Rapid Stimulation of Human Dentate Gyrus Function with Acute Mild Exercise
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Targeted Dorsal Dentate Gyrus Or Whole Brain Irradiation in Juvenile Mice Differently Affects Spatial Memory and Adult Hippocampal Neurogenesis
biology Article Targeted Dorsal Dentate Gyrus or Whole Brain Irradiation in Juvenile Mice Differently Affects Spatial Memory and Adult Hippocampal Neurogenesis Céline Serrano 1, Morgane Dos Santos 2, Dimitri Kereselidze 1, Louison Beugnies 1, Philippe Lestaevel 1, Roseline Poirier 3,*,† and Christelle Durand 1,*,† 1 Laboratory of Experimental Radiotoxicology and Radiobiology (LRTOX), Research Department on the Biological and Health Effects of Ionizing Radiation (SESANE), Institute for Radiological Protection and Nuclear Safety (IRSN), 92260 Fontenay-aux-Roses, France; [email protected] (C.S.); [email protected] (D.K.); [email protected] (L.B.); [email protected] (P.L.) 2 Laboratory of Radiobiology of Accidental Exposure (LRAcc), Research Department in Radiobiology and Regenerative Medicine (SERAMED), Institute for Radiological Protection and Nuclear Safety (IRSN), 92260 Fontenay-aux-Roses, France; [email protected] 3 Paris-Saclay Neuroscience Institute (Neuro-PSI), University Paris-Saclay, UMR 9197 CNRS, F-91405 Orsay, France * Correspondence: [email protected] (R.P.); [email protected] (C.D.) † These authors contribute equally to this work. Simple Summary: The effects of exposure of the juvenile brain to doses of ionizing radiation Citation: Serrano, C.; Dos Santos, M.; (IR) ≤ 2 Gy on cognitive functions in adulthood are not clearly established in humans, and exper- Kereselidze, D.; Beugnies, L.; imental data are scarce. To elucidate how IR can impact the postnatal brain, we evaluated and Lestaevel, P.; Poirier, R.; Durand, C. compared the effect of whole brain (WB) or hippocampal dorsal dentate gyrus (DDG) X-ray exposure Targeted Dorsal Dentate Gyrus or (0.25–2 Gy) on spatial memory, three months after irradiation in mice. -
Lesions of Perirhinal and Parahippocampal Cortex That Spare the Amygdala and Hippocampal Formation Produce Severe Memory Impairment
The Journal of Neuroscience, December 1989, 9(12): 4355-4370 Lesions of Perirhinal and Parahippocampal Cortex That Spare the Amygdala and Hippocampal Formation Produce Severe Memory Impairment Stuart Zola-Morgan,’ Larry Ft. Squire,’ David G. Amaral,2 and Wendy A. Suzuki2J Veterans Administration Medical Center, San Diego, California, 92161, and Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, The Salk Institute, San Diego, California 92136, and 3Group in Neurosciences, University of California, San Diego, La Jolla, California 92093 In monkeys, bilateral damage to the medial temporal region Moss, 1984). (In this notation, H refers to the hippocampus, A produces severe memory impairment. This lesion, which in- to the amygdala, and the plus superscript (+) to the cortical cludes the hippocampal formation, amygdala, and adjacent tissue adjacent to each structure.) This lesion appears to con- cortex, including the parahippocampal gyrus (the H+A+ le- stitute an animal model of medial temporal lobe amnesia like sion), appears to constitute an animal model of human me- that exhibited by the well-studied patient H.M. (Scoville and dial temporal lobe amnesia. Reexamination of histological Milner, 1957). material from previously studied monkeys with H+A+ lesions The H+A+ lesion produces greater memory impairment than indicated that the perirhinal cortex had also sustained sig- a lesion limited to the hippocampal formation and parahip- nificant damage. Furthermore, recent neuroanatomical stud- pocampal cortex-the H+ lesion (Mishkin, 1978; Mahut et al., ies show that the perirhinal cortex and the closely associated 1982; Zola-Morgan and Squire, 1985, 1986; Zola-Morgan et al., parahippocampal cortex provide the major source of cortical 1989a). -
A Role for the Left Angular Gyrus in Episodic Simulation and Memory
