BRAIN & BEHAVIOR RESEARCH FOUNDATION Scientific Council Dinner PRESENTING THE KLERMAN & FREEDMAN AWARDS FRIDAY, JULY 27, 2018 METROPOLITAN CLUB NEW YORK 1 Welcome to the Scientific Council Dinner 24th ANNUAL KLERMAN PRIZE where we will present the 2018 Klerman FOR EXCEPTIONAL CLINICAL RESEARCH & Freedman Awards. Albert R. Powers III, M.D., Ph.D. The Scientific Council, led by its founding President, Dr. Herbert Pardes, review Yale University School of Medicine and select the most promising research ideas with the greatest potential to lead to further breakthroughs. We thank them for their time, expertise, and HONORABLE MENTION judgement to support the mission of the Foundation. Tonight we will recognize and honor the exceptional work of some of the out- Timothy Y. Mariano, M.D., Ph.D., MSc standing researchers who have received awards through the Brain & Behavior Harvard Medical School Research Foundation’s Young Investigator Grant program, which supports Brigham and Women’s Hospital young scientists as they gather pilot data and “proof of concept” for their Butler Hospital innovative clinical and basic research. The Prizes are named for Gerald L. Klerman and Daniel X. Freedman, two neuro- psychiatry pioneers who played seminal roles as researchers, teachers, physicians and administrators. Their outstanding contributions continue to inspire scientists st who knew them, as well as those who are just entering the field. The prizewinners 21 ANNUAL FREEDMAN PRIZE are selected by committees of the Foundation’s Scientific Council. FOR EXCEPTIONAL BASIC RESEARCH Five young researchers are being recognized tonight for their work in psychosis, non-invasive brain stimulation to treat chronic back pain which can often lead Byungkook Lim, Ph.D. to depression and anxiety, stress induced depression and autism spectrum University of California, San Diego disorders, memory disorders and adaptive decision making that goes awry in mental illness. HONORABLE MENTIONS Following dinner, Dr. Pardes will lead an engaging discussion on the state of research and psychiatry with select members of our Scientific Council. Christina Gremel, Ph.D. The Brain & Behavior Research Foundation continues to support the most University of California, San Diego promising ideas in brain research across disciplines, institutions and continents. We hope that as you learn about the achievements of this evening’s honorees Ueli Rutishauser, Ph.D. they will inspire your continued support of our work toward a future in which all Cedars-Sinai Medical Center, Los Angeles people living with a psychiatric condition lead full, productive, and happy lives. Sincerely, Jeffrey Borenstein, M.D. President & CEO 2 3 KLERMAN KLERMAN THE KLERMAN PRIZE Prizewinners Honorable Mentions 1995 Dr. Rajiv Tandon 1995 Dr. Elizabeth D. Abercrombie The Klerman Prize, established in 1994 by Myrna M. Weissman, Ph.D., in Dr. Kim T. Mueser memory of her late husband, Gerald L. Klerman, M.D., honors exceptional 1996 Dr. Hans C. Brieter Dr. Jose V. Pardo clinical research by a Young Investigator Grantee. 1997 Dr. Schahram Akbarian 1996 Dr. Steven E. Arnold Dr. Helen S. Mayberg A distinguished psychiatric researcher and mentor at the National Institute of 1998 Dr. Michael Maes 1997 Dr. Andrew J. Francis Mental Health (NIMH) and a member of the faculties of Yale, Harvard and 1999 Dr. Andrew L. Stoll Dr. Katharine A. Phillips Cornell Universities, Dr. Klerman served from 1977 to 1980 as chief administrator 1998 Dr. Cameron S. Carter at the Alcohol, Drug Abuse and Mental Health Administration. 2000 Dr. Susan K. Schultz Dr. Mark R. Serper At the NIMH, Dr. Klerman became a central figure in the psychopharmacology 2001 Dr. Cameron S. Carter 1999 Dr. Shitij Kapur service center’s collaborative study of phenothiazine as a treatment for acute Dr. Josephy R. Hibbeln Dr. Brian F. O’Donnell schizophrenia and in the program on the psychobiology of depression. He led Dr. Sarah H. Lisanby 2000 Dr. Mark S. George planning of multi-site studies defining affective and anxiety disorders as well as Dr. Perry F. Renshaw Dr. Sohee Park the development and evaluation of treatments. 2002 Dr. E. Sherwood Brown 2002 Dr. Stephan Heckers Dr. John W. Newcomer Dr. Anissa Abi Dargham While pioneering studies of psychotropic medications, he developed and Dr. Jeffrey H. Meyer tested interpersonal psychotherapy, a treatment now used throughout 2003 Dr. Ramin Mojtabai Dr. Yvette I. Sheline the world. 2004 Dr. Helen Link Egger 2003 Dr. Catherine Monk Dr. Gerard Sanacora Dr. Weissman is herself an eminent depression researcher at Columbia Dr. Joan L. Luby 2005 Dr. Anne L. Glowinski University and the New York State Psychiatric Institute. She has received 2005 Dr. Melissa P. DelBello Dr. Gerard Sanacora three Distinguished Investigator Grants and the Brain & Behavior Research 2006 Dr. Hilary P. Blumberg 2006 Dr. Stephan Eliez Foundation 1994 Outstanding Achievement Prize in Mood and Affective Dr. Jordan W. Smoller Disorders (renamed The Colvin Prize in 2012). In 2013, she joined the 2007 Dr. Beng-Choon Ho 2007 Dr. Yuval Y. Neria Foundation’s Scientific Council. 