July 22, 2014 u vol. 111 u no. 29 u 10391–10780

Cover image: Pictured are islets of Langerhans, coated with biocompatible and permeable hydrogels. Alice A. Tomei et al. developed a method for encapsulating the islets with thin, complete, and uniform coatings of similar thickness on islets of different sizes. The authors found that encapsulation does not impair islet function and may allow for islet transplanta- tion without immunosuppression. See the article by Tomei et al. on pages 10514–10519. Image courtesy of Alice A. Tomei. From the Cover

10514 Encapsulation of islets of Langerhans 10580 Mitochondrial pore components 10604 Age and polio transmission 10620 Game theory and population genetics 10636 Passenger pigeon population fluctuation

Contents COMMENTARIES 10396 Identifying the components of the elusive mitochondrial THIS WEEK IN PNAS permeability transition pore Jason Karch and Jeffery D. Molkentin See companion article on page 10580 10391 In This Issue 10398 Diverse forms of selection in evolution and computer science LETTERS (ONLINE ONLY) Nicholas H. Barton, Sebastian Novak, and Tiago Paixão See companion article on page 10620 E2915 Are viral small RNA regulating Dengue virus replication beyond serotype 2? 10400 Pleistocene range dynamics and episodic rarity in an Esteban Finol extinct bird A. Townsend Peterson E2917 Reply to Finol: Viral small RNA from Dengue virus and See companion article on page 10636 its regulatory role in different serotypes Mazhar Hussain and Sassan Asgari

PNAS PLUS SCIENCE AND CULTURE—How science intersects with culture

10402 Significance Statements 10393 Science and Culture: Hunting fractals in the music of Brief statements written by the authors about the significance of J. S. Bach their papers. Stephen Ornes

QNAS INAUGURAL ARTICLE

10394 QnAs with Thomas Jessell 10404 Structure of a new DNA-binding domain which regulates Prashant Nair pathogenesis in a wide variety of fungi Matthew B. Lohse, Oren S. Rosenberg, Jeffery S. Cox, Robert M. Stroud, Janet S. Finer-Moore, Free online through the PNAS open access option. and Alexander D. Johnson

