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Treatment of Stimulant Use Disorders

Treatment of Stimulant Use Disorders

EVIDENCE-BASED RESOURCE GUIDE SERIES

Treatment of Use Disorders Treatment of Stimulant Use Disorders Acknowledgments This report was prepared for the Department of and Services, Substance and Services Administration (SAMHSA) under contract number HHSS283201700001/ 75S20319F42002 with SAMHSA. Donelle Johnson served as contracting officer representative. Disclaimer The views, opinions, and content of this publication are those of the authors and do not necessarily reflect the views, opinions, or policies of SAMHSA. Nothing in this document constitutes a direct or indirect endorsement by SAMHSA of any non-federal entity’s products, services, or policies, and any reference to non- federal entity’s products, services, or policies should not be construed as such. Public Domain Notice All material appearing in this publication is in the public domain and may be reproduced or copied without permission from SAMHSA. Citation of the source is appreciated. However, this publication may not be reproduced or distributed for a fee without the specific, written authorization of the Office of , SAMHSA. Electronic Access This publication may be downloaded from http://store.samhsa.gov Recommended Citation and Mental Health Services Administration (SAMHSA): Treatment of Stimulant Use Disorders. SAMHSA Publication No. PEP20-06-01-001 Rockville, MD: National Mental Health and Substance Use Policy Laboratory. Substance Abuse and Mental Health Services Administration, 2020. Originating Office National Mental Health and Substance Use Policy Laboratory, Substance Abuse and Mental Health Services Administration, 5600 Fishers Lane, Rockville, MD 20857, SAMHSA Publication No. PEP20-06-01-001. Nondiscrimination Notice SAMHSA complies with applicable federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.

SAMHSA cumple con las leyes federales de derechos civiles aplicables y no discrimina por motivos de raza, color, nacionalidad, ni edad.

Treatment of Stimulant Use Disorders Acknowledgments II MESSAGE FROM THE ASSISTANT SECRETARY FOR MENTAL HEALTH AND SUBSTANCE USE, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

As the first U.S. Department of Health and Human Services Assistant Secretary for Mental Health and Substance Use at the Substance Abuse and Mental Health Services Administration (SAMHSA), I am pleased to present this new resource: Treatment of Stimulant Use Disorders. In response to the charge of the 21st Century Act to disseminate information on evidence-based practices and service delivery models, the National Mental Health and Substance Use Policy Lab has developed the Evidence-Based Resource Guide Series focused on the prevention and treatment of substance use disorders and mental illnesses. With this guide, SAMHSA’s goal is to inform health care providers, healthcare administrators, policy makers, and community members of the rising rates of stimulant use and the need for targeted treatment programs and practices.

Stimulant use is on the rise in the . According to the 2018 National Survey on Use and Health, an estimated 5.1 million people aged 12 or older misused prescription in the past year; approximately 1.9 million people aged 12 or older used in the past year with significant increases in use in those aged 26 and older; and 5.5 million people aged 12 or older used in the past year.1 Overdose linked to psychostimulants increased approximately 22 percent from 2017 to 2018 and have increased more than three fold over the past five years. Deaths from cocaine, which can be laced with , increased by 5 percent from 2017 to 2018 and are more than double what they were in 2015.2 The combination of all types of stimulants with unknown amounts of fentanyl increases the risk of overdose and overdose substantially.3

This guide discusses effective practices to treat stimulant use disorders, clinical challenges associated with these disorders, and implementation strategies that can be used to address those challenges. I encourage you to use this guide to identify treatment practices you can implement to address stimulant use in your healthcare settings and communities.

Elinore F. McCance-Katz, MD, PhD Assistant Secretary for Mental Health and Substance Use U.S. Department of Health and Human Services

1 Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health (HHS Publication No. PEP19-5068, NSDUH Series H-54). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. Retrieved from https://www.samhsa.gov/data/. 2 National Institute on Drug Abuse. (2019). Overdose death rates. Retrieved from https://www.drugabuse.gov/related-topics/ trends-statistics/overdose-death-rates 3 National Institute on Drug Abuse. (2019). DrugFacts: What is fentanyl? Retrieved from https://www.drugabuse.gov/publications/ drugfacts/fentanyl

Treatment of Stimulant Use Disorders Message from Assistant Secretary for Mental Health and Substance Use III Evidence-Based Resource Guide FOREWORD Series Overview

The Substance Abuse and Mental Health Services practices that reduce stimulant use, lower the risk of Administration (SAMHSA), and specifically, its National overdose, and promote recovery from stimulant use Mental Health and Substance Use Policy Laboratory disorders. This guide reviews the literature and , (Policy Lab), is pleased to fulfill the charge of the examines evidence-based practices, determines key 21st Century Cures Act to disseminate information on components of those practices, identifies challenges and evidence-based practices and service delivery models to strategies for implementation, and discusses evaluation prevent substance misuse and help people with substance of implemented evidence-based practices. The purpose use disorders (SUD), serious mental illnesses (SMI), and of this document is to identify potential treatment serious emotional disturbances (SED) get the treatment strategies and evidence-based practices for stimulant use and support they need. disorders and does not include all resources required for implementation of those practices. Treatment and recovery for SUD, SMI, and SED can vary based on a number of geographic, socio-economic, Expert panels of federal, state, and non-governmental cultural, gender, race, ethnicity, and age-related factors participants provide input for each guide in this series. which can complicate evaluating the effectiveness The panels include accomplished scientists, researchers, of services, treatments, and supports. Despite these service providers, community administrators, federal and variations, however, there is substantial evidence to state policy makers, and people with lived experience. inform the types of resources that can help reduce Members provide input based on their knowledge of substance use, lessen symptoms of mental illness, and healthcare systems, implementation strategies, evidence- improve quality of life. based practices, provision of services, and policies that foster change. The Evidence-Based Resource Guide Series is a comprehensive set of modules with resources to improve Research shows that implementing evidence-based health outcomes for people at risk for, with, or recovering practices requires a comprehensive, multi-pronged from mental and/or substance use disorders. It is designed approach. This guide is one piece of an overall approach for practitioners, administrators, community leaders, and to implement and sustain change. Readers are encouraged others considering an intervention for their organization or to visit the SAMHSA website for additional tools and community. A priority topic for SAMHSA is encouraging technical assistance opportunities.

Treatment of Stimulant Use Disorders Evidence-Based Resource Guide Series Overview 1 Content of the Guide FOCUS OF THE GUIDE This guide contains a foreword and five chapters. The chapters are meant to Stimulant use is rising and becoming a crisis similar to the stand alone and do not need to be read in order. Each chapter is designed to be epidemic. Illicit stimulants, brief and accessible to healthcare providers, healthcare system administrators, like cocaine and , community members, policy makers, and others working to meet the needs of are more accessible and have people at risk for, experiencing, or recovering from mental and/or substance use evolved to be purer, cheaper, and disorders. The goal of this guide is to review the literature on treating stimulant more potent. Stimulants are harmful use disorders, distill the research into recommendations for practice, and provide to the cardiovascular system and examples of how practitioners use these practices in their programs. 1 can cause and , , and even death. FW Evidence-Based Resource Guide Series Overview Treating to stimulants is critical, but especially challenging. Introduction to the series. Unlike , there is no FDA- 1 Issue Brief approved currently available for stimulant use disorders. Overview of current approaches and challenges to addressing stimulant use disorders in communities. People who misuse opioids— which suppress the functioning of 2 What Research Tells Us the central —and Current evidence on effectiveness of the following practices stimulants in combination, often do included in the guide to address stimulant use disorders: so to reverse or modulate the effect Motivational Interviewing, , of the other.1 Community Approach, and Cognitive Behavioral . This guide presents four evidence- based programs and practices that 3 Guidance for Selecting and Implementing address treatment of stimulant use. Evidence-based Practices It supports SAMHSA’s Strategic Plan Practical information to consider when selecting and Objective 3.4 to: implementing practices to address stimulant use disorders. “Support the identification and 4 Examples of Stimulant Use Treatment Programs adoption of evidence-based Descriptions of programs that use practices from Chapter 2 practices, programs, and policies to address stimulant use disorders. that prevent substance use, increase provision of substance use disorders 5 Resources for Evaluation and Quality treatment, and enable individuals to Improvement achieve long-term recovery.” Guidance and resources for implementing best practices, This guide covers cocaine and outcomes, and improving quality. -type stimulants that increase and energy; heighten ; elevate pressure, rate, and respiration; and cause behavioral excitement. The guide also recognizes the misuse of prescription stimulants, such as and , found in used for conditions like -deficit hyperactivity disorder (ADHD), , and .

