Scientific Council Dinner PRESENTING the KLERMAN & FREEDMAN AWARDS

BRAIN & BEHAVIOR RESEARCH FOUNDATION Scientific Council Dinner PRESENTING THE KLERMAN & FREEDMAN AWARDS

FRIDAY, JULY 27, 2018 METROPOLITAN CLUB NEW YORK

1 Welcome to the Scientific Council Dinner 24th ANNUAL KLERMAN PRIZE where we will present the 2018 Klerman FOR EXCEPTIONAL CLINICAL RESEARCH & Freedman Awards. Albert R. Powers III, M.D., Ph.D. The Scientific Council, led by its founding President, Dr. Herbert Pardes, review Yale University School of Medicine and select the most promising research ideas with the greatest potential to lead to further breakthroughs. We thank them for their time, expertise, and HONORABLE MENTION judgement to support the mission of the Foundation. Tonight we will recognize and honor the exceptional work of some of the out- Timothy Y. Mariano, M.D., Ph.D., MSc standing researchers who have received awards through the Brain & Behavior Harvard Medical School Research Foundation’s Young Investigator Grant program, which supports Brigham and Women’s Hospital young scientists as they gather pilot data and “proof of concept” for their Butler Hospital innovative clinical and basic research. The Prizes are named for Gerald L. Klerman and Daniel X. Freedman, two neuro- psychiatry pioneers who played seminal roles as researchers, teachers, physicians and administrators. Their outstanding contributions continue to inspire scientists st who knew them, as well as those who are just entering the field. The prizewinners 21 ANNUAL FREEDMAN PRIZE are selected by committees of the Foundation’s Scientific Council. FOR EXCEPTIONAL BASIC RESEARCH Five young researchers are being recognized tonight for their work in psychosis, non-invasive brain stimulation to treat chronic back pain which can often lead Byungkook Lim, Ph.D. to depression and anxiety, stress induced depression and autism spectrum University of California, San Diego disorders, memory disorders and adaptive decision making that goes awry in mental illness. HONORABLE MENTIONS Following dinner, Dr. Pardes will lead an engaging discussion on the state of research and psychiatry with select members of our Scientific Council. Christina Gremel, Ph.D. The Brain & Behavior Research Foundation continues to support the most University of California, San Diego promising ideas in brain research across disciplines, institutions and continents. We hope that as you learn about the achievements of this evening’s honorees Ueli Rutishauser, Ph.D. they will inspire your continued support of our work toward a future in which all Cedars-Sinai Medical Center, Los Angeles people living with a psychiatric condition lead full, productive, and happy lives.

