human 222 Methylphenidate Achiral 0.1 to 50 ng/mL K EDTA 54 mg (Thermo) Plasma 2 Methylphenidate LC-MS/MS Human 100 to 30000 pg/mL(D) K EDTA 54 mg Chiral(L&D) (API 6500) Plasma 2 223 Methylphenidate LC-MS/MS Human 50 to 4000 pg/mL(L) K EDTA 54 mg Chiral(L&D) (API 6500) Plasma 2

Methylphenidate LC-MS/MS Human Sodium fluoride & 15 to 3000 pg/mL (L) 60 mg Chiral(L&D) (Thermo) Plasma Potassium oxalate 224 Methylphenidate LC-MS/MS Human Sodium fluoride & 200 to 40000 pg/mL (D) 60 mg Chiral(L&D) (Thermo) Plasma Potassium oxalate

LC-MS/MS Human Sodium fluoride 225 Methylprednisolone 0.4 to 51 ng / mL - (API 3000) Plasma potassium oxalate

80mg/mL LC-MS/MS Human Sodium Fluoride & 226 Methylprednisolone 0.4 to 75 ng/mL Injectable (API 6500) Plasma Potassium Oxalate suspension LC-MS/MS Human Sodium 227 Metoprolol 1 to 512 ng / mL 200 mg (API 3000) Plasma heparin LC-MS/MS Human 10.01 to 228 Metformin K EDTA 1000 mg (API 3000) Plasma 2002 ng / mL 2 LC-MS Human Not 229 Metformin 2 to 256 µg / mL 1000 mg (API 150) Urine applicable LC-MS/MS Human 230 Methazolamide 5 to 10000 ng / mL K EDTA 150 mg (Waters QPXE) Plasma 2 Human LC-MS/MS 231 Methazolamide Whole 100 to 50000 ng / mL K EDTA 150 mg (Waters QPXE) 2 Blood NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human 232 Methazolamide 5 to 9800 ng/mL K EDTA 150 mg (Thermo) Plasma 2 LC-MS/MS Human 5mg/0.1 mL Nasal Midazolam 1 to 200 ng/mL K EDTA (Thermo) Plasma 2 Spray 233 New LC-MS/MS Human α‐Hydroxy Midazolam 0.1 to 20 ng/mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 234 Methocarbamol 0.05 to 20 µg/mL K EDTA New (Thermo) Plasma 2 LC-MS/MS Human 235 Minocycline 4 to 3500 ng / mL K EDTA 45 mg to 135 mg (Thermo) Plasma 2 LC-MS/MS Human Sodium 236 Mirtazapine 0.5 to 128 ng / mL - (API 300 or 3000) Plasma heparin LC-MS/MS Human Lithium Misoprostol Acid 10 to 1280 pg / mL - (Thermo) Plasma heparin 237 LC-MS/MS Human Lithium Diclofenac 20 to 2560 ng / mL - (Thermo) Plasma heparin LC-MS/MS Human 238 Mometasone furoate 0.5 to 100 pg/mL K EDTA 50 µg Nasal spray New (Thermo) Plasma 2 LC-MS/MS Human 239 Mometasone furoate 0.25 to 50.032 pg/mL K EDTA 50 µg Nasal spray New (API 6500) Plasma 2 LC-MS/MS Human 240 Monomethyl fumarate 10 to 6000 ng/mL K EDTA 120 mg (API 6500) Plasma 2 LC-MS/MS Human Monomethyl fumarate 20 to 5000 ng / mL K EDTA 240 mg DMF (Thermo) Plasma 2 241 LC-MS/MS Human Monoethyl fumarate 20 to 5000 ng / mL K EDTA (Thermo) Plasma 2 Human 242 Mycophenolic Acid HPLC-UV 0.1 to 51 µg / mL K EDTA - Plasma 2 LC-MS/MS Human Mycophenolate Mofetil 0.04 to 20 ng / mL K EDTA 250 mg (Thermo) Plasma 2 243 LC-MS/MS Human Mycophenolic Acid 0.1 to 51 µg / mL K EDTA - (Thermo) Plasma 2 6-Methoxy-2- HPLC Human 244 0.5 to 32 µg / mL Heparin - Naphthaleneacetic Acid - Flurosence Plasma N LC-MS/MS Human Nadolol 2 to 256 ng / mL K EDTA - (API 3000) Plasma 2 245 LC-MS/MS Human Bendroflumethiazide 1 to 128 ng / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Human 246 Naloxone 1 to 500 pg/mL K EDTA 20 mg (API 6500) Plasma 2 LC-MS/MS 247 Naloxone Human plasma 0.02 to 20 ng/mL K EDTA 0.4 mg/mL (Thermo) 2 LC-MS/MS Human Naloxone‐3‐β‐D‐Glucuronide 1 to 300 ng/mL K EDTA 20 mg (API 6500) Plasma 2 248 LC-MS/MS Human Oxycodone 0.5 to 150 ng/mL K EDTA 40 mg (API 6500) Plasma 2 Sodium heparin for Human or LC-MS/MS human plasma; Naltrexone Dog 0.1 to 205 ng / mL 50 mg (API 3000) K EDTA for dog Plasma 3 plasma 249 Sodium heparin for Human or LC-MS/MS human plasma; 6-ß-Naltrexol Dog 0.1 to 205 ng / mL - (API 3000) K3EDTA for dog Plasma plasma LC-MS/MS Human Not Naltrexone 1 to 512 ng / mL - (API 3000) Urine applicable 250 LC-MS/MS Human 9.947 to Not 6-ß-Naltrexol - (API 3000) Urine 5092 ng / mL applicable Human 251 Naproxen HPLC - Flurosence 0.5 to 128 µg / mL Heparin - Plasma LC-MS/MS Human 252 Nebivolol 15 to 5000 pg/mL K EDTA 5 mg (API 6500) Plasma 2 Human LC-MS (API 150) 6.25 to 800 ng / mL Heparin - Plasma Human 253 2- LC-MS (API 150) 1.88 to 240 ng / mL Heparin - Plasma m- Human LC-MS (API 150) 1.25 to 160 ng / mL Heparin - Chlorophenylpiperazine Plasma NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human Niacin 20 to 2000 ng / mL K EDTA 1000 mg (Thermo) Plasma 2 254 LC-MS/MS Human Nicotinuric acid 20 to 2000 ng / mL K EDTA - (Thermo) Plasma 2 Human 255 Nifedipine LC-MS (API 150) 0.5 to 200 ng / mL K EDTA 60 mg Plasma 3 LC-MS/MS Human 256 Nifedipine 0.5 to 200 ng / mL K EDTA 60 mg (API 3000) Plasma 2 LC-MS/MS Human 257 Nintedanib 0.050- 20 ng/mL K EDTA 150mg (Thermo) Plasma 2 LC-MS/MS 258 Nitisinone Human plasma 10 to 2500 ng/mL K EDTA 10 mg (Thermo) 2 Human Sodium 259 Nitrofurantoin HPLC-UV 20 to 2560 ng / mL - Plasma heparin LC-MS/MS Human 25mg/5mL 260 Nitrofurantoin 5 to 1000 ng/mL K EDTA (Thermo) Plasma 2 suspension LC-MS/MS Human Nitroglycerin 20 to 4000 pg/mL K EDTA (API 6500) Plasma 2 LC-MS/MS Human 261 1,3-Dinitroglycerin 40 to 4000 pg/mL K EDTA 1.5mg (API 6500) Plasma 2 LC-MS/MS Human 1,2-Dinitroglycerin 40 to 8000 pg/mL K EDTA (API 6500) Plasma 2 Human Nizatidine HPLC-UV 10 to 5120 ng / mL Heparin 300 mg Plasma 262 Human Desmethylnizatidine HPLC-UV 5 to 2560 ng / mL Heparin - Plasma Human 263 Norfloxacin HPLC - Flurosence 20 to 2560 ng / mL K EDTA - Plasma 3 Human 264 Nortriptyline HPLC-UV 1 to 64 ng / mL K EDTA - Plasma 3 LC-MS/MS Human 265 