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Bottom-Up Synthesis and Sensor Applications of Biomimetic Nanostructures
materials Review Bottom-Up Synthesis and Sensor Applications of Biomimetic Nanostructures Li Wang 1,*, Yujing Sun 2, Zhuang Li 2, Aiguo Wu 3 and Gang Wei 4,* Received: 25 November 2015; Accepted: 7 January 2016; Published: 18 January 2016 Academic Editor: Erik Reimhult 1 College of Chemistry, Jilin Normal University, Haifeng Street 1301, Siping 136000, China 2 State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, China; [email protected] (Y.S.); [email protected] (Z.L.) 3 Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Material Technology and Engineering, Chinese Academy Sciences, Ningbo 315201, China; [email protected] 4 Faculty of Production Engineering, University of Bremen, Am Fallturm 1, D-28359 Bremen, Germany * Correspondence: [email protected] (L.W.); [email protected] (G.W.); Tel.: +86-139-4441-1011 (L.W.); +49-421-2186-4581 (G.W.) Abstract: The combination of nanotechnology, biology, and bioengineering greatly improved the developments of nanomaterials with unique functions and properties. Biomolecules as the nanoscale building blocks play very important roles for the final formation of functional nanostructures. Many kinds of novel nanostructures have been created by using the bioinspired self-assembly and subsequent binding with various nanoparticles. In this review, we summarized the studies on the fabrications and sensor applications of biomimetic nanostructures. The strategies for creating different bottom-up nanostructures by using biomolecules like DNA, protein, peptide, and virus, as well as microorganisms like bacteria and plant leaf are introduced. -
Enantioselective Total Synthesis of (-)-Deoxoapodine
Enantioselective total synthesis of (-)-deoxoapodine The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Kang, Taek, et al., "Enantioselective total synthesis of (-)- deoxoapodine." Angewandte Chemie International Edition 56, 44 (Sept. 2017): p. 13857-60 doi 10.1002/anie.201708088 ©2017 Author(s) As Published 10.1002/anie.201708088 Publisher Wiley Version Author's final manuscript Citable link https://hdl.handle.net/1721.1/125957 Terms of Use Creative Commons Attribution-Noncommercial-Share Alike Detailed Terms http://creativecommons.org/licenses/by-nc-sa/4.0/ HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Angew Manuscript Author Chem Int Ed Engl Manuscript Author . Author manuscript; available in PMC 2018 October 23. Published in final edited form as: Angew Chem Int Ed Engl. 2017 October 23; 56(44): 13857–13860. doi:10.1002/anie.201708088. Enantioselective Total Synthesis of (−)-Deoxoapodine Dr. Taek Kang§,a, Dr. Kolby L. White§,a, Tyler J. Mannb, Prof. Dr. Amir H. Hoveydab, and Prof. Dr. Mohammad Movassaghia aDepartment of Chemistry, Massachusetts Institute of Technology Cambridge, MA 02139 (USA) bDepartment of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA) Abstract The first enantioselective total synthesis of (−)-deoxoapodine is described. Our synthesis of this hexacyclic aspidosperma alkaloid includes an efficient molybdenum-catalyzed enantioselective ring-closing metathesis reaction for desymmetrization of an advanced intermediate that introduces the C5-quaternary stereocenter. After C21-oxygenation, the pentacyclic core was accessed via an electrophilic C19-amide activation and transannular spirocyclization. A biogenetically inspired dehydrative C6-etherification reaction proved highly effective to secure the F-ring and the fourth contiguous stereocenter of (−)-deoxoapodine with complete stereochemical control. -
Biomimetic Total Synthesis of Natural Products