Sincerely,

Jeffrey Borenstein, M.D. President & CEO

2 3 KLERMAN KLERMAN THE KLERMAN PRIZE Prizewinners Honorable Mentions

1995 Dr. Rajiv Tandon 1995 Dr. Elizabeth D. Abercrombie The Klerman Prize, established in 1994 by Myrna M. Weissman, Ph.D., in Dr. Kim T. Mueser memory of her late husband, Gerald L. Klerman, M.D., honors exceptional 1996 Dr. Hans C. Brieter Dr. Jose V. Pardo clinical research by a Young Investigator Grantee. 1997 Dr. Schahram Akbarian 1996 Dr. Steven E. Arnold Dr. Helen S. Mayberg A distinguished psychiatric researcher and mentor at the National Institute of 1998 Dr. Michael Maes 1997 Dr. Andrew J. Francis Mental Health (NIMH) and a member of the faculties of Yale, Harvard and 1999 Dr. Andrew L. Stoll Dr. Katharine A. Phillips Cornell Universities, Dr. Klerman served from 1977 to 1980 as chief administrator 1998 Dr. Cameron S. Carter at the Alcohol, Drug Abuse and Mental Health Administration. 2000 Dr. Susan K. Schultz Dr. Mark R. Serper At the NIMH, Dr. Klerman became a central figure in the psychopharmacology 2001 Dr. Cameron S. Carter 1999 Dr. Shitij Kapur service center’s collaborative study of phenothiazine as a treatment for acute Dr. Josephy R. Hibbeln Dr. Brian F. O’Donnell schizophrenia and in the program on the psychobiology of depression. He led Dr. Sarah H. Lisanby 2000 Dr. Mark S. George planning of multi-site studies defining affective and anxiety disorders as well as Dr. Perry F. Renshaw Dr. Sohee Park the development and evaluation of treatments. 2002 Dr. E. Sherwood Brown 2002 Dr. Stephan Heckers Dr. John W. Newcomer Dr. Anissa Abi Dargham While pioneering studies of psychotropic medications, he developed and Dr. Jeffrey H. Meyer tested interpersonal psychotherapy, a treatment now used throughout 2003 Dr. Ramin Mojtabai Dr. Yvette I. Sheline the world. 2004 Dr. Helen Link Egger 2003 Dr. Catherine Monk Dr. Gerard Sanacora Dr. Weissman is herself an eminent depression researcher at Columbia Dr. Joan L. Luby 2005 Dr. Anne L. Glowinski University and the New York State Psychiatric Institute. She has received 2005 Dr. Melissa P. DelBello Dr. Gerard Sanacora three Distinguished Investigator Grants and the Brain & Behavior Research 2006 Dr. Hilary P. Blumberg 2006 Dr. Stephan Eliez Foundation 1994 Outstanding Achievement Prize in Mood and Affective Dr. Jordan W. Smoller Disorders (renamed The Colvin Prize in 2012). In 2013, she joined the 2007 Dr. Beng-Choon Ho 2007 Dr. Yuval Y. Neria Foundation’s Scientific Council. 2008 Dr. Gabriel Alejandro Dr. Carolyn M. Salafia de Erausquin 2011 Dr. Brian M. D’Onofrio Dr. Jennifer S. Silk 2009 Dr. Alina Suris 2012 Dr. Johanne Renaud KLERMAN PRIZE SELECTION COMMITTEE 2010 Dr. Daniel P. Dickstein Dr. Manpreet Kaur Singh Dr. Mani N. Pavuluri 2013 Dr. Daniel Mueller 2011 Dr. Chadi Calarge Dr. Andrea Danese Responsible for selecting the Klerman MEMBERS Prizewinners, the following Foundation Martin B. Keller, M.D. 2012 Dr. Jess G. Fiedorowicz 2014 Dr. Mazen A. Kheirbek Dr. Bo Li Scientific Council Members make up Brown University the Selection Committee: 2013 Dr. James McPartland 2015 Dr. Chadi Abdallah Rachel G. Klein, Ph.D. Dr. Carrie J. McAdams 2014 Dr. Denis Jabaudon CHAIR New York University 2016 Dr. Erin C. Dunn Robert M.A. Hirschfeld, M.D. 2015 Dr. Alan Anticevic Nina R. Schooler, Ph.D. Dr. Avram Holmes Well Cornell Medical College, State University of New York, Downstate 2016 2017 Dr. Danai Dima Cornell University Dr Katie McLaughlin Karen Dineen Wagner, M.D., Ph.D. Dr. Carolyn Rodriguez 2017 Dr. Jennifer C. Felger University of Texas Medical Branch at Galveston