Norethindrone 50 to 15000 pg / mL K EDTA 0.35 mg / 1 mg (Thermo) Plasma 2 LC-MS/MS Human 266 RS-Norketotifen 0.2 to 70 ng/mL K EDTA 8 mg (Thermo) Plasma 2 LC-MS/MS Human S-Norketotifen 1 - 1000 ng/mL K EDTA 4 mg/8mg/16mg (Thermo) Plasma 2 267 LC-MS/MS Human R- Norketotifen 1 - 1000 ng/mL K EDTA NA (Thermo) Plasma 2 O LC-MS/MS Human 268 Olanzapine 0.2 to 25 ng / mL K EDTA 10 mg (API 3000) Plasma 2 LC-MS/MS Human Olmesartan 6 to 1536 ng / mL K EDTA 40 mg (API 3000) Plasma 2 269 LC-MS/MS Human 2.01 to Hydrochlorthiazide K EDTA 25 mg (API 3000) Plasma 512.46 ng / mL 2 LC-MS/MS Human Sodium 270 Omeprazole 1 to 1024 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human 271 Omeprazole 5 to 3450 ng / mL K EDTA 40 mg (Thermo) Plasma 2 LC-MS/MS Human 272 Omeprazole 5 to 3400 ng/mL K EDTA 20 mg (Thermo) Plasma 2 LC-MS/MS Human Lithium 273 Ondansetron 0.5 to 128 ng / mL 8 mg (API 3000) Plasma heparin LC-MS/MS Human 300 mg/ 274 Oxcarbazepine 0.01 to 10 µg / mL K EDTA (API 3000) Plasma 2 5 mL 10,11-dihydro-10- LC-MS/MS Human 275 0.05 to 51.2 µg / mL K EDTA - Hydroxycarbamazepine (API 3000) Plasma 2 LC-MS/MS Human 300 mg/ Oxcarbazepine 0.01 to 5.12 µg / mL K EDTA (Thermo) Plasma 2 5 mL 276 10,11-dihydro-10- LC-MS/MS Human 0.05 to 25.6 µg / mL K EDTA - Hydroxycarbamazepine (Thermo) Plasma 2 LC-MS/MS Human 277 Oxycodone 0.1 to 60 ng / mL K EDTA 5 mg (Thermo) Plasma 2 LC-MS/MS Human 278 Oxycodone 0.5 to 150 ng / mL K EDTA 80 mg (Thermo) Plasma 2 LC-MS/MS Human Oxycodone 0.1 to 101 ng / mL Heparin - (API 3000) Plasma 279 LC-MS/MS Human Oxymorphone 0.1 to 100 ng / mL Heparin - (API 3000) Plasma LC-MS/MS Human Oxycodone 0.234 to 60 ng / mL K EDTA 20 mg (Thermo) Plasma 2 280 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method 280 LC-MS/MS Human Oxymorphone 0.234 to 60 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Oxycodone 0.5 to 255 ng / mL K EDTA - (API 3000) Plasma 3 LC-MS/MS Human 281 Noroxycodone 0.5 to 256 ng / mL K3EDTA - (API 3000) Plasma LC-MS/MS Human Oxymorphone 0.1 to 51.2 ng / mL K EDTA - (API 3000) Plasma 3 LC-MS/MS Human Oxybutynin 0.16 to 20 ng / mL Heparin - (API 300 or 3000) Plasma 282 LC-MS/MS Human Desethyloxybutynin 0.3 to 40 ng / mL Heparin - (API 300 or 3000) Plasma LC-MS/MS Human Oxymorphone 40 to 1280 pg / mL K EDTA - (Thermo) Plasma 2 283 LC-MS/MS Human Hydroxy Oxymorphone 25 to 800 pg / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Oxymorphone 40 to 3200 pg / mL K EDTA 10 mg (Thermo) Plasma 2 284 LC-MS/MS Human Hydroxy Oxymorphone 25 to 2000 pg / mL K EDTA 10 mg (Thermo) Plasma 2 LC-MS/MS Human 0.025 to Oxymorphone K EDTA 20 mg (Thermo) Plasma 8.000 ng/mL 2 285 