Intracellular cholesterol transport proteins: roles in health and disease Soffientini, Ugo; Graham, Annette Published in: Clinical Science DOI: 10.1042/CS20160339 Publication date: 2016 Document Version Author accepted manuscript Link to publication in ResearchOnline Citation for published version (Harvard): Soffientini, U & Graham, A 2016, 'Intracellular cholesterol transport proteins: roles in health and disease', Clinical Science, vol. 130, no. 21, pp. 1843-1859. https://doi.org/10.1042/CS20160339 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Take down policy If you believe that this document breaches copyright please view our takedown policy at https://edshare.gcu.ac.uk/id/eprint/5179 for details of how to contact us. Download date: 26. Sep. 2021 Intracellular Cholesterol Transport Proteins: Roles in Health and Disease Ugo Soffientini§ and Annette Graham* Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, United Kingdom *Corresponding Author: Professor Annette Graham, Dept of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, 70 Cowcaddens Road, Glasgow G4 0BA, UK T: +44(0) 141 331 3722 F: +44(0) 141 331 3208 E:
[email protected] §Present Address: Dr Ugo Soffientini, Jarrett Building, Veterinary Research Facility, University of Glasgow, Garscube, GlasgowG61 1QH, UK. Abstract Effective cholesterol homeostasis is essential in maintaining cellular function, and this is achieved by a network of lipid-responsive nuclear transcription factors, and enzymes, receptors and transporters subject to post-transcriptional and post-translational regulation, while loss of these elegant, tightly regulated homeostatic responses is integral to disease pathologies.