Shuji Ogino Harvard Medical School, Brigham and Women's Hospital

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Shuji Ogino Harvard Medical School, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, and Broad Institute of MIT and Harvard, USA Shuji Ogino, MD, PhD, is Professor of Pathology at Harvard Medical School, Brigham and Women's Hospital (BWH), and Dana-Farber Cancer Institute; Professor (Epidemiology) at Harvard T.H. Chan School of Public Health; Chief of Program in MPE Molecular Pathological Epidemiology at BWH; and Associate Member of Broad Institute of MIT and Harvard. Dr. Ogino received MD and PhD degrees from University of Tokyo, and MS degree in Epidemiology from Harvard T.H. Chan School of Public Health. Dr. Ogino received numerous awards and honors, including Ramzi Cotran Young Investigator Award (2011) from United States and Canadian Academy of Pathology (USCAP), and Executive Officer’s Award (2004) and Meritorious Service Award (2012) from Association for Molecular Pathology (AMP); elected membership of American Society for Clinical Investigation (ASCI) since 2014; recognition as “The Most Influential Scientific Minds: 2014” and “Highly Cited Researcher” in 2015, 2016, and 2017 by Thomson Reuters and Clarivate Analytics (Web of Science); Outstanding Investigator Award from National Cancer Institute, NIH, USA since 2015; and Outstanding Investigator Award from American Society for Investigative Pathology (ASIP). Dr. Ogino has been spearheading to lead integrative science of “Molecular Pathological Epidemiology (MPE)” with its paradigm-shifting effects on population health sciences. Dr. Ogino founded The International MPE Meeting Series in 2013, and its 4th meeting occurred in May 2018 in Boston, USA. With his unique viewpoints, Dr. Ogino has created novel paradigms, concepts, and frameworks, including “GWAS-MPE approach”, “unique tumor principle”, “unique disease principle”, “colorectal continuum model”, and “etiologic field effect model”. Dr. Ogino has also created new research frontiers such as “lifecourse – MPE model”, “social MPE model”, “causal inference – MPE model”, “pharmaco-MPE model”, and “immuno-MPE model”. .

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The Practice of Epidemiology
The Practice of Epidemiology A Meta-Regression Method for Studying Etiologic Heterogeneity across Disease Subtypes Classified by Multiple Biomarkers Molin Wang, Aya Kuchiba, Shuji Ogino Correspondence to Molin Wang, Departments of Biostatistics and Epidemiology, Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, 677 Huntington Ave., Boston, Massachusetts (email: [email protected]) Abbreviations: CIMP, CpG island methylator phenotype; HPFS, Health Professionals Follow-up Study; MPE, molecular pathological epidemiology; MSI, microsatellite instability; MSS, microsatellite stable; NHS, the Nurses’ Health Study; OR, odds ratio; RR, relative risk; RRR, ratio of relative risk. We use standardized official symbol BRAF, which is described at www.genenames.org. Word count main abstract: 200 Word count text: 3615 N.Figures: 0 N.Tables: 2 Appendices: 0 1 Abstract In interdisciplinary biomedical, epidemiological, and population research, it is increasingly necessary to consider pathogenesis and inherent heterogeneity of any given health condition and outcome. As the unique disease principle implies, no single biomarker can perfectly define disease subtypes. The complex nature of molecular pathology and biology necessitates biostatistical methodologies to simultaneously analyze multiple biomarkers and subtypes. To analyze and test for heterogeneity hypothesis across subtypes defined by multiple categorical and/or ordinal markers, the authors developed a meta-regression method that can utilize existing statistical software for mixed model analysis. This method can be used to assess whether the exposure- subtype associations are different across subtypes defined by one marker while controlling for other markers, and to evaluate whether the difference in exposure- subtype association across subtypes defined by one marker depends on any other markers.
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Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis
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Molecular Pathological Epidemiology Gives Clues to Paradoxical Findings
Molecular Pathological Epidemiology Gives Clues to Paradoxical Findings The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Nishihara, Reiko, Tyler J. VanderWeele, Kenji Shibuya, Murray A. Mittleman, Molin Wang, Alison E. Field, Edward Giovannucci, Paul Lochhead, and Shuji Ogino. 2015. “Molecular Pathological Epidemiology Gives Clues to Paradoxical Findings.” European Journal of Epidemiology 30 (10): 1129–35. https://doi.org/10.1007/ s10654-015-0088-4. Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:41392032 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#OAP HHS Public Access Author manuscript Author Manuscript Author ManuscriptEur J Epidemiol Author Manuscript. Author Author Manuscript manuscript; available in PMC 2016 October 07. Published in final edited form as: Eur J Epidemiol. 2015 October ; 30(10): 1129–1135. doi:10.1007/s10654-015-0088-4. Molecular Pathological Epidemiology Gives Clues to Paradoxical Findings Reiko Nishiharaa,b,c, Tyler J. VanderWeeled,e, Kenji Shibuyac, Murray A. Mittlemand,f, Molin Wangd,e,g, Alison E. Fieldd,g,h,i, Edward Giovannuccia,d,g, Paul Lochheadi,j, and Shuji Oginob,d,k aDepartment of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Ave., Boston, Massachusetts 02115 USA bDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Ave., Boston, Massachusetts 02215 USA cDepartment of Global Health Policy, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan dDepartment of Epidemiology, Harvard T.H.