LC-MS/MS Human 0.025 to Hydroxy Oxymorphone K EDTA 20 mg (Thermo) Plasma 8.000 ng/mL 2 P LC-MS/MS Human 286 Pantoprazole 20 to 5120 ng / mL K EDTA 40 mg (API 3000) Plasma 2 Human Sodium 287 HPLC - Flurosence 0.2 to 50 ng / mL - Plasma heparin Human Sodium 288 Paroxetine HPLC - Flurosence 1.6 to 200 ng / mL - Plasma heparin Human 289 Pentoxifylline HPLC-UV 5 to 240 ng / mL K EDTA - Plasma 3 LC-MS/MS Human 290 Pergolide 0.2 to 1.28 ng / mL Heparin - (API 3000) Plasma LC-MS/MS Human 50 mg/mL Oral 291 Phenobarbital 20 to 2000 ng/mL K EDTA New (Thermo) Plasma 2 solution LC-MS/MS Human 292 Phenylephrine (Total) 4 to 512 ng / mL K EDTA 10 mg New (Thermo) Plasma 2 LC-MS/MS Human 293 Phenylephrine 40 to 3000 ng / mL K EDTA New (API 6500) Plasma 2 Human 293 Phenytoin HPLC-UV 0.04 to 2.56 µg / mL K EDTA - Plasma 3 LC-MS/MS Human Phytonadione- Trans 0.3 to 100 ng/mL K EDTA 5 mg New (API 6500) Plasma 2 294 LC-MS/MS Human Phytonadione- Cis 0.3 to 100 ng/mL K EDTA 5 mg New (API 6500) Plasma 2 LC-MS/MS Human Phytonadione- Trans 1 to 500 ng/mL K EDTA 5 mg New (API 6500) Plasma 2 295 LC-MS/MS Human Phytonadione- Cis 1 to 500 ng/mL K EDTA 5 mg New (API 6500) Plasma 2

LC-MS/MS Human Sodium fluoride and 296 Pomalidomide 0.2 to 125 ng/mL 4 mg New (API 6500) Plasma Potassium oxalate

LC-MS/MS Human 297 Pramipexole 50 to 3200 pg / mL K EDTA - (Thermo) Plasma 2 *Prasugrel active metabolite LC-MS/MS Human 298 0.2 to 150 ng / mL K EDTA 10 mg of Prasugrel (R-138727) (Thermo) Plasma 2 *Prasugrel inactive metabolite LC-MS/MS Human 299 0.25 to 127 ng / mL K EDTA 10 mg of Prasugrel (R-95913) (Thermo) Plasma 2 LC-MS/MS Human Sodium Pravastatin 0.25 to 128 ng / mL - (API 3000) Plasma heparin 300 LC-MS/MS Human Sodium 3‐α‐Hydroxy Pravastatin 0.25 to 128 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sodium Pravastatin 1 to 512 ng / mL 80 mg (API 3000) Plasma heparin 301 LC-MS/MS Human Sodium 3‐α‐Hydroxy Pravastatin 1 to 512 ng / mL - (API 3000) Plasma heparin NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human Sodium Pravastatin 1 to 512 ng / mL 80 mg (Thermo) Plasma heparin 302 LC-MS/MS Human Sodium 3‐α‐Hydroxy Pravastatin 1 to 512 ng / mL - (Thermo) Plasma heparin LC-MS/MS Human Primidone 0.2 to 25 µg / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Human 303 Phenobarbital 0.2 to 25 µg / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Human Phenylethylmalonamide 0.2 to 25 µg / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Human 304 Progesterone 0.04 to 40 ng/mL K EDTA 200 mg (API 6500) Plasma 2 Propafenone LC-MS/MS 0151 to 499.457 ng/mL 305 Human Plasma K2EDTA 425 mg New 5-OH Propafenone (Thermo Altis) 