PNAS u July 22, 2014 u vol. 111 u no. 29 u iii–viii Downloaded by guest on September 24, 2021 COMPUTER SCIENCES PHYSICAL SCIENCES 10620 Algorithms, games, and evolution Erick Chastain, Adi Livnat, Christos Papadimitriou, APPLIED MATHEMATICS and Umesh Vazirani 10411 A simple generative model of collective online behavior See Commentary on page 10398 James P. Gleeson, Davide Cellai, Jukka-Pekka Onnela, Mason A. Porter, and Felix Reed-Tsochas EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 10604 The role of older children and adults in wild 10468 Spin crossover in ferropericlase and velocity poliovirus transmission heterogeneities in the lower mantle Isobel M. Blake, Rebecca Martin, Ajay Goel, Nino Zhongqing Wu and Renata M. Wentzcovitch Khetsuriani, Johannes Everts, Christopher Wolff, Steven Wassilak, R. Bruce Aylward, and Nicholas C. Grassly 10491 Stone tools from the ancient Tongan state reveal prehistoric interaction centers in the Central Pacific APPLIED PHYSICAL SCIENCES Geoffrey R. Clark, Christian Reepmeyer, Nivaleti 10416 SERS and MD simulation studies of a kinase inhibitor Melekiola, Jon Woodhead, William R. Dickinson, demonstrate the emergence of a potential drug and Helene Martinsson-Wallin discovery tool 10624 Flight performance of the largest volant bird Dhanasekaran Karthigeyan, Soumik Siddhanta, Annavarapu Daniel T. Ksepka Hari Kishore, Sathya S. R. R. Perumal, Hans Ågren, Surabhi Sudevan, Akshay V. Bhat, Karanam Balasubramanyam, Rangappa Kanchugarakoppal Subbegowda, Tapas K. ENGINEERING Kundu, and Chandrabhas Narayana 10514 Device design and materials optimization of conformal coating for islets of Langerhans 10422 Role of projection in the control of bird flocks Alice A. Tomei, Vita Manzoli, Christopher A. Fraker, Daniel J. G. Pearce, Adam M. Miller, George Rowlands, Jaime Giraldo, Diana Velluto, Mejdi Najjar, Antonello and Matthew S. Turner Pileggi, R. Damaris Molano, Camillo Ricordi, Cherie L. 10427 Collective spin 1 singlet phase in high-pressure oxygen Stabler, and Jeffrey A. Hubbell Yanier Crespo, Michele Fabrizio, Sandro Scandolo, 10773 Intratumor heterogeneity alters most effective and Erio Tosatti drugs in designed combinations 10433 The magnetoelectrochemical switch Boyang Zhao, Michael T. Hemann, Petru Lunca Popa, Neil T. Kemp, Hicham Majjad, Guillaume and Douglas A. Lauffenburger Dalmas, Vina Faramarzi, Christian Andreas, Riccardo Hertel, and Bernard Doudin ENVIRONMENTAL SCIENCES 10473 Unspeciated organic emissions from combustion sources CHEMISTRY and their influence on the secondary organic aerosol budget in the United States 10438 Unusual kinetics of thermal decay of dim-light Shantanu H. Jathar, Timothy D. Gordon, Christopher J. photoreceptors in vertebrate vision Hennigan, Havala O. T. Pye, George Pouliot, Peter J. Adams, Ying Guo, Sivakumar Sekharan, Jian Liu, Victor S. Batista, Neil M. Donahue, and Allen L. Robinson John C. Tully, and Elsa C. Y. Yan 10444 Detouring of cisplatin to access mitochondrial genome PHYSICS for overcoming resistance Sean Marrache, Rakesh K. Pathak, and Shanta Dhar 10479 4D multiple-cathode ultrafast electron microscopy John Spencer Baskin, Haihua Liu, and Ahmed H. Zewail 10450 Alteration of the lipid profile in lymphomas induced by MYC overexpression 10485 Giant vacuum forces via transmission lines Livia S. Eberlin, Meital Gabay, Alice C. Fan, Arvin M. Ephraim Shahmoon, Igor Mazets, and Gershon Kurizki Gouw, Robert J. Tibshirani, Dean W. Felsher, and Richard N. Zare 10456 Crystal structure and encapsulation dynamics of ice SOCIAL SCIENCES II-structured neon hydrate Xiaohui Yu, Jinlong Zhu, Shiyu Du, Hongwu Xu, Sven C. ANTHROPOLOGY Vogel, Jiantao Han, Timothy C. Germann, Jianzhong 10491 Stone tools from the ancient Tongan state Zhang, Changqing Jin, Joseph S. Francisco, reveal prehistoric interaction centers in the and Yusheng Zhao Central Pacific 10462 Testing for memory-free spectroscopic coordinates by Geoffrey R. Clark, Christian Reepmeyer, Nivaleti 3D IR exchange spectroscopy Melekiola, Jon Woodhead, William R. Dickinson, Joanna A. Borek, Fivos Perakis, and Peter Hamm and Helene Martinsson-Wallin 10744 Covalent agonists for studying G protein-coupled 10497 Environmental impact of geometric earthwork receptor activation construction in pre-Columbian Amazonia Dietmar Weichert, Andrew C. Kruse, Aashish Manglik, John Francis Carson, Bronwen S. Whitney, Francis E. Christine Hiller, Cheng Zhang, Harald Hübner, Brian K. Mayle, José Iriarte, Heiko Prümers, J. Daniel Soto, Kobilka, and Peter Gmeiner and Jennifer Watling

