Thyroidectomy for the treatment of Graves' thyrotoxicosis in thioamide- induced agranulocytosis and sepsis Citation: Knight, Colin L., Cooray, Shamil D., Kulkarni, Jaideep, Borschmann, Michael and Kotowicz, Mark 2017, Thyroidectomy for the treatment of Graves' thyrotoxicosis in thioamide- induced agranulocytosis and sepsis, Endocrinology, diabetes & metabolism, Article ID: 17- 0071, pp. 1-6. DOI: http://www.dx.doi.org/10.1530/EDM-17-0071 © 2017, The Authors Reproduced by Deakin University under the terms of the Creative Commons Attribution Non- Commercial No-Derivatives Licence Downloaded from DRO: http://hdl.handle.net/10536/DRO/DU:30109157 DRO Deakin Research Online, Deakin University’s Research Repository Deakin University CRICOS Provider Code: 00113B ID: 17-0071 10.1530/EDM-17-0071 C L Knight and others Thyroidectomy when thyrotoxic ID: 17-0071; September 2017 with agranulocytosis DOI: 10.1530/EDM-17-0071 Thyroidectomy for the treatment of Graves’ thyrotoxicosis in thioamide-induced agranulocytosis and sepsis Colin L Knight1, Shamil D Cooray1, Jaideep Kulkarni1, Michael Borschmann2,3 and Mark Kotowicz1,4,5 1Department of Endocrinology and Diabetes, University Hospital Geelong, Geelong, Victoria, Australia, Correspondence 2Ear, Nose and Throat, Head and Neck Surgery, St. John of God Hospital, Geelong, Victoria, Australia, should be addressed 3Director of Otolaryngology, University Hospital Geelong, Geelong, Victoria, Australia, 4Deakin University to C Knight School of Medicine, Geelong, Victoria, Australia, and 5Melbourne Clinical School-Western Campus, Email Department of Medicine, The University of Melbourne, St. Albans, Victoria, Australia
[email protected] Summary A 51 year old man presented with sepsis in the setting of thioamide-induced agranulocytosis. Empiric broad-spectrum antibiotics was followed by directed narrow-spectrum antibiotics, and his neutrophil count recovered with support from granulocyte-colony stimulating factor (G-CSF) analogue transfusions.