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The Molecular Mechanisms That Control Thrombopoiesis
The molecular mechanisms that control thrombopoiesis Kenneth Kaushansky J Clin Invest. 2005;115(12):3339-3347. https://doi.org/10.1172/JCI26674. Review Series Our understanding of thrombopoiesis — the formation of blood platelets — has improved greatly in the last decade, with the cloning and characterization of thrombopoietin, the primary regulator of this process. Thrombopoietin affects nearly all aspects of platelet production, from self-renewal and expansion of HSCs, through stimulation of the proliferation of megakaryocyte progenitor cells, to support of the maturation of these cells into platelet-producing cells. The molecular and cellular mechanisms through which thrombopoietin affects platelet production provide new insights into the interplay between intrinsic and extrinsic influences on hematopoiesis and highlight new opportunities to translate basic biology into clinical advances. Find the latest version: https://jci.me/26674/pdf Review series The molecular mechanisms that control thrombopoiesis Kenneth Kaushansky Department of Medicine, Division of Hematology/Oncology, University of California, San Diego, San Diego, California, USA. Our understanding of thrombopoiesis — the formation of blood platelets — has improved greatly in the last decade, with the cloning and characterization of thrombopoietin, the primary regulator of this process. Thrombopoietin affects nearly all aspects of platelet production, from self-renewal and expansion of HSCs, through stimulation of the proliferation of megakaryocyte progenitor cells, to support of the maturation of these cells into platelet-pro- ducing cells. The molecular and cellular mechanisms through which thrombopoietin affects platelet production provide new insights into the interplay between intrinsic and extrinsic influences on hematopoiesis and highlight new opportunities to translate basic biology into clinical advances. -
Dr. Kenneth Kaushansky's Report to the University Senate April 6, 2020
Dr. Kenneth Kaushansky’s report to the University Senate April 6, 2020 Dear Members of the Health Sciences Campus of Stony Brook University, I write today to update members of the Health Sciences Schools and Hospital on our efforts to overcome the COVID-19 pandemic, at least in Suffolk County and perhaps, far beyond. In short, we have mounted an amazing effort as the winds of the pandemic are building up, with ever- increasing numbers of infected individuals being identified. We have prepared for the coming “perfect storm.” And we have begun to model what the campus will look like when the flood waters begin to recede. And while our efforts to buffer the storm have been very well coordinated on many, many fronts, I will summarize our efforts by category. Disclaimer: What follows is a fairly detailed description of the efforts of hundreds of leaders from every corner of Stony Brook Medicine, from clinical to research, from basic to applied, from medical to nursing to technologists, and the spectacular response of several thousand members of the Renaissance School of Medicine (RSOM) and about 7,000 staff members of Stony Brook University Hospital (SBUH). For those who are faint of heart, or overtired (and hence already poised to nod off), please feel free to read as little of this note as you like! And if you are a numbers geek, you might be most interested in section 2, below. With that disclaimer aside, let me begin by explaining the basis for the coordination just mentioned, what I like to call the COVID choreography. -
October 2018