8142 • The Journal of Neuroscience, August 23, 2017 • 37(34):8142–8149 Behavioral/Cognitive A Role for the Left Angular Gyrus in Episodic Simulation and Memory X Preston P. Thakral, XKevin P. Madore, and XDaniel L. Schacter Department of Psychology, Harvard University, Boston, Massachusetts 02138 Functional magnetic resonance imaging (fMRI) studies indicate that episodic simulation (i.e., imagining specific future experiences) and episodic memory (i.e., remembering specific past experiences) are associated with enhanced activity in a common set of neural regions referred to as the core network. This network comprises the hippocampus, medial prefrontal cortex, and left angular gyrus, among other regions. Because fMRI data are correlational, it is unknown whether activity increases in core network regions are critical for episodic simulation and episodic memory. In the current study, we used MRI-guided transcranial magnetic stimulation (TMS) to assess whether temporary disruption of the left angular gyrus would impair both episodic simulation and memory (16 participants, 10 females). Relative to TMS to a control site (vertex), disruption of the left angular gyrus significantly reduced the number of internal (i.e., episodic) details produced during the simulation and memory tasks, with a concomitant increase in external detail production (i.e., semantic, repetitive, or off-topic information), reflected by a significant detail by TMS site interaction. Difficulty in the simulation and memory tasks also increased after TMS to the left angular gyrus relative to the vertex. In contrast, performance in a nonepisodic control task did not differ statistically as a function of TMS site (i.e., number of free associates produced or difficulty in performing the free associate task). -
Toward a Common Terminology for the Gyri and Sulci of the Human Cerebral Cortex Hans Ten Donkelaar, Nathalie Tzourio-Mazoyer, Jürgen Mai
Toward a Common Terminology for the Gyri and Sulci of the Human Cerebral Cortex Hans ten Donkelaar, Nathalie Tzourio-Mazoyer, Jürgen Mai To cite this version: Hans ten Donkelaar, Nathalie Tzourio-Mazoyer, Jürgen Mai. Toward a Common Terminology for the Gyri and Sulci of the Human Cerebral Cortex. Frontiers in Neuroanatomy, Frontiers, 2018, 12, pp.93. 10.3389/fnana.2018.00093. hal-01929541 HAL Id: hal-01929541 https://hal.archives-ouvertes.fr/hal-01929541 Submitted on 21 Nov 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. REVIEW published: 19 November 2018 doi: 10.3389/fnana.2018.00093 Toward a Common Terminology for the Gyri and Sulci of the Human Cerebral Cortex Hans J. ten Donkelaar 1*†, Nathalie Tzourio-Mazoyer 2† and Jürgen K. Mai 3† 1 Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands, 2 IMN Institut des Maladies Neurodégénératives UMR 5293, Université de Bordeaux, Bordeaux, France, 3 Institute for Anatomy, Heinrich Heine University, Düsseldorf, Germany The gyri and sulci of the human brain were defined by pioneers such as Louis-Pierre Gratiolet and Alexander Ecker, and extensified by, among others, Dejerine (1895) and von Economo and Koskinas (1925). -
Functional Connectivity of the Angular Gyrus in Normal Reading and Dyslexia (Positron-Emission Tomography͞human͞brain͞regional͞cerebral)
Proc. Natl. Acad. Sci. USA Vol. 95, pp. 8939–8944, July 1998 Neurobiology Functional connectivity of the angular gyrus in normal reading and dyslexia (positron-emission tomographyyhumanybrainyregionalycerebral) B. HORWITZ*†,J.M.RUMSEY‡, AND B. C. DONOHUE‡ *Laboratory of Neurosciences, National Institute on Aging, and ‡Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 Communicated by Robert H. Wurtz, National Eye Institute, Bethesda, MD, May 14, 1998 (received for review January 19, 1998) ABSTRACT The classic neurologic model for reading, not functionally connected during a specific task. On the other based on studies of patients with acquired alexia, hypothesizes hand, if rCBF in two regions is correlated, these regions need functional linkages between the angular gyrus in the left not be anatomically linked; their activities may be correlated, hemisphere and visual association areas in the occipital and for example, because both receive inputs from a third area (for temporal lobes. The angular gyrus also is thought to have more discussion about these connectivity concepts, see refs. 8, functional links with posterior language areas (e.g., Wer- 10, and 11). nicke’s area), because it is presumed to be involved in mapping Based on lesion studies in many patients with alexia, it has visually presented inputs onto linguistic representations. Us- been proposed that the posterior portion of the neural network ing positron emission tomography , we demonstrate in normal mediating reading in the left cerebral hemisphere involves men that regional cerebral blood flow in the left angular gyrus functional links between the angular gyrus and extrastriate shows strong within-task, across-subjects correlations (i.e., areas in occipital and temporal cortex associated with the functional connectivity) with regional cerebral blood flow in visual processing of letter and word-like stimuli (12–14). -
