(12) United States Patent (10) Patent No.: US 7,761,312 B2 Brown (45) Date of Patent: *Jul

USOO7761312B2

(12) United States Patent (10) Patent No.: US 7,761,312 B2 BrOWn (45) Date of Patent: *Jul. 20, 2010

(54) REMOTE HEALTH MONITORING AND (58) Field of Classification Search ...... 600/300; MAINTENANCE SYSTEM 128/900 (75)75 Inventor: sphen James Brown, Woodside, CA (56) See applicationReferences file for complete Cited search history. (73) Assignee: Health Hero Network, Inc., Palo Alto, U.S. PATENT DOCUMENTS CA (US) 3,426,150 A 2/1969 Tygart (*) Notice: Subject to any disclaimer, the term of this (Continued) patent is extended or adjusted under 35 FOREIGN PATENT DOCUMENTS U.S.C. 154(b) by 0 days. EP O251520 1, 1988 This patent is Subject to a terminal dis- (Continued) claimer. OTHER PUBLICATIONS (21) Appl. No.: 11/396.558 +5 V Powered Isolated RS-232 Drivers/Receivers Maxim Integrated Products. (22) Filed: Apr. 4, 2006 (Continued) 65 Prior Publication D Primary Examiner Gerald J. O’Connor (65) rior Publication Data Assistant Examiner—Linh-Giang Michelle Le US 2006/O1789 14 A1 Aug. 10, 2006 (74) Attorney, Agent, or Firm—Christopher P. Maiorana, PC Related U.S. Application Data (57) ABSTRACT A system and method is described that enables a health care (60) Division of application No. 09/422,046, filed on Oct. provider to monitor and manage a health condition of a 20, 1999, now Pat. No. 7,624,028, which is a continu patient. The system includes a health care provider apparatus ation of application No. 09/271,217, filed on Mar. 17, operated by a health care provider and a remotely program 1999, now Pat. No. 6,168,563, which is a continuation mable patient apparatus that is operated by a patient. The in-part of application No. 08/481.925, filed on Jun. 7, health care provider develops a script program using the 1995, now Pat. No. 5,899,855, which is a continuation health care provider apparatus and then sends the Script pro of application No. 08/233,397, filed on Apr. 26, 1994, gram to a remotely programmable patient apparatus through now abandoned, which is a continuation-in-part of a communication network Such as the World WideWeb. The application No. 07/977.323, filed on Nov. 17, 1992, Script program is a computer-executable patient protocol that now Pat. No. 5,307.263, said application No. 09/271, provides information to the patient about the patients health condition and that interactively monitors the patient health 217 is a continuation-in-part of application No. condition by asking the patient questions and by receiving 08/946,341, filed on Oct. 7, 1997, now Pat. No. 5,997, answers to those questions. The answers to these health 476, which is a continuation-in-part of application No. related questions are then forwarded as patient data from the 08/847,009, filed on Apr. 30, 1997, now Pat. No. 5,897, remotely programmable patient apparatus to the health care 493. provider apparatus through the communication network. The patient data may also include information Supplied by a (60) Provisional application No. 60/041,746, filed on Mar. physiological monitoring device Such as a blood glucose 28, 1997, provisional application No. 60/041,751, monitor that is connected to the remotely programmable filed on Mar. 28, 1997. patient apparatus. When the patient data arrives at the health (51) Int. Cl. care provider apparatus, the patient data is processed for further management of the patients health condition by the A6 IB5/00 (2006.01) health care provider, such as forwarding another script pro G06F 9/00 (2006.01) gram to the remotely programmable patient apparatus. (52) U.S. Cl...... 705/3; 705/2; 705/4; 600/300; 128/900 22 Claims, 25 Drawing Sheets ar. ----- Y

- - - - 42- - - -

Prof. L. Ell v2 "Rig's vs.

PUR

S8 58 A/ SEAF s US 7,761.312 B2 Page 2

U.S. PATENT DOCUMENTS 4,799,156 1, 1989 Shavit et al. 4,799,199 1, 1989 Scales, III et al. 2, 1971 Rawson et al. 3,566,365 4,803,625 2, 1989 Fu et al. ------600,483 3,566,370 2, 1971 Worthington, Jr. et al. 4,807,169 2, 1989 Overbeck 3,581,072 5, 1971 Nymeyer 4,835,372 5, 1989 Gombrich et al. 3,768,014 10, 1973 Smith 4,838,275 6, 1989 Lee 3,808.502 4, 1974 Babilius 4,846,797 7, 1989 Howson et al. 3,810,102 5, 1974 Parks et al. 4,853.521 8, 1989 Claeys et al. 3,811,116 5, 1974 Takeuchi, et al. 4,853,854 8, 1989 Behar et al. 3,883,235 5, 1975 Lynn et al. 4,858,354 8, 1989 Gettler 3,910,257 10, 1975 Fletcher et al. 4,858,617 8, 1989 Sanders 3,920,005 11, 1975 Gombrich et al. 4,883,062 11, 1989 Nicholson 3.996,928 12, 1976 Marx 4,890,621 1, 1990 Hakky 4,004,577 1, 1977 Sarnoff 4,894,777 1, 1990 Negishi et al. 4,051,522 9, 1977 Healy et al. 4,897,869 1, 1990 Takahashi 4,060,915 12, 1977 Conway 4,899,306 2, 1990 Greer 4,110,918 9, 1978 James et al. 4,899,839 2, 1990 Dessertine et al. 4,130,881 12, 1978 Haessler et al. 4,903,201 2, 1990 Wagner 4,150,284 4, 1979 Trenkler et al. 4,907,973 3, 1990 Hon 4,151.407 4, 1979 McBride et al. 4,916,441 4, 1990 Gombrich 4,151,831 5, 1979 Lester 4,931,934 6, 1990 Snyder 4,173,971 11, 1979 Karz 4,933,873 6, 1990 Kaufman et al. 4,216,462 8, 1980 McGrath et al. 4,933,876 6, 1990 Markoff et al. 4,227,526 10, 1980 Goss 4,949,248 8, 1990 Caro 4,253.521 3, 1981 Savage 4,950,246 8, 1990 Muller 4,259,548 3, 1981 Fahey et al. 4.950.264 8, 1990 Osborn, III 4,270,547 6, 1981 Steffen et al. 4,953,552 9, 1990 DeMarzo 4,296,756 10, 1981 Dunning et al. 4,958,632 9, 1990 Duggan 4,296,796 10, 1981 Wulf 4,958,641 9, 1990 Digby et al. 4,347,568 8, 1982 Giguere et al. 4,960, 118 10, 1990 Pennock 4,347,851 9, 1982 Jundanian 4,967,756 11, 1990 Hewitt 4,360,345 11, 1982 Hon 4,977,899 12, 1990 Digby et al. 4,403,303 9, 1983 Howes et al. 4,978,303 12, 1990 Lampbell 4.412.287 10, 1983 Braddock, III 4,978,335 12, 1990 Arthur, III 4.417.306 11, 1983 Citron et al. 4,979,509 12, 1990 Hakky 4,422,081 12, 1983 Woods 4,995.402 2, 1991 Smith et al. 4,428,733 1, 1984 Kumar-Misir 4,996,642 2, 1991 Hey 4449,536 5, 1984 Weaver 5,007.429 4, 1991 Treatch et al. 4,465,077 8, 1984 Schneider 5,009,645 4, 1991 Silver et al. 4473,884 9, 1984 Behl 5,016,172 5, 1991 Dessertine 4,518,361 5, 1985 Conway 5,019,974 5, 1991 Beckers 4,519,398 5, 1985 Lisiecki et al. 5,024,225 6, 1991 Fang 4,531,527 7, 1985 Reinhold, Jr. 5,025,374 6, 1991 Roizen et al. 4,546,436 10, 1985 Schneider et al. 5,033,474 7, 1991 Varelis et al. 4,549,179 10, 1985 Stendardo 5,034,807 7, 1991 Von Kohorn 4,566.461 1, 1986 Lubell et al. 5,035,625 7, 1991 Munson et al. 4,576,578 3, 1986 Parker et al. 5,036,462 7, 1991 Kaufman et al. 4,592,258 6, 1986 Halm 5,036,852 8, 1991 Leishman 4,592,546 6, 1986 Fascenda et al. 5,049,487 9, 1991 Phillips et al. 4,625,733 12, 1986 Saynajakangas 5,050,612 9, 1991 Matsumura 4,627.445 12, 1986 Garcia 5,056,059 10, 1991 Tivig et al. 4,636,137 1, 1987 Lemelson 5,059,394 10, 1991 Phillips et al. 4,674,652 6, 1987 Aten et al. 5,065,315 11, 1991 Garcia 4,685,059 8, 1987 Yamamoto 5,068,536 11, 1991 Rosenthal 4,686,624 8, 1987 Blum et al. 5,074,317 12, 1991 Bondell et al. 4,694.490 9, 1987 Harvey et al. 5,077,476 12, 1991 Rosenthal 4,695,954 9, 1987 Rose et al. 5,077,665 12, 1991 Silverman et al. 4,706,207 11, 1987 Hennessy et al. 5,084,828 1, 1992 Kaufman et al. 4,712,562 12, 1987 Ohayon et al. 5,095,798 3, 1992 Okada et al. 4,722,349 2, 1988 Baumberg 5,099,424 3, 1992 Schneiderman 4,729,381 3, 1988 Harada et al. 5,104,380 4, 1992 Holman et al. 4,730,253 3, 1988 Gordon 5,109,403 4, 1992 Sutphin 4,731,726 3, 1988 Allen, III 5,109,414 4, 1992 Harvey et al. 4,738,451 4, 1988 Logg 5,109,974 5, 1992 Beer et al. 4,749,354 6, 1988 Kerman 5,111,396 5, 1992 Mills et al. 4,751,642 6, 1988 Silva et al. 5,111,817 5, 1992 Clark et al. 4,757,022 T. 1988 Shults et al. 5,111,818 5, 1992 Suzuki et al. 4,768,229 8, 1988 Benjamin et al. 5,119,829 6, 1992 Saito et al. 4,773,492 9, 1988 RuZumna 5, 120,230 6, 1992 Clark et al. 4,779,199 10, 1988 Yoneda et al. 5, 120,421 6, 1992 Glass et al. 4,782,511 11, 1988 Nemec et al. 5,128,552 7, 1992 Fang et al. 4,789.928 12, 1988 Fujisaki 5,128,752 7, 1992 Von Kohorn 4,796,639 1, 1989 Snow et al. 5,134.391 7, 1992 Okada US 7,761.312 B2 Page 3