iv u www.pnas.org Downloaded by guest on September 24, 2021 ECONOMIC SCIENCES 10532 Identification of a two-component fatty acid kinase 10503 Irrational exuberance and neural crash warning responsible for host fatty acid incorporation by signals during endogenous experimental Staphylococcus aureus market bubbles Joshua B. Parsons, Tyler C. Broussard, Jeffrey L. Bose, Alec Smith, Terry Lohrenz, Justin King, P. Read Montague, Jason W. Rosch, Pamela Jackson, Chitra Subramanian, and Colin F. Camerer and Charles O. Rock 10538 The Legionella effector SidC defines a unique family SOCIAL SCIENCES of ubiquitin ligases important for bacterial phagosomal remodeling 10411 A simple generative model of collective online behavior FoSheng Hsu, Xi Luo, Jiazhang Qiu, Yan-Bin Teng, James P. Gleeson, Davide Cellai, Jukka-Pekka Onnela, Jianping Jin, Marcus B. Smolka, Zhao-Qing Luo, Mason A. Porter, and Felix Reed-Tsochas and Yuxin Mao 10544 Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator BIOLOGICAL SCIENCES Koji Takeo, Shun Tanimura, Takehiro Shinoda, Satoko Osawa, Ivan Krasmirov Zahariev, Naoki Takegami, Yoshiko ANTHROPOLOGY Ishizuka-Katsura, Naoko Shinya, Shizuka Takagi-Niidome, 10509 Temporal labyrinths of eastern Eurasian Aya Tominaga, Noboru Ohsawa, Tomomi Kimura-Someya, Pleistocene humans Mikako Shirouzu, Satoshi Yokoshima, Shigeyuki Yokoyama, Xiu-Jie Wu, Isabelle Crevecoeur, Wu Liu, Song Xing, Tohru Fukuyama, Taisuke Tomita, and Takeshi Iwatsubo and Erik Trinkaus BIOPHYSICS AND COMPUTATIONAL BIOLOGY APPLIED BIOLOGICAL SCIENCES E2947 Catalytic strategy used by the myosin motor to hydrolyze ATP 10514 Device design and materials optimization of conformal Farooq Ahmad Kiani and Stefan Fischer coating for islets of Langerhans Alice A. Tomei, Vita Manzoli, Christopher A. Fraker, 10416 SERS and MD simulation studies of a kinase inhibitor Jaime Giraldo, Diana Velluto, Mejdi Najjar, Antonello demonstrate the emergence of a potential drug Pileggi, R. Damaris Molano, Camillo Ricordi, Cherie L. discovery tool Stabler, and Jeffrey A. Hubbell Dhanasekaran Karthigeyan, Soumik Siddhanta, Annavarapu Hari Kishore, Sathya S. R. R. Perumal, Hans Ågren, Surabhi BIOCHEMISTRY Sudevan, Akshay V. Bhat, Karanam Balasubramanyam, Rangappa Kanchugarakoppal Subbegowda, Tapas K. E2918 Phosphoproteomic analysis identifies the tumor Kundu, and Chandrabhas Narayana suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3 10438 Unusual kinetics of thermal decay of dim-light Jacob A. Galan, Kathryn M. Geraghty, Geneviève Lavoie, photoreceptors in vertebrate vision Evgeny Kanshin, Joseph Tcherkezian, Viviane Calabrese, Ying Guo, Sivakumar Sekharan, Jian Liu, Victor S. Batista, Grace R. Jeschke, Benjamin E. Turk, Bryan A. Ballif, John C. Tully, and Elsa C. Y. Yan John Blenis, Pierre Thibault, and Philippe P. Roux 10550 Energy landscape views for interplays among folding, E2928 DEAD-box protein CYT-19 is activated by exposed helices binding, and allostery of calmodulin domains in a group I intron RNA Wenfei Li, Wei Wang, and Shoji Takada Inga Jarmoskaite, Hari Bhaskaran, Soenke Seifert, 10556 Simple chained guide trees give high-quality protein and Rick Russell multiple sequence alignments E2937 Molecular mechanisms for the regulation of histone Kieran Boyce, Fabian Sievers, and Desmond G. Higgins mRNA stem-loop–binding protein by phosphorylation 10562 Modulation of frustration in folding by Jun Zhang, Dazhi Tan, Eugene F. DeRose, Lalith Perera, sequence permutation Zbigniew Dominski, William F. Marzluff, Liang Tong, R. Paul Nobrega, Karunesh Arora, Sagar V. and Traci M. Tanaka Hall Kathuria, Rita Graceffa, Raul A. Barrea, Liang 10404 Structure of a new DNA-binding domain which regulates Guo, Srinivas Chakravarthy, Osman Bilsel, pathogenesis in a wide variety of fungi Thomas C. Irving, Charles L. Brooks III, Matthew B. Lohse, Oren S. Rosenberg, Jeffery S. Cox, and C. Robert Matthews Robert M. Stroud, Janet S. Finer-Moore, and Alexander D. Johnson CELL BIOLOGY 10520 Ancient translation factor is essential for tRNA-dependent 10568 Ras transformation uncouples the kinesin-coordinated cysteine biosynthesis in methanogenic archaea cellular nutrient response Yuchen Liu, Akiyoshi Nakamura, Yuto Nakazawa, Elma Zaganjor, Lauren M. Weil, Joshua X. Gonzales, Nozomi Asano, Kara A. Ford, Michael J. Hohn, Isao John D. Minna, and Melanie H. Cobb Tanaka, Min Yao, and Dieter Söll 10574 Metformin and phenformin deplete tricarboxylic acid 10526 Crystal structure of mammalian cycle and glycolytic intermediates during cell selenocysteine-dependent iodothyronine deiodinase transformation and NTPs in cancer stem cells suggests a peroxiredoxin-like catalytic mechanism Andreas Janzer, Natalie J. German, Karina N. Ulrich Schweizer, Christine Schlicker, Doreen Braun, Gonzalez-Herrera, John M. Asara, Marcia C. Haigis, Josef Köhrle, and Clemens Steegborn and Kevin Struhl

