Research Letters

Principal and main co-investigators in the ATAC Trial Web Appendix Argentina—Dr F Coppola, Dr C Bas: Hospital Aleman, Capital Federal, Buenos Aires; Dr J Itala, Dr G Cortese: Hospital de Clinicas, Buenos The ATAC Trialists group Aires University, Capital Federal, Buenos Aires; Dr A Nuñez de Pierro, Steering Committee Membership Dr D Allemand: Hospital General de Agudos-Juan Fernandez, Capital Professor A Howell (Chairman): Christie Hospital, Manchester, UK; Federal, Buenos Aires; Dr H Guixa, Dr R Testa: Hospital Italiano, Professor Judith Adams: University of Manchester, Manchester, UK; Capital Federal, Buenos Aires; Dr J Lebron, University of Buenos Aires, Professor M Baum: University College London (UCL), London, UK; Capital Federal, Buenos Aires; Australia—Professor G Gill, Dr J Kollias: Professor AR Bianco: Universita Degli Studi Di Napoli Federico II, Royal Adelaide Hospital, Adelaide, SA; Dr J Chirgwin, Dr M Leyden: Napoli Italy; Dr A Buzdar (Vice Chairman): The University of Texas, MD Box Hill Hospital, Box Hill, VIC; Dr J Beith, Dr A Sullivan: Royal Prince Anderson Cancer Center, Houston, USA; Professor D Cella: Albert Hospital, Camperdown, NSW; Dr S Della-Fiorentina, Northwestern University, Evanston, Illinois, USA; Dr M Coibion: Dr A Goldrick: Liverpool Hospital, Liverpool, NSW; Dr J Chirgwin, Institut Bordet, Bruxelles, Belgium; Professor R Coleman: Cancer Maroondah Hospital, Maroondah, VIC; Research Centre, Weston Park Hospital, Sheffield, UK; Associate Professor G Richardson, Dr S Hart: Monash Medical Centre, Dr M Constenla: Hospital Montecelo, Pontevedra, Spain; Melbourne, VIC; Associate Professor G Toner, Dr P Francis: Professor J Cuzick (Independent Statistician): Cancer Research UK, Peter MacCallum Cancer Institute, East Melbourne, VIC; Dr R Snyder, London, UK; Professor Dr W Distler: Frauenklinik Carl Gustav Carus Dr I Burns: St Vincents Hospital, Melbourne, VIC; Universität Dresden, Dresden, Germany; Professor M Dowsett: The Royal Professor M Friedlander, Dr D Goldstein: Prince of Wales Hospital, Marsden Hospital, London, UK; Mr S Duffy: St James’s University Randwick, NSW; Professor J Forbes, Dr D Jackson: University of Hospital, Leeds, UK; Professor R Eastell: University of Sheffield, Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, NSW; Sheffield, UK; Professor LJ Fallowfield, University of Sussex, Brighton, Belgium—Dr A Makar, Dr D Van den Weyngaert: AZ Middelheim, UK; Professor J Forbes: Newcastle Mater Misericordiae Hospital, NSW, Antwerpen; Professor D Gangji, Dr T Velu: Hôpital Erasme, Brussels; Australia; Professor WD George: Beatson Oncology Centre, Western Dr M Coibion, Dr J-M Nogaret: Institut Bordet, Brussels; Dr P Neven, Infirmary, Glasgow, UK; Sr J Gray: Belfast City Hospital, Belfast, UK; Dr Laurent: St Jan Ziekenhuis, Brussels; Dr J De Mol, Dr F Van Aelst: Dr J-P Guastalla: Centre Léon Bérard, Lyon, France; Mr R Hellmund, Heilig Hart Ziekenhuis, Roeselare; Canada—Dr SR Sehdev MD: Dr G Hoctin-Boes: AstraZeneca Pharmaceuticals, Wilmington, USA; Queen Lynch Medical Centre, Brampton, Ontario; Dr R Simard: Mrs J Houghton(Trial Secretary), Dr N Williams: Clinical Trials Group of Complexe Hospitalier de la Sagami, Chicoutimi, Québec; J Mackey MD, the Department of Surgery, UCL, London, UK; Professor Dr JGM Klijn: Cross Cancer Institute, Edmonton, Alberta; Dr J Dufresne MD: Dr. Daniel den Hoed Kliniek and University Hospital, Rotterdam, CHUS Hospital Fleurimont, Fleurimont, Québec; Dr WS Lofters: Rotterdam, The Netherlands; Dr GY Locker: Evanston Northwestern Kingston Regional Cancer Center, Kingston, Ontario; Dr DR Holland: Healthcare, Northwestern University Feinberg School of Medicine, Lethbridge Cancer Centre, Lethbridge, Alberta; Dr HL Solow: Markham Evanston, IL, USA; Dr J Mackey: Cross Cancer Institute, Edmonton, Stouffville