5,137,028 8, 1992 Nishimura 5,415, 167 5, 1995 Wilk 5,142,358 8, 1992 Jason 5,429,140 7, 1995 Burdea et al. 5,142,484 8, 1992 Kaufman et al. 5.431,690 7, 1995 Schaldach et al. 5,143,378 9, 1992 Joel 5.431,691 7, 1995 Snell et al. 5,171,977 12, 1992 Morrison 5.434,611 7, 1995 Tamura 5,176,502 1, 1993 Sanderson et al. 5.437,278 8, 1995 Wilk 5, 182,707 1, 1993 Cooper et al. 5.438,607 8, 1995 Przygoda, Jr. et al. 5,204,670 4, 1993 Stinton 5.438,983 8, 1995 Falcone 5,216,597 6, 1993 Beckers 5,441,047 8, 1995 David et al. 5,217,379 6, 1993 Kirschenbaum et al. 5.449,334 9, 1995 Kingsbury 5,219,322 6, 1993 Weathers 5,454,721 10, 1995 Kuch 5,222,020 6, 1993 Takeda 5,454,722 10, 1995 Holland et al. 5,226,431 7, 1993 Bible et al. 5,456,606 10, 1995 McIntyre 5,226,895 7, 1993 Harris 5,456,692 10, 1995 Smith, Jr. et al. 5,227,874 7, 1993 Von Kohorn 5,458,123 10, 1995 Unger 5,228,450 7, 1993 Sellers 5,462,051 10, 1995 Oka et al. 5,229, 116 7, 1993 Edgar et al. 5,465,082 11, 1995 Chaco 5,230,629 7, 1993 Buschke 5,467,269 11, 1995 Flaten 5,231990 8, 1993 Gauglitz 5,471,039 11, 1995 Irwin, Jr. et al. 5,233,520 8, 1993 Kretsch et al. 5,471.382 11, 1995 Tallman et al. 5,243,515 9, 1993 Lee 5.483.276 1, 1996 Brooks et al. 5,249,044 9, 1993 Von Kohorn 5.488.412 1, 1996 Majeti et al. 5,251,126 10, 1993 Kahn et al. 5.488.423 1, 1996 Walkingshaw etal. 5,261.401 11, 1993 Baker et al. 5,501,231 3, 1996 Kaish 5,262,943 11, 1993 Thibado et al. 5,502,636 3, 1996 Clarke 5,265,888 11, 1993 Yamamoto et al. 5,502,726 3, 1996 Fischer 5,266, 179 11, 1993 Nankai et al. 5,504,519 4, 1996 Remillard 5,275, 159 1, 1994 Griebel 5,507,288 4, 1996 Bocker et al. 5,277, 197 1, 1994 Church et al. 5,517,405 5, 1996 McAndrew et al. 5,282.247 1, 1994 Kirschenbaum et al. 5,518,001 5, 1996 Snell 5,282,950 2, 1994 Dietze et al. 5,519,058 5, 1996 Gonicket al. 5,295.491 3, 1994 Gevins 5,519,433 5, 1996 Lappington et al. 5,299,121 3, 1994 Brill et al. 5,523,232 6, 1996 Sechler 5,301,105 4, 1994 Cummings, Jr. 5,524,637 6, 1996 Erickson 5,304,112 4, 1994 Mirklas et al. 5,527,239 6, 1996 Abbondanza 5,304,468 4, 1994 Phillips et al. 5,536,249 T/1996 Castellano et al. 5,307,263 4, 1994 Brown 5,537.401 T/1996 Tadamura et al. 5,309,919 5, 1994 Snell et al. 5,542,420 8, 1996 Goldman et al. 5,311,324 5, 1994 Temma et al. 5,544,646 8, 1996 Lloyd et al. 5,316,008 5, 1994 Suga et al. 5,544,649 8, 1996 David et al. 5,319,363 6, 1994 Welch et al. 5,546,943 8, 1996 Gould 5,321,009 6, 1994 Baeder et al. 5,549,117 8, 1996 Tacklind et al. 5,325,288 6, 1994 Satou 5,550,575 8, 1996 West et al. 5,325,293 6, 1994 Dorne 5,553,609 9, 1996 Chen et al. 5,325.478 6, 1994 Shelton et al. 5,558,086 9, 1996 Smith et al. 5,329,459 T. 1994 Kaufman et al. 5,558,638 9, 1996 Evers et al. 5,329,608 T. 1994 Bocchieri et al. 5,564,429 10, 1996 Bornn et al. 5,331,549 T. 1994 Crawford, Jr. 5,569,212 10, 1996 Brown 5,331,555 T. 1994 Hashimoto et al. 5,572.421 11, 1996 Altman et al. 5,333,981 8, 1994 Pronovost et al. 5,572,646 11, 1996 Kawai et al. 5,335,338 8, 1994 Proesel 5,574,828 11, 1996 Hayward et al. 5,336.245 8, 1994 Adams et al. 5,576,952 11, 1996 Stutman et al. 5,339,821 8, 1994 Fujimoto 5,579,775 12, 1996 Dempsey et al. 5,341,291 8, 1994 Roizen et al. 5,583,758 12, 1996 McIlroy et al. 5,343,239 8, 1994 Lappington et al. 5,583,763 12, 1996 Atcheson et al. 5,344,324 9, 1994 O'Donnell et al. 5,590,648 1/1997 Mitchell et al. 5,347,453 9, 1994 Maestre 5,592.491 1/1997 Dinkins 5,348,008 9, 1994 Bornn et al. 5,593,349 1/1997 Miguel et al. 5,355,893 10, 1994 Micket al. 5,593,390 1/1997 Castellano et al. 5,357.427 10, 1994 Langen et al. 5,594,637 1/1997 Eisenberg et al. 5,359,509 10, 1994 Little et al. 5,596,994 1/1997 Bro 5,366,896 11, 1994 Margrey et al. 5,597,307 1/1997 Redford et al. 5,368,562 11, 1994 Blomquist et al. 5,601.435 2, 1997 Quy 5,371,687 12, 1994 Holmes, II et al. 5,602,597 2, 1997 Bertram 5,375,604 12, 1994 Kelly et al. 5,613,495 3, 1997 Mills et al. 5,377,100 12, 1994 Pope et al. 5,615,277 3, 1997 Hoffman 5,377,258 12, 1994 Bro 5,615,339 3, 1997 Ban 5,381,138 1, 1995 Stair et al. 5,619,991 4, 1997 Sloane 5,390,238 2, 1995 Kirk et al. 5,624,265 4, 1997 Redford et al. 5,399,821 3, 1995 Inagaki et al. 5,628.309 5, 1997 Brown 5,408.609 4, 1995 Malgogne et al. 5,629,981 5, 1997 Nerlikar 5,410,471 4, 1995 Alyfuku et al. 5,631,844 5, 1997 Margrey et al. 5,410,474 4, 1995 Fox 5,633,910 5, 1997 Cohen US 7,761.312 B2 Page 4