Biomimetic Total Synthesis of Natural Products Thesis submitted for the degree of Doctor of Philosophy Hiu Chun Lam Bsc (Hons.) Chemistry Department of Chemistry University of Adelaide Aug, 2017 To my family II Declaration I certify that this work contains no material which has been accepted for the award of any other degree or diploma in my name, in any university or other tertiary institution and, to the best of my knowledge and belief, contains no material previously published or written by another person, except where due reference has been made in the text. In addition, I certify that no part of this work will, in the future, be used in a submission in my name, for any other degree or diploma in any university or other tertiary institution without the prior approval of the University of Adelaide and where applicable, any partner institution responsible for the joint-award of this degree. I give consent to this copy of my thesis, when deposited in the University Library, being made available for loan and photocopying, subject to the provisions of the Copyright Act 1968. I also give permission for the digital version of my thesis to be made available on the web, via the University’s digital research repository, the Library Search and also through web search engines, unless permission has been granted by the University to restrict access for a period of time. I acknowledge the support I have received for my research through the provision of an Australian Government Research Training Program Scholarship Hiu Chun Lam Date III Acknowledgements First, I would like to thank my supervisor Dr. -
Posttranslational Chemical Installation of Azoles Into Translated Peptides ✉ ✉ Haruka Tsutsumi1,2, Tomohiro Kuroda1,2, Hiroyuki Kimura 1, Yuki Goto 1 & Hiroaki Suga 1
ARTICLE https://doi.org/10.1038/s41467-021-20992-0 OPEN Posttranslational chemical installation of azoles into translated peptides ✉ ✉ Haruka Tsutsumi1,2, Tomohiro Kuroda1,2, Hiroyuki Kimura 1, Yuki Goto 1 & Hiroaki Suga 1 Azoles are five-membered heterocycles often found in the backbones of peptidic natural products and synthetic peptidomimetics. Here, we report a method of ribosomal synthesis of azole-containing peptides involving specific ribosomal incorporation of a bromovinylglycine 1234567890():,; derivative into the nascent peptide chain and its chemoselective conversion to a unique azole structure. The chemoselective conversion was achieved by posttranslational dehydro- bromination of the bromovinyl group and isomerization in aqueous media under fairly mild conditions. This method enables us to install exotic azole groups, oxazole and thiazole, at designated positions in the peptide chain with both linear and macrocyclic scaffolds and thereby expand the repertoire of building blocks in the mRNA-templated synthesis of designer peptides. 1 Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, Japan. 2These authors contributed equally: Haruka Tsutsumi, ✉ Tomohiro Kuroda. email: [email protected]; [email protected] NATURE COMMUNICATIONS | (2021) 12:696 | https://doi.org/10.1038/s41467-021-20992-0 | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-021-20992-0 zoles, such as oxazoles and thiazoles, are five-membered heterocycles often found in the backbone of peptidic UCAG DNA template U A 1,2 Phe Tyr Cys C natural products . Such azole-containing natural pep- U Ser O Leu A tides exhibit a variety of bioactivities, including antitumor, anti- Trp G – His U H2N 3 9 C Leu Pro Arg C OH fungal, antibiotic, and antiviral activities . -
Metal Organic Frameworks in Heterogeneous Catalysis: Recent Progress, New Trends and Future Perspectives