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Integration of Molecular Pathology, Epidemiology and Social Science for Global Precision Medicine
Expert Review of Molecular Diagnostics ISSN: 1473-7159 (Print) 1744-8352 (Online) Journal homepage: http://www.tandfonline.com/loi/iero20 Integration of molecular pathology, epidemiology and social science for global precision medicine Akihiro Nishi, Danny A Milner Jr, Edward L Giovannucci, Reiko Nishihara, Andy S Tan, Ichiro Kawachi & Shuji Ogino To cite this article: Akihiro Nishi, Danny A Milner Jr, Edward L Giovannucci, Reiko Nishihara, Andy S Tan, Ichiro Kawachi & Shuji Ogino (2015): Integration of molecular pathology, epidemiology and social science for global precision medicine, Expert Review of Molecular Diagnostics, DOI: 10.1586/14737159.2016.1115346 To link to this article: http://dx.doi.org/10.1586/14737159.2016.1115346 Published online: 04 Dec 2015. Submit your article to this journal Article views: 82 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iero20 Download by: [University of California, San Francisco] Date: 31 December 2015, At: 13:21 Perspectives Integration of molecular pathology, epidemiology and social science for global precision medicine Expert Rev. Mol. Diagn. Early online, 1–13 (2015) Akihiro Nishi1,2, The precision medicine concept and the unique disease principle imply that each patient has Danny A Milner Jr3,4, unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic Edward L alterations and interactions between cells (including immune cells) and exposures, including Giovannucci5,6,7, dietary, environmental, microbial and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze Reiko Nishihara5,6,8,9, 9,10 disease risk factors and develop statistical methodologies to maximize utilization of big data Andy S Tan , on populations and disease pathology.
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Dismantling the One-Size-Fits-All Model of Medicine
Dismantling the One-Size-Fits-All Model of Medicine Shuji Ogino Professor, Pathology Professor, Department of Epidemiology CURRENT RESEARCH AFFILIATION A new field within medicine brings personalized care to Dana-Farber Cancer Institute the forefront of treatment EDUCATION For a long time, treating patients has operated on a “one-size-fits-all” model in which we M.D., 1993 , University of Tokyo School of Medicine have assumed that all patients with a given disease name have similar problems and thus, Ph.D., in Pathology, 2001 , University of Tokyo Graduate School of Medicine need the same treatment. This phenomenon, termed the homogeneity assumption, has M.S., in Epidemiology, 2010 , Harvard School of Public Health recently been debunked by the “Unique Disease Principle” which states that disease is fundamentally different in each individual it affects. Dr. Shuji Ogino, of the Dana-Farber Cancer Institute, created and continues to develop the blossoming field of Molecular AWARDS Pathological Epidemiology (MPE). Through the emergence of MPE as a new field, he hopes 2011 Ramzi Cotran Young Investigator Award, United States and Canadian Academy of to make broad impacts and contribute to overall advancements of science for maximum Pathology benefits to human beings in the world, by means of transforming paradigms and frameworks 2012 Meritorious Service Award, Association for Molecular Pathology of biomedical and health sciences. Dr. Ogino’s approach is bringing personalized care back to 2014 The Best of AACR Journals (selected as the corresponding author) care providers while producing results that save lives. 2014 Most Influential Scientific Minds: 2014, selected by Thomson Reuters Although MPE is a relatively new field, having been first introduced to academia in 2010, Dr.