5,635,532 6, 1997 Samid 5,803,625 9, 1998 Lee 5,640,569 6, 1997 Miller et al. 5,806,057 9, 1998 Gormley et al. 5,640,953 6, 1997 Bishop et al. 5,810,747 9, 1998 Brudny et al. 5,642,731 7, 1997 Kehr 5,812,983 9, 1998 Kumagai 7, 1997 Evans 10, 1998 Mansfield et al.

5,642.936 5,819,735 5,651,363 7, 1997 Kaufman et al. 5,822,544 * 10, 1998 Chaco et al. .... 5,651,775 7, 1997 Walker et al. 5,822,715 10, 1998 Worthington et al. 5,659,691 8, 1997 Durward et al. 5,825.283 10, 1998 Camhi 5,659,793 8, 1997 Escobar et al. 5,827,180 10, 1998 Goodman 5,660, 176 8, 1997 Iliff 5,828,940 10, 1998 Learman 5,664,228 9, 1997 Mital 5,828,943 10, 1998 Brown 5,666,487 9, 1997 Goodman et al. 5,832,446 11, 1998 Neuhaus 5,670,711 9, 1997 Detournay et al. 5,832,448 11, 1998 Brown 5,675,635 10, 1997 Vos et al. 5,835,896 11, 1998 Fisher et al. 5,678,562 10, 1997 Sellers 5,840,020 11, 1998 Heinonen et al. 5,678,571 10, 1997 Brown 5,842,976 12, 1998 Williamson 5,679,075 10, 1997 Forrest et al. 5,845,265 12, 1998 Woolston 5,680,590 10, 1997 Parti 5,856,086 1/1999 Kozal et al. 5,680,866 10, 1997 Kangas et al. 5,868,669 2, 1999 Iliff 5,687,322 11, 1997 Deaton et al. 5,868,683 2, 1999 Protopapas et al. 5,687,717 11, 1997 Halpernet al. 5,875.432 2, 1999 Sehr 5,687,734 11, 1997 Dempsey et al. 5,879,163 3, 1999 Brown et al. 5,689,652 11, 1997 Lupien et al. 5,882.338 3, 1999 Gray 5,690,690 11, 1997 Nappholz et al. 5,884.282 3, 1999 Robinson 5,692.906 12, 1997 Corder 5,885.245 3, 1999 Lynch et al. 5,704,364 1, 1998 Saltzstein et al. 5,887,133 3, 1999 Brown et al. 5,704,366 1, 1998 Tacklind et al. 5,889,950 3, 1999 Kuzma 5,704,902 1, 1998 Vandenbelt et al. 5,893,077 4, 1999 Griffin 5,704,922 1, 1998 Brown 5,893,098 4, 1999 Peters et al. 5,708,709 1, 1998 Rose 5,897.403 4, 1999 Hourimsky 5,710,178 1, 1998 Samid 5,897,493 4, 1999 Brown 5,710,818 1, 1998 Yamato et al. 5,899,855 5, 1999 Brown 5,710,918 1, 1998 Lagarde et al. 5,911,132 6, 1999 Sloane 5,711,297 1, 1998 Iliff 5,911,687 6, 1999 Sato et al. 5,714,319 2, 1998 Joutel et al. 5,913,310 6, 1999 Brown 5,715.451 2, 1998 Marlin 5,918,603 7, 1999 Brown 5,715,823 2, 1998 Wood et al. 5,920,477 7, 1999 Hofbert et al. 5,717,739 2, 1998 Dyer et al. 5,922,071 7, 1999 Taylor et al. 5,717,913 2, 1998 Driscoll 5,930,804 7, 1999 Yu 5,720,733 2, 1998 Brown 5,933,136 8, 1999 Brown 5,722,418 3, 1998 Bro 5,935,060 8, 1999 Iliff 5,727,153 3, 1998 Powell 5,940,801 8, 1999 Brown 5,729,594 3, 1998 Klingman 5,941,829 8, 1999 Saltzstein et al. 5,730,124 3, 1998 Yamauchi 5,944,659 8, 1999 Flach et al. 5,730,654 3, 1998 Brown 5,945,651 8, 1999 Chorosinski et al. 5,732,696 3, 1998 Rapoport et al. 5,950,632 9, 1999 Reber et al. 5,732,709 3, 1998 Tacklind et al. 5,951,300 9, 1999 Brown 5,734.413 3, 1998 Lappington et al. 5,954,640 9, 1999 Szabo 5,746,697 5, 1998 Swedlow et al. 5,954,641 9, 1999 Kehr et al. 5,748,083 5, 1998 Rietkerk 5,956,501 9, 1999 Brown 5,749,081 5, 1998 Whiteis 5,960,403 9, 1999 Brown 5,749,083 5, 1998 Koda et al. 5,960,440 9, 1999 Brenner 5,752,234 5, 1998 Withers 5,961,332 * 10, 1999 Joao ...... 434,236 5,754,740 5, 1998 Fukuoka et al. 5,961.446 10, 1999 Beller et al. 5,754,763 5, 1998 Bereiter 5,963,948 10, 1999 Shilcrat 5,760,771 6, 1998 Blonder et al. 5,966.526 10, 1999 Yokoi 5,772,585 6, 1998 Lavin et al. 5,968,730 10, 1999 Merigan et al. 5,778,882 7, 1998 Raymond et al. 5,971,855 10, 1999 Ng 5,782,814 7, 1998 Brown et al. 5,971,922 10, 1999 Arita et al. 5,785,650 7, 1998 Akasaka et al. 5,978,766 11, 1999 Luciw 5,787,295 7, 1998 Nakao 5,979,757 11, 1999 Tracy et al. 5,788,428 8, 1998 Ward et al. 5,983,003 11, 1999 Lection et al. 5,791,342 8, 1998 Woodard 5,983,217 11, 1999 Khosravi-Sichani et al. 5,792,117 8, 1998 Brown 5,983,277 11, 1999 Heile et al. 5,792.204 8, 1998 Snell 5,985.559 11, 1999 Brown 5,793,969 8, 1998 Kamentsky et al. 5,987.471 11, 1999 Bodine et al. 5,794,219 8, 1998 Brown 5,987,519 11, 1999 Peifer et al. 5,794,251 8, 1998 Watanabe et al. 5.988,855 11, 1999 Marobin 5,796,393 8, 1998 MacNaughton et al. 5,995,969 11, 1999 Lee et al. 5,799,318 8, 1998 Cardinal et al. 5.997,475 12, 1999 Bortz 5,800.458 9, 1998 Wingrove 5,997.476 12, 1999 Brown 5,802.494 9, 1998 Kuno 5.997,502 12, 1999 Reilly et al. 5,802,534 9, 1998 Hatayama et al. 5.999,975 12, 1999 Kittaka et al. US 7,761.312 B2 Page 5