Health Centre, Markham, Ontario; Dr JA Gapski: Trillium Alberta, Canada; Professor RE Mansel: University of Wales College of Health Centre, Mississauga, Ontario; Dr SH Rubin: South East Health Medicine, Cardiff, UK; Professor JM Nabholtz: Hartman Oncology Care Oncology Department, Moncton Hospital, Moncton, New Institute, Levallois-Perret, France; Dr T Nagykalnai: Uzsoki U Hospital, Brunswick; Dr A Robidoux: CHUM Campus Hotel-Dieu, Montreal, Budapest, Hungary; Dr A Nicolucci: Givio Co-ordinating Centre, Québec; B L’Esperance MD: Hôpital du Sacre-Coeur de Montreal, Consorzio Mario Negri Sud, Centro Di Ricerchi Farmacologichi, Québec; Dr LC Panasci: McGill Department of Oncology, Montreal, E Biomedichi, Chieta, Italy; Dr U Nylen: Radiumhemmet, Karolinska Québec; Dr LA Zibdawi MD: Southlake Regional Health Centre, Sjukhuset, Stockholm, Sweden; Mr R Sainsbury: University College Newmarket, Ontario; Dr J Chang: Lakeridge Health, Oshawa, Ontario; London (UCL), London, UK; Dr F Sapunar, Dr VJ Suarez-Mendez: Dr S Arif MD: Penticton Regional Hospital, Penticton, British AstraZeneca Pharmaceuticals, Macclesfield, UK; Professor JS Tobias: Columbia; Dr RF Wierzbicki: Peterborough Regional Health Center The Meyerstein Institute of Clinical Oncology, Middlesex Hospital, Oncology Clinic, Peterborough, Ontario; Dr BP Findlay: Hotel Dieu London, UK. Hospital Oncology Department, Québec City, Québec; Dr J Robert, International Project Team CHAUQ-Hospital du St-Sacrement, Québec City, Québec; Dr S Lebel: A Doe, Dr F Sapunar, Dr VJ Suarez-Mendez: AstraZeneca Hospital Laval, Québec City, Québec; Dr M Jancewicz: Allan Blair Pharmaceuticals, Macclesfield, UK; E Foster: ISD Cancer Clinical Cancer Center, Regina, Saskatchewan; Dr MJ Burnell: Atlantic Health Trials Team, Edinburgh, UK; J Houghton, N Williams: Clinical Trials Sciences Corp, Saint John, New Brunswick; Dr A Sami: Saskatoon Group of the Department of Surgery, UCL, London, UK; A Nicolucci: Cancer Centre, Saskatoon, Saskatchewan; Dr PLD Walde: Algoma Mario Negri Institute, Chieta, Italy; S Pollard: Clinical Trials Research Regional Cancer Program, Sault Ste Marie, Ontario; Dr PK Ganguly: Unit, Leeds, UK H Bliss Murphy Cancer Centre, St Johns, Newfoundland; Data Monitoring Committee Dr CJ Germond MD: Northeastern Ontario Regional Cancer Center, Dr M Buyse: International Institute for Drug Development (IDDI), Sudbury, Ontario; Dr Y Rahim: Toronto East General Hospital, Toronto, Brussels, Belgium; Professor J Cuzick (Independent statistician), Ontario; Dr JJ Wilson: Humber River Regional Hospital, Weston, Mr C Wale: Cancer Research UK, London, UK; Dr R Margolese: McGill Ontario; Dr AL Cooke: Manitoba Cancer Treatment and Research University, The Sir Mortimer B Davis Jewish General Hospital, Montreal, Foundation, Winnipeg, Manitoba; Czech Republic—Dr K Petrakova, Québec, Canada; Professor JJ Body: Institute J Bordet, Bruxelles, Dr R Demlova: Masarykuv onkologicky ustav, Brno; Dr P Vodvarka, Belgium. Dr T Kysela: FNsP Ostrava, Ostrava Poruba; Dr B Konopasek, Collaborative/Operational Groups Dr P Mares: Vseobecna fakultni nemocnice, Praha; France— JF Forbes (Group Co-ordinator), JK Wakeham (Study Coordinator): Professor J-E Mention: Centre de Gyneco-Obst, CHU, Amiens; Australian New Zealand Breast Cancer Trials Group Operations Office; Dr D Serin, Dr Y Goubely-Brewer: Clinique Ste Catherine, Avignon; S de Placido (Study Co-ordinator), C Carlomagno (Study Co-ordinator): Professor J-P Labat, Dr J-P Malhaire: CHU Brest, Brest; Dr G Devulder, Universita Degli Studi Di Napoli Federico II, Italy; A Nicolucci (Group Dr S Mirdat-Dako: Centre Hospitalier Laënnec, Creil; Co-ordinator), M Belfiglio (Study Co-ordinator), M Valentini (Study Professor JM Nabholtz: Hartman Oncology Institute, Levallois-Perret, Co-ordinator): GIVIO Group, Consorzio