PNAS u July 22, 2014 u vol. 111 u no. 29 u v Downloaded by guest on September 24, 2021 10580 An uncoupling channel within the c-subunit ring 10624 Flight performance of the largest volant bird

of the F1FO ATP synthase is the mitochondrial Daniel T. Ksepka permeability transition pore 10630 Divergence of Drosophila melanogaster repeatomes in Kambiz N. Alavian, Gisela Beutner, Emma Lazrove, response to a sharp microclimate contrast in Evolution Silvio Sacchetti, Han-A Park, Pawel Licznerski, Canyon, Israel Hongmei Li, Panah Nabili, Kathryn Hockensmith, Morven Graham, George A. Porter, Jr., Young Bun Kim, Jung Hun Oh, Lauren J. McIver, and Elizabeth A. Jonas Eugenia Rashkovetsky, Katarzyna Michalak, Harold R. See Commentary on page 10396 Garner, Lin Kang, Eviatar Nevo, Abraham B. Korol, and Pawel Michalak 10586 TOR complex 2-Ypk1 signaling is an essential positive 10636 Drastic population fluctuations explain the rapid regulator of the general amino acid control response and autophagy extinction of the passenger pigeon Ariadne Vlahakis, Martin Graef, Jodi Nunnari, Chih-Ming Hung, Pei-Jen L. Shaner, Robert M. Zink, Wei-Chung Liu, Te-Chin Chu, Wen-San Huang, and Ted Powers and Shou-Hsien Li 10592 Tif1γ regulates the TGF-β1 receptor and promotes See Commentary on page 10400 physiological aging of hematopoietic stem cells Ronan Quéré, Laetitia Saint-Paul, Virginie Carmignac, Romain Z. Martin, Marie-Lorraine Chrétien, Anne GENETICS Largeot, Arlette Hammann, Jean-Paul Pais de Barros, E2967 Optimized CRISPR/Cas tools for efficient germline and Jean-Noël Bastie, and Laurent Delva somatic genome engineering in Drosophila Fillip Port, Hui-Min Chen, Tzumin Lee, and Simon L. Bullock DEVELOPMENTAL BIOLOGY 10642 Mutation of a major CG methylase in rice causes 10598 Dynamic regulation of eve stripe 2 expression genome-wide hypomethylation, dysregulated genome reveals transcriptional bursts in living expression, and seedling lethality Drosophila embryos Lanjuan Hu, Ning Li, Chunming Xu, Silin Zhong, Xiuyun Lin, Jacques P. Bothma, Hernan G. Garcia, Emilia Jingjing Yang, Tianqi Zhou, Anzhi Yuliang, Ying Wu, Esposito, Gavin Schlissel, Thomas Gregor, Yun-Ru Chen, Xiaofeng Cao, Assaf Zemach, Sachin and Michael Levine Rustgi, Diter von Wettstein, and Bao Liu 10648 FGF5 is a crucial regulator of hair length in humans Claire A. Higgins, Lynn Petukhova, Sivan Harel, Yuan Y. Ho, ECOLOGY Esther Drill, Lawrence Shapiro, Muhammad Wajid, 10422 Role of projection in the control of bird flocks and Angela M. Christiano Daniel J. G. Pearce, Adam M. Miller, George Rowlands, and Matthew S. Turner 10654 Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals 10497 Environmental impact of geometric earthwork Kaixiong Ye, Jian Lu, Fei Ma, Alon Keinan, construction in pre-Columbian Amazonia and Zhenglong Gu John Francis Carson, Bronwen S. Whitney, Francis E. Mayle, José Iriarte, Heiko Prümers, J. Daniel Soto, and Jennifer Watling IMMUNOLOGY AND INFLAMMATION 10604 The role of older children and adults in wild E2977 Adaptive immunity to murine skin commensals poliovirus transmission Wei Shen, Wenqing Li, Julie A. Hixon, Nicolas Isobel M. Blake, Rebecca Martin, Ajay Goel, Nino Bouladoux, Yasmine Belkaid, Amiran Dzutzev, Khetsuriani, Johannes Everts, Christopher Wolff, Steven and Scott K. Durum Wassilak, R. Bruce Aylward, and Nicholas C. Grassly 10660 Bioengineering T cells to target carbohydrate to treat 10610 Invasive plants have broader physiological niches opportunistic fungal infection Steven I. Higgins and David M. Richardson Pappanaicken R. Kumaresan, Pallavi R. Manuri, Nathaniel D. Albert, Sourindra Maiti, Harjeet Singh, Tiejuan Mi, Jason Roszik, Brian Rabinovich, Simon ENVIRONMENTAL SCIENCES Olivares, Janani Krishnamurthy, Ling Zhang, Amer M. Najjar, M. Helen Huls, Dean A. Lee, 10615 Herbarium specimens show contrasting phenological Richard E. Champlin, Dimitrios P. Kontoyiannis, responses to Himalayan climate and Laurence J. N. Cooper Robbie Hart, Jan Salick, Sailesh Ranjitkar, and Jianchu Xu 10666 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling Elizabeth S. Gold, Alan H. Diercks, Irina Podolsky, EVOLUTION Rebecca L. Podyminogin, Peter S. Askovich, Piper M. E2957 The fossilized birth–death process for coherent Treuting, and Alan Aderem calibration of divergence-time estimates 10672 Commensal microbes drive intestinal inflammation by Tracy A. Heath, John P. Huelsenbeck, and Tanja Stadler + IL-17–producing CD4 T cells through ICOSL and OX40L 10620 Algorithms, games, and evolution costimulation in the absence of B7-1 and B7-2 Erick Chastain, Adi Livnat, Christos Papadimitriou, Lijun Xin, Tony T. Jiang, Vandana Chaturvedi, Jeremy M. and Umesh Vazirani Kinder, James M. Ertelt, Jared H. Rowe, Kris A. Steinbrecher, See Commentary on page 10398 and Sing Sing Way