6,001,065. A 12, 1999 DeVito 6,648,820 B1 1 1/2003 Sarel 6,012,051 A 1/2000 Sammon et al. 6,840,904 B2 1/2005 Goldberg 6,014,626 A 1/2000 Cohen 6,849,045 B2 2, 2005 Iliff 6,018,738 A 1/2000 Breese et al. 6,875,174 B2 4/2005 Braun et al. 6,020,883. A 2/2000 Herz et al. 6,942,622 B1 9, 2005 Turcott 6,022,315 A 2, 2000 Iliff 6,968.375 B1 11/2005 Brown 6,022,615 A 2/2000 Rettenbacher 7041468 B2 5 2006 Drucker et al. : A 32. Sey 7,077,810 B2 2. Lange et al. 6,029,138 A 2/2000 Khorasani et al. T.I. R 2. S. 6,032,036 A 2/2000 Maystreet al. J. ww. 6,032,119 A 2/2000 Brown et al. 7,223,236 B2 5/2007 Brown 6,035,328 A 3, 2000 Soukal 7,252,636 B2 8, 2007 Brown 6,046,021 A 4/2000 Bochner 7,305,348 B1 12/2007 Brown 6,046,761 A 4/2000 Echerer 7,359,993 B1 4/2008 Durairaj et al. 6,049,794. A 4/2000 Jacobs et al. 2001/0031071 A1 10, 2001 Nichols 6,055.314 A 4/2000 Spies et al. 2002fOO 10597 A1 1/2002 Mayer et al. 6,055,506 A 4/2000 Frasca, Jr. 2002.0035478 A1 3, 2002 Levitt et al.

6,068,615 A 5, 2000 Brown et al. 2003, OO73884 A1 4/2003 Goldberg 6, 101478 A 8, 2000 Brown 2004/0106855 A1 6/2004 Brown

6,113,578 A 9, 2000 Brown 2004/01 17207 A1 6/2004 Brown 6,138,145 A 10/2000 Kawanaka 2004/01 17208 A1 6/2004 Brown

6,151,586 A 11/2000 Brown 2004/01 1721.0 A1 6/2004 Brown 6,167,362 A 12/2000 Brown et al. 2005, 0071197 A1 3/2005 Goldberg &E f 'g EON FOREIGN PATENT DOCUMENTS 6,177,940 B1 1/2001 Bond et al. EP O286456 10, 1988 6,186,145 B1 2/2001 Brown EP O32O749 6, 1989 6,189,029 B1 2/2001 Fuerst EP 370599 5, 1990 D439,242 S 3, 2001 Brown et al. EP O370599 5, 1990 6,196,970 B1 3, 2001 Brown EP O353O46 10, 1990 6,210,272 B1 4/2001 Brown EP O461910 12/1991 6.212,550 B1 4/2001 Segur EP 508912 10, 1992 6,221,012 B1 4/2001 Maschke et al. EP 526,166 2, 1993 6,225,901 B1 5, 2001 Kail EP O558975 9, 1993 6,233,539 B1 5, 2001 Brown EP 653718 11, 1994 6,234,964 B1 5, 2001 Iliff EP O653718 5, 1995 6,240,393 B1 5, 2001 Brown EP 676709 10, 1995 6,246,992 B1 6, 2001 Brown EP 676709 A2 10, 1995 6,248,065 B1 6, 2001 Brown EP 68O727 11, 1995 6,249,809 B1 6, 2001 Bro EP 0697669 2, 1996 6,254,536 B1 7, 2001 DeVito EP T61160 3, 1997 6,260,022 B1 7/2001 Brown EP O8131551 12/1997 6,270,455 B1 8, 2001 Brown EP O251520 1, 1998 6,270,456 B1 8, 2001 Iliff EP O996O75 4/2000 6,283,761 B1 9/2001 Joao ...... 434,236 GB 2218831 11, 1989 6,302,844 B1 10/2001 Walker et al. GB 2225637 6, 1990 6,330,426 B2 12/2001 Brown et al. JP 54OO5785 1, 1979 6,334,778 B1 1/2002 Brown JP 54146633 11, 1979 6,352,523 B1 3, 2002 Brown et al. JP 62-226278 10, 1987 6,368,273 B1 4/2002 Brown JP 62226,278 10, 1987 6,370,513 B1 4/2002 Kolawa et al. JP 5155O24 6, 1993 6,375,469 B1 4/2002 Brown JP 5266OO2 10, 1993 6,375,614 B1 4/2002 Braun et al. JP 1995407095963 4f1995 6,379,301 B1 4/2002 Worthington et al. WO WO-85O1667 4f1985 6,381,577 B1 4/2002 Brown WO WO-90.00367 1, 1990 6,402,691 B1 6, 2002 Peddicord et al. WO WO-9109374 6, 1991 6,403,897 B1 6, 2002 Bluth et al. WO WO-93/O1489 1, 1993 6.421,633 B1 7/2002 Heinonen et al. WO WO-9302622 2, 1993 6.424,249 B1 7/2002 Houvener WO WO-9416774 8, 1994 6,428,124 B1 8, 2002 Bluth et al. WO WO-95-09386 4f1995 6,436,036 B1 8, 2002 Miller-Kovach et al. WO WO-95/09386 4f1995 6,443,890 B1 9, 2002 Schulze et al. WO WO-95/20199 7, 1995 6,513,532 B2 2/2003 Mault et al. WO WO-9520 199 7, 1995 6,606,374 B1 8, 2003 Rokoffet al. WO WO-95-22131 8, 1995 US 7,761.312 B2 Page 6

