Cell Death and Differentiation (2003) 10, 621–633 & 2003 Nature Publishing Group All rights reserved 1350-9047/03 $25.00 www.nature.com/cdd Review The apoptosis database KS Doctor1, JC Reed1, A Godzik1 and PE Bourne*,1,2 Introduction 1 The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, The set of known proteins that directly regulate apoptosis has USA 2 San Diego Supercomputer Center, University of California San Diego, 9500 grown rapidly over the last 15 years. This growth will continue Gilman Drive, La Jolla, CA 92093-0505, USA until all the proteins directly involved in the cell death signaling * Corresponding author: PE Bourne, Tel: 858-534-8301; Fax: 858-822-0873, process are known. This assortment of proteins with wide E-mail:
[email protected] ranging biochemical functions is linked together conceptually in the minds of apoptosis researchers. Assembling an up-to- Received 10.9.02; revised 3.12.02; accepted 10.12.02 date view of this conceptual collection of proteins within the Edited by Dr Green context of apoptosis requires a considerable effort, or more specifically, complete immersion into the field. One principal Abstract goal of an apoptosis review article is to assemble such a collection of protein annotations as an educational and The apoptosis database is a public resource for researchers research resource. The apoptosis database described here and students interested in the molecular biology of apoptosis. is designed to fulfil the same goal, but to immediately allow the The resource provides functional annotation, literature user to dig deeper using local and remote information and to references, diagrams/images, and alternative nomenclatures always remain current with respect to the proteins known to be on a set of proteins having ‘apoptotic domains’.