NEWS FROM THE OFFICE OF GOVERNMENT AND COMMUNITY RELATIONS Hailing Increased Graduation Rate, President Delivers 2018 State of the University Address Stony Brook University President Samuel L. Stanley Jr. delivered his ninth State of the University address on October 3, expressing appreciation to administrators, faculty and staff for their hard work and dedication and reinforcing the University's commitment to excellence and innovation. President Stanley Delivers the 2018 State of the University Address After acknowledging elected representatives and public officials in attendance, and members of the Stony Brook Council, President Stanley shared the past year's highlights and milestones, including completing the most successful fundraising campaign in SUNY's history. He spoke of Stony Brook's increasingly positive impact on Long Island's economy, the year-over-year rise in student enrollment and graduation rates, and an expanding Stony Brook University Hospital landscape. Read the full story Up In Albany On the Hill In Our Community In the Spotlight Justice Sotomayor Visits with Stony Brook Students Supreme Court Justice Sonia Sotomayor stressed the vital importance of appreciating family and friends in speaking to Stony Brook University freshmen on October 17. When she was sworn in as the first Latina on the high court nine years ago, Sotomayor recalled, she was deeply moved by the presence not only of President Barack Obama and Vice President Joe Biden, but all the people who had been a part of her life through the Supreme Court Justice Sonia Sotomayor shares inspirational years. "They were there. And they had life advice while speaking to Stony Brook University walked the journey of my life with me, and freshmen. -
University Senate Minutes
University Senate Minutes http://naples.cc.sunysb.edu/Admin/usenate.nsf/pages/minutes University Senate Minutes October 9, 2006 Meeting was called to order at 3:30 p.m. by Bill Godfrey I. Approval of tentative agenda: approved II. Approval of minutes from September 11, 2006. Approved with minor spelling corrections. III. Provost’s Report (R. McGrath): The Provost announced a new initiative in Computational Sciences. The initiative will strengthen computation science at Stony Brook and will also enhance ties with BNL. BNL Director Sam Aronson and Provost McGrath will serve as interim co-directors of what they call the New York Center for Computation Science. They have devised a draft plan for building up the Center. The Empire Innovation Program, supported by new funds from New York State, will recruit outstanding new tenure track faculty to SUNY in disciplines with potential to attract federal research funding. Stony Brook University’s new College of Journalism has been granted $1.7 million from the Knight Foundation to begin a freshman program in News Literacy. The Official announcement of the award and program will be announced later this fall. The Provost introduced Graham Glynn, Executive Director of Teaching, Learning and Technology: Dr. Glynn started out as a faculty member in pharmacy and got interested in teaching and how technology can help improve the communication between students and faculty. He had the task of being the first person to put the School of Pharmacy at the University of Nebraska in Omaha on-line. He has a lot of experience with business education as well as technology and in hiring instructional designers to support general pedagogy not just technology. -
UW Medicine School of Medicine Science in Medicine Lecturers, 1993-Present
UW Medicine School of Medicine Science in Medicine Lecturers, 1993-Present Presenter Name Lecture Type Year Department/Institution Lecture Title Francis S. Collins, M.D., Ph.D. Annual 1993-94 Center for Human Genome Research/NIH unknown Russell Ross, Ph.D. Distinguished Scientist 1993-94 Pathology unknown David Kimelman, Ph.D. New Investigator 1993-94 Biochemistry unknown Janice S. Blum, Ph.D. New Investigator 1993-94 Immunology unknown Michael W. Schwartz, M.D. New Investigator 1993-94 Medicine unknown Alan Chait, M.D. Science in Medicine 1993-94 Medicine unknown Christopher B. Wilson, M.D. Science in Medicine 1993-94 Immunology and Pediatrics unknown Neil M. Nathanson, Ph.D. Science in Medicine 1993-94 Pharmacology unknown Sheila A. Lukehart, Ph.D. Science in Medicine 1993-94 Medicine, Infectious Diseases unknown Susan Ott Ralph, M.D. Science in Medicine 1993-94 Medicine, Metabolism unknown Susan R. White, Ph.D. WWAMI 1993-94 Washington State University unknown Harold E. Varmus, M.D. Annual 1994-95 Director, NIH unknown Bertil Hille, Ph.D. Distinguished Scientist 1994-95 Physiology and Biophysics unknown Julie Overbaugh, Ph.D. New Investigator 1994-95 Microbiology unknown UW School of Medicine, Office of Research and Graduate Education For more information about the Science in Medicine lecture series contact [email protected] UW Medicine School of Medicine Science in Medicine Lecturers, 1993-Present Presenter Name Lecture Type Year Department/Institution Lecture Title Krzysztof Palczewski, Ph.D. New Investigator 1994-95 Ophthalmology unknown Mark A. Kay, M.D., Ph.D. New Investigator 1994-95 Medicine/Medical Genetics unknown Denise A. Galloway, Ph.D. -