Treatment of Stimulant Use Disorders Evidence-Based Resource Guide Series Overview 2 The framework below provides an overview of this guide. The guide addresses stimulant use disorders, including illicit and prescription stimulants. The focus of the guide is on treatment practices that have been evaluated with . The review of these interventions in Chapter 2 of the guide includes specific outcomes, practitioner types, and delivery settings for the practices.

Treatment of Stimulant Use Disorders Evidence-Based Resource Guide Series Overview 3 CHAPTER In 2018, 5.5 million people in the United States aged 12 1 or older used cocaine within the past year and 1.9 million people aged 12 or older used methamphetamine in the past year.4

Issue Brief

This chapter presents an overview of stimulant use Misuse of prescription stimulants and abuse of illicit disorders, specifically focusing on its prevalence in the stimulants, such as cocaine and amphetamines, continues population and its impact on individuals and society. to rise in the United States. In 2018, the amount of cocaine and seized in certain parts of Stimulant use disorders include a range of problems the country exceeded that of opioids.3 associated with the use of methamphetamine, cocaine, and other amphetamines. Diagnosis of a stimulant disorder is The number of people using stimulants for the first based on the occurrence of at least two of the following has significantly increased since 2015,4 and while the trend within a 12 month period.2 in overall stimulant use is concerning, increases in related overdose deaths may be even greater cause for alarm. • Taking more stimulants than intended • Failing to cut down or control use of stimulants, STIMULANT USE IN PAST YEAR ACROSS GENERAL despite wanting to do so POPULATION, 2007-2018 • Spending excessive amounts of time in activities surrounding stimulant use • Experiencing urges and cravings for stimulants • Failing to meet the obligations of home, school, or • Continuing to take stimulants, even if it has led to relationship or social problems • Giving up or reducing important recreational, social, or work-related activities because of stimulant use • Using stimulants in situations in which it is physically hazardous • Continuing to use stimulants even if there is an that it is causing or worsening a physical or psychological problem • Experiencing an increase in tolerance to stimulants • Having withdrawal symptoms when not taken *Source: CDC ; NCHS, National Vital Statistics System, Mortality

Treatment of Stimulant Use Disorders Issue Brief 4 The number of cocaine- and other psychostimulant-related PERCENTAGE OF POPULATION WITHIN SPECIFIC deaths has climbed sharply over the past few years. This AGE GROUPS WHO REPORT USING STIMULANTS can be partially explained by an increase in polydrug use. WITHIN THE PAST YEAR, 2018 In recent years, more than 50 percent of all stimulant- related overdose deaths have also involved opioids.5

Specifically, the practice of intentional or unintentional misuse of fentanyl (a synthetic opioid reliever) with stimulants is on the rise. Much of the methamphetamines and cocaine sold on the streets contain unpredictable levels of fentanyl. People buying these street products are often unaware of the combination of stimulant and fentanyl which suppresses respiration and increases the risk for overdose and death.

STIMULANT-RELATED OVERDOSE DEATHS ACROSS GENERAL POPULATION, 2007-2018

*Source: National Survey on Drug Use and Health, 2018 ** Numbers in parentheses represent total populations for the specific age groups.

PERCENTAGE OF POPULATION WITHIN SPECIFIC RACES WHO REPORT USING STIMULANTS WITHIN THE PAST YEAR, 2018

*Source: CDC WONDER; NCHS, National Vital Statistics System, Mortality

Cocaine misuse is highest among adults aged 18 to 25, while methamphetamine misuse is highest among those aged 26 to 49. Methamphetamine misuse rates are particularly high among American Indians and Alaska Natives (AI/AN) who, according to Centers for Control and Prevention (CDC) data, also have the highest risk for methamphetamine-related overdose deaths. These data also show that Black or African American communities have the highest risk for cocaine-related *Source: National Survey on Drug Use and Health, 2018 overdose deaths.6 NH/OPI: Native Hawaiian and Other Pacific Islanders AI/AN: American Indian Alaska Native

Treatment of Stimulant Use Disorders Issue Brief 5 Research highlights some of the reasons different genders of other serious cardiovascular complications can occur, give for using stimulants. For example, females cite such as , valvular disease, stroke, and an increased “increased energy,” while males cite “enhanced sexual risk for heart attack.10, 20-21 experience” as their prime reasons.7 There are also geographical differences in the prevalence of stimulant Chronic stimulant use can permanently alter brain misuse across the country, with cocaine used more widely structure, leading to impaired cognitive, neurological, and in eastern states and methamphetamines used more in the emotional systems. Because stimulant use releases large West and Midwest.8 amounts of and , chronic use may cause mood fluctuations, , and depression, even when not taking the drug(s). Long-term use of cocaine Impact of the Problem and methamphetamines can cause decreased attention, Short-Term Impact , impaired memory, inhibited , and 22-24 The short-term effects of stimulant use vary depending on reduced motor skills. These long term impacts pose several factors, including the combination of substances challenges for recovery, but successful treatment can used, , , dosage, and level enable people to return to a productive and meaningful life. of prior use. However, in broad terms, stimulants are Depending on the substance used and the route known to cause increased , reduced appetite, of administration, chronic stimulant use may also and of brought on by the rapid release cause a variety of other adverse physical effects. of , including dopamine, serotonin, and Methamphetamine use, for example, may result in 9-10 . “,” a condition characterized by rapid tooth 25 The adverse effects of stimulant use are well- decay and gum disease. Nasal (snorting) may documented. Stimulant use can cause acute conditions, result in loss of smell, a deviated septum, frequent nose 26 such as accelerated , , and bleeds, and other damage to the nasal cavity. 27 28-2 bronchodilation, which the cardiovascular stimulants may result in lung and airway damage. system.10-11 Likewise, use can produce elevated body temperature, which can result in potentially deadly Between 2008 and 2015, amphetamine-related , either alone or in combination with hospitalizations more than tripled, increasing environmental factors.10 In addition, stimulant use can from 55,447 instances to 206,180.28 As of 2019, cause a host of adverse psychological or neurological methamphetamine has surpassed opioids as the effects, including attacks, , , leading cause of overdose death in many western 29 , and even violent behavior.12-14 and secondary U.S. states. complications such as local site , life- threatening , and/or neurological .15 Impact on Society Stimulant overdose can cause other serious symptoms, Stimulant use also has detrimental societal effects, including , fainting, , and death.16 including negative outcomes for children who have a As is evident by overdose data, the number of stimulant parent who uses, heightened crime in communities, overdoses resulting in death are climbing dramatically. costs associated with enforcement and incarceration, environmental damage, and premature deaths. The subacute effects of stimulant use are often experienced once the initial drug reaction of wakefulness Stimulant use by pregnant mothers can have long-term and euphoria wear off. These effects can include , health and development consequences for their children depression, chronic , increased appetite, impaired (e.g., delayed motor development, poor language skills, memory, and (the inability to feel ).17-19 and cognitive and behavioral issues). Babies born to mothers who use stimulants are often premature and Long-Term Impact smaller in size than babies born to mothers who did not.30-31 Chronic stimulant use may result in a number of health issues. In the long-term, persistent hypertension and a host

Treatment of Stimulant Use Disorders Issue Brief 6 Continued stimulant use by one or both parents is also individuals who misuse other substances.35-36 associated with neglectful or abusive parenting, as well cocaine, , and methamphetamine-related as higher prevalence of children entering the foster care offenses accounted for more than 75 percent of all system and using stimulants themselves.32-34 federally-sentenced drug offenses.39

The process used to produce and synthesize stimulants ASSOCIATION WITH RISKY BEHAVIOR in clandestine laboratories can release toxins into the environment and create hazardous by-products. These People who use stimulants are more likely to conditions can cause explosions–a potential harm to those engage in unprotected sex and sex with multiple in the laboratory and neighboring community.40-41 The 37- 38 partners. In addition, intravenous administration U.S. Department of Justice estimates that every pound of of stimulants may result in reusing or sharing methamphetamines produced results in five to six pounds needles, , and other paraphernalia. These of hazardous waste, which is rarely disposed of properly.42 behaviors place people who misuse stimulants at higher risk for HIV and other blood-borne The greatest societal costs of stimulant use are associated pathogens, such as B and . with adverse health effects and, tragically, premature This is of concern because chronic stimulant use is deaths. Amphetamine-related hospital costs totaled linked to weakened immune response, increased $436 million in 2003, and increased to $2.17 billion by susceptibility to , and accelerated retroviral 28 replication.1, 30-31 2015. Cocaine overdose caused 14,666 deaths in 2018; methamphetamines and other psychostimulants caused People who use methamphetamines are more likely to 12,676 deaths. Overall, stimulant-related deaths in 2018 perpetrate domestic than those who do not. accounted for roughly 40 percent of all overdose deaths in 6 They are also more likely to commit crimes than the United States.