Mario Negri Sud, Italy; France; Professor D Houze De L’Aunoit, Dr J-Y Charvolin: Hôpital E Foster (Principal Trial Co-ordinator and CCTT contact): ISD Cancer St Philibert, Lomme; Dr J-P Guastalla, Dr J Guastalla: Centre Léon Clinical Trials Team, Edinburgh, UK, [email protected]; Bérard, Lyon; Dr R Coquard, Dr B Velay: Clinique St Jean, Lyon; S Pollard (Head of Pharmaceutical Collaboration): Clinical Trials Dr C Lejeune, Dr D Hadjadj-Aoul: Hôpital de la Conception, Marseille; Research Unit, University of Leeds, Leeds, UK; J Houghton (Senior Dr M Untereiner: Hôpital-Clinique Claude Bernard, Metz; Lecturer in Clinical Trials and CTG contact), N Williams (Trial Co- Professor PI Laffargue, Hôpital Arnaud de Villeneuve, Montpellier; ordinator): Clinical Trials Group of the Department of Surgery, UCL, Dr M Rios: Centre Alexis Vautrin, Nancy; Dr J-M Vannetzel, London, UK, [email protected]. Dr R Mahjoubi: Centre Chirurgical Henri Hartmann, Neuilly sur Seine;

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Dr R Samak: Cabinet Medical, Nice; Dr F Morvan, Dr F Rousseau: Professor O de Carlos: Hospitais da Universidade de Coimbra, Centre Hospitalier, Pontoise; Dr C Veyret, Dr JP Julien: Centre Henri Coimbra, Portugal; Dr O Candeias, Dr B da Costa: Hospital de Sta. Becquerel, Rouen; Dr P Quetin: Centre Paul Strauss, Strasbourg; Maria, Lisboa; Dr RA Alves Dias dos reis: Hospital de S. Joao, Porto, Professor J-P Brettes, Dr C Mathelin: Hôpital Civil, Strasbourg; Portugal; Dr A Alcazar: Hospital Reynaldo dos Santos, Vila Franca de Germany—Professor Dr W Distler, Dr A Schindelhauer: Frauenklinik Xira, Portugal; Slovak Republic—Professor S Spanik, Dr I Vochyanova: Carl Gustav Carus Universität Dresden; Professor MW Beckmann, Onkologicky ustav sv. Alzbety, Bratislava; Dr M Wagnerova, Universität Erlangen-Nuernberg, Erlangen; Dr C Oberhoff, Dr I Andrasina: FNsP L Pasteura, Kosice; South Africa—Dr A Maxwell: Dr D Hanisch: Universitätklinikum Essen, Essen; Berea; Professor L Goedhals, Dr L Smith: Nationale Hospital, Professor A Schneider: Friedrich-Schiller Universität Jena, Jena; Bloemfontein; Professor I Werner, Dr E Murray: Groote Schuur Professor Dr W Eiermann, Dr G Raab: Frauenklinik vom Roten Kreuz, Hospital, Cape Town; Dr J Apffelstaedt, Dr I Loubser: Tyerberg München; Hungary—Dr C Polgar: National Oncology Institute, Hospital, Cape Town, South Africa; Dr D Hacking, Durban Oncology Budapest; Dr K Moskovits, Dr Z Nagy: St Imre Hospital, Budapest; Centre, Westridge, Durban; Dr G Landers: Parklands Hospital, Durban; Dr T Nagykalnai, Dr L Landherr: Uzsoki st. Hospital, Budapest; Dr D Vorobiof: Sandton Oncology Centre, Sandton, Johannesburg; Dr T Pinter, Dr G Herodek: Petz Aladar Hospital, Gyor; Dr B Piko, Spain—Dr L Giner: Hospital San Juan de Alicante, Alicante; Dr I Szegedi: Pandy Kalman County Hospital, Gyula; Dr J Szanto, Dr B Molins: Hospital Germans Trias i Pujol, Barcelona; Dr L Marazi: BAZ County Hospital, Miskolc; Dr Z Kahan: SZTE Dra C Alonso Muñoz: Hospital Santa Cruz y San Pablo, Barcelona; Oncotherapy Clinic, Szeged; Ireland—Mr E McDermott, Dr J Baselga, Dr J Tabernero: Hospital Vall D’Hebron, Barcelona; Professor N O’Higgins: St Vincent’s Hospital, Dublin; Dr M Beltrán, Dr E Canals: Hospital Josep Trueta, Gerona; Professor T Gorey: The Mater Hospital, Dublin, Ireland; Dr S Menjon: Virgen de las Nieves, Granada; Dra L Calvo: Hospital Professor F Given, Dr S Tormey: University College Galway, Galway; Juan Canalejo, La Coruña; Dr M Dolores: Hospital General de Galicia, Italy—Dr M Bonsignori, Dr S Rossini, Ospedale Torrette, Ancona; La Coruña; Dr JR Mel, Dr G Quintero: Hospital Xeral de Logo, Lugo; Dr F Di Vito, Dr M Cucchi: Ospedale Regionale, Aosta; Dr F Testore, Dr P España: Hospital Clinica Puerta de Hierro, Madrid; Dr D Manga, Mrs L Giaretto: Dr Ospedale Civile, Asti; Dr F