04 05 2018 Albert R. Powers III, M.D., Ph.D. is an Assistant Professor at KLERMAN the Yale University Department of Psychiatry and Medical Director of the PRIME Psychosis Research Clinic at Yale. PRIZEWINNER In addition to treating patients who suffer from the earliest symp- FOR EXCEPTIONAL CLINICAL RESEARCH toms of psychosis, he uses computational approaches to understand how sensory systems might go awry to produce hallucinations and other psychotic symptoms. As a graduate student, Dr. Powers studied multisensory integration, or the process by which the brain combines information from the different senses into a meaningful representation of the world around us. In particular, he focused upon the ability of this process to change with perceptual learning. He found that audiovisual integration is capable of far more flexibility than was previously thought, and that the changes in behavior accompanying that flexibility are accompanied by robust brain network “ The work I have completed changes. Together these findings carry implications for treatment approaches for would simply not have been disorders in which these processes may be possible without my 2015 Young abnormal, such as schizophrenia, autism, Investigator Award. Together and dyslexia. we have laid the foundation for Dr. Powers applied this background in even more fundamental dis- sensory neuroscience to a study conducted coveries as our understanding with Yale researcher Philip Corlett, Ph.D. Aided by a Young Investigator grant, their of the computational under- work resulted in the first evidence for a pinnings of psychosis grows. computational model of hallucinations. Receiving the Klerman Award is While completing this work, Dr. Powers an incredible honor because of completed his psychiatric training, spending most of his outpatient time at its storied history and impres- the cutting-edge Specialized Treatment sive roster of past awardees, Early in Psychosis (STEP) Clinic, where he but most of all because it learned team-based care for first-episode represents the esteem of my Albert R. Powers III, M.D., Ph.D. psychosis and gained a passion for caring Assistant Professor of Psychiatry for this patient population. colleagues for the work I have been able to accomplish with Yale University Dr. Powers received his B.A. from Yale University in 2004, and his Ph.D. and M.D. the support of the BBRF.” from Vanderbilt University School of 2015 Young Investigator Grant Medicine in 2012.

06 07 Timothy Mariano, M.D., Ph.D., M.Sc. is an Instructor of Psychiatry at Harvard Medical School and an Associate Psychiatrist at 2018 Brigham and Women’s Hospital. KLERMAN PRIZE Dr. Mariano’s research interests and clinical work focus on HONORABLE MENTION neuromodulation, or the electromagnetic stimulation of brain and other nerve cells to modify their activity. Dr. Mariano studies a type of noninvasive brain stimulation called transcranial direct current stimulation (tDCS) as a potential treatment for the emotional symptoms of chronic low back pain. Chronic low back pain is a disabling and costly disease, substantially burdening patients, families, and the health care system. Estimates suggest it may affect 15 percent to 45 percent of individuals. The emotional symptoms—or “suffering” aspect—of chronic low back pain underlies much of the syndrome’s disability and reduced quality of life, and the can lead to associated psychiatric disorders such as anxiety, depression—and even suicide. Current pain-relieving treatments do not address these emotional symptoms, and medications such as prescription opioids often provide only short-term relief while having serious side effects including addiction and overdose deaths.

In Dr. Mariano’s lab, researchers have carried out preliminary studies using tDCS “ My Young Investigator Grant came to determine how the treatment may impact emotional symptoms of pain and to determine as I was navigating the critical the technique’s safety in treating chronic low transition from psychiatry trainee back pain. The treatment passes a weak elec- to junior faculty. It immediately trical current through two electrodes placed allowed me to protect research on the scalp to a region of the brain involved in emotional pain processing. Results from a time—so critical to early career 21-person study suggest that the treatment clinician-scientists trying to estab- may reduce interference and disability in daily lish research independence—and life from pain, as well as reduce symptoms collect promising data that has of depression. If the results are confirmed in larger clinical trials, the technique would be already led to new research Timothy Y. Mariano, M.D., Ph.D., M.Sc. a major advance in the treatment of chronic collaborations and will support Instructor of Psychiatry pain—without reliance on opioid medications. future grant applications. I am Harvard Medical School Dr. Mariano received a B.S. in biomedical excited to expand the clinical use engineering from Harvard College in 2003 of noninvasive neuromodulation and an M.S. in cognitive neuroscience from Brigham and Women’s Hospital to alleviate the suffering of some Butler Hospital the University of Oxford in 2006. He joined the Medical Scientist Training Program at of our most severely disabled Case Western Reserve University, receiving patients.” 2015 Young Investigator Grant his Ph.D. in biomedical engineering in 2009 and his M.D. degree in 2011. He completed his residency in general psychiatry at Brown 08 University in 2015. 09 FREEDMAN FREEDMAN THE FREEDMAN PRIZE Prizewinners Honorable Mentions