Metal–Organic Frameworks in Heterogeneous Catalysis: Recent Progress, New Trends, and Future Perspectives Item Type Article Authors Bavykina, Anastasiya; Kolobov, Nikita; Khan, Il Son; Bau, Jeremy; Galilea, Adrian; Gascon, Jorge Citation Bavykina, A., Kolobov, N., Khan, I. S., Bau, J. A., Ramirez, A., & Gascon, J. (2020). Metal–Organic Frameworks in Heterogeneous Catalysis: Recent Progress, New Trends, and Future Perspectives. Chemical Reviews. doi:10.1021/ acs.chemrev.9b00685 Eprint version Post-print DOI 10.1021/acs.chemrev.9b00685 Publisher American Chemical Society (ACS) Journal Chemical Reviews Rights This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemical Reviews, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.chemrev.9b00685. Download date 04/10/2021 08:34:35 Link to Item http://hdl.handle.net/10754/662392 Metal Organic Frameworks in Heterogeneous Catalysis: Recent Progress, New Trends and Future Perspectives Anastasiya Bavykina,† Nikita Kolobov,† Il Son Khan,† Jeremy A. Bau,† Adrian Ramirez† and Jorge Gascon *† † King Abdullah University of Science and Technology, KAUST Catalysis Center (KCC), Advanced Catalytic Materials, Thuwal, 23955-6900, Saudi Arabia [email protected] Abstract More than 95% (in volume) of all today’s chemical products are manufactured through catalytic processes, making research into more efficient catalytic materials a thrilling and very dynamic research field. In this regard, Metal Organic Frameworks (MOFs) offer great opportunities for the rational design of new catalytic solids, as highlighted by the unprecedented number of publications appearing over the last decade. -
Aggregation, of Nanoparticles 19 Dispersion and Transformation 22
325 Index a bismuth nanoparticles aggregation, of nanoparticles 19 chemical reduction 129 dispersion and transformation 22 one pot synthesis 130 mineralization 24 polyol method 129 schematic representation of 21 solvothermal method 130 albumin 294–296 thermal decomposition 128 alginate-BSA nanoparticles 296 bismuth sulphide -helix content of lysozyme 92 protein mediated 231 alumina nanoparticles solvothermal synthesis 230 precipitation method 147 sonochemical method 229 sol–gel synthesis 145 template synthesis 230 template method 146–147 blood–brain barrier (BBB) 9 aluminum nanoparticles Boltzmann entropy, characteristics of catalytic decomposition 130 44 templated synthesis 132 Boltzmann–Gibbs entropy formulae thermal decomposition 132 44 antimony oxide bottom-up approach, for nanostructures biosynthesis 151 18–19 bulk and nanoscale, properties of 13 BSA–Acacia nanoparticles 297 chemical reduction 151 chemical synthesis 149 c Gibbs energy 148 cadmium sulphide hydrothermal method 151 carbon 28 microemulsion method 149–150 chemical synthesis 231, 236 customized synthesis 237 antimony sulphide (Sb2S3) hydrothermal method 228 electrochemical method 232 laser ablation technique 228 green synthesis 234–235, 237 solvothermal method 227 hot injection method 233 thermal decomposition method b 233, 236 biomolecules 69 carbonyl decomposition 102 BSA-Acacia nanoparticles 297 CdSe quantum dot-lysozyme interaction nucleic acid nanoparticles 313–314 94 biosynthetic methods, for metal CdSe quantum dots 77, 78 nanoparticle preparation 13 cerium oxide -
UNIVERSITY of CALIFORNIA Los Angeles Biomimetic Synthesis Of
UNIVERSITY OF CALIFORNIA Los Angeles Biomimetic Synthesis of Noble Metal Nanoparticles and Their Applications as Electro-catalysts in Fuel Cells A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Materials Science and Engineering by Yujing Li 2012. © Copyright by Yujing Li 2012 ABSTRACT OF THE DISSERTATION Biomimetic Synthesis of Noble Metal Nanoparticles and Their Applications as Electro-catalysts in Fuel Cells by Yujing Li Doctor of Philosophy in Materials Science and Engineering University of California, Los Angeles, 2012 Professor Yu Huang, Chair Today, proton electrolyte membrane fuel cell (PEMFC) and direct methanol fuel cell (DMFC) are attractive power conversion devices that generate fairly low or even no pollution, and considered to be potential to replace conventional fossil fuel based power sources on automobiles. The operation and performance of PEMFC and DMFC depend largely on electro-catalysts positioned between the electrode and the membranes. The most commonly used electro-catalysts for PEMFC and DMFC are Pt-based noble metal nanoparticles, so catalysts share close to 50% of the total cost of the fuel cell. The synthesis of such nanoscale electro-catalysts are commonly limited to harsh conditions (high temperature, high pressure), organic solvent, high amount of stabilizing agent, to achieve the size and morphological control. There is no rational guideline for the ii selection of stabilizing agent for specific materials, leading to the current "trial and error" -