Recchia, Dr S De Filippis: Dr A Alonso: Hospital Gregorio Marañón, Madrid; Dr M Repolles Ospedale Civile, Avezzano; Dr LR Vito: 1st Oncologia Mater Dei-Bari, Escarda: Hospital Ramón y Cajal, Madrid; Dr P Aramburo, Dr JE Alés: Bari; M De Lena, Dr F Schittulli: Istituto Scientifico Oncologico, Bari; Hospital Ruber Internacionale, Madrid; Dr R Alvarez: Hospital Central Dr A Martoni, Dr E Piana: Ospedale S Orsola-M Malpighi, Bologna; De Asturias, Oviedo; Dr M Constenla, Dr R Garcia: Hospital Mentecelo, Dr G Marini, Dr P Marpicati: Spedali Civili, Brescia; Dr M Pintus, Pontevedra; Dr JM Lopez-Vega: Hospital Marques de Vadecilla, Dr A Tedde: Ospedale Oncologico A Businco, Cagliari; Dr M Botta, Santander; Dr JA Moreno Nogueira, Dr P Borrego: Hospital Virgen del Dr D Degiovanni: Ospedale S Spirito, Casale Monferrato; Dr L Basilico, Rocio, Sevilla; Dr J Montalar, Dra A Santaballa: Hospital La Fe, Dr M Taraborrelli: Ospedale SS Annunziata, Chieti; Dr S Bravi, Valencia; Dr V Guillem, Dr A Llombart: Instituto Valenciano de Dr F Biagioni: Ospedale Civile, Città di Castello; Dr D Cosentino: Oncologia, Valencia; Dr G Huidoboro Vence, Dr J Casal: Hospital Ospedale S. Anna, Como; Dr G Scognamiglio, Dr A Beretta: Ospedale Meixoeiro, Vigo; Sweden—Dr S-Å Olsson, Dr L Ryden: Sjukhuset, Valduce, Como; Professor P Marchetti, Dr ME D’Addario: Università Ängelholm; Associate Professor S Rotstein, Dr D Pettersson-Sköld: degli Studi, Coppito (L’Aquila); Dr M Obialero, Dr F Peradotto: Danderyds sjukhus, Stockholm; Dr B Börjesson B Bengt: Ospedale Civile, Cuorgné; Professor P Malacame: Arcispedale S. Anna, Länssjukhuset, Halmstad; Dr P-E Jönsson, Dr M Malmberg: Ferrara; Dr A Nuzzo, Dr L Laudadio: Ospedale Floraspe Renzetti, Helsingborg Hospital, Helsingborg; Dr L Lovén, Dr I Grybäck: Lanciano; Dr M D’Aprile, Dr M Natali: Ospedale S Maria Goretti, Centralsjukhuset, Kristianstad; Dr C Ingvar, Dr P Lindblom: University Latina; Dr G Cruciani, Dr E Montanari: Ospedale Umberto I, Lugo; Hospital, Lund; Dr S B Holmberg: SU/Mölndal Hospital, Mölndal, Dr E Aitini, Dr G Cavazzini: Ospedale C Poma, Mantova; Sweden; Dr U Nylén, Dr E Lidbrink: Karolinska sjukhuset, Stockholm; Professor V Adamo, Professor G Altavilla: Policlinico Universitario Dr T Fornander, Dr G Winblad: Södersjukhuset, Stockholm; “G Martino”, Messina; Dr G Gardani: Ospedale S. Gerardo, Monza; Dr R Fernstad, Dr L Löfgren: St Görans Sjukhus, Stockholm; Dr AR Bianco: Universita Degli Studi Di Napoli Federico II, Napoli; Dr T Ambré, Dr M Nilsson: Centrallasarettet, Växjö; Netherlands— Dr A De Matteis, Dr G Landi: Istituto Nazionale Studi e Cura Tumori Dr L Siegenbeek van Heukelom: Medisch Centrum Alkmaar, Alkmaar; “G Pascale”, Napoli; Dr G D’Aiuto, Dr R Thomas Istituto Nazionale Mrs AH Baan, Dr D van Geldere: Ziekenhuis Amstelveen, Amstelveen; Tumori “G Pascale”, Napoli; Dr R Lauria, Dr M De Laurentis: Dr F Valster: St Lievensberg Ziekenhuis, Bergen Op Zoom; Universita Federico II, Napoli; Dr A Fornasiero, Dr S Monfardini: Dr E Maartense: Reinier de Graaf Gasthuis, Delft; Dr P van der Velden: Ospedale Civile, Padova; Dr G Brignone, Dr L Mesi: Ospedale St het Van Weel-Bethesda Ziekenhuis, Dirksland; Dr G van der Linden: Oncologico M Ascoli, Palermo; Professor A Riccardi, Dr P Pugliese: Albert Schweitzer Ziekenhuis, Dordrecht; Dr D Halkema: Albert Policlinico S Matteo, Pavia; Dr G Pavia, Dr T Porro: Ospedale Civile, Schweitzer Ziekenhuis, Dordrecht. Dr C Dijkhuis: Oosterschelde Rho; Dr F Cognetti, Dr P Papaldo: Istituto Regina Elena, Roma; Ziekenhuis, Goes; Mrs Dr M van Hennik: Beatrix Ziekenhuis, Dr G Gasparini, Dr MA Castellana: Ospedale S Filippo Neri, Roma; Gorinchem; Dr P Willemse: Academisch Ziekenhuis Groningen, Dr M Mattarei, Dr S Robbiati: Ospedale Civile S Maria delle Grazie, Groningen; Mrs Dr H de Graff: Medisch Centrum Leeuwarden, Rovereto; Professor