vi u www.pnas.org Downloaded by guest on September 24, 2021 MEDICAL SCIENCES 10503 Irrational exuberance and neural crash warning 10444 Detouring of cisplatin to access mitochondrial genome signals during endogenous experimental for overcoming resistance market bubbles Sean Marrache, Rakesh K. Pathak, and Shanta Dhar Alec Smith, Terry Lohrenz, Justin King, P. Read Montague, and Colin F. Camerer 10678 Efficient germ-line transmission obtained with transgene-free induced pluripotent 10720 CA3 size predicts the precision of memory recall stem cells Martin J. Chadwick, Heidi M. Bonnici, Sen Wu, Yuanyuan Wu, Xi Zhang, and Eleanor A. Maguire and Mario R. Capecchi 10726 The transcription factor Fezf2 directs the differentiation 10684 Tumor suppressor p53 cooperates with SIRT6 to of neural stem cells in the subventricular zone toward regulate gluconeogenesis by promoting FoxO1 a cortical phenotype nuclear exclusion Annalisa Zuccotti, Corentin Le Magueresse, Min Chen, Ping Zhang, Bo Tu, Hua Wang, Ziyang Cao, Ming Angela Neitz, and Hannah Monyer Tang, Chaohua Zhang, Bo Gu, Zhiming Li, Lina 10732 Intramuscular injection of α-synuclein induces CNS Wang, Yang Yang, Ying Zhao, Haiying Wang, α-synuclein pathology and a rapid-onset motor Jianyuan Luo, Chu-Xia Deng, Bin Gao, Robert G. phenotype in transgenic mice Roeder, and Wei-Guo Zhu Amanda N. Sacino, Mieu Brooks, Michael A. 10690 Discrete conformations of epitope II on the hepatitis C Thomas, Alex B. McKinney, Sooyeon Lee, Robert W. virus E2 protein for antibody-mediated neutralization Regenhardt, Nicholas H. McGarvey, Jacob I. Ayers, and nonneutralization Lucia Notterpek, David R. Borchelt, Todd E. Golde, Lu Deng, Li Ma, Maria Luisa Virata-Theimer, Lilin Zhong, and Benoit I. Giasson Hailing Yan, Zhong Zhao, Evi Struble, Stephen Feinstone, Harvey Alter, and Pei Zhang 10738 Neural correlates of auditory streaming in an objective behavioral task 10696 G-CSF Induces Membrane Expression of a Naoya Itatani and Georg M. Klump Myeloperoxidase Glycovariant that Operates as an E-selectin Ligand on Human Myeloid Cells Cristina I. Silvescu and Robert Sackstein PHARMACOLOGY 10744 Covalent agonists for studying G protein-coupled receptor activation MICROBIOLOGY Dietmar Weichert, Andrew C. Kruse, Aashish Manglik, 10702 Rhizobial homologs of the fatty acid transporter FadL Christine Hiller, Cheng Zhang, Harald Hübner, Brian K. facilitate perception of long-chain acyl-homoserine Kobilka, and Peter Gmeiner lactone signals Elizaveta Krol and Anke Becker 10749 Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the 10708 Enhancement of protein expression by alphavirus acetylcholine binding protein replicons by designing self-replicating Katarzyna Kaczanowska, Michal Harel, Zoran subgenomic RNAs Radic, Jean-Pierre Changeux, M. G. Finn, Dal Young Kim, Svetlana Atasheva, Alexander J. and Palmer Taylor McAuley, Jessica A. Plante, Elena I. Frolova, David W. C. Beasley, and Ilya Frolov 10755 Mechanisms underlying the activation of G-protein– gated inwardly rectifying K+ (GIRK) channels by the 10714 Modeling ecological drivers in marine viral novel anxiolytic drug, ML297 communities using comparative metagenomics Nicole Wydeven, Ezequiel Marron Fernandez de Velasco, and network analyses Yu Du, Michael A. Benneyworth, Matthew C. Hearing, Bonnie L. Hurwitz, Anton H. Westveld, Jennifer R. Rachel A. Fischer, Mark John Thomas, C. David Weaver, Brum, and Matthew B. Sullivan and Kevin Wickman