A Mineralogical View of Apatitic Biomaterials
1 1 2 Revision 1 3 MS #5732R 4 5 6 7 8 9 10 11 A Mineralogical View of Apatitic Biomaterials 12 13 14 Jill Dill Pasteris 15 Department of Earth and Planetary Sciences and 16 Institute for Materials Science and Engineering 17 Washington University in St. Louis 18 St. Louis, MO 63130-4899 19 20 [email protected] 21 22 23 24 25 26 27 28 29 30 Revised version submitted to American Mineralogist 31 July 6, 2016 32 33 34 35 36 37 38 39 40 41 2 42 Abstract 43 44 Biomaterials are synthetic compounds and composites that replace or assist missing or 45 damaged tissue or organs. This review paper addresses calcium phosphate biomaterials that are 46 used as aids to or substitutes for bones and teeth. The viewpoint taken is that of mineralogists 47 and geochemists interested in (carbonated) hydroxylapatite, its range of compositions, the 48 conditions under which it can be synthesized, and how it is used as a biomaterial either alone or 49 in a composite. Somewhat counterintuitively, the goal of most medical or materials science 50 researchers in this field is to emulate the properties of bone and tooth, rather than the 51 hierarchically complex materials themselves. The absence of a directive to mimic biological 52 reality has permitted the development of a remarkable range of approaches to apatite synthesis 53 and post-synthesis processing. Multiple means of synthesis are described from low-temperature 54 aqueous precipitation, sol gel processes, and mechanosynthesis to high-temperature solid-state 55 reactions and sintering up to 1000 °C. -
S41467-021-25198-Y.Pdf
ARTICLE https://doi.org/10.1038/s41467-021-25198-y OPEN Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman ✉ ✉ Xiangfeng Lin1,2, Xianghui Liu1,2, Kai Wang1,2, Qian Li1,2, Yan Liu 1 & Can Li 1 Polyketide oligomers containing the structure of tetracyclic isochroman comprise a large class of natural products with diverse activity. However, a general and stereoselective 1234567890():,; method towards the rapid construction of this structure remains challenging due to the inherent instability and complex stereochemistry of polyketide. By mimicking the biosynthetic pathway of this structurally diverse set of natural products, we herein develop an asymmetric hetero-Diels–Alder reaction of in-situ generated isochromene and ortho-quinonemethide. A broad range of tetracyclic isochroman frameworks are prepared in good yields and excellent stereoinduction (up to 95% ee) from readily available α-propargyl benzyl alcohols and 2- (hydroxylmethyl) phenols under mild conditions. This direct enantioselective cascade reac- tion is achieved by a Au(I)/chiral Sc(III) bimetallic catalytic system. Experimental studies indicate that the key hetero-Diels-Alder reaction involves a stepwise pathway, and the steric hindrance between in-situ generated isochromene and t-Bu group of Sc(III)/N,N’-dioxide complex is responsible for the enantioselectivity in the hetero-Diels–Alder reaction step. 1 State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China. 2 University of Chinese Academy of ✉ Sciences, Beijing, China. email: [email protected]; [email protected] NATURE COMMUNICATIONS | (2021) 12:4958 | https://doi.org/10.1038/s41467-021-25198-y | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-021-25198-y etracyclic isochromans, a type of polyketide oligomers1–3, intermediates, but also expand the limitation of substrates cata- Tare ubiquitously present in numerous natural products and lyzed by Diels–Alderase enzymes28–34. -
Microwave-Assisted Synthesis of Coordination and Organometallic Compounds