1998 Dr. Yukiko Goto 1998 Dr. Eric E. Turner The Freedman Prize honors the late Daniel X. Freedman, M.D., a pioneer in Dr. Elizabeth Van Bockstaele biological psychiatry and psychopharmacology and a founding member of the 1999 Dr. Stewart A. Anderson 1999 Dr. Emmanuel N. Pothos Brain & Behavior Research Foundation Scientific Council. It is awarded to a 2000 Dr. Edwin G. Abel Dr. Laurence H. Tecott Young Investigator Grantee for exceptional basic studies. 2001 Dr. Kelsey C. Martin 2000 Dr. Wayne Drevets Dr. Bernice E. Morrow Dr. Freedman was an innovator in bringing the biological sciences to psychiatry. He was Professor of Psychiatry at Yale University, the University of Chicago and 2002 Dr. Jon R. Backstrom 2001 Dr. Michael J. Caterina Dr. Aurelio A. Galli at the UCLA School of Medicine. He was Chair of the Department of Psychiatry 2003 Dr. Jose A. Esteban at the University of Chicago for 17 years and Executive Vice Chair of the UCLA 2002 Dr. Michael W. Quick 2004 Dr. Luca Santarelli Dr. Fu-Ming Zhou Department of Psychiatry and Biobehavioral Sciences for eight years. 2005 Dr. Lisa M. Monteggia 2003 Dr. William A. Carlezon While at Yale University in the 1950s, Dr. Freedman worked extensively with Dr. Gleb P. Shumyatsky 2006 Dr. Michael D. Ehlers patients with schizophrenia and their families, and developed a particular interest 2004 Dr. Michael D. Ehlers in the clinical phenomena of psychosis, such as hallucinations. During this time, 2007 Dr. Thomas A. Blanpied Dr. Sheena Ann Josselyn he spent a year at the National Institute of Mental Health (NIMH) to research the 2008 Dr. Evelyn K. Lambe 2005 Dr. Steven A. Thomas effects of LSD on neurotransmitters in the brain and discovered that it altered the Dr. Fang Liu functioning of serotonin. This began his professional focus on the role of serotonin 2009 Dr. Kerry J. Ressler 2006 Dr. Stewart A. Anderson in brain function. He went on to discover similar neurochemical processes in 2010 Dr. David A. Baker Dr. Gabriella D’ Arcangelo the brain during environmental stress and in childhood autism. He also studied Dr. Karoly Mirnics elements of schizophrenia and Huntington’s disease, brain mechanisms in allergy 2011 Dr. Alexandre Bonnin 2007 Dr. Fang Liu and the way that drugs interact with the central nervous system to alter behavior. Dr. Luca Santarelli 2012 Dr. Zhiping Pang 2008 Dr. M. Margarita Behrens 2013 Dr. Garret Stuber Dr. Akira Sawa FREEDMAN PRIZE SELECTION COMMITTEE 2014 Dr. Theodore D. Satterthwaite 2009 Dr. Jean-Martin Beaulieu Dr. Colleen Ann McClung 2015 Dr. Michael M. Halassa 2010 Dr. Vincent P. Ferrera Responsible for selecting the Freedman MEMBERS 2016 Dr. Kay Tye Dr. Benjamin Philpot Prizewinners, the following Foundation Joseph T. Coyle, M.D. 2017 Dr. Ilana Witten 2011 Dr. Alberto Bacci Scientific Council Members make up McLean Hospital Dr. Andrew A. Pieper the Selection Committee: Harvard Medical School Affiliate 2012 Dr. Marie Carlen Ronald S. Duman, Ph.D. Dr. Genevieve Konopka CHAIR Yale University 2013 Dr. Carmen Andreescu Ariel Y. Deutch, Ph.D. Dr. David Foster Vanderbilt University Fritz A. Henn, M.D., Ph.D. Dr. Hiroki Taniguchi Peter W. Kalivas, Ph.D. 2014 Dr. Elena Ivleva Medical University of South Carolina Dr. Aristotle N. Voineskos Husseini K. Manji, M.D., FRCPC 2015 Dr. Kristen J. Brennand Johnson & Johnson PRD Dr. Nandakumar Narayanan Visiting Professor, Duke University 2016 Dr. Conor Liston Eric J. Nestler, M.D., Ph.D. Dr. Margaret Cho Icahn School of Medicine at Mount Sinai 2017 Dr. Marcelo de Oliveiera Dietrich Bryan L. Roth, M.D., Ph.D. Dr. Elise B. Robinson University of North Carolina School of Medicine