0.503 to 399.562 ng/mL LC-MS/MS Human 306 Pseudoephedrine 1 to 400 ng/mL Sodium Heparin 30mg / 120 mg (API 6500) Plasma Q LC-MS/MS Human 307 1 to 1024 ng / mL K EDTA 200 mg (Thermo) Plasma 2 LC-MS/MS Human 308 Quetiapine 1 to 1000 ng / mL K EDTA 20 mg (Waters QPXE) Plasma 2 R LC-MS/MS Human 309 Rabeprazole 2 to 1024 ng / mL K EDTA 20 mg (API 3000) Plasma 2 LC-MS/MS Human Ramipril 0.05 to 6 ng / mL K EDTA 2.5 mg (API 3000) Plasma 3 310 LC-MS/MS Human Ramiprilat 0.05 to 6 ng / mL K EDTA - (API 3000) Plasma 3 LC-MS/MS Human Ramipril 0.05 to 6 ng / mL K EDTA 2.5 mg (Thermo) Plasma 2 311 LC-MS/MS Human Ramiprilat 0.05 to 6 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Ramipril 0.05 to 51 ng / mL K EDTA 10 mg (API 3000) Plasma 3 312 LC-MS/MS Human Ramiprilat 0.05 to 51 ng / mL K EDTA - (API 3000) Plasma 3 LC-MS/MS Human Ramipril 0.05 to 51 ng / mL K EDTA 10 mg (Thermo) Plasma 2 313 LC-MS/MS Human Ramiprilat 0.05 to 51 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 314 Ranitidine 15 to 1920 ng / mL K EDTA 300 mg (Thermo) Plasma 2 Human Rifabutin LC-MS (API 150) 10 to 1280 ng / mL K EDTA - Plasma 2 Human 315 25-O-Desacetylrifabutin LC-MS (API 150) 2.5 to 320 ng / mL K EDTA - Plasma 2 Human Clofazimine LC-MS (API 150) 5 to 640 ng / mL K EDTA - Plasma 2 LC-MS/MS Human 316 Risedronate 0.2 to 25 ng / mL K EDTA 35 mg (Thermo) Plasma 2 LC-MS/MS Human 317 Risedronate 0.2 to 128 ng / mL K EDTA 75 mg (Thermo) Plasma 2 LC-MS/MS Human Transdermal Patch 318 Rivastigmine 0.3 to 63 ng / mL K EDTA (Thermo) Plasma 2 9.5 mg LC-MS/MS Human 319 Rivastigmine 0.3 to 63 ng / mL K EDTA 9.5 mg (API 6500) Plasma 2 LC-MS/MS Human Sodium 320 Rosiglitazone 2 to 1024 ng / mL 8 mg (API 3000) Plasma heparin LC-MS/MS Human 321 Rosuvastatin 0.1 to 25 ng / mL K EDTA 20 mg (Thermo) Plasma 2 LC-MS/MS Human 322 Rosuvastatin 0.5 to 100 ng / mL K EDTA 40 mg (Thermo) Plasma 2 S LC-MS/MS Human 323 Scopolamine 1 to 400 pg/mL K EDTA 1 mg Patch (API 6500) Plasma 2 LC-MS/MS Human Sodium 0.25 to 250 ng / mL 100 mg (API 3000) Plasma heparin 324 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method 324 LC-MS/MS Human Sodium N- 0.25 to 250 ng / mL - (API 3000) Plasma heparin LC-MS/MS Human Sildenafil 1 to 500 ng/mL K EDTA 10 mg/mL (API 6500) Plasma 2 325 LC-MS/MS Human N-Desmethyl Sildenafil 0.5 to 75 ng/mL K EDTA - (API 6500) Plasma 2 LC-MS/MS Human Sodium Simvastatin 0.1 to 25 ng / mL - (API 300 or 3000) Plasma heparin 326 Simvastatin LC-MS/MS Human Sodium 0.1 to 25 ng / mL - Hydroxy Acid (API 300 or 3000) Plasma heparin LC-MS/MS Human Simvastatin 0.1 to 51.2 ng / mL K EDTA 80 mg (Thermo) Plasma 2 327 Simvastatin LC-MS/MS Human 0.1 