Involvement of Human Left Dorsolateral Prefrontal Cortex in Perceptual Decision Making Is Independent of Response Modality
Involvement of human left dorsolateral prefrontal cortex in perceptual decision making is independent of response modality H. R. Heekeren*†‡§, S. Marrett¶, D. A. Ruff*, P. A. Bandettini*¶, and L. G. Ungerleider*ʈ *Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-9663; †Max Planck Institute for Human Development, 14195 Berlin, Germany; ‡Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; §Berlin NeuroImaging Center, Charite´University Medicine Berlin, 10117 Berlin, Germany; and ¶Functional MRI Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-9663 Contributed by L. G. Ungerleider, May 12, 2006 Perceptual decision making typically entails the processing of such as the DLPFC, during high-motion-coherence trials, i.e., trials sensory signals, the formation of a decision, and the planning and in which the sensory evidence is greatest, than during low- execution of a motor response. Although recent studies in mon- coherence trials. keys and humans have revealed possible neural mechanisms for As in the visual system, in the somatosensory system, in a task perceptual decision making, much less is known about how the in which the monkey must decide which of two vibratory stimuli decision is subsequently transformed into a motor action and has a higher frequency, the monkey’s decision can be predicted whether or not the decision is represented at an abstract level, i.e., by subtracting the activities of two populations of sensory independently of the specific motor response. To address this neurons in the secondary somatosensory cortex (SII) that prefer issue, we used functional MRI to monitor changes in brain activity high and low frequencies, respectively (10). -
Default Mode Network in Childhood Autism Posteromedial Cortex Heterogeneity and Relationship with Social Deficits
ARCHIVAL REPORT Default Mode Network in Childhood Autism: Posteromedial Cortex Heterogeneity and Relationship with Social Deficits Charles J. Lynch, Lucina Q. Uddin, Kaustubh Supekar, Amirah Khouzam, Jennifer Phillips, and Vinod Menon Background: The default mode network (DMN), a brain system anchored in the posteromedial cortex, has been identified as underconnected in adults with autism spectrum disorder (ASD). However, to date there have been no attempts to characterize this network and its involvement in mediating social deficits in children with ASD. Furthermore, the functionally heterogeneous profile of the posteromedial cortex raises questions regarding how altered connectivity manifests in specific functional modules within this brain region in children with ASD. Methods: Resting-state functional magnetic resonance imaging and an anatomically informed approach were used to investigate the functional connectivity of the DMN in 20 children with ASD and 19 age-, gender-, and IQ-matched typically developing (TD) children. Multivariate regression analyses were used to test whether altered patterns of connectivity are predictive of social impairment severity. Results: Compared with TD children, children with ASD demonstrated hyperconnectivity of the posterior cingulate and retrosplenial cortices with predominately medial and anterolateral temporal cortex. In contrast, the precuneus in ASD children demonstrated hypoconnectivity with visual cortex, basal ganglia, and locally within the posteromedial cortex. Aberrant posterior cingulate cortex hyperconnectivity was linked with severity of social impairments in ASD, whereas precuneus hypoconnectivity was unrelated to social deficits. Consistent with previous work in healthy adults, a functionally heterogeneous profile of connectivity within the posteromedial cortex in both TD and ASD children was observed. Conclusions: This work links hyperconnectivity of DMN-related circuits to the core social deficits in young children with ASD and highlights fundamental aspects of posteromedial cortex heterogeneity. -