2008 Dr. Gabriel Alejandro Dr. Carolyn M. Salafia de Erausquin 2011 Dr. Brian M. D’Onofrio Dr. Jennifer S. Silk 2009 Dr. Alina Suris 2012 Dr. Johanne Renaud KLERMAN PRIZE SELECTION COMMITTEE 2010 Dr. Daniel P. Dickstein Dr. Manpreet Kaur Singh Dr. Mani N. Pavuluri 2013 Dr. Daniel Mueller 2011 Dr. Chadi Calarge Dr. Andrea Danese Responsible for selecting the Klerman MEMBERS Prizewinners, the following Foundation Martin B. Keller, M.D. 2012 Dr. Jess G. Fiedorowicz 2014 Dr. Mazen A. Kheirbek Dr. Bo Li Scientific Council Members make up Brown University the Selection Committee: 2013 Dr. James McPartland 2015 Dr. Chadi Abdallah Rachel G. Klein, Ph.D. Dr. Carrie J. McAdams 2014 Dr. Denis Jabaudon CHAIR New York University 2016 Dr. Erin C. Dunn Robert M.A. Hirschfeld, M.D. 2015 Dr. Alan Anticevic Nina R. Schooler, Ph.D. Dr. Avram Holmes Well Cornell Medical College, State University of New York, Downstate 2016 2017 Dr. Danai Dima Cornell University Dr Katie McLaughlin Karen Dineen Wagner, M.D., Ph.D. Dr. Carolyn Rodriguez 2017 Dr. Jennifer C. Felger University of Texas Medical Branch at Galveston 04 05 2018 Albert R. Powers III, M.D., Ph.D. is an Assistant Professor at KLERMAN the Yale University Department of Psychiatry and Medical Director of the PRIME Psychosis Research Clinic at Yale. PRIZEWINNER In addition to treating patients who suffer from the earliest symp- FOR EXCEPTIONAL CLINICAL RESEARCH toms of psychosis, he uses computational approaches to under- stand how sensory systems might go awry to produce hallucinations and other psychotic symptoms. As a graduate student, Dr. Powers studied multisensory integration, or the process by which the brain combines information from the different senses into a meaningful representation of the world around us. In particular, he focused upon the ability of this process to change with perceptual learning. He found that audiovisual integration is capable of far more flexibility than was previously thought, and that the changes in behavior accompanying that flexibility are accompanied by robust brain network “ The work I have completed changes. Together these findings carry implications for treatment approaches for would simply not have been disorders in which these processes may be possible without my 2015 Young abnormal, such as schizophrenia, autism, Investigator Award. Together and dyslexia. we have laid the foundation for Dr. Powers applied this background in even more fundamental dis- sensory neuroscience to a study conducted coveries as our understanding with Yale researcher Philip Corlett, Ph.D. Aided by a Young Investigator grant, their of the computational under- work resulted in the first evidence for a pinnings of psychosis grows. computational model of hallucinations. Receiving the Klerman Award is While completing this work, Dr. Powers an incredible honor because of completed his psychiatric training, spending most of his outpatient time at its storied history and impres- the cutting-edge Specialized Treatment sive roster of past awardees, Early in Psychosis (STEP) Clinic, where he but most of all because it learned team-based care for first-episode represents the esteem of my Albert R. Powers III, M.D., Ph.D. psychosis and gained a passion for caring Assistant Professor of Psychiatry for this patient population. colleagues for the work I have been able to accomplish with Yale University Dr. Powers received his B.A. from Yale University in 2004, and his Ph.D. and M.D. the support of the BBRF.” from Vanderbilt University School of 2015 Young Investigator Grant Medicine in 2012. 06 07 Timothy Mariano, M.D., Ph.D., M.Sc. is an Instructor of Psychiatry at Harvard Medical School and an Associate Psychiatrist at 2018 Brigham and Women’s Hospital. KLERMAN PRIZE Dr. Mariano’s research interests and clinical work focus on HONORABLE MENTION neuromodulation, or the electromagnetic stimulation of brain and other nerve cells to modify their activity. Dr. Mariano studies a type of noninvasive brain stimulation called transcranial direct current stimulation (tDCS) as a potential treatment for the emotional symptoms of chronic low back pain. Chronic low back pain is a disabling and costly disease, substantially burdening patients, families, and the health care system. Estimates suggest it may affect 15 percent to 45 percent of individuals. The emotional symptoms—or “suffering” aspect—of chronic low back pain underlies much of the syndrome’s disability and reduced quality of life, and the can lead to associated psychiatric disorders such as anx- iety, depression—and even suicide. Current pain-relieving treatments do not address these emotional symptoms, and medications such as prescription opioids often provide only short-term relief while having serious side effects including addiction and overdose deaths. In Dr. Mariano’s lab, researchers have carried out preliminary studies using tDCS “ My Young Investigator Grant came to determine how the treatment may impact emotional symptoms of pain and to determine as I was navigating the critical the technique’s safety in treating chronic low transition from psychiatry trainee back pain.