10 11 2018 Byungkook Lim, Ph.D. is an Assistant Professor of FREEDMAN Neurobiology in the Division of Biological Sciences at the University of California, San Diego. PRIZEWINNER Dr. Lim’s research investigates the neural circuitry behind stress- FOR EXCEPTIONAL BASIC RESEARCH induced depression and autism spectrum disorder (ASD). The onset of depression is often triggered by stressful or unpleasant events, and studies in animals have shown that repeated social stress can induce pervasive and long-lasting behavioral changes similar to those seen in people with major depressive disorder. However, researchers know very little about the neural changes that underlie these changes in behavior. Dr. Lim’s lab closely examines the distinct neural circuits behind stress-induced behaviors in mice to better understand this phenomenon, using a variety of tools including viral tracing and manipulation of neural circuits, deep brain imaging, and optogenetics. In their work focusing on the brain’s reward circuitry in depressive behaviors, they found that different depressive behaviors, such as impaired social interactions and lack of moti- vation, have distinct neural circuitries. This discovery could help to devise revolutionary circuit- specific diagnoses and treatments. Their research has also pinpointed circuitry in a part of the brain called the lateral septum as a potentially important hub involved in social dysfunction seen in several animal models of ASD. They are working to understand how the lateral “ The Young Investigator Award septum may be affected by early life stress funding helped me carry out that leads to social dysfunction in ASD, challenging and risky projects depression, and schizophrenia. when I was just establishing Dr. Lim graduated from Seoul National my own independent research University, Korea, with a B.S. in Molecular group. The fact that my propos- Biology and M.S. in Biochemistry in 2001, and received his Ph.D. in Neurobiology from al was selected by a renowned Byungkook Lim, Ph.D. University of California, Berkeley in 2008. selection committee gave He worked as a postdoctoral fellow with me confidence and support Assistant Professor of Neurobiology Robert Malenka, M.D., Ph.D. in the Stanford during a critical time as a University of California, San Diego University Department of Psychiatry and Behavioral Sciences. young scientist.” 2015 Young Investigator Grant

12 13 2018 Christina M. Gremel, Ph.D. is an Assistant Professor of FREEDMAN PRIZE Psychology at the University of California, San Diego, and is affiliated HONORABLE MENTION with The Neurosciences Graduate Program. Dr. Gremel’s lab examines the neural bases of goal-directed behavior. People with underlying psychiatric pathologies often have difficulties making causal judgments about their actions and the associated consequences. For example, addicts continue to make poor decisions and habitually use drugs even in the face of harsh consequences. This disruption to decision-making processes is observed in disorders ranging from schizophrenia to depression, suggesting there may be common underlying neural circuitry involved in the problem. To better understand this disruption, Dr. Gremel and her colleagues have studied how neural circuits in the brain’s orbital frontal cortex and basal ganglia function to control the balance between goal- directed and habitual behaviors during normal and dysfunctional decision making. They identified a mechanism in the orbital frontal cortex that is disrupted in alcohol-dependent mice, making it difficult for the mice to carry out goal-directed decisions. However, the team also showed that increasing the activity in this area of the brain can restore some aspects of proper self-control “ The Young Investigator Grant following alcohol dependence. The findings really helped launch my could help researchers discover new targeted ways to treat psychiatric disorders research program, and gave such as addiction that are characterized by me the resources I needed to disruptions in decision making. lay a foundation for dissecting Dr. Gremel received her B.S. in neuroscience how the brain does adaptive from the University of Minnesota in 2002, decision making and how that and her Ph.D. in behavioral neuroscience goes awry in disease. This sup- from Oregon Health & Sciences University in Christina M. Gremel, Ph.D. 2008. She worked as a postdoctoral fellow port from the Brain & Behavior Assistant Professor of Psychology at the National Institutes of Health in the Research Foundation helped me The Neurosciences Graduate Program National Institute on Alcohol Abuse and obtain research funding from Alcoholism with Drs. Rui Costa and David University of California, San Diego the NIH and other foundations Lovinger before starting her own laboratory at UC San Diego. to continue this work.” 2015 Young Investigator Grant