A Farris, Dr G Sanna: Istituto Clinical Medica, Leeuwarden; Dr A de Boer: Ljsselland Ziekenhuis, Ljssel; Sassari; Dr C Vucusa, Dr M Viglietta: Ospedale SS Annunziata, Dr E Bruggink, Dr L Strobbe: Nijmeegs Interconfessioneel, Ziekenhuis Savigliano; Dr G Fornari, Dr A Turletti: Ospedale Evangelico Valdese, Canisius Wilhelmina, Nijmegen; Dr D de Gooyer: Ziekenhuis Torino; Dr G Nastasi: Ospedale Civile S. Isidoro, Trescore Balneario; Franciscus, Roosendaal; Dr van der Gaast: Academisch Ziekenhuis Professor M Tordiglione: AO Ospedale di Circolo e Fondazione Macchi, Rotterdam/Dijlzigt, Rotterdam; Professor Dr J Klijn, Varese; New Zealand—Mr I Campbell; Dr R Gannaway: Waikato Mrs Dr C Seynaeve: Academisch Ziekenhuis Rotterdam, loc. Hospital Breast Care Centre, Hamilton; Poland—Dr J Tujakowski, Daniel den Hoed, Rotterdam; Dr P Wismans, Haven Ziekenhuis, Dr M Osmanska: Regional Oncology Centre, Bydoszcz; Rotterdam; Dr M Baggen: Ikazia Ziekenhuis Rotterdam, Rotterdam; Dr P Koralewski, Dr M Urbanska: Ludwick Rydygier Memorial Mrs Dr M Leijs: St Clara Ziekenhuis, Rotterdam; Dr J Braun: Schieland Hospital, Krakow; Dr B Karczmarek-Borowska, Dr B Kukielka-Budny: Ziekenhuis Schiedam, Schiedam; Dr F Erdkamp: Maasland Ziekenhuis, Regional Oncology Centre, Lublin; Dr M Teresiak, Dr P Laski: Regional Sittard; Dr F Kauw: Albert Schweitzer Ziekenhuis, Sliedrecht; Oncology Centre, Pozan; Dr M Krzakowski, Dr E Pucula: Maria Dr A van Reisen: Ziekenhuis Zeeuws Vlaanderen, loc. de Honte, Sklodowska-Curie Memorial Oncology Centre, Warszawa; Portugal— Terneuzen, The Netherlands; Dr C van der Heul: St Elisabeth Dr D Jardim da Pena, Dr R Nabiço: Hospital de S Marcos, Braga, Ziekenhuis, Tilburg; Dr J Ruit: Vlietland Ziekenhuis, Vlaardingen; Portugal; Dr M Barros: Centro Hospitalar das Caldas da Rainha, Caldas Dr L Kerhofs: Ziekenhuis Walcheren, Vlissingen; Dr R Hellingman: de Rainha; Dr M Chumbo: Hospital Condes de Castro Guimaraes, Zweedse Rode Kruis Ziekenhuis, Zierikzee; Dr E Trommel: Cascais; Dr O Campos, Dr H Gervasio: IPO - Hospital de Dia, Coimbra; Albert Schweitzer Ziekenhuis, Zwijndrecht; Dr J Coenen: Isala Dr I Botto: Maternidade Bissaya Barreto, Coimbra, Portugal; Klinieken, loc. Sophia, Zwolle; Turkey—Professor E Baltali:

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Hacettepe University, Oncology Hospital, Ankara; Professor A Aydiner: Royal Victoria Infirmary, Newcastle-upon-Tyne; Mr C Gaffney: Glan Istanbul University Oncology Institiute Faculty, Istanbul; UK— Hafren NHS Trust, Royal Gwent Hospital, Newport; Mr M Stokes, Dr A Hutcheon, Dr T Sarkar: Aberdeen Royal Infirmary, Aberdeen; Daisy Hill Hospital, Newry; Mr J Dawson, Mr S Powis: Northampton Mr T Bates, Mr N Griffiths: South Kent Hospitals NHS Trust, William General Hospital NHS Trust, Northampton; Mr I Goulbourne: North Harvey Hospital, Ashford; Mr M Carr: Cheviot & Wansbeck NHS Trust, Tyneside Health Care NHS Trust, North Tyneside General Hospital, Wansbeck General Hospital, Ashington; Dr C Alcock: Stoke Mandeville North Shields; Dr A Makris, Dr E Maher: Mount Vernon & Watford Hospital NHS Trust, Aylesbury; Dr B Lavery, Dr E Sugden: Horton Hospitals NHS Trust, Mount Vernon Hospital, Northwood; Professor Hospital Radcliffe Hospitals NHS Trust, Banbury; Professor N Stuart, JR Robertson, Professor R Blamey: Nottingham City Hospital NHS Mr Derek Crawford: Gwynedd Hospital NHS Trust, Bangor; Trust, Nottingham; Mr R Nangalia, Mr H Bishop: George Eliot Hospital Mr S Dolan, Mr G Odling-Smee: Belfast City Hospital NHS Trust, NHS Trust, Nuneaton; Mr I McIntosh: Royal Oldham Hospital, Belfast; Mr A Aukland, Dr D Spooner: Sandwell Healthcare NHS Trust, Oldham; Mr D Pinto, Sperrin Lakelands: Health & Social Care Trust, Sandwell District General Hospital, Birmingham; Mr H Bishop, Tyrone County Hospital, Omagh; Dr B Lavery, Dr A