Vitae 2 of 10
Marc Fasanella, PhD 12 Friendship Drive • Rocky Point, NY 11778 • 631. 335. 9137 • [email protected] • marcfasanella.com Professional Experience Managing Partner & Design / Build Specialist • Ecological Design Partners, Rocky Point, NY, 1/19 - present Focusing on regenerative land use and construction practice as well as guidance in the adaptive re-use and management of property. Expertise ranging from alternative architecture and architectural restoration to low-maintenance, permaculture-based landscape, including the incorporation of a biodiversity plan and rainwater collection system. Founder / Education Director • The Ecological Culture Initiative, Hampton Bays, NY, 1/16 -12/18 Initiated and co-developed: Farm to Table Dinner series, Farmer’s Market outreach initiative, Environmental Film and Lecture Series, Heritage Vegetable Garden, Permaculture Internship Program, Organic Gardening Certificate Program, Honey Bee Pollinator Project, Community Seed Library, and Community Yoga program. ECI Mission: Foster an ecology-based evolution of the local community through advocacy, education, and practical assistance. Restore the best practices of the past and advance the most regenerative design principles of our time. Academic Experience Visiting Professor: Ecological Art, Architecture & Design, 09/09-01/17 Sustainability Studies Program, School of Marine & Atmospheric Sciences, Stony Brook University, Stony Brook, NY Courses Developed and / or Taught: Agro-Ecology / Architects of Ecosystems / Artists & Designers of the East End / -
THE BROOK Pewi( Fellowshipil
VOLUME 8. NO. 1 WATE R! FROM THE CREATURES THAT INHABIT THE SEA, TO THE STUFF HUMANS DUMP INTO IT, STONY BROOK SCIENTISTS PLUMB THE DEPTHS. WHAT'S FROM PRESIDENT SHIRLEY STRUM KENNY bling external fundraising, we have by now increased our e nUniversity, the final monthsI turned of back my Presidencyto my Inaugural of Stony Address Brook Stony Brook Foundation endowment more than fivefold for a broadened perspective on the almost 15 years and the net assets by 724 percent. Deferred maintenance that have spun by so rapidly. I have often talked about had crippled the campus' abilities to serve its students and how Stony Brook has come "so far, so fast," and that is faculty; we have not only moved light years ahead on true-a mere 51 years from the initial class of 148 fresh- campus maintenance, we have added 73 new buildings men to today's 24,000 students and 14,500 employees. including 15 residence halls, and two new campuses. Three tenths of that time has been on my watch, and yet I used as a theme that day E.M. Forster's words in amazingly I have presided over the awarding of 46 percent Howard's End: Only connect. My version was: "Only of our total number of degrees. And so I began to wonder connect the arts and the sciences, the teachers and the stu- how far we have come in that decade and a half since my dents, the University and the community, the research and inaugural vision and promises. the applications, the work and the pleasure, the individual Some things have not changed at all, at least to my ambition and the University's aspirations. -
Hunting for Hematopoietic Transcriptional Networks COMMENTARY Kenneth Kaushanskya,1