WO WO-95221.31 8, 1995 ness Wire; p. 926.1084; Sep. 26, 1995; Dialog: File 148, WO WO-9529447 11, 1995 AcciiO8167091. WO WO-96,07908 3, 1996 CD-ROM Mavericks: Proprietary TV-Based Players, Byte WO WO-96-13015 5, 1996 WO WO-96.25877 8, 1996 Guide to CD-ROM, pp. 100-105. WO WO-9636923 11, 1996 Central Fetal Monitoring Systems with Optical Disk Storage, WO WO-97/08605 3, 1997 New Technology Brief, (Nov./Dec. 1998), vol. 2, No. 6, pp. WO WO-9708605 3, 1997 249-251. WO WO-97-12544 4f1997 Cheng, Joe H., “PCT Search Report', (Jan. 11, 1996). WO WO-97.12544 4f1997 DigiPet Instruction Manual, 1997. WO WO-9737738 10, 1997 Digital Doggie: retrieved from URL http://www.virtualpet. WO WO-98, 16895 4f1998 com/vp/farm/gigapet/ddoggie.htm Apr. 23, 2000. WO WO-98.31275 7, 1998 Douglas, A.S., et al., “Hand-Held Glucose Monitor and WO WO-9839.933 9, 1998 Recorder. Proceedings of the Annual International Confer WO WO-99-27483 6, 1999 ence of the IEEE Engineering in Medicine and Biology Soci WO WO-99-42029 8, 1999 ety, New Orleans, LA, (Nov. 1988), pp. 747-748. OTHER PUBLICATIONS Edelson: “Fashion Reevaluates Flickering Fortunes of TV Home Shopping; WWD, v.170 n87; p. 1(3); Nov. 8, 1995: Adilman; “Videogames: Knowing the Score”; Creative Com Dialog: File 148, AcciO8289119. puting; v9; p. 224(5): Dec. 1983; Dialog: File 148. Acci EP European Search Report, From 6858P005EP. (Mar. 27, O1891055. 1998). AdOptimizer Ad Management Software for Websites, Fabietti, P.G., et al., “Wearable System for Acquisition, Pro Newsbytes, pNEW 10040041, Oct. 4, 1996. cessing and Storage of the Signal from Amperometric Glu Albisser, A.M. “Intelligent Instrumentation in Diabetic Man agement, CRC Critical Reviews in Biomedical Engineering, cose Sensors”. The International Journal of Artificial Organs, vol. 17, No. 1, pp. 1-24. (1991), vol. 14, No. 3, pp. 175-178. Anonymous, “Health Hero Network, Inc. Receives First Finston, “Parent + Teacher = Healthy Child”, Diabetes Fore Ever FDA Clearance for Connecting Medical Devices to cast, (Apr. 1994), V47 n9; p. 26(5); Dialog: file 149. Acci Internet”, PR Newswire, (Dec. 2, 1993), 3 pages. 15804228. Antique Collector, Putting the Lot on the Net, vol. 66, Issue Fox, “Not My Type: Type B Behavior, Type I Diabetes Plus 9, p. 26, Downloaded from Corporate Resource Net, Nov./ Stress Equals Blood Sugar Blues”, Health, (Mar. 1998), v2.0 Dec. 1995. n3: pp. 22(1): Dialog: File 149, Acci 06397.959. Bai, “Design of home healthcare network”, IEEE 1997 pp. Franklin; “Proposed Auction Rules for PCS: The FCC Plans 1657-1658. to Use Competitive Bidding, but Exact Procedures are Unde Billiard, A., et al. “Telematic Transmission of Computerized fined”; Cellular Business; v10 n13; p. 18(2): Dec. 1993: Dia Blood Glucose Profiles for IDDm Patients, Diabetes Care, log: File 148, AcciO6787310. (Feb. 1991), vol. 14, No. 2, pp. 130-134. Frieberger, Paul, “Video GameTakes on Diabetes Superhero Blood Glucose Monitors, Portable Health Device, (1998), Captain Novolin Offers Treatment Tips', San Francisco vol. 17(9), pp. 253-271. Examiner, (Jun. 26, 1992), Fourth Edition, Business Section Bower, “Brain Clues to Energy-efficient Learning, Science B1. News, (Apr. 1992), v. 141; p. 215(1): Dialog: File 647, Acctii Furnham, et al; “Measuring Locus of Control: a Critique of 12123949. General Children's Health- and Work-related Locus of Con Brenman et al.: “Interaction of Nitric Oxide Synthase with the trol Questionnaires'; British Journal of Psychology; v84 na; Postsynaptic Density Protein PSD-95 and C.1-Syntrophin p. 443(37); Nov. 1993: Dialog: File 88, Acci 14903135. Mediated by PDZDomains”; Cell: Vol. 84, pp. 757-767, Mar. Future of the Virtual Pet Industry, 1997 retrieved on Apr. 23, 8, 1996; Ref: XP-002104701. 2000. Retrieved from . (Dec. 1, 1999), 3. Gardner, et al.: “Comprehension and Appreciation of Humor Bruce, et al., “The Effects of Sympathetic Nervous System ous Material Following Brain Damage: Brain; Sep. 1975; Activation and Psychological Stress . . . ; Diabetologia; 98(3): pp. 399-412: Dialog: File 153, AcciO2859983. (14 35(9): 1992: 835-843: Dialog: File 5, Acch9629427. (9 pages). pages). Gauntlet (for PC) rulebook by Mindscape Inc. (Gauntlet by Brunetti, P. et al., “A Simulation Study on a Self-Turning Apple):1985. Portable Controller of Blood Glucose'. The International Giga Farm; retrieved from URL http://www.virtualpet.com/ Journal of Artificial Organs, (1993), Vol. 16, No. 16, pp. Vp/farm/gigapet/gpfarm/gpfarm.htm Apr. 23, 2000. 51-57. Giga Pets, 1997 retrieved on Apr. 23, 2000, Retrieved from Caprihan, A., et al., “A Simple Microcomputer for Biomedi . cal Signal Processing, IECI 78 Annual Conference Pro Gordon; “Auctions Become High Tech': Dealer Business; ceedings on Industrial Applications of Microprocessors, v29 n7; p. 21(4); Mar. 1995; Dialog: File 148, (Mar. 20, 1978), 18-23. AcciiO7862.519. Cathay Pacific Airways-USA receives more than 1,300 bids Guiffrida, et al., Should We Pay the Patient? Review of Finan during first five days of CyberAuction; Business Wire, Oct. cial Incentives to enhance Patient Compliance. Biomedical 18, 1995, p. 10181119. Journal, (1997), vol. 315, pp. 703-707. Cathay Pacific Airways-USA to Hold First-Ever Internet Hauben, Jay R. “A Brief History of the Cleveland Free-Net', CyberAuction: CyberTravelers Can Bid for 50 Business available at http://www.ais.org/-irh/acn7-1.a09.html, (1995) Class Round Trips to Hong Kong No Minimum Bid; Busi pp. 1-4. US 7,761.312 B2 Page 7