Centers for Disease Control and Prevention. (2019). Annual surveillance report of drug-related risks and outcomes - United States. Washington DC: U.S. Department of Health and Human Services. Taxy, S., Samuels, J., & Adams, W. (2015). Drug offenders in federal : Estimates of characteristics based on linked data. U.S. Department of Justice, Office of Justice Programs, Bureau of Justice. Winkelman, T. N., Admon, L. K., Jennings, L., Shippee, N. D., Richardson, C. R., & Bart, G. (2018). Evaluation of amphetamine- related hospitalizations and associated clinical outcomes and costs in the United States. Journal of American Medical Association, 1(6), e183758-e183758.

Treatment of Stimulant Use Disorders Issue Brief 7 Reference List

1 Ellis, R. J., Childers, M. E., Cherner, M., Lazzaretto, 10 Panenka, W. J., Procyshyn, R. M., Lecomte, T., D., Letendre, S., & Grant, I. (2003). Increased MacEwan, G. W., Flynn, S. W., Honer, W. G., human immunodeficiency virus loads in active & Barr, A. M. (2013). Methamphetamine use: A methamphetamine users are explained by reduced comprehensive review of molecular, preclinical and effectiveness of antiretroviral therapy. The Journal clinical findings.Drug and Dependence, of Infectious Diseases, 188 (12), 1820-1826. 129(3), 167-179. 2 American Psychiatric Association. (2013). 11 Fonseca, A. C., & Ferro, J. M. (2013). Drug abuse Diagnostic and statistical manual of mental and stroke. Current and disorders (5th ed.). https://doi.org/10.1176/appi. Reports, 13(2), 325. books.9780890425596 12 Goldstein, R. A., DesLauriers, C., Burda, A., & 3 National Emerging Threats Initiative. (2019). Johnson-Arbor, K. (2009). Cocaine: History, social Emerging threats report 2019: Status and factors implications, and toxicity: A review. Seminars in affecting the United States. Washington, DC: U.S. Diagnostic , 26 (1) 10-17. Office of National Drug Control Policy. 13 Akindipe, T., Wilson, D., & Stein, D. J. (2014). 4 Substance Abuse and Mental Health Services Psychiatric disorders in individuals with Administration: Center for Behavioral Health methamphetamine dependence: Prevalence and risk Statistics and Quality. (2019). Key substance use and factors. Metabolic Brain Disease, 29(2), 351-357. mental health ndicators in the United States: Results 14 Davison, D., & Parrott, A. C. (1997). from the 2018 National Survey on Drug Use and (MDMA) in recreational users: Self-reported Health (HHS Publication No. PEP19-5068, NSDUH psychological and physiological effects. Human Series H-54). Rockville, MD: Substance Abuse and : Clinical and Experimental, Mental Health Services Administration. 12(3), 221-226. 5 Kariisa, M., Scholl, L., Wilson, N., Seth, P., & 15 Wurcel, A. G., Merchant, E. A., Clark, R. P., & Hoots, B. (2019). deaths involving Stone, D. R. (2015). Emerging and underrecognized cocaine and psychostimulants with abuse potential - complications of illicit drug use. Clinical Infectious United States, 2003-2017. Morbidity and Mortality Diseases, 61(12), 1840-1849. Weekly Report, 68(17), 388. 16 6 Liechti, M. E., Kunz, I., & Kupferschmidt, H. Centers for Disease Control and Prevention. (2018). (2005). Acute medical problems due to Ecstasy use. Annual surveillance report of drug-related risks Case-series of emergency department visits. Swiss and outcomes—United States. Surveillance Special Medical Weekly, 135(43-44), 652-657. Report, Atanta, GA: Centers for Disease Control and 17 Prevention, Verheyden, S. L., Henry, J. A., & Curran, H. V. ‐ ‐ 7 (2003). Acute, sub acute and long term subjective Maxwell, J. C. (2014). A new survey of consequences of ‘ecstasy’(MDMA) consumption methamphetamine users in treatment: Who they are, in 430 regular users. Human Psychopharmacology: why they like “meth,” and why they need additional Clinical and Experimental, 18(7), 507-517. services. Substance Use & misuse, 49(6), 639-644. 18 8 McGregor, C., Srisurapanont, M., Jittiwutikarn, Seth, P., Scholl, L., Rudd, R. A., & Bacon, S. (2018). J., Laobhripatr, S., Wongtan, T., & White, J. M. Overdose deaths involving opioids, cocaine, and (2005). The nature, time course and severity of psychostimulants—United States, 2015–2016. methamphetamine withdrawal. Addiction, 100(9), Morbidity and Mortality Weekly Report, 67(12), 349. 1320-1329. 9 Ciccarone, D. (2011). Stimulant abuse: 19 Leventhal, A. M., Kahler, C. W., Ray, L. A., et al. , cocaine, methamphetamine, (2008). Anhedonia and amotivation in psychiatric treatment, attempts at . Primary outpatients with fully remitted stimulant use Care: Clinics in Office Practice, 38(1), 41-58. disorder. The American Journal on , 17(3), 218-223.