14 15 2018 Ueli Rutishauser, Ph.D. is an Associate Professor in Neu- FREEDMAN PRIZE roscience in the Departments of Neurosurgery, Neurology and Biomedical Sciences at the Cedars-Sinai Medical Center. He holds HONORABLE MENTION a joint visiting appointment at the Division of Biology and Biological Engineering at the California Institute of Technology.

Dr. Rutishauser’s laboratory investigates the neural mechanisms of learning, memory, and decision making. Memory disorders are a critical aspect of many psychiatric disorders, including schizophrenia, post-traumatic stress disorder, bipolar disorders, and depression. The disease burden by memory disorders on patients as well as their families is immense, and is often not addressed even if the underlying disorder can successfully be treated with medication. In addition, successful treatment of a psychiatric condition often creates significant issues with memory as a side effect. To learn more about the underpinnings of memory in the brain, Dr. Rutishauser and his colleagues have made human single-neuron “ My BBRF award was instrumen- recordings in human patients who are tal in allowing me to start my undergoing neurosurgical procedures for epilepsy or Parkinson’s disease, collecting own independent laboratory. these rare recordings directly in humans It provided the critical funding while they make, maintain, and recall needed to perform my first pilot memories. For the first time, they found studies, to publish my first major ‘persistently active’ neurons in a part of the brain called the hippocampus that remain senior-author paper, and to active as long as a particular memory is demonstrate validity of my ideas held in mind. The ability to directly measure to the field. As a result, I am now and manipulate these neurons is a critical able to pursue an ambitious step forward, because impaired short-term memory is a key impairment in many mental research program on decipher- disorders and is thought to be the result of ing the neural mechanisms of Ueli Rutishauser, Ph.D. impaired coordination between persistently human memory by utilizing neu- active cells that can potentially be restored Associate Professor in Neuroscience rosurgical procedures to directly by electrical stimulation or medication. Cedars-Sinai Medical Center, Los Angeles study the human nervous system. Dr. Rutishauser studied computer science The goal of my studies is to devel- for his B.S. and received his Ph.D. in op treatments for the devastating 2015 Young Investigator Grant computation and neural systems from Caltech in 2008. After postdoctoral studies memory disorders that result at Caltech and the Max Planck Institute for from mental illness.” Brain Research in Frankfurt, Germany, he started his own lab in 2012.