Hauser, et al., “Will Computers Replace or Complement the Marx, Wendy, “More than just the Scores: ESPNET Diabetes Educator?’’. The Medical Journal of Australia, (Oct. SportsZone is a model for expanding brand names online'. 5, 1992), vol. 157, 489-491. InformationWeek, n576 p. 61(2), Apr. 22, 1996. Horio, Hiroyuki, et al., “Clinical Telecommunication Net Mazzola, et al., “Video Diabetes: A Teaching Tool for Chil work System for Home Monitoring. Medical & Biological dren with Insulin-Dependent Diabetes’. Proceedings 7th Engineering & Computing, (Mar. 1994), Vol. 32, 227-230. Annual Symposium on Computer Applications in Medical How Flash Memory Works, Internet printout of URL address: Care; Washington, DC: Dialog. (Oct. 1983), File 8. Acci http://www.howstuffworks.com/flash-memory4.htm. (Sep. O1624.462. 28, 2002), 2 pages. McCullagh, PJ et al., “Computerized paradigms for eliciting Howey, et al., “A Rapidly Absorbed Analogue of Human the contingent negative variation event-related potential.” Insulin': Diabetes, vol.43, Mar. 1994, pp.396–402. (7 pages). Proceedings of the Annual International Conference of the Hunter, “Technological Advances in Bedside Monitoring: Engineering in Medicine & Biology Society, IEEE, Conf. 14, Biosensors”, Archives and Laboratory Medicine, (Jul. 1987), p. 2481-2483, Oct. 1992. pp. 633-636. Meissner, et al., “Building an Integrated Clinical and Hutheesing, Nikhil, “An on-line gamble'. Forbes, v 157 in 10 Research Network”, Proceedings of the SPIE, (Oct. 24, p. 288(1), May 20, 1996. 1995), vol. 2618, p. 92-99. Introducing the Next Generation of About Your Diabetes, Miles, Laughton E., “A Portable Microcomputer for Long U.S. Pharmacopical Convention and American Diabetes Term Physiological Monitoring in the Home and Work Envi Association, (1993). ronment, Medical Monitoring in the Home and Work Envi Jaffrey et al.: “PIN: An Associated Protein Inhibitor of ronment, (1990), pp. 47-57. Neuronal Nitric Oxide Synthase': Science; vol. 274; Nov. 1, Mims; “Psychological Testing: Computers & Electronics: 1996; Ref: XP 002050.141. v23; p. 22(6): Feb. 1985; Dialog: File 47, Acci 2654858. Jimison et al., “Patient-Specific explanation in models of Moore, “New Applications Break Through Storage Bound chronic disease', Revised Feb. 1992 Artificial Intelligence in aries”. Computer Technology Review, (Oct. 1999), Vol. 19, Medicine 4 (1992) 191-205. No. 10 p. 1. Jones, Chris, “Microsoft readies DocObject; technology will Mule. rulebook by Electronic Arts, 1983. allow document editing in Web browsers’, InfoWorld, v 18 Nano Baby Instructions; retrieved from file://C:\My n18 p. 48(1), Apr. 29, 1996. Documents\Nano Baby Instructions.htm Apr. 23, 2000. Kauffmann, et al., “Epidemiological Study of the Genetics Nano Fighter Pets; retrieved from URL http://www. and Environment of Asthma, Bronchial Hyperresponsiveness virtualpet.com/vp/farm/nano/nfighter.htm Apr. 23, 2000. and Atrophy', Am. J. Respir. Crit. Care Med., (1997), Vol. Nano Page, 1997 retrieved on Apr. 23, 2000, Retrieved from 156, pp. S123-S129. . Kaufman, Steven, B., “The Learning Game', Nation’s Busi Octhigotchi Instruction Manual, 1997. Dino-Kun Instruction ness, (Nov. 1993). Manual, 1997. Kennedy et al.: “Television Computer Games: A New Lookin O'Donnell; “Alan’s At It Again”: Bond Buyer, v309 n29448: Performance Testing’: Aviat Space Environ Med; Jan. 1982, p. 1(3): Jul. 21, 1994: Dialog: File 148, AcciO7478.152. 53(1): pp. 49-53. (5 pages); Dialog Abstract: File 155, Onsale Joins Fray as Online Shopping Picks Up Speed: AcciiO353751. Internet Booms; Computer Reseller News; Jun. 5, 1995; p. Kuykendall, V.G., et al., “Assessment of Self-Monitored 73; Dialog: File 16, Acci;05649796. Blood Glucose results Using a Reflectance Meter with Onsale Onsale Brings Thrill of Auctions and Bargain Hunting Memory and Microcomputer'. Symposium on Computer Online: Unique Internet retail service debuts with week-long Applications in Medical Care, (Jan. 1981), Vol. 70, pp. charity auction for the Computer Museum in Boston, May 24, 98-102. 1995; Dialog Abstract: File 610, AcciO489267. Lachnit, Carroll, “Hawkin's Online Auction’. Photo District Pfeiffer, E. F., “The Glucose Sensor: The Missing Link in News, Vol. 16, Issue 1, p. 18, Jan. 1996. Diabetes Therapy'. Hormone and Metabolic Research, Lacyk, John, “PCT Search Report', (Jun. 12, 1997). (1990), Vol. 24m Suppl. pp. 154-164. Latman, N.S., “Evaluation of Electronic, Digital Blood Glu Playmates Toys deals knockout blow to virtual pet competi cose Monitors’, Biomedical Instrumentation and Technol tors with introduction of Nano FighterTM For Boys: New ogy, (1991), vol. 25, No. 1, 43-49. Nano Pet Fighting Pet Press Release; retrieved from URL Leyerle, Beverly J., et al., “The PDMS as a Focal Point for http://www.virtualpet.com/vp/farm/nano/nfightpr.htm Apr. Distributed Patient Data'. International Journal of Clinical 23, 2000. Monitoring and Computing, (1988), Vol. 5, pp. 155-161. Playmates Toys leads Americas virtual pet craze into its next Luebke, Cathy, “Barrett-Jackson Auction Turns High-Tech'. generation by introducting talking Nano Pals; Talking Nano Business Journal, vol. 16, Issue 12, pp. 11, Jan. 19, 1996. Pet Press Release; Nov. 18, 1997; retrieved from URL http:// Makikawa, M., et al., “Microprocessor-Based Memory www.virtualpet.com/vp/farm/nano/talkn/tmpress.htm on Apr. Device for Ambulatory Heart Rate and Physical Activity 23, 2000. Recording, Methods of Information in Medicine, (1994), Poitout, V., et al. “A Glucose Monitoring System for on Line vol. 33, No. 1, pp. 94-96. Estimation in Man of Blood Glucose Concentration Using a Marsh, David G. “Approaches Toward the Genetic Analysis Miniaturized Glucose Sensor Implanted in the Subcutaneous of Complex Traits Asthma and Atrophy'. Am. J. Respir.Crit. Tissue and a Wearable Control Unit, Diabetologia, (1993), Care Med., (1997), vol. 156, pp. S-133-S138. vol. 36, pp. 658-663. Martinez, Fernando D., “Complexities of the Genetics of Polson, Gary “Recent Developments and Trends in Keychain Asthma, Am.J. Respir. Crit. Care Med., (1997), Vol. 156, pp. Virtual Pets.” 1997 retrieved on Apr. 23, 2000), Retrieved S117-S122. from . US 7,761.312 B2 Page 8