17 Microwave-assisted Synthesis of Coordination and Organometallic Compounds Oxana V. Kharissova, Boris I. Kharisov and Ubaldo Ortiz Méndez Universidad Autónoma de Nuevo León, Monterrey, México 1. Introduction Microwave irradiation (MW) as a “non-conventional reaction condition” (Giguere, 1989) has been applied in various areas of chemistry and technology to produce or destroy diverse materials and chemical compounds, as well as to accelerate chemical processes. The advantages of its use are the following (Roussy & Pearce, 1995): 1. Rapid heating is frequently achieved, 2. Energy is accumulated within a material without surface limits, 3. Economy of energy due to the absence of a necessity to heat environment, 4. Electromagnetic heating does not produce pollution, 5. There is no a direct contact between the energy source and the material, 6. Suitability of heating and possibility to be automated. 7. Enhanced yields, substantial elimination of reaction solvents, and facilitation of purification relative to conventional synthesis techniques. 8. This method is appropriate for green chemistry and energy-saving processes. The substances or materials have different capacity to be heated by microwave irradiation, which depends on the substance nature and its temperature. Generally, chemical reactions are accelerated in microwave fields, as well as those by ultrasonic treatment, although the nature of these two techniques is completely distinct. Microwave heating (MWH) is widely used to prepare various refractory inorganic compounds and materials -
Repurposing Modular Polyketide Synthases and Non-Ribosomal Peptide Synthetases for Novel Chemical Biosynthesis
Downloaded from orbit.dtu.dk on: Oct 05, 2021 Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis Hwang, Soonkyu; Lee, Namil; Cho, Suhyung; Palsson, Bernhard; Cho, Byung-Kwan Published in: Frontiers in Molecular Biosciences Link to article, DOI: 10.3389/fmolb.2020.00087 Publication date: 2020 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): Hwang, S., Lee, N., Cho, S., Palsson, B., & Cho, B-K. (2020). Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis. Frontiers in Molecular Biosciences, 7, [87]. https://doi.org/10.3389/fmolb.2020.00087 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. fmolb-07-00087 May 13, 2020 Time: 17:31 # 1 REVIEW published: 15 May -
1 Natural Products MS (Pharm.) Semester I CORE SUBJECTS
Natural Products M. S. (Pharm.) Semester I CORE SUBJECTS (All COMPULSORY) Course Code Course Name Credits NP-510 Separation and Chromatographic Techniques 1 NP-520 Phytochemistry 2 NP-530 Synthetic Biology of Medicinal Plants and Agro-technologies 1 Biomimetic synthesis, Total synthesis, and Semi-synthesis of NP-540 1 Natural Products-I MC-530 Spectral Analysis 1 MC-540 Principle and Applications of NMR 1 GE-510 Biostatistics 2 GE-511 Seminar 0.5 LG-510 General Laboratory Experience 2.5 ELECTIVE SUBJECTS (FOR 4 CREDITS) EL-501 Biochemical Engineering Fundamentals 2 EL-502 Biotechnology in Pharmaceutical Sciences 1 EL-503 Industrial safety and green chemistry 1 EL-504 Computer Application in Biomedical Engineering 1 EL-505 Biological System Analysis and Control 1 EL-506 Productivity in management and reengineering 1 EL-507 Biosynthesis of Natural Products 1 EL-508 Chemotherapy of Parasitic and Microbial Infections 1 Choose any core courses of other department (BT/MC/MD/PA/PC/PE) Semester II CORE SUBJECTS (COMPULSORY) Course Code Course Name Credits NP-610 Natural Products and Bio-organic Chemistry 2 NP-620 Natural Products based Drug Discovery 2 NP-630 Phytopharmaceuticals and its Standardization aspects 2 1 NP-640 Structure Elucidation of Natural Products 2 Biomimetic Synthesis, Total synthesis and semi synthesis of NP-650 1 Natural Products – II GE-611 Seminar 0.5 LS-610 General Lab Experience in the Area of Specialization 2.5 ELECTIVE SUBJECTS (FOR 4 CREDITS) EL-601 Biomechanics 2 EL-602 Mathematical Methods in Biomedical Engineering