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8th Annual Meeting of the International Cytokine & Interferon Society 1 - 4 November Virtual Meeting Structure-Function & Systems Biology of Cytokines FINAL PROGRAM www.seattle.cytokinesociety.org content 03 Welcome Message 04 Committee Members 05 Invited Speakers 06 Award Winners 07 Milstein Abstract Award Winners 08 - 09 Program Overview 10 Program Day 1 11 - 13 Program Day 2 14 - 15 Program Day 3 16 - 18 Program Day 4 21 - 35 Lightning Talks 39 Sponsors Acknowlegement 41 - 46 Company Profiles 47 Cytokines 2021 2 welcome message Dear Colleagues and partners, We would like to wish you a warm welcome to the very first Cytokines 2020 virtual Meeting, which promise to be a lively and fully interactive meeting with a flavor of Seattle! This is a unique opportunity for you to connect with more than 1000 colleagues from around the world, enjoy more than 123 presentations with live Q&A and 230 lightning talks. The ICIS Annual Meetings have a distinguished history of presenting cutting edge research from internationally recognized scientists. In recognition of the role of cytokines in COVID-19 and the extraordinary research being done by the cytokine & interferon community, the Local Organizing Committee of the International Cytokine & Interferon Society (ICIS) has re-shaped the program to include the latest findings on SARS-CoV-2/host interactions and COVID-19. The pandemic underscores the importance of this meeting and our research to understand the systems biology of cytokines and interferons in human health and disease. Nearly all of the major breakthroughs in COVID-19 treatments and vaccine development have connections to ICIS members in academia, government and industry. Reflecting the diverse scientific interests in the field of cytokine biology, sessions impacting all aspects of cytokine and interferon basic science, clinical development, and medicine will update you on these activities to reveal promising research that will lead to or has already launched cytokine- based therapeutics and immune-modifying biologics to treat COVID-19, cancer, autoimmunity, infectious disease and vaccine applications. We believe this will be a fantastic meeting with many networking and learning opportunities no matter which time zone you are in! We wish you a successful meeting! Michael Gale Jr., Chair Ram Savan, Co-Chair University of Washington University of Washington 3 committee members Local Organizing Committee International Advisory Committee Michael Gale Jr., Ph.D., Simon Jones, Ph.D., University of Washington, Seattle, USA, meeting chair Cardiff University, Cardiff, UK Ram Savan, Ph.D., Eleanor Fish, Ph.D., University of Washington, Seattle, USA, meeting co-chair FAAS, University of Toronto, Toronto, Canada Sarah Gaffen, Ph.D., Kate Fitzgerald, Ph.D., University of Pittsburgh, Pittsburgh, USA University of Massachusetts Medical School, Worcester, USA Naeha Subramanian, Ph.D., Institute for Systems Biology, Seattle, USA Georg Schett, M.D., Friedrich-Alexander-University, Erlangen, Germany Steve Ziegler, Ph.D., Benaroya Research Institute, Seattle, USA Akinori Takaoka, M.D., Ph.D., Hokkaido University, Sapporo, Japan Yueh-Ming Loo, Ph.D., AstraZeneca, Inc., Gaithersburg, USA You-Me Kim, Ph.D., Pohang University of Science and Technology, Pohang, Renee Ireton, Ph.D., South Korea University of Washington, Seattle, USA ICIS Officers & Council Members ICIS Committee Chairs Katherine A. Fitzgerald Awards Committee: President (2019-2021) Fabienne MacKay, Chair & Luke O’Neill, Co-Chair Christopher Hunter Development Committee: President-Elect (2019-2021) Simon Jones Dusan Bogunovic Finance Committee: Treasurer (2019-2021) Dusan Bogunovic John W. Schoggins Membership/Communications: Secretary (2018-2020) Stacy M. Horner & Howard Young (Co-Chairs) Nancy Reich Marshall Meetings Committee: Past President (2019-2021) Brendan Jenkins David Artis (2018 – 2020) Nomenclature Committee: Ludmila Prokunina-Olsson Sarah Gaffen (2019 – 2021) Nominating Committee: Anne O’Garra (2019 – 2021) Thomas Decker Hiroki Yoshida (2018-2020) Publications Committee: Scott Durum, Chair & Cristina Bergamaschi, Co-Chair Michael Gale Jr. Cytokines 2020 Chair Standards Committee: Gareth Jones Joan Oefner Managing Director (ex-officio) 4 invited speakers Kristina Adams-Waldorf, University of Washington, USA Jennifer Lund, Fred Hutchinson Cancer Research Center, USA Judith Allen, University of Manchester, UK Jack Major, Francis Crick Institute, UK Maninjay Atianand, University of Pittsburgh, USA Matteo Massara, University of Lausanne, CH Glen Barber, University of Miami, USA Mandy McGeachy, University of Pittsburgh, USA Ralph Baric, UNC Gillings School of Global Public Health, USA Andrew McKenzie, MRC, University of Cambridge, UK Betsy