to 25.6 ng / mL K EDTA - Hydroxy Acid (Thermo) Plasma 2 Human LC-MS/MS 328 Sirolimus Whole 0.4 to 51 ng / mL K EDTA 2 mg (API 3000) 2 Blood LC-MS/MS Human 329 Sitagliptin 1 to 512 ng / mL K EDTA 100 mg (Thermo) Plasma 2 HPLC Human 330 Sotalol 10 to 2560 ng / mL heparin - - Flurosence Plasma Human Sulfamethoxazole HPLC-UV 0.2 to 102 µg / mL K EDTA - Plasma 3 331 Human Trimethoprim HPLC-UV 0.02 to 2.56 µg / mL K EDTA 50 mg Plasma 3 LC-MS/MS Human Sufentanil 0.01 to 1.28 ng / mL K EDTA - (Thermo) Plasma 2 332 LC-MS/MS Human Triazolam 0.1 to 12.8 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human Sufentanil 2 to 256 pg / mL K EDTA 10 mcg (Thermo) Plasma 2 333 LC-MS/MS Human Triazolam 0.05 to 6.4 ng / mL K EDTA 200 mcg (Thermo) Plasma 2 LC-MS Human Sulfasalazine 20 to 2560 ng / mL K EDTA - (API 150) Plasma 3 LC-MS Human Sulfapyridine 200 to 25600 ng / mL K EDTA - (API 150) Plasma 3 334 LC-MS Human 5-Aminosalicylic Acid 20 to 2560 ng / mL K EDTA - (API 150) Plasma 3 LC-MS Human Acetyl-5-Aminosalicylic Acid 10 to 1280 ng / mL K EDTA - (API 150) Plasma 3 LC-MS/MS Human 335 Sumatriptan 0.1 to 40 ng/mL K EDTA 20 mg (Thermo) Plasma 2 Human LC-MS/MS Plasma 336 Sumatriptan 0.5 to 128 ng / mL K EDTA - (API 300 or 3000) or Pig 3 Plasma T Human LC-MS/MS 337 Tacrolimus Whole 0.2 to 25 ng / mL K EDTA 0.5 to 4 mg (Thermo) 2 Blood LC-MS/MS Human 338 Tamoxifen 0.25 to 64 ng / mL K EDTA 20 mg (API 3000) Plasma 2 LC-MS Human Tamoxifen 0.25 to 64 ng / mL Heparin - (API 150) Plasma 339 LC-MS Human N-Desmethyltamoxifen 0.25 to 64 ng / mL Heparin - (API 150) Plasma LC-MS/MS Human 340 Tamsulosin 0.05 to 25 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 341 Temazepam 4 to 1024 ng / mL K EDTA 30 mg (API 3000) Plasma 2 HPLC Human 342 Terazosin 0.5 to 64 ng / mL Heparin - - Flurosence Plasma Human 343 Terbinafine HPLC-UV 0.01 to 2.5 µg / mL K EDTA 250 mg Plasma 3 LC-MS/MS Human 344 Testosterone 0.1 to 25 ng / mL K EDTA 1% gel (Waters QPXE) Plasma 2 LC-MS/MS Human 345 Testosterone 0.1 to 25 ng/mL N/AP 1.62 % Gel New (Thermo) Serum LC-MS/MS Human 0.015 to 3.84 ng / mL K EDTA 50 mg (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human 346 α‐Dihydrotetrabenazine 0.625 to 160 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human β‐Dihydrotetrabenazine 0.469 to 120 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 347 Tetracycline 200 to 20000 ng / mL K EDTA 500 mg (Thermo) Plasma 2 Human 348 Theophylline HPLC-UV 0.15 to 19 µg / mL K EDTA - Plasma 3 LC-MS/MS Human Ticagrelor 2.5 to 1500 ng/mL K EDTA 90mg (Thermo) Plasma 2 349 LC-MS/MS Human Deshydroxyethoxy Ticagrelor 1 to 300 ng/mL K EDTA 90mg (Thermo) Plasma 2 Human 350 Ticlopidine HPLC-UV 10 to 1280 ng / mL K EDTA - Plasma 3 LC-MS/MS Human 351 Tofacitinib 0.2 to 100 ng/mL K EDTA 11 mg and 5 mg (Thermo) Plasma 2 Human LC-MS/MS Plasma Sodium 352 Topiramate 5 to 2560 ng / mL 50 mg (API 3000) or Dog heparin Plasma LC-MS/MS Human Sodium 353 Topiramate 50 to 12800 ng / mL 200 mg (API 3000) Plasma heparin LC-MS/MS Human 25 mg/mL oral 354 Topiramate 2 to 1000 ng/mL K EDTA New (Thermo) Plasma 2 solution LC-MS/MS Human 355 Torsemide 10 to 10240 ng / mL K EDTA - (API 300 or 3000) Plasma 3 HPLC Human 2.5 to 320 ng / mL K EDTA - - Flurosence Plasma 3 356 HPLC Human O-Desmethyltramadol 2.5 to 320 ng / mL K EDTA - - Flurosence Plasma 3 Human Plasma LC-MS/MS 357 Tramadol or 2 to 1024 ng / mL K EDTA 89 mg (API 3000) 2 Mouse Plasma Human Plasma LC-MS/MS O-Desmethyltramadol or 1 to 512 ng / mL K EDTA - (API 3000) 2 Mouse 358 Plasma Human Plasma LC-MS/MS O,N-di-Desmethyltramadol or 1 to 512 ng / mL K EDTA - (API 3000) 2 Mouse Plasma LC-MS/MS Human Not Tramadol 0.2 to 50 µg / mL - (API 3000) Urine applicable LC-MS/MS Human Not 359 O-Desmethyltramadol 0.05 to 12.5 µg / mL - (API 3000) Urine applicable O,N-di- LC-MS/MS Human Not 0.05 to 12.5 µg / mL - Desmethyltramadol (API 3000) Urine applicable LC-MS/MS Dog Tramadol 2 to 1024 ng / mL K EDTA 89 mg (API 3000) Plasma 2 360 LC-MS/MS Dog O-Desmethyltramadol 1 to 512 ng / mL K EDTA - (API 3000) Plasma 2 LC-MS/MS Human Tramadol 2 to 1024 ng / mL K EDTA 89 mg (Thermo) Plasma 2 LC-MS/MS Human O-Desmethyltramadol 1 to 512 ng / mL K EDTA - (Thermo) Plasma 2 361 O,N-di- LC-MS/MS Human 1 to 512 ng / mL K EDTA - Desmethyltramadol (Thermo) Plasma 2 LC-MS/MS Human Meloxicam 3.75 to 1920 ng / mL K EDTA - (Thermo) Plasma 2 LC-MS/MS Human 362 Tramadol 2 to 500 ng/mL K EDTA 100 mg (Thermo) Plasma 2 LC-MS/MS Human 363 Tramadol 2 to 800 ng/mL K EDTA 200 mg (Thermo) Plasma 2 HPLC Human 364 10 to 2560 ng / mL Heparin - - Flurosence Plasma Triamcinolone LC-MS/MS Human 365 0.025 to 6.4 ng/mL K EDTA 10 mg/mL acetonide (Thermo) Plasma 2 NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human Trimebutine 1 to 256 ng / mL K EDTA 96 mg (Thermo) Plasma 2 366 LC-MS/MS Human N-Desmethyltrimbutine 10 to 2560 ng / mL K EDTA - (Thermo) Plasma 2 U LC-MS Human Ursodiol 100 to 12800 ng / mL K EDTA - (API 150) Plasma 3 Glycoursodeoxycholic LC-MS Human 367 150 to 19200 ng / mL K EDTA - Acid (API 150) Plasma 3 Tauroursodeoxycholic LC-MS Human 100 to 12800 ng / mL K EDTA - Acid (API 150) Plasma 3 V LC-MS/MS Human 368 Valsartan 20 to 10240 ng / mL K EDTA 160 mg (API 3000) Plasma 2 LC-MS/MS Human 369 Valsartan 10 to 5000 ng/mL K EDTA 80 mg (Waters) Plasma 