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Copyright © 1988 by Veterinary Infectious Disease Organization First published 1988 in Saskatoon by VIDO (Veterinary Infectious Disease Organization), 124 Veterinary Road, Saskatoon, Sask., Canada, S7N OWO ISBN 0-88880-203-x Designed by Roberts Poole Communications Printed by Mid West Litho Inc. All rights reserved. No part of this publication may be reproduced or used in any form or by any means without written permission from VIDO. ii TABl[ Of CONT[NTS CHAPTER Foreward . vii Dedication . viii Thanks ....... .. ...... .. .. ........ .. .. ..... ... ix My Name .................. ............ ........ .. 2 The Idea ....... .......... .. ..... ......... .. .. 7 3 The Funding (The Mega-Dollars Initial Fundingl . ..... .... 12 a) The Calgary Initiative and the Government of Saskatchewan . 12 bl The Alberta Commitment . 21 4 The Follow-Up Funding . 26 a) The Livestock Industry . 26 b) Foundations . 35 c) Saskatchewan Provincial Government . 38 d) Alberta Provincial Government . 38 e) B.C. Provincial Government . 39 f) Manitoba Provincial Government . 39 g) Federal Government of Canada . 39 h) Invention Revenue . 40 i) Grants . 41 iii j) Contracts . 43 k) Interest . 45 I) "In Kind " Contributions ....... .... ............. 45 i) Publications . 45 ii) "Grassroots" . 45 iii) Symposium Favors. 46 iv) The Swine Technical Group . 46 v) The University of Saskatchewan . 46 5 The Building .................... .. ................. 48 a) The Requirement Study .......... .. ........ .. .. ... 48 b) Building Plans .................................... 51 i) Size and Cost of Plan "A" vs Plan "B" .. ...... .. 51 ii) Choice of the Architect ........................ 56 iii) The Tour . .. ........... .. .. .... .. ....... 56 iv) Other Architectural Problems .. .. ............... 58 A) Animal Isolation Ventilation ... ... ......... 58 B) Sterilization of Air .. ... .. .. ... ............ 59 C) Preventing Transmission of Micro- organisms Between Isolation Units ......... 60 0) Isolation Anterooms .. ...... .. ............. 61 E) The Isolator Lab ................. ......... 62 F) Fumigator . .. ....... ..................... 62 G) Electronic Scales . .... .............. ...... 63 H) Trailers . ................................ 64 v) Going to Tender .............................. 66 vi) The Ground-Breaking Ceremony ................. 67 vii) Moving In ................................... 68 viii) Unique Building Features ...................... 69 A. Isolation Units and Isolator Lab .............. 69 B. High Porosity Fence .. ... .... .. ..... ..... 69 C. Computer Control of Machines ............... 69 0. Heat Recovery System .... ................ 70 E. The Autoclave Room ....................... 70 F. Corridor Lighting Baffles ............... .. ... 70 ix) Abandoned Building Features ................... 70 A. Definitive Artwork ......................... 70 B. Television in Animal Isolation Units ........... 72 C. Elevator to the Basement ................... 72 0. Farm Facilities ............................ 73 E. Parking .................................. 76 F. Specific Pathogen-Free Rea ring Facilities for Chickens and Turkeys ................... 77 G. The Swine and Cattle Research Outbuildings ... 77 H. The Galan-Broadbent Door .................. 77 I. Radiotelemetry ............................ 78 iv c) The Official Open ing . 78 6 The VIDO Philosophy, Constitution and Bylaws . 83 a) Philosophy . 83 b) Constitution . 87 c) Bylaws . 89 d) Staff Agreements . 90 7 The Management . 93 a) Management Staff . 93 b) The Adm inistrative Boards . 95 i) Governing Committee . 95 ii) The Board of Advisors . 96 iii) The Board of Directors . 101 iv) Guests to the Boards . 105 c) Internal Meetings . 107 i) Entire Staff . 107 ii) Scientific Project Meetings ................. : . 108 iii) Scientific Staff Meetings . 108 d) The Personnel . 109 8 The Research . 111 a) The Ten-Year Research Plans . 111 b) Mycoplasmas . 113 c) Calf Scours (Neonatal Diarrhoea) . 114 i) The Termeunde Project ...... .. ....... ... .... 118 ii) E. coli Enterotoxins . 119 d) The Economics of Animal Disease . 120 e) Miniatures of Disease Outbreaks . 122 i) Neonatal Diarrhea . 123 ii) Rotavirus & Coronavirus ...... ............. .. .. 124 iii) Swine Haemophilus pleuropneumoniae .... ... .. 126 iv) Turkey Hemorrhagic Enteritis ............... 127 v) Shipping Fever . 127 f) The VICOGEN Narrative - A Canadian Success Story . 128 g) The Hemorrhagic Enteritis Saga . 138 h) Rotavirus and Coronavirus Vaccines . 144 i) Swine Diseases . 147 1) "All -in All-out" Program . 149 2) Pasteu rella Studies . 149 3) Tl -59 Calcu lator Program . 150 4) Swine Techn ical Group . 150 5) Hemoph ilus pleuropneumonia . 152 6) Prairie Swine Center Assistance . 153 j) Shipping Fever . 153 i) Mycoplasmas . 153 ii) Bacteria and Viruses .. ..... .... .......... .. .. 154 v ~ ~ - -==,,__ _____ - -~- iii) Immu nological Studies . 155 iv) Potential Imm unizi ng Agents . 156 v) The Feedlot Epidem iological Project . 156 k) Biotechnology ............................. 159 I) BIOSTAR Inc. 163 m) Vetgen . 167 9 Miscellaneous . ... .... .. .. ..... ....... ........... 170 a) Honorary Doctorates . 170 b) Think-Tank Retreats . 170 c) Beer Nights . 171 d) Parties ................................ ...... .... 172 e) The Pallister Roast ..... ... 173 f) The Safety Committee . 174 g) The SPARC Committee . 175 h) The Canadian Encyclopedia of 1985 Pays Attention to Me . 178 i) Research Collaborators . 179 j) Visiting Scientists . 179 k) Tours . 180 I) Innovation Place . .... ............ ... ........ .... 181 m) Fact Sheets . 182 Epilogue . 183 About the Author . 186 Appendices A Summary of Brief to Calgary Initiative . 192 B 1957 - Brief to Alberta Government from AVMA . 195 C Final Agreement Between Devonian, U. of S. and Governments of Saskatchewan and Alberta . 198 D Two 10-Year Research Plans . 203 E List of Guests of the Board . 207 F List of Personnel . 239 G VIDO Publications . 241 H List of Research Collaborators Over the Years . 244 I "VIDO's Voyage" by Dr. A.E. Pallister, 1981 . ..