Dentate Gyrus Population Activity During Immobility Supports Formation of Precise Memories
bioRxiv preprint doi: https://doi.org/10.1101/2020.03.05.978320; this version posted April 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Dentate gyrus population activity during immobility supports formation of precise memories Martin Pofahl1, Negar Nikbakht1, André N. Haubrich1, Theresa Nguyen1, Nicola Masala1, Oliver Braganza1, Jakob H. Macke2, Laura A. Ewell1, Kurtulus Golcuk1 and Heinz Beck1,3 * 1 Institute for Experimental Epileptology and Cognition Research, University of Bonn, Germany 2 Computational Neuroengineering, Department of Electrical and Computer Engineering, Technical University of Munich, Germany 3 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V., Bonn, Germany * Correspondence should be addressed to: Heinz Beck Institute for Cognition Research and Experimental Epileptology, University of Bonn Sigmund-Freud Str. 25 53105 Bonn Tel.: 0228 6885 270 Fax: 0228 6885 294 e-mail: [email protected] Figures: 5 Supplementary Figures: 9 Supplementary Movies: 2 bioRxiv preprint doi: https://doi.org/10.1101/2020.03.05.978320; this version posted April 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Abstract The hippocampal dentate gyrus is an important relay conveying sensory information from the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has been proposed to act as a pattern separator. -
The Primary Cilium: the Tiny Driver of Dentate Gyral Neurogenesis
In: Neurogenesis Research ISBN: 978-1-62081-723-0 Editors: Gerry J. Clark and Walcot T. Anderson © 2012 Nova Science Publishers, Inc. No part of this digital document may be reproduced, stored in a retrieval system or transmitted commercially in any form or by any means. The publisher has taken reasonable care in the preparation of this digital document, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of information contained herein. This digital document is sold with the clear understanding that the publisher is not engaged in rendering legal, medical or any other professional services. Chapter V The Primary Cilium: The Tiny Driver of Dentate Gyral Neurogenesis James F. Whitfield1, Balu Chakravarthy1, Anna Chiarini2 and Ilaria Dal Prà2 1Molecular Signaling Group, National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario, Canada 2Histology and Embryology Section, Department of Life and Reproduction Sciences, University of Verona Medical School, Verona, Italy Abstract An emerging picture of the brain is one in which both neurons and astrocytes have an immobile protuberance, a tiny sensory antenna. Each of these antennae is studded with a region-specific selection of receptors and maintains a busy, energy-consuming bidirectional traffic along its microtubular spine (axoneme) of parts of signaling machineries and messages to the cell center from the receptors about mechanical strains and external events. These messages are merged with those from the swarm of synapses on the cell’s dendrites to frame appropriate responses. -
An Event-Related Functional Magnetic Resonance Imaging Study
Neural Correlates of Memory for Items and for Associations: An Event-related Functional Magnetic Resonance Imaging Study Ame´lie M. Achim and Martin Lepage Downloaded from http://mitprc.silverchair.com/jocn/article-pdf/17/4/652/1757197/0898929053467578.pdf by guest on 18 May 2021 Abstract & Although results from cognitive psychology, neuropsychol- coding, greater prefrontal, hippocampal, and parietal activation ogy, and behavioral neuroscience clearly suggest that item was observed for associations, but no significant activation was and associative information in memory rely on partly different observed for items at the selected threshold. During recog- brain regions, little is known concerning the differences and nition, greater activation was observed for associative trials in similarities that exist between these two types of information as the left dorsolateral prefrontal cortex and superior parietal a function of memory stage (i.e., encoding and retrieval). We lobules bilaterally, whereas item recognition trials showed used event-related functional magnetic resonance imaging to greater activation of bilateral frontal regions, bilateral anterior assess neural correlates of item and associative encoding and medial temporal areas, and the right temporo-parietal junction. retrieval of simple images