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Integration of Pharmacology, Molecular Pathology, and Population Data Science to Support Precision Gastrointestinal Oncology
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The Second International Molecular Pathological Epidemiology (MPE) Meeting
The Second International Molecular Pathological Epidemiology (MPE) Meeting December 4-5, 2014 Jimmy Fund Auditorium, Dana-Farber Cancer Institute A Welcome from IMPEM Chair December 4th, 2014 Dear Colleagues, WELCOME to The Second International Molecular Pathological Epidemiology (MPE) Meeting! As the Conference Chair, I welcome you to this unique meeting! The number of registrants has exceeded 100, from about 15 countries, and 15 US States! I hope that you find this transdisciplinary meeting to be an active and informative forum for exchanging viewpoints and generating new ideas. I hope that you will talk to many attendees, who are experts and have great visions for our future. On April 24 (my ?th birthday), 2013, The First International MPE Meeting was held in Boston as a closed meeting. We regret that we could not invite most of you at that time. The purpose of the first meeting was to discuss and get a consensus on how to make a strategic plan in this emerging area. It was agreed that we would launch the open meeting series. We have been working to realize the open meeting since then. For this second meeting, you can see that discussion topics span from pathology, epidemiology, biostatistics and bioinformatics. It is increasingly common to characterize molecular features of disease (particularly, cancer) in routine clinical practice and epidemiologic research. It provides us with challenges as well as enormous opportunities. We hope that, even if we cannot be an expert in all of these areas, we can work together to address the challenges and take advantages of the opportunities.
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Regular Aspirin Use Associates With
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Molecular Pathological Epidemiology of Colorectal Neoplasia: an Emerging Transdisciplinary and Interdisciplinary Field
Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Ogino, S., A. T. Chan, C. S. Fuchs, and E. Giovannucci. 2010. “Molecular Pathological Epidemiology of Colorectal Neoplasia: An Emerging Transdisciplinary and Interdisciplinary Field.” Gut 60 (3): 397–411. https://doi.org/10.1136/gut.2010.217182. Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:41392080 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA NIH Public Access Author Manuscript Gut. Author manuscript; available in PMC 2012 March 1. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Gut. 2011 March ; 60(3): 397±411. doi:10.1136/gut.2010.217182. Molecular Pathologic Epidemiology of Colorectal Neoplasia: An Emerging Transdisciplinary and Interdisciplinary Field Shuji Ogino, Andrew T. Chan, Charles S. Fuchs, and Edward Giovannucci Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA (SO); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA USA (SO, CSF); Cancer Epidemiology Program and Gastrointestinal Malignancies Program, Dana- Farber/Harvard
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Aspirin Exerts High Anti-Cancer Activity in PIK3CA-Mutant Colon Cancer Cells
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Shuji Ogino CV
Ogino, Shuji, M.D., Ph.D. 1/10/2019 Curriculum Vitae PART I: General Information Date Prepared: December 2018 Name: Shuji Ogino Office Address: Program in MPE Molecular Pathological Epidemiology Department of Pathology Brigham and Women’s Hospital Dana-Farber Cancer Institute 450 Brookline Avenue, DFCI Room SM1036A Boston, MA 02215, USA Work Phone: 1-617-632-1972 Fax: 1-617-582-8558 Work E-Mail: [email protected] Assistant's E-Mail: [email protected] Place of Birth: Akashi-City, Japan Education 1993 MD Medicine University of Tokyo, Japan 2001 PhD Pathology and Pathogenesis University of Tokyo, Japan (Advisor, Prof. Masashi Fukayama) 2010 MS Epidemiology Harvard School of Public Health, USA Postdoctoral Training 07/95-06/97 Resident Anatomic and Clinical Pathology Allegheny General Hospital, Medical College of Pennsylvania, USA 07/97-06/99 Resident Anatomic and Clinical Pathology Case Western Reserve University, University Hospitals of Cleveland, USA 07/99-06/00 Fellow Molecular Pathology University of Pennsylvania, USA 07/00-10/01 Post-doc Molecular Pathology University of Pennsylvania, USA (PI, Robert B. Wilson, MD, PhD) Faculty Academic Appointments 11/01-09/04 Instructor Pathology Harvard Medical School, USA 10/04-06/08 Assistant Professor Pathology Harvard Medical School, USA 07/08-01/15 Associate Professor Pathology Harvard Medical School, USA 07/12-03/15 Associate Professor Epidemiology Harvard T.H. Chan School of Public Health, USA 02/15- Professor Pathology Harvard Medical School, USA 1 Ogino, Shuji, M.D., Ph.D. 1/10/2019 04/15- Professor Epidemiology Harvard T.H. Chan School of Public Health, USA Appointments at Hospitals / Affiliated Institutions 11/01- Pathologist Pathology Brigham and Women’s Hospital, USA 11/01-06/16 Faculty Member Medical Oncology Dana-Farber Cancer Institute, USA 07/16- Faculty Member Oncologic Pathology Dana-Farber Cancer Institute, USA Other Professional Positions 2004- Member Dana-Farber Harvard Cancer Center, USA 2015- Faculty Member Program in Quantitative Genomics, Harvard T.H.
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Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803
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