Treatment of Stimulant Use Disorders Issue Brief 8 20 Riezzo, I., Fiore, C., De Carlo, D., Pascale, N., 32 Brown, J. A., & Hohman, M. (2006). The impact of Neri, M., Turillazzi, E. & Fineschi, V. (2012). Side methamphetamine use on parenting. Journal of Social effects of cocaine abuse: Multiorgan toxicity and Work Practice in the Addictions, 6(1-2), 63-88. pathological consequences. Current Medicinal 33 Cunningham, S., & Rafert, G. (2008). Parental , 19(33), 5624-5646. methamphetamine use and foster care: Is the growth 21 Maraj, S., Figueredo, V. M., & Lynn Morris, D. in foster care admissions explained by the growth (2010). Cocaine and the heart. Clinical , in meth use? Social Science Research Network, 33(5), 264-269. Available at https://papers.ssrn.com/sol3/papers. 22 Spronk, D. B., van Wel, J. H., Ramaekers, J. G., & cfm?abstract_id=1299095. Verkes, R. J. (2013). Characterizing the cognitive 34 Delaney-Black, V., Chiodo, L. M., Hannigan, J. effects of cocaine: A comprehensive review. H., Greenwald, M. K., Jannise, J., Patterson, G., Neuroscience & Biobehavioral Reviews, 37(8), Huestis, M. A., Partridge, R. T., Ager, J., & Sokol, R. 1838-1859. J. (2011). Prenatal and postnatal cocaine exposure 23 Volkow, N. D., Chang, L., Wang, G.-J., et al. (2001). predict teen cocaine use. Neurotoxicology and Association of reduction with Teratology, 33(1), 110-119. psychomotor impairment in methamphetamine 35 Dowling, C., & Morgan, A. (2018). Is abusers. American Journal of , 158(3), methamphetamine use associated with domestic 377-382. violence? Trends and Issues in Crime and Criminal 24 Zickler, P. (2002). Methamphetamine abuse linked to Justice, 563, 1-15. impaired cognitive and motor skills despite recovery 36 Gizzi, M. C., & Gerkin, P. (2010). of dopamine transporters. NIDA Notes, 17(1), 1. Methamphetamine use and criminal behavior. 25 Rhodus, N. L., & Little, J. W. (2005). International Journal of Offender Therapy and Methamphetamine abuse and “meth mouth.” Comparative Criminology, 54(6), 915-936. Northwest Dentistry, 84(5), 29, 31, 33-27. 37 Semple, S. J., Patterson, T. L., & Grant, I. (2004). 26 Millard, D. R., & Mejia, F. A. (2001). The context of sexual risk behavior among Reconstruction of the nose damaged by cocaine. heterosexual methamphetamine users. Addictive and Reconstructive , 107(2), 419-424. Behaviors, 29(4), 807-810. 38 27 Restrepo, C. S., Carrillo, J. A., Martínez, S., Ojeda, Novoa, R. A., Ompad, D. C., Wu, Y., Vlahov, D., P., Rivera, A. L., & Hatta, A. (2007). Pulmonary & Galea, S. (2005). Ecstasy use and its association complications from cocaine and cocaine-based with sexual behaviors among drug users in New substances: Imaging manifestations. Radiographics, York City. Journal of Community Health, 30(5), 27(4), 941-956. 331-343. 39 28 Winkelman, T. N., Admon, L. K., Jennings, Taxy, S., Samuels, J., & Adams, W. (2015). L., Shippee, N. D., Richardson, C. R., & Bart, Drug offenders in federal prison: Estimates of G. (2018). Evaluation of amphetamine-related characteristics based on linked data. Washington, hospitalizations and associated clinical outcomes DC: US Department of Justice. and costs in the United States. JAMA Network Open, 40 Baldwin, G. C., Roth, M. D., & Tashkin, D. P. 1(6), e183758-e183758. (1998). Acute and chronic effects of cocaine on 29 Hedegaard, H., Bastian, B. A., Trinidad, J. P., the and the possible link to AIDS. Spencer, M., & Warner, M. (2019). Regional Journal of , 83(1-2), 133-138. differences in the most frequently involved in 41 Salamanca, S. A., Sorrentino, E. E., Nosanchuk, drug overdose deaths: United States, 2017. National J. D., & Martinez, L. R. (2015). Impact of Vital Statistics Reports, 68(12), 1-15. methamphetamine on infection and immunity. 30 Behnke, M., & Smith, V. C.(2013). Prenatal Frontiers in Neuroscience, 8, 445. substance abuse: Short-and long-term effects on the 42 Scott, M. S., & Dedel, K. (2006). Clandestine exposed fetus. Pediatrics, 131(3), e1009-e1024. methamphetamine labs. Washington, DC: US 31 Wouldes, T., LaGasse, L., Sheridan, J., & Lester, Department of Justice. B. (2004). Maternal methamphetamine use during and child outcome: What do we know. New Zealand Medical Journal, 117(1206), 1-10.

Treatment of Stimulant Use Disorders Issue Brief 9 CHAPTER 2

What Research Tells Us

The purpose of this chapter is to provide an overview of • Provide evidence of effectiveness four practices to treat stimulant use disorders: • Have accessible resources for implementation and fidelity • Motivational interviewing • Contingency management Evidence Review and Rating • Community reinforcement approach Authors completed a comprehensive review of published • Cognitive behavioral therapy research for each selected practice to determine its Stimulant use disorders not only have adverse effects on strength as an evidence-based practice. Eligible research the physical and mental health of individuals, but they studies had to: are also a public health problem with significant negative • Employ a randomized or quasi-experimental impacts on society. In the absence of pharmacological design, or treatment that are approved by the U.S. and Drug • Be a single sample pre-post design or an Administration (FDA), practitioners rely heavily on epidemiological study with a strong counterfactual behavioral and psychosocial interventions and practices. study (i.e., a study that analyzes what would have Literature around these practices is often inconsistent, happened in the absence of the intervention). making identification of the most effective treatment methods challenging.1 Descriptive and implementation studies, and meta- analyses were not included in the review, but Through an extensive literature review and consultation were documented to provide context and identify with experts, authors identified four practices used to treat implementation supports for the practices. stimulant use disorders. Based on a systematic review of the available evidence, each selected practice received a rating. Each eligible study was reviewed for evidence of measurable reductions in stimulant use. In addition, Practice Selection trained reviewers checked each study to ensure rigorous methodology, asking questions such as: To be considered for inclusion in this guide, eligible • Are experimental and comparison groups practices had to meet the following criteria: demographically equivalent, with the only • Must be clearly defined and replicable difference being that participants in the • Address stimulant misuse reduction as a primary experimental group received the intervention and outcome those in the comparison group received treatment • Are currently in use as usual or with no or minimal intervention?

Treatment of Stimulant Use Disorders What Research Tells Us 10 • Was baseline equivalence established between the treatment and comparison groups on outcome measures? • Were missing data addressed appropriately? • Were outcome measures reliable, valid, and collected consistently from all participants?

Using these criteria, each study’s causal impact was assessed and given a rating of low, moderate, or high. Only randomized controlled trials, quasi-experimental designs, and epidemiological studies with a strong comparison were eligible to receive a high or moderate rating.

Causal Impact: Evidence demonstrating that an intervention causes, or is responsible for, the outcome measured in the study’s sample population.

After all studies for a practice were assessed and rated, the practice was placed into one of three categories based on its causal evidence level.4

4 See Appendix 2 for more information about the evidence review process.

Treatment of Stimulant Use Disorders What Research Tells Us 11 Identification of Practices Associated with Treatment of Stimulant Use Disorders

Motivational Interviewing OUTCOMES ASSOCIATED WITH Strong Evidence MOTIVATIONAL INTERVIEWING Studies included in this evidence review Goal demonstrated that use of MI for people with Motivational interviewing (MI) is a treatment approach stimulant use disorders was associated with that helps individuals overcome ambivalent feelings reductions in: and insecurities. In the process, individuals become • Number of days of stimulant use motivated to change their behavior and reduce or stop • Amount of stimulant used per day their stimulant use. All outcomes were measured using either urine Developers of motivational interviewing define it or participant self-report. The time as “a directive, client-centered counselling style between treatment and follow-up varied from for eliciting behavior change by helping clients zero months (immediately post-treatment) to six explore and resolve .”2 months.

Five underlying principles guide how providers should Studies typically included participants who were aged interact with clients while using this practice.2 Providers 18 and older, had no language barriers, and met criteria in should: the Diagnostic and Statistical Manual of Mental Disorders • Express through reflective listening (DSM) for stimulant use disorders either through screening • Identify discrepancies between a client’s goals or self-report. Individuals with cognitive impairment, or values and their current behavior serious mental illness, risk, or inability to provide • Avoid arguments and direct confrontations with informed consent were not included in these studies. a client • Adjust to a client’s resistance rather than This evidence review also included studies, each of which opposing it directly included one of the following participant characteristics: • Support self- and • Adolescents and younger adults (ages 16–22) • Men who have sex with men Typical Settings • Individuals who exhibit co-occurring psychotic Motivational interviewing is effective in a wide range disorders (not requiring acute in- of healthcare settings, from primary healthcare clinics psychiatric services) to general or specialized hospitals. Studies included in • with intentional or unintentional this evidence review tested the effectiveness of MI for traumatic treating people with stimulant use disorders in walk-in health clinics, urban trauma centers, private or university- Practitioner Types run health clinics, community-based health clinics, and Motivational interviewing is intended for use by a wide community-based sites. variety of practitioners, including primary care and behavioral health professionals, peer providers, and Demographic Groups for Intervention criminal justice personnel. Training on MI is available for Motivational interviewing is intended for use across clinicians, non-clinicians, peers, and those with minimal 3-4 genders, ages, races, and ethnicities. This counseling or no training in counseling or therapy. approach can also be used with specific groups within the population, such as men who have sex with men.5

Treatment of Stimulant Use Disorders What Research Tells Us 12 Studies of MI for treating stimulant use disorders Intensity and Duration of Treatment involved clinical staff who were trained in the approach. Use of MI for reducing substance use, and, more These clinicians were either trained community workers specifically, for reducing and ending stimulant use, does or bilingual peers (experienced substance use outreach not have a prescribed time period; it can range from workers who were themselves in recovery). a single session of 15 minutes to multiple hour-long sessions. This review of recent studies shows that there are no generalizable conclusions around the number or length of sessions needed to reduce stimulant use.