Jones: Oxford Mr R Salem: The Royal Bolton Hospital, Bolton: Dr T Hickish, Radcliffe Hospital NHS Trust, The Churchill Hospital, Oxford; Mr A Skene: Royal Bournemouth & Christchurch NHS Trust, Royal Mr C Tyrell, Dr S Prance: Plymouth Hospital NHS Trust, Derriford Bournemouth Hospital, Bournemouth; Dr C Bradley, Hospital, Plymouth; Dr C Tyrrell, Dr P Macleod: Plymouth Hospital Dr Dennis Parker: Bradford Royal Infirmary, Bradford; Mr S Cawthorn, NHS Trust, Derriford Hospital, Plymouth; Mr C Yiangou, Dr M Shere: Frenchay Healthcare NHS Trust, Frenchay Hospital, Professor P Perry: Portsmouth Hospital NHS Trust, Portsmouth; Bristol; Dr S Goodman, Dr E Whipp: United Bristol Healthcare NHS Mr I McIntosh: Birch Hill Hospital, Rochdale; Dr M Quigley: Havering Trust, Bristol Royal Infirmary, Bristol; Dr A Moody: West Suffolk Hospitals NHS Trust, Oldchurch Hospital, Romford; Miss Z Saad, Hospital NHS Trust, Bury St Edmunds; Dr C Wilson, Dr E Cox: Dr E Hoare: Salford Royal Hospitals NHS Trust, Hope Hospital, Addenbrookes’s NHS Trust Hospital, Cambridge; Professor R Mansel, Salford; Professor R Coleman, Mr S Kohlhardt: Weston Park Hospital, Miss H Sweetland: University Hospital of Wales NHS Trust, Cardiff; Sheffield; Mr B Harrison: Northern General Hospital, Sheffield; Dr P Sauven, Dr S Chandrasekharan: Mid Essex Hospital Services NHS Dr R Agrawal: Royal Shrewsbury NHS Trust, Shrewsbury; Trust, Chelmsford and Essex Centre, Chelmsford; Mr G Layer: St Peters Dr M Galea:Ealing Hospital NHS Trust, Ealing Hospital, Southall; Hospital NHS Trust, Chertsey; Dr P Murray, Miss F MacNeill: Essex Dr G Fraser: Stirling Royal Infirmary, Stirling; Mr P England: Stepping Rivers Healthcare NHS Trust, Essex County Hospital, Colchester; Hill Hospital, Stockport; Mr C Hennessy, Mr A Peel: North Tees Mr J Fox: Castle Hill Hospital, Cottingham; Mr A Ball: Crawley General Hospital, Stockton-on-Tees; Mr AKR Al Debbagh: Trafford Horsham NHS Trust, Crawley Hospital, Crawley; Mr G Rawsthorne: General Hospital, Trafford; Dr S Kelly, Dr K Stepp: Royal Cornwall Mid-Cheshire Hospitals NHS Trust, Leighton Hospital, Crewe; Hospitals NHS Trust, Treliske Hospital, Truro; Dr S Kumar: Mr R Burns, Mr R Blunt: Dudley Group of Hospitals NHS Trust, Pinderfield Hospital, Wakefield; Dr R Grieve, Mr T Waterworth: Russells Hall Hospital, Dudley; Dr J Dewar, Mr A Thompson: Walsgrave Hospitals NHS Trust, Walsgrave; Mr G Copeland: Ninewells Hospital & Medical School, Dundee; Dr W Taylor, Warrington Hospital NHS Trust, Warrington; Dr D Jones: South Mr A Cook: North Durham NHS Tryst, Dryburn Hospital, Durham; Warwickshire General Hospitals NHS Trust, Warwick; Dr A Robinson, Dr I Kunkler: Western General Hospital, Edinburgh; Dr D Cameron, Dr C Trask: Southend Healthcare NHS Trust Hospital, Westcliffe-on- Professor R Leonard: Western General Hospital, Edinburgh; Sea; Professor P Barrett-Lee: Velindre NHS Trust Hospital, Whitchurch; Mr W Cunliffe, Mr D Browell: Gateshead Hospitals NHS Trust, Queen Dr V Hall: Royal Hampshire County Hospital, Winchester & Eastleigh Elizabeth Hospital, Gateshead; Professor WD George, Dr AN Harnett, Healthcare NHS Trust, Winchester; Mr D Berstock, Dr R Errington: Dr CT Twelves: Western Infirmary, Glasgow; Mr DC Smith: Victoria Wirral Hospital NHS Trust, Wirral; Dr D Fairlamb: Royal Infirmary, Glasgow; Mr M Kissin: The Royal Surrey County and St Wolverhampton Hospitals NHS Trust, New Cross Hospital, Lukes NHS Trust, Royal Surrey County Hospital, Guildford; Wolverhampton; Mr A Salman, Mr A Johri: Worthing Southlands Mr V Modgill, Mr P Surtees: Halifax Royal Infirmary, Halifax; Hospital NHS Trust, Worthing Hospital, Worthing; Dr S Goodman, Mr R Knox, Harrogate District Hospital, Harrogate; Dr J Joffe: Dr G Sparrow: East Somerset NHS Trust, Yeovil District Hospital, Huddersfield Royal Infirmary, Huddersfield; Dr