Barnes, Feinstein Institutes for Medical Research, USA Daniel McVicar, National Cancer Institute, USA Dan Barouch, Harvard Medical School, USA Vineet D. Menachery, University of Texas, USA Alina Baum, Beth Israel Deaconess Medical Center, USA Anna Molofsky, UC San Francisco, USA Sonja Best, NIH, Rocky Mountains Labs, USA Kathleen Neuzil, University of Maryland, USA Estelle Bettelli, Benaroya Research Institute, USA Timothy Nice, Oregon and Health Sciences University, USA Catherine Blish, Stanford University Medical Center, USA Mariko Okada, Osaka University, JP Igor Brodsky, University of Pennsylvania, USA Selinda Orr, Queen’s University Belfast, UK Helen Y Chu, University of Washington, USA Chandrashekhar Pasare, Cincinnati Children’s, USA Jörn Coers, Duke University, USA Louis Picker, Oregon Health & Science University, USA Antonio del Sol, University of Luxembourg, LU Fiona Powrie, University of Oxford, UK Michael Diamond, Washington University, USA Anne Puel, The Rockefeller University, USA Marlène Dreux, INSERM, FR Lalita Ramakrishnan, University of Cambridge, UK Eleanor Fish, University of Toronto, CA Gwendalyn Randolph, Washington University, USA Kate Fitzgerald, University of Massachusetts Medical School, USA Barbara Rehermann, NIH, USA Sarah L. Gaffen, University of Pittsburgh, USA Boris Reizis, NYU Langone, USA Chris Garcia, Stanford University, USA Aaron Ring, Yale University, USA Michael Y. Gerner, University of Washington, USA Ellen Rothenberg, Caltech, USA Sara Hamilton, University of Minnesota, USA John Schoggins, UT Southwestern, USA Jorge Henao-Mejia, University of Pennsylvania, USA Rafick-Pierre Sékaly, Case Western Reserve University, USA Kristin Hogquist, University of Minnesota, USA Gregory F. Sonnenberg, PhD, Cornell University, USA Stacy Horner, Duke University, USA George Stark, Cleveland Clinic, USA Curt Horvath, Northwestern University, USA Daniel Stetson, University of Washington, USA Christopher Hunter, University of Pennsylvania, USA Naeha Subramanian, Institute for Systems Biology, USA Jennifer Hyde, University of Washington, USA Mehul Suthar, Emory Vaccine Center, USA Ruaidhri Jackson, Harvard Medical School, USA Elia Tait-Wonjo, University of Washington, USA Simon Jones, Cardiff University, UK Reiko Tanaka, Imperial College London, UK Jonathan Kagan, Boston Children’s Hospital, USA Benjamin TenOever, Icahn School of Medicine, USA Eiryo Kawakami, Chiba University, JP Jenny Ting, University of North Carolina, USA Nichole Klatt, University of Minnesota, USA Shannon Turley, Genentech, USA Robyn Klein, Washington University, USA Monika Wolkers, University of Amsterdam, NL Venkatesh Gary Krishnan, Eli Lilly & Co., USA Joshua Woodward, University of Washington, USA Vijay K. Kuchroo, Harvard Medical School, USA Autumn York, Yale University, USA Warren J. Leonard, NIH, USA Ivan Zanoni, Boston Children’s Hospital, USA David Levy, NYU Langone, USA Zhenyu Zhong, UT Southwestern, USA P'ng Loke, NIAID, NIH, USA Steven Ziegler, Benaroya Research Institute, USA Carrie L. Lucas, Yale University, USA 5 2020 ICIS Award Winners The Seymour & Vivian Milstein Award for ICIS Honorary ICIS-Luminex Excellence in Interferon ICIS-BioLegend William E. Paul Award for Lifetime Membership John R. Kettman & Cytokine Research Excellence in Cytokine Research Award Early-Career Award Warren J. Leonard, MD Sarah l. Gaffen, Ph.D. Vijay K. Kuchroo, DVM, Ph.D. Anne O’Garra, FRS, FMedSci Gregory F. Sonnenberg, Ph.D. NIH Distinguished Gerald P. Rodnan Professor of Samuel L. Wasserstrom Senior Group Leader, Laboratory Associate Professor of Microbiology Investigator, Chief, Rheumatology, Director of Professor Of Neurology At of Immunoregulation & & Immunology in Medicine, Laboratory of Molecular Basic Rheumatology Research Harvard Medical School & Infection, The Francis Crick Department of Medicine, Immunology, and Director, University of Pittsburgh School Director, Evergrande Center For Institute, London, England Gastroenterology Division, Immunology Center, of Medicine Department of Immunologic Diseases Harvard Department of Microbiology & National Heart, Lung, and Medicine, Division of Medical School And Brigham Immunology, Jill Robert’s Institute Blood Institute, NIH, Rheumatology and Clinical And Women’s Hospital, for Research in IBD, Weill Cornell Bethesda, U Immunology, Pittsburgh, USA Boston, USA Medicine, Cornell University, New York, NY USA ICIS Distinguished Milstein Young Investigator The Christina Service Award Awards Fleischmann Award to Young Women Investigators Joan Saluzzi-Oefner Aaron M Ring, MD, Ph.D. Elia Tait Wojno, Ph.D. Zhenyu Zhong, Ph.D. Carrie L Lucas, Ph.D. ICIS Managing Director Assistant Professor of Assistant Professor Assistant ProfessorDepartment of Assistant Professor of Regensburg, Germany – Immunobiology Department