Contingency Management OUTCOMES ASSOCIATED WITH Strong Evidence CONTINGENCY MANAGEMENT Studies included in this evidence review Goal demonstrated that use of CM for people with Contingency management (CM) is a type of behavioral stimulant use disorders was associated with therapy grounded in the principles of operant reductions in: conditioning. is a method of • Number of days of stimulant use in which desired behaviors are reinforced with • Stimulant cravings prizes, privileges, or cash. • New stimulant use For treatment of stimulant use disorders, incentivized • HIV risk behaviors behaviors might include: All outcomes were measured using either urine toxicology, participant self-report, or the Addiction • Attendance at treatment sessions Severity Index Scale.11 The time between • to prescribed medications for other treatment and follow-up varied from zero months health conditions (immediately post-treatment) to nine months. • Provision of stimulant-negative urine specimens In a clinical setting, reinforcement is often provided in the web-based, facilitating access for people in geographically form of vouchers that can be exchanged for goods and diverse and difficult to reach places.9-10 services. It may also include access to certain privileges, the opportunity to win a prize, or even direct cash payments. Studies included in this evidence review tested the effectiveness of CM for treating people with stimulant use While CM may be structured in several different ways, disorders at community-based substance use or mental health two widely used approaches include: clinics, private or university-run health clinics, • The Fishbowl Method (popularized by Dr. maintenance facilities, and community-based sites. Two Nancy Petry) where clients who have earned an studies also had a web-based component of CM.11 incentive draw a token from a “fishbowl” for a Demographic Groups for Intervention chance to win a prize of varying value • Voucher-Based Reinforcement Therapy Contingency management is used across genders, ages, (popularized by Dr. Stephen Higgins) where clients races, and ethnicities in both individual and group earn vouchers for completion of desired behaviors settings. The approach can also be used with specific with the level of vouchers increasing according to groups within the population, such as men who have sex an escalating schedule of reinforcement with men, people with co-occurring opioid use disorders, and individuals with severe mental disorders.12-15 Typical Settings A wide range of healthcare settings, including primary Studies included in this evidence review involved adult healthcare clinics, community outpatient programs, and participants who were aged 18 and older, had no language inpatient settings, can use CM effectively.6-8 In addition, barriers, and met criteria in the DSM for stimulant use CM systems have been adapted to be computerized or disorders either through screening or self-report.

Treatment of Stimulant Use Disorders What Research Tells Us 13 Practitioner Types that these staff were trained and tested on CM protocols, A variety of professionals, such as primary care often with the use of scripts or role-. , behavioral health professionals, and criminal Intensity and Duration of Treatment justice personnel, can implement CM.16-18 Training or Contingency management therapy does not have a coursework in behavioral analysis is available to support prescribed time period, as it consists of a reinforcer- implementation of this intervention. based framework often used in combination with other For most studies in this evidence review, research staff, . Many clinical evaluations of CM follow a 12- who may or may not have had clinical backgrounds, week schedule and feature frequent drug screenings (two implemented the CM procedures. Some studies specified to three weekly).

Community Reinforcement Approach OUTCOMES ASSOCIATED WITH Strong Evidence THE COMMUNITY REINFORCEMENT APPROACH Goal Studies included in this evidence review One behavioral therapy approach that is commonly used demonstrated that use of CRA for people with in combination with CM is the community reinforcement stimulant use disorders was associated with approach (CRA). This treatment was originally developed reductions in: by Nathan Azrin and his colleagues for alcohol use • Cocaine disorder, and was later adapted for , • Addiction severity particularly cocaine use. The goal of CRA is to identify • behaviors reinforcing stimulant use and make a substance- Drug use (e.g., number of weeks of usage, frequency per week, amount spent free lifestyle more rewarding than one that includes drugs per week) and alcohol. All outcomes were measured using either CRA includes multiple elements such as such as urine toxicology, participant self-report, or the analyzing clients’ substance use, relationship counseling, Addiction Severity Index Scale. The time between vocational guidance, and job skills training. CRA therapy treatment and follow-up varied from zero months also focuses on building social and drug refusal skills. (immediately post-treatment) to nine months. Ultimately clients are encouraged to make substantial behavioral changes, engage in new recreational activities public outpatient treatment facilities, and urban treatment 19 and develop new social networks. facilities that offer both inpatient and outpatient services. When used in combination with CM, clients who One study also used an online CRA learning program. demonstrate positive behaviors such as drug abstinence, are Demographic Groups for Intervention typically provided material incentives to encourage skills The community reinforcement approach is used across development to build a rewarding substance-free life. genders, ages, races, and ethnicities in both individual and Typical Settings group settings. The adolescent version of CRA involves The community reinforcement approach is often immediate family in the treatment program. There is delivered through inpatient programs, home visits, and also a family training version that aims to increase the in combination with incentives/vouchers. Practitioners client’s engagement in the program through a concerned can also implement it successfully in a typical outpatient significant other. treatment context, where they see clients weekly at a Studies included in this evidence review involved adult 20 clinic. participants who were aged 18 and older, had no language Studies included in this evidence review tested the barriers, and met criteria in the DSM for stimulant use effectiveness of CRA for treating people with stimulant disorders either through screening or self-report. use disorders at community-based substance use clinics,

Treatment of Stimulant Use Disorders What Research Tells Us 14 Practitioner Types For most studies in this evidence review, clinical staff A variety of professionals who possess strong, implemented CRA by following procedures outlined in fundamental counseling skills, such as supportiveness, the manual A Community Reinforcement Plus Vouchers empathy, and a caring attitude, can implement this Approach.21 approach. This could include primary care and Intensity and Duration of Treatment behavioral health professionals as well as . Per the manual mentioned above, CRA recommends a CRA requires therapists to be directive, energetic, and 24-week treatment program. Each week, clients meet one engaging. to two times for counseling and submit two to three urine specimens.21

Cognitive Behavioral Therapy COMPUTER-BASED COGNITIVE Strong Evidence BEHAVIORAL THERAPY A newer approach to CBT uses a digital format Goal for delivery to clients. This format draws on the Cognitive behavioral therapy (CBT) is a short-term, goal- National Institute on Drug Abuse’s CBT manual oriented treatment that enables individuals and offers CBT sessions either online or through to understand their current problems, challenges, and an app. Computer-based CBT can be used in experiences in order to change their behaviors and regular clinical settings as an effective supplement to usual outpatient treatment for stimulant patterns of thinking. CBT helps clients develop accurate dependence.23 assessments of circumstances and their feelings so they can develop realistic strategies. CBT is used also Given the multimedia format of the treatment, it is to address depressive and other cognitive more affordable and can be made more broadly distortions associated with depression, generalized anxiety available than standard therapy treatments. disorders, and substance use disorders. Additionally, computer-based CBT can help reach and serve minority or geographically remote Through CBT, people with stimulant use disorders are groups who may have limited access to such trained to evaluate faulty patterns of thinking, actions, services. and negative feelings associated with their drug use. CBT is tailored to the needs of the individual, with the goals

Treatment of Stimulant Use Disorders What Research Tells Us 15 of each therapy session uniquely based on the client’s Practitioner Types experiences with stimulant use and personal circumstances. A variety of professionals trained in CBT principles can implement it, such as behavioral health professionals, Typical Settings primary care staff, and criminal justice personnel. The Practitioners can use CBT effectively in a wide range National Association of Cognitive-Behavioral Therapists of healthcare settings, from inpatient psychiatric offers CBT training for mental health professionals, as rehabilitation to community outpatient programs.22 well as non-professionals with a four-year college degree. Studies included in the current evidence review looked In the studies included in the current evidence review, at CBT’s use in private health clinics, community-based trained clinicians delivered all in-person CBT sessions. outpatient treatment programs, outpatient methadone programs, and through online formats. 23 Intensity and Duration of Treatment Cognitive behavioral therapy is typically customized to OUTCOMES ASSOCIATED WITH the needs of each individual. Most people who seek CBT TRADITIONAL AND COMPUTER- for stimulant use disorders receive counseling for a period BASED COGNITIVE BEHAVIORAL ranging from 5 to 10 months. THERAPY A standard therapeutic session is approximately 50 Studies included in this review demonstrated minutes. During this time, the therapist and client work that CBT or computer-based CBT for people with together to understand existing thought patterns associated stimulant use disorders were associated with with the client’s current problems and develop strategies reductions in: to overcome those concerns. Group counseling rarely • Quantity of stimulants consumed per week utilizes CBT. • Frequency of stimulant use per week • Risky sexual behaviors All outcomes were measured using either urine toxicology, participant self-report, or the Addiction Severity Index Scale. The time between treatment and follow-up varied between zero months (immediately post-treatment) to 12 months.