B Lavery, Yeovil; Mr S Nicholson: York District Hospital, York; USA—SJ Yee, Professor A Harris: Oxford Radcliffe Hospital NHS Trust, John MD: Arcadia, CA; J Feigert MD: Arlington Fairfax Hemat-Oncology, Radcliffe Hospital, Headington, Oxford; Mr S Raymond: St Albans & Arlington, VA;RO Kerr MD: Southwest Regional Cancer Center, Austin, Hemel Hempstead NHS Trust; Dr B Lavery, Dr N Rowell: South Bucks TX; K Tkaczuk MD: University of Maryland Cancer Center, Baltimore, NHS Trust, Wycombe General Hospital, High Wycombe; Dr J LeVay, MD; M Thant MD: Maryland Hematology/Oncology Associates, Mr T Archer: Ipswich Hospitals NHS Trust, Ipswich; Mr A Nejim, Baltimore, MD; CE Hartz MD: Eastern Maine Medical Center, Cancer Dr I Hutchinson: Airedale General Hospital, Keighley; Mr M Care of Maine, Bangor, ME; GP Miletello MD: Baton Rouge General Lansdown, Dr T Perren: St James’s University Hospital, Leeds; Regional Cancer Center, Baton Rouge, LA; W Popovic MD: Illinois Mr K Horgan, Dr D Dodwell: Leeds General Infirmary, Leeds; Oncology Ltd, Belleville, IL; DB Myers MD: Billings Interhospital Mr C Holcombe: Royal Liverpool University Hospital NHS Trust, Royal Oncology Project, Billings, MT; MR Thomas MD: Mid Dakota Clinic, Liverpool Hospital, Liverpool; Mr J Rainey: St Johns Hospital, Howden, Bismarck, ND; P Radice: Lynn Regional Cancer Center-West, Boca Livingston; Dr G Howard: Western General Hospital, Edinburgh; Raton, FL; MS Rubin MD: Florida Cancer Specialists, Bonita Springs, Mr S Holt, Mr Y Sharaiha: Llanelli & Dinefwr NHS Trust, Price Phillip FL; E Levine MD: Roswell Park Cancer Institute, Buffalo, NY; CF White Hospital, Llanelli; Professor J Tobias, Dr M Gaze: UCL Hospitals NHS MD: Lahey Clinic, Department of Medical Oncology, Burlington, MA; Trust, The Middlesex Hospital, London; Dr J Mansi, Mr N Sacks: K Weeman MD: Aultman Hospital, Clinical Research Cancer Center, St Georges NHS Trust Hospital, Tooting, London; Dr C Coulter, Canton, OH; L Schlabach MD: University Oncology Associates, Dr S Stewart: St Marys NHS Trust Hospital, London; Dr A Jones, Chattanooga, TN; M Vohra MD: Creticos Cancer Center, Chicago, IL; Mr T Davidson: Royal Free Hampstead NHS Trust, The Royal Free P Silverman MD: University Hospitals of Cleveland, Ireland Cancer Hospital, London; Mr JRC Sainsbury: University College London, Center, Cleveland, OH; DL Headley DO: Cancer Center of Colorado London; Dr A Jones, Mr A Wilson: Whittington Hospital NHS Trust, Springs, Colorado Springs, CO; MF Gonzalez MD: Liberty London; Professor I Smith, Mr G Gui: The Royal Marsden Hospital Hematology/Oncology, Columbia, SC; LR Laufman MD: Community NHS Trust, The Royal Marsden Hospital, London; Mr D Matheson: Clinical Oncology Program, Columbus, OH; JL Blum MD PhD: Texas Macclesfield District General Hospital, Macclesfield; Oncology, Dallas, TX; H Shaw MD: Duke University Medical Center, Professor A Howell, Dr A Wardley: Christie Hospital, Manchester; Durham, NC; H Puc MD, Hematology & Oncology Associates of CNY, Dr L Barr, Dr N Bundred: Withington Hospital, Manchester; East Syracuse, NY; JM Rothman MD: The Regional Cancer Center, Erie, Miss P Durning, Mr A Clason: James Cook University Hospital, PA; GY Locker MD: Evanston Northwestern Healthcare, Northwestern Middlesborough; Mr R Souter: Milton Keynes General Hospital, Milton University Feinberg School of Medicine, Evanston, IL; N Robert MD: Keynes; Mr C Griffith, Mr A Griffiths: Newcastle Hospitals NHS Trust, Fairfax Northern Virginia Hematology-Oncology, Fairfax, VA;