Potter, David, “Fundamentals of PC-Based Data Acquisi Telemedicine Provides Two-Way Computer Link for Parents tion'. Sensors, (Feb. 1994), pp. 12-20. of Very Premature Infants. PR Newswire. p1007NEM034. Reis, H, “Telemedicine: Transmitting Expertise to the Point Oct. 7, 1996. of Care Toward an Electronic Patient Record'; '97, Nashville, Theme Hospital, product review 1996 retrieved Apr. 21, TN, Apr. 27-May 3, 1997, pp. 248-256, v. 3. 2000. Retrieved from . communities; new Disney community in Florida is focus of Towards a partnership of care, M2 Presswire, Jun. 14, 2000. program. Business Wire, p. 10011142. Oct. 1, 1996. United Healthcare’s OPTUM Division goes online to better Results of the world's first on-line auction, http://www. health by announcing a unique internet application. PR christies.com. Newswire, p0801MNTH004. Aug. 1, 1996. RO Auction Auctioneers Property Database System and Updike, Stuart J., et al., “Laboratory Evaluation of New Reus RO Auction Auctioneers Accounting System; RO-Auction able Blood Glucose Sensor, Diabetes Care, (Nov./Dec. 1998), vol. 11, No. 10, pp. 801-807. features; Dec. 4 1995. Valla, et al., “A Structured Pictorial Questionnaire to Assess Roberts; “Diabetes and Stress: A Type A Connection?”. Psy DSM-III-R-based Diagnosis in Children (6-11 years): Jour chology Today, (Jul. 1987), v.21; pp. 22(1): Dialog: File 149, nal of Abnormal Child Psychology: V22 nA; p. 403(21); Aug. Acci 05038381. 1994; Dialog: File 88, Acci 15759542. Rose, V. L., et al., “Decentralized Testing for Prothrombin Vallera, D. A., et al., “Accuracy of Portable Blood Glucose Time and Activated Partial Thromboplastin Time Using a Dry Monitoring, American Journal of Clinical Pathology, Chemistry Portable Analyser, Archives of Pathology and (1991), vol. 95, No. 2, pp. 247-252. Laboratory Medicine, (Jun. 1993), Vol. 117, pp. 611-617. Virtual Pet Product Reviews, 1997 retrieved on Apr. 23, Save the earth artrock auction, http://www.commerce.com. 2000. Retrieved from . Schement, “An Intelligent Controller for Neurophysiological Virtual Tomagutchi, 1998 retrieved Apr. 23, 2000, Experiments.” Proceeding of the Annual Symposium on Retrieved from . 1992, p. 528, line 1-p. 529, line 21. Voelker, Rebecca, “Shoe Leather Therapy is Gaining on TB’. Schenkels, P., “Supplementary European Search Report', Jama, (Mar. 13, 1996), vol. 275, 743. Application No. EP9792 2716, (Mar. 11, 2002). Wilkins, Aaron. “Expanding Internet access for health care Schork, Nicholas J., “Genetics of Complex Disease'. Am.J. consumers’. Health Care Management Review, Summer, Jul. Respir. Crit. Care Me., (1997), vol. 156, pp. S103-S109. 1999, 24-30. Schrezenmeir, J. et al., “Computer Assisted Insulin Dosage Wyatt, J. C., "Clinical Data Systems, Part 2: Components and Techniques”. Lancet, (Dec. 1994), Vol. 344, No. 8937, pp. Adjustment Perspective for Diabetes Control', Hormone 1609-1614. and Metabolic Research, Supplement Series, (1990), Vol. 24. Yoshizawa, Daisuke, et al., “The Development of a Data pp. 116-123. Processing System with Personal Computer MSX Standard Seigmann:"Nowhere to Go but Up'. PC Week: V12 na2, p. System for Flow Injection Analysis”, Journal of Flow Injec A5(1): Oct 23, 1995; Dialog: File 148, AcciiO8222496. tion Analysis, (1988), V.5, No. 2, pp. 101-110. Seybold New Horizons teams with Duke, Real Media: The Albisser, A.M. “Intelligent Instrumentation in Diabetic Man Seybold Report on Desktop Publishing, V10 n12 p. 24(1), agement, CRC Critical Reviews in Biomedical Engineering, Aug. 12, 1996. vol. 17, No. 1, pp. 1-24. Shandle, Jack, “Who Will Dominate the Desktop in the Billiard, A., et al. “Telematic Transmission of Computerized 90's?”, , Electronics, Feb. 1990, pp. 48-50. (3 pages) Cited by Blood Glucose Profiles for IDDm Patients, Diabetes Care, 2 patents. (Feb. 1991), vol. 14, No. 2, pp. 130-134. Shults, Marc C. et al., “A Telemetry-Instrumentation System Blood Glucose Monitors, Portable Health Device, (1998), for Monitoring Multiple Subcutaneously Implanted Glucose vol. 17(9), pp. 253-271. Sensors’, IEEE Transactions on Biomedical Engineering, Horio, Hiroyuki, et al., “Clinical Telecommunication Net (Oct. 1994), vol. 41, No. 10, pp. 931-942. work System for Home Monitoring. Medical & Biological Skolnick et al. “Simultaneous Analysis of Multiple Engineering & Computing, (Mar. 1994), Vol. 32, 227-230. Polymorphic Loci Using Amplified Sequence Hunter, “Technological Advances in Bedside Monitoring: Polymorphisms (ASPs): Genomics. 2: 273-279. Biosensors”, Archives and Laboratory Medicine, (Jul. 1987), Soeldner, J.S., “Treatment of Diabetes Mellitus by Devices', pp. 633-636. The American Journal of Medicine, (Jan. 1981), Vol. 70. Introducing the Next Generation of About Your Diabetes, 183-194. U.S. Pharmacopical Convention and American Diabetes Association, (1993). Spitzer et al.: “The moderating effect of age on self-care': Jimison et al., “Patient-Specific explanation in models of Western Journal of Nursing Research, V18, n2, p. 136(13), chronic disease', Revised Feb. 1992 Artificial Intelligence in Apr. 1996. Medicine 4 (1992) 191-205. Talking Nano Puppy; retrieved from URL http://www. Kuykendall, V.G., et al., “Assessment of Self-Monitored virtualpet.com/vp/farm/nano/talkn/talkin.htm Apr. 23, 2000. Blood Glucose results Using a Reflectance Meter with Tamagotchi, 1997 retrieved on Apr. 23, 2000), Retrieved Memory and Microcomputer'. Symposium on Computer from . Applications in Medical Care, (Jan. 1981), Vol. 70, pp. Tandy Radio Shack, “The description of the Tandy Radio 98-102. Shack TRS-80 Model 100/102 device available at http:// Latman, N.S., “Evaluation of Electronic, Digital Blood Glu www.old-computuers.com/musuem/computer.asp?c=233”. cose Monitors’, Biomedical Instrumentation and Technol World WideWeb, (Feb. 13, 2004), 1-3. ogy, (1991), vol. 25, No. 1, 43-49. US 7,761.312 B2 Page 9

Makikawa, M., et al., “Microprocessor-Based Memory 1991 00 00 Diabcare User Manual HHOO7288 Device for Ambulatory Heart Rate and Physical Activity HHOOT331. Recording, Methods of Information in Medicine, (1994), 1991 07 23 Dept of Health and Human vol. 33, No. 1, pp. 94-96. Services the Physician Guide from the K864318 Miles, Laughton E., “A Portable Microcomputer for Long 51OK. Term Physiological Monitoring in the Home and Work Envi 1992 00 00 Durant Medicine and Science in Sports and ronment, Medical Monitoring in the Home and Work Envi Exercise 24(2)265-271. ronment, (1990), pp. 47-57. 1992 11 17 O7977323 Transmittal Letter. Pfeiffer, E. F., “The Glucose Sensor: The Missing Link in 1993 00 00 Camit S Manual v3.00. Diabetes Therapy'. Hormone and Metabolic Research, 1994 05 00 Szolovits Guardian Angel Patient (1990), Vol. 24m Suppl. pp. 154-164. Centered Health Information Systems. Poitout, V., et al. “A Glucose Monitoring System for on Line 1994 07 00 Genesereth Software Agents. Estimation in Man of Blood Glucose Concentration Using a 1995 08 10 Lai Abstraction Models at System Miniaturized Glucose Sensor Implanted in the Subcutaneous Level for Networked Interactive Multimedia Tissue and a Wearable Control Unit, Diabetologia, (1993), Scripting. vol. 36, pp. 658-663. 1995 09 01 Lunt The Smart Cards Are Here. Reis, H, “Telemedicine: Transmitting Expertise to the Point 1995. 10 30 Mortorala introduces PCMCIA28. of Care Toward an Electronic Patient Record'; '97, Nashville, 8 Modem. TN, Apr. 27-May 3, 1997, pp. 248-256, v. 3. 1995 11 00 Hoffman General Purpose Telemetry 0000 00 00 American Heritage Dictionary pa. for Analog Biomedical Signals. 0000 00 00 American Heritage Dictionary pe. 1996 00 00 Williams Motivational Predictors of 0000 00 00 Definition of Weight Loss. Client Server from PCMAG COM. 1996 07 12 Iliff U.S. Appl. No. 60/021,614. 0000 00 00 The Merriam Webster Online 2001 09 24 O930O856 Amendment. Dictionary display. 2003 04 21 O9422046 Amendment with Affidavit. 0000 00 00 The Merriam Webster Online 2005 06 13 11150145 Amendment. Dictionary graphic. 2006 O3 29 11150145 OA. 2006 06 19 09237194 Office Actions Response. 0000 00 00 The Merriam Webster Online 2006 06 26 11150145 Amendment. Dictionary pictorial. 2006 08 17. Abbott v Dexcom 06-514. 0000 00 00 The Merriam Webster Online 2006 08 17 Request for Re Dictionary symbol. examination 5899855 90008234. 0000 00 00 The Merriam Webster Online 2006 09 21 09237194 Declation of Stephen Dictionary symbolic. Brown with Attached Exhibits Y and Z thereof. 0000 00 00 The Merriam Webster Online 2006 09 22 11150145 OA. Dictionary Video. 2006 09 27 09422046. Office Actions Response. 0000 00 00 Websters Dictionary II com. 2006 10 27 11150145 Amendment. 0000 00 00 Websters Dictionary II con. 2007 01 04. 11150145 Amendment. 0000 00 00 Websters Dictionary II i. 2007 05 09 Leapfrog v Fisher Price. 0000 00 00 Websters Dictionary II m. 2007 10 29 Request for Re 1978 11 00 Licklider Applications of information examination 5899855 900O8909. Networks Proceedings of the JEEE Vol. 66 No. 11. 2007 11 09 Request for Re 1980 01 00 Haynes Geriatrics. How to Detect examination 7223236 90010053. manage Low Patient Compliance in Chronic Illness. 2007 11 15 Request for Re 1980 1 1 00 Haynes Hypertension Can simple examination 7223236 90010053. Clinical measurements detect patient noncompliance. 2008 01 25 Dept of Health and Human 1986 00 00 Physicians Guide Using the Health Services The Physicians Guide Become publicly Buddy System. Available. 1986 10 19 Thompson and Vandenberg, Clinical Bio 2008 O6 20 O9422046 OA. chemistry (1986) 19:255-261. 2008 06 20 Alere First Supplemental Response 1987 O6 O2 U.S. Appl. No. to Plaintiff Interrogatories. 07/096,998 Lee Amendment. 2008 08 01 Excerpts from the Prosecution 1988 00 00 Hughes Bedside Terminals Clinicom History for US Patent 5899855. MD. 2008 08 01 Inter Party Re 1988 O8 10 U.S. Appl. No. Exam 7223236 95000386. 06/879,900 Fu Amendment. 2008 08 01 Request for Re 1989 00 00 Velho et al., Biomed. Biochim. Acta (1989) examination 5601435 90009237. 48(11/12):957:964. 2008 08 01 Request for Re 1989 05 00 Paperny Adolescent Pregnancy examination 58791.63 90009238. Prevention by Health Education Computer Games 2008 08 01 Request for Re Computer Assisted Instruction. examination 6151586 90009240. 1989 10 12 Diabcare Flyer Boehringer Mannheim 2008 08 01 Request for Re HH1 O1661-HH1 O1668. examination 616 1095 90009239. 1990 00 00 Matthews et al BMJ Analysis of 2008 08 01 Request for Re serial measurement in medical research. examination 7223236 95000386. US 7,761.312 B2 Page 10