Demographic Groups for Intervention Cognitive behavioral therapy is a widely used approach, employed across genders, ages, races, and ethnicities.24 Studies reviewed for this guide included participants aged 18 and older who met DSM criteria for stimulant use and dependence, and who did not have any other mental illness or psychotic disorder needing more intensive or targeted treatment and only one study focused on men who have sex with men.

Treatment of Stimulant Use Disorders What Research Tells Us 16 Summary of Evidence Review

Practice Motivational Contingency Community Cognitive Behavioral Interviewing Management Reinforcement Therapy Approach Review rating Strong Evidence Strong Evidence Strong Evidence Strong Evidence Focus of the practice Resolving clients’ Positively Identifying behaviors Helping clients improve ambivalent feelings reinforcing desired that reinforce stimulant the quality of their lives and insecurities behaviors use and making a not by changing their and enhancing the substance-free lifestyle circumstances, but internal more rewarding than one altering their needed to change that includes substances of those circumstances their behavior Can be used in outpatient healthcare     settings Can be used in inpatient healthcare     settings Specific training  --   available Web-based version --    available Can be practiced by  ------peers Has been used successfully with     males and females Special populations Men who have sex Men who have Adolescents -- with whom the with men sex with men; practice has Co-occurring been successfully opioid use implemented disorder; Severe mental disorders Intensity and Duration No prescribed No prescribed No prescribed No prescribed intensity of Treatment intensity and duration intensity and intensity and duration; and duration; typical duration; typically recommended for 24 range of 5 to 10 months 12 weeks weeks

Treatment of Stimulant Use Disorders What Research Tells Us 17 Reference List

1 De Giorgi, R., Cassar, C., D’alò, G. L., Ciabattini, 9 McPherson, S. M., Burduli, E., Smith, C. L., Herron, M., Minozzi, S., Economou, A., Tambelli, R., J., Oluwoye, O., Hirchak, K., Orr, M. F., McDonell, Luchese, F., Saulle, R., Amato, L., Janiri, L., & De M. G., & Roll, J. (2018). A review of contingency Crescenzo, F. (2018). Psychosocial interventions management for the treatment of substance-use in stimulant use disorders: A systematic review and disorders: Adaptation for underserved populations, qualitative synthesis of randomized controlled trials. use of experimental , and personalized Rivista Di Psichiatria, 53(5), 233-255. optimization strategies. Substance Abuse and 2 Miller, W. R., & Rollnick, S. (1991). Motivational Rehabilitation, 9, 43. interviewing: Preparing people to change addictive 10 Kurti, A. N., Davis, D. R., Redner, R., Jarvis, B. behaviour. New York: Guilford Press. P., Zvorsky, I., Keith, D. R., Bolivar, H. A., White, 3 DiClemente, C. C., Corno, C. M., Graydon, M. T. J., Rippberger, P., Markesich, C., Atwood, G., M., Wiprovnick, A. E., & Knoblach, D. J. (2017). & Higgins, S. (2016). A review of the literature on Motivational interviewing, enhancement, and brief remote monitoring in incentive-based interventions over the last decade: A review of interventions for health-related behavior change. reviews of efficacy and effectiveness. of Translational Issues in Psychological Science, 2(2), Addictive Behaviors, 31(8), 862. 128-152. 11 4 Lundahl, B., Moleni, T., Burke, B. L.Butters, R., McLellan, A. T., Luborsky, L., Woody, G. E., & Tollefson, D., Butler, C., & Rollnick, S. (2013). O’Brien, C. P. (1980). An improved diagnostic Motivational interviewing in medical care settings: A evaluation instrument for substance abuse patients: systematic review and meta-analysis of randomized The Addiction Severity Index. Journal of Nervous controlled trials. Patient Education and Counseling, and Mental Disease, 168 (1), 26-33. 93(2), 157-168. 12 Menza, T. W., Jameson, D. R., Hughes, J. P., 5 Parsons, J. T., Rosof, E., Punzalan, J. C., & Maria, L. Colfax, G. N., Shoptaw, S., & Golden, M. R. D. (2005). Integration of motivational interviewing (2010). Contingency management to reduce and cognitive behavioral therapy to improve HIV methamphetamine use and sexual risk among men medication adherence and reduce substance use who have sex with men: A randomized controlled among HIV-positive men and women: Results of a trial. BMC Public Health, 10(1), 774-786. pilot project. AIDS Patient Care & STDs, 19(1), 31- 13 Peirce, J. M., Petry, N. M., Stitzer, M. L., et al. 39. (2006). Effects of lower-cost incentives on stimulant 6 Hagedorn, H. J., Noorbaloochi, S., Simon, A. abstinence in treatment: A B.Bangerter, A., Sitzer, M. L., Stetler, C. B., & national drug abuse treatment clinical trials network Kivlahan, D. (2013). Rewarding early abstinence in study. Archives of General Psychiatry, 63(2), 201- Veterans Health Administration addiction clinics. 208. Journal of Substance Abuse Treatment, 45(1), 109- 14 Petry, N. M., Alessi, S. M., & , C. J. (2013). 117. A randomized study of contingency management 7 Henggeler, S. W., Halliday-Boykins, C. A., in cocaine-dependent patients with severe and Cunningham, P. B., Randall, J., Shapiro, S. B., & persistent mental health disorders. Drug & Alcohol Chapman, J. E. (2006). Juvenile drug court: Enhancing Dependence, 130(1-3), 234-237. outcomes by integrating evidence-based treatments. 15 Bellack, A. S., Bennett, M. E., Gearon, J. S., Brown, Journal of Consulting and , 74(1), C. H., & Yang, Y. (2006). A randomized clinical 42. trial of a new behavioral treatment for drug abuse 8 Barry, D., Sullivan, B., & Petry, N. M. (2009). in people with severe and persistent mental illness. Comparable efficacy of contingency management Archives of General Psychiatry, 63(4), 426-432. for among African American, Hispanic, and White methadone maintenance clients. Psychology of Addictive Behaviors, 23(1), 168-174.

Treatment of Stimulant Use Disorders What Research Tells Us 18 16 Hartzler, B., Lash, S. J., & Roll, J. M. (2012). 21 Budney, A., & Higgins, S. (1998). A community Contingency management in substance abuse reinforcement plus vouchers approach: Treating treatment: A structured review of the evidence for cocaine addiction (NIH Publication No. 98-4309). its transportability. Drug and , Rockville, MD: National Institute on Drug Abuse. 122(1-2), 1-10. 22 Randall, M., & Finkelstein, S. H. (2007). Integration 17 Marlowe, D. B., Festinger, D. S., Dugosh, K. of cognitive behavioral therapy into psychiatric L., Arabia, P. L., & Kirby, K. C. (2008). An rehabilitation day programming. Psychiatric effectiveness trial of contingency management in Rehabilitation Journal, 30(3), 199. a felony preadjudication drug court. Journal of 23 Carroll, K. M., Ball, S. A., Martino, S., Nich, Applied Behavior Analysis, 41(4), 565-577. C., Babuscio, T. A., Nuro, K. F., Gordon, M. A., 18 Prendergast, M. L., Hall, E. A., Roll, J., & Warda, Portnoy, G. A., Rounsaville, B. J. (2008). Computer- U. (2008). Use of vouchers to reinforce abstinence assisted delivery of cognitive-behavioral therapy and positive behaviors among clients in a drug court for addiction: A randomized trial of CBT4CBT. treatment program. Journal of Substance Abuse American Journal of Psychiatry, 165(7), 881-888. Treatment, 35(2), 125-136. 24 Graham, J. R., Sorenson, S., & Hayes-Skelton, S. 19 Shearer, J. (2007). Psychosocial approaches to A. (2013). Enhancing the cultural sensitivity of psychostimulant dependence: A systematic review. cognitive behavioral interventions for anxiety in Journal of Substance Abuse Treatment, 32(1), 41-52. diverse populations. The Behavior Therapist, 36(5), 20 Miller, W. R., Meyers, R. J., & Hiller-Sturmhöfel, 101. S. (1999). The community-reinforcement approach. Alcohol Research & Health, 23(2), 116-121.