16 17 SCIENTIFIC COUNCIL BOARD OF DIRECTORS

PRESIDENT Alan Frazer, Ph.D. John S. March, M.D., M.P.H. PRESIDENT & CEO Directors Herbert Pardes, M.D. Robert R. Freedman, M.D. Stephen Maren, Ph.D. Fred H. Gage, Ph.D. Daniel Mathalon, Ph.D., M.D. Jeffrey Borenstein, M.D. VICE PRESIDENT EMERITUS Aurelio Galli, Ph.D. Helen S. Mayberg, M.D. Carol Atkinson Floyd E. Bloom, M.D. Mark S. George, M.D. Bruce S. McEwen, Ph.D. Elliot S. Gershon, M.D. Ronald McKay, Ph.D. PRESIDENT, Donald M. Boardman Ted Abel, Ph.D. Mark A. Geyer, Ph.D. James H. Meador-Woodruff, M.D. SCIENTIFIC COUNCIL J. Anthony Boeckh Anissa Abi-Dargham, M.D. Jay N. Giedd, M.D. Herbert Y. Meltzer, M.D. Susan Lasker Brody, MPH Schahram Akbarian, M.D.,Ph.D. Jay A. Gingrich, M.D., Ph.D. Kathleen Merikangas, Ph.D. Herbert Pardes, M.D. Huda Akil, Ph.D. David Goldman, M.D. Richard J. Miller, Ph.D. Suzanne Golden Susan G. Amara, Ph.D. Joshua A. Gordon, M.D., Ph.D. Karoly Mirnics, M.D., Ph.D. Bonnie D. Hammerschlag Stewart A. Anderson, M.D. Elizabeth Gould, Ph.D. Bita Moghaddam, Ph.D. Nancy C. Andreasen, M.D., Ph.D. Anthony A. Grace, Ph.D. Charles B. Nemeroff, M.D., Ph.D. Officers John Kennedy Harrison II Amy F.T. Arnsten, Ph.D. Paul Greengard, Ph.D. Eric J. Nestler, M.D., Ph.D. Carole H. Mallement Gary S. Aston-Jones, Ph.D. Raquel Gur, M.D., Ph.D. Andrew A. Nierenberg, M.D. Jay M. Baraban, M.D., Ph.D. Suzanne N. Haber, Ph.D. Patricio O’Donnell, M.D., Ph.D. CHAIRMAN Milton Maltz Deanna Barch, Ph.D. Philip D. Harvey, Ph.D. Dost Ongur, M.D., Ph.D. Marc R. Rappaport Jack D. Barchas, M.D. Stephan Heckers, M.D. Steven M. Paul, M.D. Stephen A. Lieber Samuel H. Barondes, M.D. René Hen, Ph.D. Godfrey D. Pearlson, M.A., M.B.B.S. Virginia M. Silver Carrie Bearden, Ph.D. Fritz A. Henn, M.D., Ph.D. Mary L. Phillips, M.D. (CANTAB) Kenneth H. Sonnenfeld, Takao Hensch, Ph.D. Marina Picciotto, Ph.D. VICE PRESIDENT Francine M. Benes, M.D., Ph.D. Ph.D., J.D. Karen F. Berman, M.D. Robert M.A. Hirschfeld, M.D. Daniel S. Pine, M.D. Wade H. Berrettini, M.D., Ph.D. L. Elliot Hong, M.D. Robert M. Post, M.D. Anne E. Abramson Barbara K. Streicker James B. Potash, M.D., M.P.H. Randy D. Blakely, Ph.D. Steven E. Hyman, M.D. Barbara Toll Pierre Blier, M.D., Ph.D. Robert B. Innis, M.D., Ph.D. Steven G. Potkin, M.D. Hilary Blumberg, M.D. Jonathan A. Javitch, M.D.,Ph.D. Pasko Rakic, M.D., Ph.D. SECRETARY Robert Weisman, Esq. Antonello Bonci, M.D. Daniel C. Javitt, M.D., Ph.D. Judith L. Rapoport, M.D. John B. Hollister Robert W. Buchanan, M.D. Dilip Jeste, M.D. Perry F. Renshaw, M.D., Ph.D., M.B.A. Peter F. Buckley, M.D. Ned Kalin, M.D. Kerry J. Ressler, M.D., Ph.D. Ed Bullmore, Ph.D. Peter W. Kalivas, Ph.D. Victoria Risbrough, Ph.D. William E. Bunney, Jr., M.D. Eric R. Kandel, M.D. Carolyn B. Robinowitz, M.D. TREASURER Joseph D. Buxbaum, Ph.D. Richard S.E. Keefe, Ph.D. Bryan L. Roth, M.D., Ph.D. Arthur Radin, CPA William Byerley, M.D. Samuel J. Keith, M.D. Laura Rowland, Ph.D. Ty Cannon, Ph.D. Martin B. Keller, M.D. John L.R. Rubenstein, M.D., Ph.D. William Carlezon, Ph.D. John R. Kelsoe, M.D. Bernardo Sabatini, M.D., Ph.D. Marc G. Caron, Ph.D. Kenneth S. Kendler, M.D. Gerard Sanacora, M.D., Ph.D. William