2008 09 23 90009281 Request for Re 1988 00 00 Douglas Hand Held Glucose Monitor. Examination 6368273. 1988 00 00 Unknown Blood Glucose Monitors. 2008 12 10 Alere Second Supplemental Response 1988 11 00 Anonymous Central Fetal Monitoring. to Plaintiff Interrogatories. 1988 11 00 Updike Laboratory Evaluation. 2008 12 10 Alere Second Supplemental Response 1990 00 00 Schrezenmeir Computer Assisted to Plaintiff Interrogatories Exhibit 1. Insulin Dosage Adjustment. 2008 12 10 Alere Second Supplemental Response 1992 07 06 Church Captain Novolin Press to Plaintiff Interrogatories Exhibit 2. Coverage Update Interoffice Memo. 2008 12 10 Alere Second Supplemental Response 1992 09 00 Anonymous News SNES Game to Plaintiff Interrogatories Exhibit 3. Helps Diabetes Education GamePlayers Nintendo 2008 12 10 Alere Second Supplemental Response Guide. to Plaintiff Interrogatories Exhibit 4. 1993 04 26 Anonymous Learning Games USA 2008 12 10 Alere Second Supplemental Response Today Life. to Plaintiff Interrogatories Exhibit 5. 1993 05 03 Anonymous Health Alert Hot Tips 2008 12 10 Alere Second Supplemental Response LA Life Daily News. to Plaintiff Interrogatories Exhibit 6. 1993 06 29 Anonymous Raya Systems Strikes 2008 12 10 Alere Second Supplemental Response Serious Note with AIDS Education Games PC to Plaintiff Interrogatories Exhibit 7. Magazine The Independent Guide to Person 2008 12 10 Alere Second Supplemental Response Computing Vol. 12 num 12. to Plaintiff Interrogatories Exhibit 8. 1993 09 00 Anonymous Successful Superhero 2008 12 10 Alere Second Supplemental Response Healthcare Group Novo Nordisk Magazine. to Plaintiff Interrogatories Exhibit 8A. 1993 12 00 Anonymous Nintendo Healthcare Wired. 2008 12 10 Alere Second Supplemental Response 1993 12 00 Anonymous Rex Roman Experimental to Plaintiff Interrogatories Exhibit 9. Surgeon Gameplayers p. 198. 2008 12 10 Alere Second Supplemental Response 1994 00 00 Raya Systems Captain Novolin to Plaintiff Interrogatories Exhibit B. Countdown Magazine Juvenile Diabetes foundation 0000 00 00 Anonymous Captain Novlin Super International The Diabetes Foundation. NES Game Guide Edutainment. 1994 03 00 Horio Clinial Telecommunication 0000 00 00 Anonymous Captain Novolin Network. Crusader for Juvenile Diabetes Gamepro Magazine. 1994 03 14 Anonymous Diabetes Educational 0000 00 00 Anonymous Captain Novolin Video Recognized by Software Publishers Developed by Novo Nordisk and Raya Systems Association Press Release Novo Nordisk. Always Seems to be the ice breaker in 1997 00 00 Kauffmann Epidemiological Study. communicating the diabetes management regimen 1997 00 00 Martinez Complexities of Genetics. to children with insulin dependent diabetes. 1997 00 00 Schork Genetics of Complex. 0000 00 00 Anonymous Captain Novolin 1997 04 27 Ries Telemedicine transmitting Education Plays an Important Role in Diabetes Expertise to point of care. Care by Helping Patients Backgrounder. 2004 02 00 Symbol Technologies: “Healthcare Mobil 0000 00 00 Anonymous Rex Ronan Experimental ity Solutions for the PPT8800”. Sergeon Nintendo Power vol. 55 p. 89-91. 2008 01 18 Determination for Re 0000 00 00 Novo Nordisk AS Backgrounder. examination 7223236 90010053. 0000 00 00 Novo Nordisk Pharmaceuticle Backgrounder. * cited by examiner U.S. Patent Jul. 20, 2010 Sheet 1 of 25 US 7,761,312 B2

8 BLOOD CLUCOSE MONITOR 24 f6 DATA mh segree

Ancient R-AP if: UNIT - - - - T26 20 46 Abitional L MONITOR 22

50 48

USER'S COMPUTER

CLEARINC HOUSE

U.S. Patent Sheet 3 of 25 US 7,761,312 B2

94 U.S. Patent Jul. 20, 2010 Sheet 4 of 25 US 7,761,312 B2

5%z. 4. notCalibration Successful. was thePlease code insert strip again.

June 1912.30pm Blood Glucose 5%z.2. 3. 109 mg (d. remove test strip

Mon Sept. 28 1992

52. 6.

Sept. 20-26 1992.

U.S. Patent Jul. 20, 2010 Sheet 5 of 25 US 7,761,312 B2

Glucose Aver 123 mg/dl 52. 5. SD 56 Num 15 NO. under 50: 13 No. hypo sym 23

June 12 9:30pm BG 113 mg/dl Regin 12.5 U NPHin 13.2 U FOOd BE Pre-meal HYPO

Mon Sept. 28 1992 5%z. 7 (7. U.S. Patent Jul. 20, 2010 Sheet 6 of 25 US 7,761,312 B2

U.S. Patent Jul. 20, 2010 Sheet 7 Of 25 US 7,761,312 B2

©oteu© |

3802 =