Treatment of Stimulant Use Disorders What Research Tells Us 19 CHAPTER 3

Guidance for Selecting and Implementing Evidence-based Practices

This chapter provides information for clinicians, program administrators, and other stakeholders interested in implementing a therapy practice to treat stimulant use disorders. It documents some clinical issues and concerns health professionals may encounter when engaging and treating people with a stimulant use disorder, as well as some strategies to address those concerns. When clients using stimulants initiate treatment, they may present multiple medical and clinical symptoms. Practitioners should be aware of these issues, consider them thoroughly for each individual client, and address them effectively before beginning any therapy. For therapy to be successful, these clinical issues must be addressed not only at the beginning of treatment, but throughout the therapeutic engagement.

Following a review of the clinical considerations for treating people with a stimulant use disorder, the chapter provides information about specific implementation challenges that stakeholders may encounter when implementing a new therapy practice. The chapter includes various strategies to overcome these challenges, along with examples from the practices reviewed in Chapter 2.

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 20 Clinical Issues to Consider When Treating Stimulant Use Disorders There are a number of issues that can present practitioners with clinical challenges and should be considered before making decisions regarding treatment planning. The table below summarizes the most common clinical issues encountered and strategies to manage them.

CLINICAL ISSUE MANAGEMENT STRATEGY Polydrug use An individual may use multiple substances • Consider the pharmacological, psychosocial, to enhance the physical or psychological and behavioral reasons for combining certain effects of each drug, to counteract the substances, evaluate for the presence of effects of one or more drugs, to prolong other substance use disorders, and implement a drug’s effects, or to experience a new targeted treatment options addressing all effect. substances for people who use multiple drugs. Overdose risk Individuals who intentionally or • Assess client awareness of dangers from unknowingly mix stimulants with fentanyl fentanyl and educate about risks. have an increased risk for overdose. • Train program staff, clients, and family members on naloxone use and make naloxone available to clients, their families, and the community.

• Monitor clients closely for symptoms from fentanyl (or ) mixed with methamphetamine or cocaine. Intoxication Stimulants increase euphoria, • “Talk down” the client in a calm environment. hyperexcitability, , locomotor activity, agitation, and psychotic • For clients who exhibit severe symptoms symptoms, including paranoia and of intoxication, consider pharmacological . treatment, for example , for acute management of agitation and distress, medication for psychosis/paranoia/ hallucinations. Co-occurring mental One of the challenges practitioners face is • Consider integrated treatment options and stimulant use making a distinction between independent regardless of the underlying cause for the dual disorders psychiatric disorders, psychiatric disorders diagnosis. as a result of the stimulant use, and psychiatric symptoms that arise from • Since lack of adequate treatment for either intoxication and withdrawal. disorder may interfere with an individual’s overall recovery, coordinate services between stimulant use disorder therapists and mental health providers if stimulant disorder treatment staff do not treat mental disorders. Psychosis Stimulant use can result in psychotic • Consider either or an symptoms, such as auditory and visual antipsychotic medication to address acute hallucinations and paranoia. Stimulant- symptoms. induced psychosis is generally transient; however, methamphetamine can produce • Consider continuation of antipsychotic persistent psychosis like . medications for long-term management of persistent psychosis.

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 21 CLINICAL ISSUE MANAGEMENT STRATEGY Violence Methamphetamine use increases chance • Be aware of the relationship between stimulant of violent behavior.1 use and violence and be of the consequences of violence on individuals using stimulants, their families, program staff, and other program participants. Cognitive deficits Stimulant misuse to attention and • Inform clients about cognitive deficits and use memory problems that can interfere with strategies that provide repetition of information functioning and treatment approaches that and do not depend on optimal memory. involve learning. • Reserve treatments that require more complex cognitive functioning until a client’s is restored after a period of abstinence.

Stimulant withdrawal As an individual stops stimulant use, • Encourage rest, mild/moderate , and a he or she may experience symptoms to manage withdrawal. like severe fatigue, insomnia, cognitive impairment, feelings of depression, anxiety, loss of energy, confusion, the inability to feel pleasure, and paranoia.2 Individuals may experience cravings • Educate clients in treatment about the powerful associated with specific cues, such as impact of cue-induced cravings and help them objects (e.g., cash), people (e.g., drug identify strategies to avoid situations in which user friends), other substances (e.g., there are “triggers.” alcohol), places (e.g., areas where stimulants are sold or used), time periods (e.g., weekends, after work), and emotional states (e.g., depression, ).3 Withdrawal may result in hypersexuality • Educate clients about the possibility of changes and impaired sexual functioning, leading in sexual function during early recovery. to psychological distress.4 Severity of disorder Clients may receive treatment services • Evaluate the clients’ needs and ensure that that and level of care at various levels within the continuum they receive services at the appropriate level of care; levels ranging from prevention and then step up to more intense treatment or and early intervention to inpatient and down to less intense treatment as needed. residential services. Assessing the required level of care for each client based on the severity of client’s disorder is critical.

Engaging and treating people actively using stimulants, in withdrawal, or in early recovery is challenging. Understanding the experience of the clients in conjunction with clinical concerns is essential for planning and implementing therapy practices to meet client needs.

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 22 ROLE OF IMPLEMENTATION SCIENCE IN HELPING PROGRAMS Implementation ADDRESS IMPLEMENTATION Challenges and Strategies BARRIERS In addition to the important clinical concerns for this Implementation science is the study of methods to promote the uptake of proven clinical practices, population, practitioners, administrators, and community programs, organizational interventions, and leaders will be most successful if they understand specific policies, with the goal of improving health. Use of challenges and strategies for successful implementation the Consolidated Framework for Implementation of new practices. The following section provides details Research (CFIR) is one way programs can on specific challenges programs could face as they conceptualize constructs associated with successful implement therapy practices, strategies to deal with those program implementation. Programs can use CFIR challenges, and the role of implementation science in as they plan and execute new programs. enhancing practice implementation. The five main domains of CFIR are: When implementing interventions to address stimulant - Includes the use disorders, there are several potential barriers to Intervention Characteristics components and attributes of the intervention, such consider. Issues related to implementing motivational as cost, strength of evidence, and complexity interviewing (MI), contingency management (CM), community reinforcement approach (CRA), and cognitive Outer Setting - Consists of the external factors that behavioral therapy (CBT) include: may implementation, including the policy and in effect, patients’ needs and resources, 1. Practice selection and the sources of implementation pressure 2. Funding, financing, and program cost 3. Program staffing Inner Setting - Considers the characteristics of 4. Coordination of care the facility contemplating implementation of a new 5. Cultural adaptation of the practice program, including the organizational culture, available resources for implementation, and the These challenges are described in detail below, along with facility’s overall structure potential actions to mitigate them. Characteristics of Individuals - Includes the Practice Selection attributes of individuals making up the organization Challenge: contemplating program implementation, and includes aspects like staff attitudes towards the Choosing the right intervention based on the severity of proposed intervention, self-efficacy to adopt new client’s illness and where they are in the addiction cycle. programs, and of the facility itself

Strategies: Process - Consists of the stages and constructs • The effectiveness of various treatment related to implementation, namely planning, interventions may be influenced by the clients’ engaging, executing, reflecting, and evaluating stage in the addiction cycle. It is necessary (constructs explain how a course of action for to consider the issue of psychosis and brain implementation is charted and carried out) functioning related to active and recent stimulant Programs can use CFIR to identify both barriers and use when choosing an intervention for stimulant factors conducive to implementation. This allows use disorders. programs to design a detailed strategies when • MI can help clients decide to enter treatment and considering new therapy practices.6 serve as a starting point in the recovery process.5 While often implemented successfully at the early stages of treatment, due to its as an add-on component to other interventions, practitioners can apply motivational strategies throughout the recovery process.6