2 LC-MS/MS Human Sodium 2 to 192 ng / mL 150 mg (API 3000) Plasma heparin 370 O- LC-MS/MS Human Sodium 4 to 384 ng / mL - Desmethylvenlafaxine (API 3000) Plasma heparin LC-MS/MS Human Sodium Venlafaxine 1 to 600 ng/mL 300 mg (Thermo) Plasma heparin 371 Orthodesmethyl LC-MS/MS Human Sodium 2 to 800 ng/mL - Venlafaxine (Thermo) Plasma heparin LC-MS/MS Human Sodium Venlafaxine 1 to 256 ng / mL 75 mg (API 3000) Plasma heparin O- LC-MS/MS Human Sodium 2 to 512 ng / mL - Desmethylvenlafaxine (API 3000) Plasma heparin N- LC-MS/MS Human Sodium 372 1 to 256 ng / mL - Desmethylvenlafaxine (API 3000) Plasma heparin N,O- LC-MS/MS Human Sodium 1 to 256 ng / mL - Didesmethylvenlafaxine (API 3000) Plasma heparin N,N,O- LC-MS/MS Human Sodium 1 to 256 ng / mL - Tridesmethylvenlafaxine (API 3000) Plasma heparin LC-MS/MS Human Not Venlafaxine 0.1 to 13 µg / mL - (API 300 or 3000) Urine applicable LC-MS/MS Human Not O-Desmethylvenlafaxine 0.2 to 25 µg / mL - (API 300 or 3000) Urine applicable LC-MS/MS Human Not 373 N-Desmethylvenlafaxine 0.1 to 13 µg / mL - (API 300 or 3000) Urine applicable N,O- LC-MS/MS Human Not 0.2 to 25 µg / mL - Didesmethylvenlafaxine (API 300 or 3000) Urine applicable N,N,O- LC-MS/MS Human Not 0.1 to 13 µg / mL - Tridesmethylvenlafaxine (API 300 or 3000) Urine applicable HPLC Human Verapamil 2 to 256 ng / mL K EDTA - - Flurosence Plasma 3 374 HPLC Human Norverapamil 2 to 256 ng / mL K EDTA - - Flurosence Plasma 3 LC-MS/MS Human Sodium Verapamil 2 to 300 ng / mL 240 mg (Thermo) Plasma heparin 375 LC-MS/MS Human Sodium Norverapamil 2 to 175 ng / mL - (Thermo) Plasma heparin HPLC Human Verapamil (chiral) 1.6 to 102 ng / mL Heparin - - Flurosence Plasma 376 HPLC Human Norverapamil (chiral) 1.61 to 102 ng / mL Heparin - - Flurosence Plasma LC-MS Human 377 Vigabatrin 0.2 to 25 µg / mL K EDTA - (API 150) Plasma 2 W LC-MS/MS Human R-Warfarin 1 to 512 ng / mL K EDTA - (API 3000) Plasma 3 378 LC-MS/MS Human S-Warfarin 1 to 512 ng / mL K EDTA - (API 3000) Plasma 3 LC-MS/MS Human 9.997 ng/mL to 1993.567 379 Warfarin K EDTA - New (Thermo) Plasma ng/mL 2 Z NOVUM PHARMACEUTICAL RESEARCH SERVICES INC SMALL MOLECULES New / Sr. Drug Name Instrument Matrix Range Anticoagulant Dose Modified No. Method LC-MS/MS Human 380 0.125 to 64 ng / mL K EDTA 5 mg (API 3000) Plasma 2 LC-MS/MS Human 381 Ziprasidone 0.5 to 256 ng / mL K EDTA 40 mg (API 3000) Plasma 2 LC-MS/MS Human Zolmitriptan 0.2 to 20 ng/mL K EDTA 5mg Nasal spray (Thermo) Plasma 2 382 LC-MS/MS Human N-desmethyl Zolmitriptan 0.1 to 10 ng/mL K EDTA 5mg Nasal spray (Thermo) Plasma 2 HPLC Human 383 Zolpidem 1 to 512 ng / mL K EDTA 10 mg - Flurosence Plasma 3