T. Carpenter, Jr., M.D. James L. Kennedy, M.D. Akira Sawa, M.D., Ph.D. Cameron S. Carter, M.D. Robert M. Kessler, M.D. Alan F. Schatzberg, M.D. BJ Casey, Ph.D. Mary-Claire King, Ph.D. Nina R. Schooler, Ph.D. Bruce M. Cohen, M.D., Ph.D. Rachel G. Klein, Ph.D. Robert Schwarcz, Ph.D. Jonathan D. Cohen, M.D., Ph.D. John H. Krystal, M.D. Philip Seeman, M.D., Ph.D. Peter Jeffrey Conn, Ph.D. Amanda J. Law, Ph.D. Yvette I. Sheline, M.D. Edwin Cook, M.D. James F. Leckman, M.D. Solomon H. Snyder, M.D., Richard Coppola, D.Sc. Francis S. Lee, M.D., Ph.D. D.Sc., D.Phil. (Hon. Causa) Rui Costa, Ph.D., HHMI Ellen Leibenluft, M.D. Vikaas Sohal, M.D., Ph.D. Joseph T. Coyle, M.D. Robert H. Lenox, M.D. Matthew State, M.D. Jacqueline N. Crawley, Ph.D. Pat Levitt, Ph.D. Murray Stein, M.D., M.P.H. John G. Csernansky, M.D. David A. Lewis, M.D. John S. Strauss, M.D. Z. Jeff Daskalakis, M.D., Ph.D. Jeffrey A. Lieberman, M.D. J. David Sweatt, Ph.D. Karl Deisseroth, M.D., Ph.D. Kelvin Lim, M.D. John A. Talbott, M.D. J. Raymond DePaulo, Jr., M.D. Irwin Lucki, Ph.D. Carol A. Tamminga, M.D. Ariel Y. Deutch, Ph.D. Gary Lynch, Ph.D. Laurence H. Tecott, M.D.,Ph.D. Wayne C. Drevets, M.D. Robert C. Malenka, M.D., Ph.D. Ming T. Tsuang, M.D., Ph.D., D.Sc. Ronald S. Duman, Ph.D. Anil K. Malhotra, M.D. Kay M. Tye, Ph.D. Stan B. Floresco, Ph.D. Husseini K. Manji, M.D., F.R.C.P.C. Leslie G. Ungerleider, Ph.D. Judith M. Ford, Ph.D. J. John Mann, M.D. Flora Vaccarino, M.D., Ph.D. Rita J. Valentino, Ph.D. Jim van Os, M.D., Ph.D., MRCPsych Jeremy Veenstra-VanderWeele, M.D. Susan Voglmaier, M.D., Ph.D. 175 Members (7 Emeritus) Nora D. Volkow, M.D. Mark von Zastrow, M.D., Ph.D. 2 Nobel Prize Winners Karen Dineen Wagner, M.D., Ph.D. Daniel R. Weinberger, M.D. 2 Former Directors of the National Institute of Myrna M. Weissman, Ph.D. Mental Health as well as the current Director Marina Wolf, Ph.D. Jared W. Young, Ph.D. 4 Recipients of the National Medal of Science L. Trevor Young, M.D., Ph.D. Jon-Kar Zubieta, M.D., Ph.D. 13 Members of the National Academy of Sciences MEMBERS EMERITUS 26 Chairs of Psychiatry & Neuroscience George K. Aghajanian, M.D. Dennis S. Charney, M.D. Departments at Leading Medical Institutions Jan A. Fawcett, M.D. Members of the National Academy of Medicine Frederick K. Goodwin, M.D. 52 Lewis L. Judd, M.D. Kenneth K. Kidd, Ph.D. 18 NYP_JournalAd_BBRF-Half_0718.indd 1 7/10/18 19 12:52 PM THE BRAIN & BEHAVIOR RESEARCH FOUNDATION is committed to allevi- ating the suffering of mental illness by awarding grants that will lead to advances and breakthroughs in scientific research. The Foundation funds the most innovative ideas in neuroscience and psychiatry to better understand the causes and develop new ways to treat brain and behavior disorders.

Since 1987, the Foundation has awarded more than $365 million to fund more than 4,000 leading scientists around the world. This has led to over $3.5 billion in additional funding for these scientists. 100% of every dollar donated for research is invested in our research grants. Our operating expenses are covered by separate foundation grants.

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