COMMENTARY Hunting for hematopoietic transcriptional networks COMMENTARY Kenneth Kaushanskya,1 Each day an adult human produces roughly 2.5 × 1011 thousands of platelets) at the site of blood vessel injury erythrocytes, 1 × 1011 leukocytes, and 1 × 1011 plate- and by providing an activated cell surface on which co- lets, numbers that can increase 10- to 20-fold in times agulation proteins (i) assemble and are activated, stabi- of heightened demand. Blood cell production, termed lizing the platelet plug, and (ii) together, initiate vascular hematopoiesis, occurs in the red marrow found mostly in healing. Without platelets, we hemorrhage. Platelets are the skull, spine, and proximal ends of the long bones of also involved in some of the most important diseases of the body. Within the marrow resides a small number of humans: By clotting on ruptured atherosclerotic plaques, hematopoietic stem cells (HSCs), the origin of all blood they cause myocardial infarction, stroke, and arterial in- cells, which undergo a series of proliferative and differ- sufficiency. By binding to circulating tumor cells, platelets entiation steps eventuating in the near half a trillion or promote metastatic spread of cancer. And when more cells produced each day. The molecular “wiring platelets are dysfunctional, they can cause pathological diagram” that regulates the production of mature blood clotting and hemorrhage. Thus, a thorough under- cells from HSCs is both cell intrinsic (gene transcription standing of platelet production—from the HSC to the factors and epigenetic changes) and cell extrinsic CMP, the MEP, the MkP, the megakaryocyte, and finally (growth factors and microenvironmental soluble and cell to circulating platelets—may shed light on a number surface proteins), although whether lineage decisions are physiological and pathological processes, as well as stochastic or directed by external factors remains a con- open doors into novel therapeutic approaches to troversial topic. -
JOB 624 Post Press
Vol. 17 Number 2 Spring 2006 POST PRESS The Official Staff and Faculty Newsletter of the C.W. Post Campus of Long Island University DECADES OF DEDICATION m i K l u h C i u e H y b o t o Toni Check Srikumar Rao h P When switchboard operator Antoinette Check came to work at C.W. Post in 1966, neither the B. Davis Schwartz Memorial Library nor Humanities Hall had yet been built. Hillwood Commons, the Interfaith Center and Brookville Hall did not exist. Toni, as she is known to friends and colleagues, watched C.W. Post grow up. “The time went very fast,” she said after being honored for her 40 years of service. “I’ve loved every minute of it.” Check was among nearly 60 staff and faculty members honored for 15, 20, 30 or 40 years of service to C.W. Post on March 6. The list included Marketing Professor Srikumar Rao, who was profiled recently in TIME magazine; Alexander Dashnaw, the director of choral studies at C.W. Post and a world-renowned conductor; and lacrosse legend Tom Postel, who coached the Pioneers to a national championship in 1996 and who played for the world champion U.S. national team in 1974. Dr. Rao was profiled in TIME this April for his new book, “Are You Ready to Succeed?” and the Creativity and Personal Mastery course he has taught at C.W. Post, Columbia University and London Business School. “I believe that your life – both personal and professional – is far more within your control than you think,” Dr. -
MARINE and ATMOSPHERIC SCIENCES (MAS) Fall 2021
MARINE AND ATMOSPHERIC SCIENCES (MAS) Fall 2021 Marine and Atmospheric Sciences (MAS) Dean Paul Shepson, Endeavour Hall 145 (631) 632-8700 Graduate Program Director Jackie Collier, Discovery Hall 145 (631) 632-8696, [email protected] Director Institute of Terrestrial and Planetary Atmospheres, Coordinator of Atmospheric Sciences Programs Brian Colle, Endeavour Hall 125, (631) 632-3174, [email protected] Faculty Director Marine Conservation and Policy Program Ellen Pikitch, Discovery Hall 169, (631)632-9599, [email protected] Graduate Admissions Coordinator Christina Fink, Endeavour Hall 107, (631) 632-8680, [email protected] Graduate Program Coordinator Ginny Clancy, Endeavour Hall 105 (631) 632-8681, [email protected] Degrees Awarded M.A. in Marine Conservation and Policy; M.S. in Marine and Atmospheric Science; Ph.D. in Marine and Atmospheric Science; M. Phil. in Marine and Atmospheric Science; Graduate Certificate in Geospatial Sciences Web Site http://www.somas.stonybrook.edu/ Application https://graduateadmissions.stonybrook.edu/apply/ Marine and Atmospheric Science The Marine and Atmospheric Sciences (MAS) graduate program is located within the School of Marine and Atmospheric Sciences (SoMAS). Research activities within SoMAS are coordinated through the Marine Sciences Research Center (MSRC), and the Institute for Terrestrial and Planetary Atmospheres (ITPA). MSRC is the center for research, graduate education, and public service in the marine sciences for the entire State University of New York system. SoMAS faculty have active research programs in all major oceanographic and atmospheric disciplines and many focus on interdisciplinary approaches to understanding environmental processes and issues. Specific areas of cross-disciplinary focus include: biogeochemical transformation of energy and elements, conservation and management of marine resources, environmental health and contaminants, environmental modeling and prediction, and patterns and impacts of global climate change. -
Newsday-Top-Doctors-2019.Pdf
YOUR GUIDE TO HEALTH & WELLNESS JULY 2019 ON LONG ISLAND FITA GOOD 3D-PRINTED BODY PARTS 840+ LI TOP DOCTORS ALSO 2019 Castle Connolly Database INSIDE Doctors’ Orders! Cancer Care Pain Treatment The best cancer care specialists in the world are also your neighbors. When you or someone you love is diagnosed with cancer, you’ll go anywhere for the best possible treatment. Fortunately, superior cancer care is close to home. MSK has three convenient Long Island locations, where patients have access to the most advanced treatment options and care specialists to guide them every step of the way. MSKCC.ORG/LONGISLAND Hauppauge Nassau Commack MORE SCIENCE. LESS FEAR. SEE WHAT OVER A CENTURY OF CANCER CARE INNOVATION CAN DO FOR YOU. MSK develops MSK Precise™ for prostate cancer, which MSK investigators contribute delivers radiation treatment to findings that lead to the in five sessions, instead of the development of chemotherapy MSK opens a regional facility conventional 50 sessions. as a treatment for cancer. in Commack, providing leading Memorial Sloan Kettering is cancer care throughout Long Island. founded as the first U.S. institution 2010 devoted solely to cancer care. 1946 2002 1884 1977 Through the visionary efforts of Dr. Jimmie Holland, 1893 MSK becomes the first 1998 Dr. William Coley develops cancer center to establish MSK opens a regional location what becomes the first a full-time psychiatry in Hauppauge, offering 2019 recognized example of service devoted solely superior care for skin cancer to psychiatric and MSK Nassau — previously in Rockville Centre — immunotherapy in to residents of Long Island. -
Campus Announcements for the Week of 03/26/2007 01. Administrative 03
Campus Announcements for the week of 03/26/2007 Table of Contents 01. Administrative 1. UUP West General Membership Meeting 03. Workshops/Courses/Training 1. EAP Lunchtime Learning, Adult Day Care..the Best Kept Secret in Long-Term Care 2. Patents, Trademarks And Copyrights 3. Health Sciences Library April Class Schedule 4. Lawson Training 5. Position Description & Advertising Requisitions (PDAAR Training) 6. Managing Multiple Priorities Workshop 7. What You Should Know About Your State Retiree Benefits 04. Conferences/Seminars/Lectures 1. Two CIDER/Ecology and Evolution Seminars 2. Topics in Atmospheric and Oceanic Sciences Seminar, 3/28/07 3. Seminar "Cell-cycle regulation of vertebrate DNA replication" 4. Biochemistry & Cell Biology Seminar: Thursday, March 29, 2007 5. The Sudan peace agreement between the north and the south: progress and prospects 6. Operation Solomon: The Daring Rescue of Ethiopian Jews - Melville Library Author Series Lecture with Stephen Spector on 3/28 7. The Stony Brook Southampton MFA in Writing and Literature Faculty Reading 8. The Stony Brook Southampton MFA Reading Series 9. The Laurence Baxter Memorial Lecture 10. Seminar in Department of Pharmacological Sciences 11. Ecology and Evolution Seminar 12. Earth-Stock 2007: A Week Long Celebration of Earth Day 13. 35 years of groundbreaking journalism: Legendary Investive Reporter Bob Woodward comes to campus 14. The Sword of Wisdom: Scholarship in a Buddhist Worldview. Lecture by Jonathan Gold, Drew University 06. Charitable 1. The 11th Annual Cody Comedy Festival to benefit the Cody Center for Autism and Developmental Disabilities 2. Caring Crafters - Wednesday, 12noon-1pm Health Sciences Library 3. Walk Teams Wanted! Join the Cody Center Walk for Developmental Disabilities Sunday, April 15 4.