in 18 healthy subjects. During en- Post hoc analyses suggested that the anterior medial temporal coding, subjects memorized items and pairs. During retrieval, activation observed during item recognition was driven mainly subjects made item recognition judgments (old vs. new) and by new items, confirming a role for this structure in novelty de- associative recognition judgments (intact vs. rearranged). Rel- tection. These results suggest that although some structures ative to baseline, item and associative trials activated bilateral such as the medial temporal and prefrontal cortex play a gen- medial temporal and prefrontal regions during both encoding eral role in memory, the pattern of activation in these regions and retrieval. -
Seed MNI Coordinates Lobe
MNI Coordinates Seed Lobe (Hemisphere) Region BAa X Y Z FP1 -18 62 0 Frontal Lobe (L) Medial Frontal Gyrus 10 FPz 4 62 0 Frontal Lobe (R) Medial Frontal Gyrus 10 FP2 24 60 0 Frontal Lobe (R) Superior Frontal Gyrus 10 AF7 -38 50 0 Frontal Lobe (L) Middle Frontal Gyrus 10 AF3 -30 50 24 Frontal Lobe (L) Superior Frontal Gyrus 9 AFz 4 58 30 Frontal Lobe (R) Medial Frontal Gyrus 9 AF4 36 48 20 Frontal Lobe (R) Middle Frontal Gyrus 10 AF8 42 46 -4 Frontal Lobe (R) Inferior Frontal Gyrus 10 F7 -48 26 -4 Frontal Lobe (L) Inferior Frontal Gyrus 47 F5 -48 28 18 Frontal Lobe (L) Inferior Frontal Gyrus 45 F3 -38 28 38 Frontal Lobe (L) Precentral Gyrus 9 F1 -20 30 50 Frontal Lobe (L) Superior Frontal Gyrus 8 Fz 2 32 54 Frontal Lobe (L) Superior Frontal Gyrus 8 F2 26 32 48 Frontal Lobe (R) Superior Frontal Gyrus 8 F4 42 30 34 Frontal Lobe (R) Precentral Gyrus 9 F6 50 28 14 Frontal Lobe (R) Middle Frontal Gyrus 46 F8 48 24 -8 Frontal Lobe (R) Inferior Frontal Gyrus 47 FT9 -50 -6 -36 Temporal Lobe (L) Inferior Temporal Gyrus 20 FT7 -54 2 -8 Temporal Lobe (L) Superior Temporal Gyrus 22 FC5 -56 4 22 Frontal Lobe (L) Precentral Gyrus 6 FC3 -44 6 48 Frontal Lobe (L) Middle Frontal Gyrus 6 FC1 -22 6 64 Frontal Lobe (L) Middle Frontal Gyrus 6 FCz 4 6 66 Frontal Lobe (R) Medial Frontal Gyrus 6 FC2 28 8 60 Frontal Lobe (R) Sub-Gyral 6 FC4 48 8 42 Frontal Lobe (R) Middle Frontal Gyrus 6 FC6 58 6 16 Frontal Lobe (R) Inferior Frontal Gyrus 44 FT8 54 2 -12 Temporal Lobe (R) Superior Temporal Gyrus 38 FT10 50 -6 -38 Temporal Lobe (R) Inferior Temporal Gyrus 20 T7/T3 -
Angular Gyrus Involvement at Encoding and Retrieval Is Associated with Durable but Less Specific Memories
9474 • The Journal of Neuroscience, September 27, 2017 • 37(39):9474–9485 Behavioral/Cognitive Angular Gyrus Involvement at Encoding and Retrieval Is Associated with Durable But Less Specific Memories Marieke van der Linden,1 XRuud M.W.J. Berkers,1 XRichard G.M. Morris,2 and Guille´n Ferna´ndez1 1Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands, and 2Centre for Cognitive and Neural Systems, The University of Edinburgh, EH8 9JZ Edinburgh, United Kingdom Afterconsolidation,informationbelongingtoamentalschemaisbetterremembered,butsuchmemorycanbelessspecificwhenitcomes to details. A neuronal mechanism consistent with this behavioral pattern could result from a dynamic interaction that entails mediation byaspecificcorticalnetworkwithassociatedhippocampaldisengagement.Wenowreportthat,inmaleandfemaleadulthumansubjects, encoding and later consolidation of a series of objects embedded in a semantic schema was associated with a buildup of activity in the angular gyrus (AG) that predicted memory 24 h later. In parallel, the posterior hippocampus became less involved as schema objects were encoded successively. Hippocampal disengagement was related to an increase in falsely remembering objects that were not presented at encoding. During both encoding and retrieval, the AG and lateral occipital complex (LOC) became functionally connected and this interaction was beneficial for successful retrieval. Therefore, a network including the AG and LOC enhances the overnight retention of schema-related memories and their simultaneous detachment from the hippocampus reduces the specificity of the memory. Key words: angular gyrus; fMRI; hippocampus; memory; schema Significance Statement This study provides the first empirical evidence on how the hippocampus and the neocortex interact dynamically when acquiring and then effectively retaining durable knowledge that is associated to preexisting knowledge, but they do so at the cost of memory specificity.