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GR Justice MD: Pacific Coast Hematol/Oncol Med Group Inc, Fountain Springs, CA, USA; R Hirsch MD: South Florida Hematology/Oncology, Valley, CA; K Yost MD: Grand Rapids Clinical Oncology Program, Pembroke Pines, FL; MS Roberts MD: Hematology Associates Ltd, Grand Rapids, MI; AU Buzdar MD: University of Texas, MD Anderson Phoenix, AZ; JI Spector MD: Berkshire Hematology Oncology, PC, Cancer Center, Houston, TX; JK Hon MD, Comprehensive Cancer Care Pittsfield, MA; N Tirumali MD: Central Interstate Medical Office, Institute, Huntsville, AL, USA; M Trimble: Hematology/Oncology Portland, OR, USA; MA Deutsch MD: Raleigh Hematology Oncology Associates, Jackson, MI; S Sanal: Florida Oncology Associates, Assoc, Raleigh, NC, USA; P Bushunow MD: Rochester General Hematology & Oncology Association, Jacksonville, FL; AM Grossman Hospital, Rochester, NY; T Woodlock MD: St. Mary’s Hospital/Unity MD: Knoxville Cancer Center, Knoxville, TN; HP DeGreen MD: Health System, Rochester, NY; DM Sahasrabudhe MD: University of Lancaster Cancer Center Ltd, Lancaster, PA, USA; NV Dimitrov MD: Rochester Cancer Center, Rochester, NY; WR Edwards MD: ACT Great Lakes Cancer Institute, Breslin Cancer Center, Lansing, MI; Medical Group, Rockford, IL; I Jaiyesimi DO: Cancer Clinical Trials HJ Allen MD: Comprehensive Cancer Center of Nevada, Las Vegas, NV; Office, Royal Oak, MI; F Kass MD: Cancer Center of Santa Barbara, JD Conroy Jr, DO, FACP, FACOI: Central PA Hematology & Med Oncol Santa Barbara, CA; W Keiser MD: Redwood Regional Medical Group, Assoc, Lemoyne, PA; K Pendergrass MD: Kansas City Oncology and Santa Rosa, CA; G Burton MD: Louisiana State Univ Medical Center, Hematology Group, Lenexa, KS; JJ Sternberg MD: Arkansas Oncology Shreveport, LA; JC Michalak MD: Siouxland Hematology/Oncology Associates, Little Rock, AR; G Sarna MD: Cedars Sinai Comprehensive Associates, Sioux City, IA; MS McHale MD: North Central Cancer Center, Los Angeles, CA; L Bhupalam MD: James Graham Hematology/Oncology, Sioux Falls, SD; JR Goodman MD: Providence Brown Cancer Center, University of Louisville, Louisville, KY; W Bate Hospital, Southfield, MI; PD Byeff MD: Hematology/Oncology, MD: Mercy Medical Center - North Iowa, Mercy Cancer Center, Mason Southington, CT; K Hoelzer MD: Regional Cancer Center, Springfield, City, IA; PV Pickens MD: Abington Hematology-Oncology Assoc, IL; EP Lester MD: Oncology Care Associates, St Joseph, MI; Meadowbrook, PA, USA; M Schwartz MD: Mount Sinai Comprehensive M Woodson MD: Hematology Oncology Consultants, St Louis, MO; Cancer Center, Miami Beach, FL; JP Singson MD: St. Francis Cancer AP Lyss MD: Missouri Baptist Cancer Center, St Louis, MO; F Senecal Care Center, Milwaukee, WI; JG Schneider MD: Winthrop University MD, Hematology Oncology Northwest, Tacoma, WA; J Horton MB Hospital, Oncology/Hematology Division, Mineola, NY; D Schneider ChB: Moffitt Cancer Center & Research Inst, Tampa, FL; J Posada MD: MD: Virginia Piper Cancer Institute, Minneapolis, MN; MW Meshad Scott & White Clinic, Temple, TX; IS Lowenthal MD: Northwestern MD: Oncology Center-Med Group, Mobile, AL; A Greco MD: Connecticut Oncology & Hematology Associates, Torrington, CT; Sarah Cannon Cancer Center, Nashville, TN; MJ Guarino MD: Cancer AN Dave MD: Cancer Treatment Centers of America at Southwestern Research Office, Newark, DE; KK Boatman MD: INTEGRIS Oncology Regional Medical Center, Tulsa, OK; G Grana MD: Cooper Cancer Services, Oklahoma City, OK; PT Silberstein MD: Creighton University Institute, Voorhees, NJ; E Gelmann MD: Georgetown University Hematology/Oncology, Omaha, NE, USA; AS Kelley MD, Ventura Medical Center, Vincent T. Lombardi Cancer Research Center, County Hematology-Oncology Specialists, Oxnard, CA; E Camacho MD: Washington, DC; M Vukelich MD: West Bend, WI; K Seetharaman MD: Comprehensive Cancer Centers at the Desert Regional Med Ctr, Palm Worcester Medical Center, Worcester, MA.

4 www.thelancet.com Published online December 8, 2004 http://image.thelancet.com/extras/04let11120webappendix.pdf For personal use. Only reproduce with permission from Elsevier Ltd.