NEUROSCIENCE PHYSIOLOGY E2987 Astrocyte activation is suppressed in both normal and 10761 Effect of sleep deprivation on the human injured brain by FGF signaling metabolome Wenfei Kang, Francesca Balordi, Nan Su, Lin Chen, Sarah K. Davies, Joo Ern Ang, Victoria L. Revell, Gordon Fishell, and Jean M. Hébert Ben Holmes, Anuska Mann, Francesca P. Robertson, Nanyi Cui, Benita Middleton, Katrin Ackermann, E2996 Genetic evidence that Celsr3 and Celsr2, together Manfred Kayser, Alfred E. Thumser, Florence I. with Fzd3, regulate forebrain wiring in a Raynaud, and Debra J. Skene Vangl-independent manner Yibo Qu, Yuhua Huang, Jia Feng, Gonzalo Alvarez-Bolado, Elizabeth A. Grove, Yingzi Yang, Fadel Tissir, Libing Zhou, PLANT BIOLOGY and Andre M. Goffinet E3015 Auxin inhibits stomatal development through E3005 Frizzled3 is required for the development of multiple MONOPTEROS repression of a mobile peptide axon tracts in the mouse central nervous system gene STOMAGEN in mesophyll Zhong L. Hua, Sangmin Jeon, Michael J. Caterina, Jing-Yi Zhang, Sheng-Bo He, Ling Li, and Jeremy Nathans and Hong-Quan Yang

PNAS u July 22, 2014 u vol. 111 u no. 29 u vii Downloaded by guest on September 24, 2021 POPULATION BIOLOGY CORRECTION 10767 Contact between bird species of different lifespans can promote the emergence of highly pathogenic avian influenza strains PSYCHOLOGICAL AND COGNITIVE SCIENCES Paul S. Wikramaratna, Oliver G. Pybus, and Sunetra Gupta 10779 Experimental evidence of massive-scale emotional contagion through social networks Adam D. I. Kramer, Jamie E. Guillory, SYSTEMS BIOLOGY and Jeffrey T. Hancock 10773 Intratumor heterogeneity alters most effective drugs in designed combinations Boyang Zhao, Michael T. Hemann, ix Subscription Form and Douglas A. Lauffenburger

EDITORIAL EXPRESSION OF CONCERN Supplement 3

PSYCHOLOGICAL AND COGNITIVE SCIENCES ARTHUR M. SACKLER COLLOQUIUM OF THE NATIONAL ACADEMY OF SCIENCES 10779 Experimental evidence of massive-scale emotional contagion through social networks Adam D. I. Kramer, Jamie E. Guillory, 10781–10896 In the Light of Evolution VIII: Darwinian Thinking and Jeffrey T. Hancock in the Social Sciences

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