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 23 • Many state Medicaid, Medicare, and private According to the Surgeon General’s Report on insurance entities may not reimburse CM Alcohol, Drugs, and Health, the three stages of and computer-based CBT treatments. addiction are: Reimbursement for both these therapies requires careful coordination with funding agencies. 1. Binge and Intoxication - The stage at which an individual consumes an Strategies: intoxicating substance and experiences its • CM costs can be reduced by limiting access to rewarding or pleasurable effects only those who test positive for stimulants at 2. Withdrawal and Negative Affect - The admission, or by discontinuing the approach stage at which an individual experiences a when practitioners observe no client response to negative emotional state in the absence of treatment.9 the substance • Computer-based CBT has potential to substantially 3. Preoccupation and - reduce healthcare costs.10-11 Automated versions The stage at which an individual seeks of CM have also proven effective and can reduce substances again after a period of costs of tracking participants’ urine and prize abstinence draw outcomes.12 As internet and computer access Some interventions are better suited at the increase, these treatment options will be more starting point of recovery within the early stages of accessible, particularly for clients in rural and 9 stimulant misuse, whereas others can be tailored remote locations. • for the end of the addiction cycle, specifically for Additional funding sources, such as federal, prevention and treatment. state, and private grants, as well as contributions from or opportunities to share costs with community partners can help overcome barriers • CM can serve as a source of positive to funding CM reinforcers. reinforcement for clients in the beginning stages • SAMHSA suggests soliciting in-kind donations of recovery.7 It can be combined with other (which might prove particularly effective at therapies, such as CRA and vouchers, to enhance providing CM incentives) and make use of duration of recovery.8 volunteers or internships to cut costs.13 • CBT can be successfully applied at any stage of the addiction cycle or encompass the full Program Staffing cycle. CBT consists of various modules and Challenges: add-ons (e.g., homework) that practitioners can • It is vital that properly trained staff be available specifically tailor to the client. to successfully implement a new treatment Funding, Financing, and Program Cost program or practice and to build program Challenge: capacity. However, this may be difficult to achieve due to staff turnover and limited time for Obtaining funding to implement treatment practices for staff to become familiar with the program. stimulant use disorders is a common challenge. • Practitioners without clinical backgrounds can deliver MI and CM. In contrast, CBT is often • Practices to treat stimulant use disorders have delivered by clinically trained professionals. several associated costs, including: Further, CBT is complex to administer, making Planning implementation o it difficult to adapt and tailor to a particular o Training practitioners or interventionists setting.9 o Performing related tasks like urinalysis • Ongoing supervision and reflective practice screens are essential elements for most stimulant use Providing incentives or other behavioral disorder interventions to ensure fidelity of o 14-15 reinforcement implementation. o Making any necessary technological en- hancements

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 24 Strategies: social determinants of health and providers • Computer-based CBT can be a viable substitute should attempt to integrate resources and social for in-person CBT, as it requires minimal staff supports from the client’s community. assistance and has a degree of flexibility in • Stimulant use treatment providers are well implementation. positioned to support systemic changes to • Self-study and the “train-the-trainer” method address social determinants in their community. can help practitioners learn how to conduct MI, Providers and other stakeholders can identify though with varying degrees of effectiveness.16 gaps in services and promote additional While self-study does not require an instructor, resources to improve social and economic a train-the-trainer approach entails sending staff conditions of their clients. to an expert-led workshop. After learning the Cultural Adaptation of Practices practice from an expert, these staff typically complete a certification process to become Challenge: trainers themselves and then train other staff. • Behavior change interventions are most effective • Having a facilitator—whether an external or when they are responsive to the clients’ cultural internal supervisor—can be a key factor in practices and ideologies.21-22 successfully implementing practices for stimulant • When behavior change interventions are adapted use disorders. For example, practitioners using MI to make them responsive to clients’ needs, program typically need three or four coaching sessions.14 staff may find it challenging to adhere to the fidelity of the practice. They may find it difficult Coordination of Care to maintain the core elements and foundational Challenge: principles of the practice during implementation. • Individuals with stimulant use disorders may have other health care needs such as HIV17 or Cultural adaptation of interventions has been life situations affecting their health and recovery defined as “the systematic modification of an (e.g., experiencing homelessness).18 Substance evidence-based treatment (EBT) or intervention use disorders and recovery from them are often protocol to consider language, culture, and associated with social determinants of health context in such a way that it is compatible with the such as income and housing instability. client’s cultural patterns, meanings, and values.”21 Culturally adapted health interventions are more Strategies: effective than usual care.22 • Using a whole-person approach, practitioners need to coordinate treatment for stimulant use disorders with care for clients’ other health Strategies: needs. • Motivational techniques are adaptable for • Models focused on care coordination, including different cultures. The processes of change and physical, mental, behavioral, and stimulant- motivational enhancement can be tailored to the use-specific services are more successful than values, beliefs, and experiences of individuals those attempting to treat only the stimulant use within different ethnic and racial categories. disorder.19 • To ensure adapted practices are implemented • Whenever possible, co-location of stimulant with their core elements upheld, it is incumbent use disorder treatment with primary care and on those doing the adaptation to collect rigorous other services allows for improved coordination data to assess the intervention for fidelity to the between physical and mental health care.20 practice. • Other life circumstances, such as low income, • When programs are not able to maintain fidelity experiencing homelessness, , to the established practice, a rigorous evaluation and child maltreatment, also affect the of the adapted practice provides evidence of the success of stimulant use disorder treatment. impact of the adapted practice on stimulant use. Coordination of care should encompass these

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 25 • For American Indian/Alaska Native Contingency Management: Using Motivational communities, the focus of motivational Incentives to Improve Drug Abuse Treatment provides interviewing on an equal or balanced an overview of CM principles, a case study of a program relationship between the therapist and the using CM, and guidance regarding how to implement 23 client seems to fit well with cultural norms. and supervise CM procedures. Motivational interviewing can also be readily incorporated into tribal practices like Talking The Contingency Management Competence Scale is Circles and Sweat Lodge Ceremonies.24 available for both treatments reinforcing abstinence and attendance. The scale is intended to be used as a fidelity Practice Resources tool, and the associated manual provides suggestions for optimal implementation of CM. In addition to the introductory, overarching implementation guidance provided above, there are Contingency Management Incentives for Sobriety several manuals and resources developed specifically to provides an overview of CM, its early research, and help stakeholders implement the practices described in the research supporting its use in treating alcohol use Chapter 2. Please note that this guide is not intended to be disorders and polydrug use. a training manual, but additional resources are available to Developing a Measure of Therapist Adherence to support implementation of these practices Contingency Management: An Application of the Many- Facet Rasch describes the development of an Motivational Interviewing Resources adherence tool for CM. Motivational Interviewing Network of Trainers (MINT) is an international organization affiliated with the developers Identifying Provider Beliefs Related to Contingency of MI, Bill Miller and Steve Rollnick. The website has Management Adoption Using the Contingency resources for MI trainings and upcoming events. Management Beliefs Questionnaire describes the development of a 32-item questionnaire used to assess TIP 35: Enhancing Motivation for Change in Substance providers’ beliefs regarding CM treatment interventions. Use Disorder Treatment is a SAMHSA publication outlining motivational strategies and how to use them in Community Reinforcement Approach (CRA) treating substance use disorders. Resources A Community Reinforcement Plus Vouchers Approach: Motivational Interviewing Supervision and Training Scale Treating Cocaine Addiction describes how to implement (MISTS), Motivation Interviewing Skill Code (MISC), a CRA that adds a voucher component, primarily with Assessment of Motivational Interviewing Groups— cocaine-using populations. The manual describes the Observer Scale (AMIGOS) and Motivational Interviewing clinical treatment approach, as well as tips related to co- Treatment Integrity (MITI) are all measures for evaluating occurring psychiatric disorders and treatment supervision. various aspects of MI practice. The Community Reinforcement Approach provides an Contingency Management Resources overview of CRA and the research supporting its efficacy. Motivational Incentives-A Proven Approach to Treatment Chestnut Health Systems EBTx Center offers training and provides information and resources on the implementation certification for CRA and Adolescent CRA. of CM practices. This includes an initial training, an interactive online course, and free software for managing Robert J. Meyers Website from one of the developers of CM clients. CRA, includes background information for the practice, details of ongoing trainings, and links to relevant A Treatment Manual for Implementing Contingency publications. Management provides a CM treatment manual that gives attention to prisoner and parolee populations.

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 26 Community Reinforcement and Family Training, Support and Prevention (CRAFT-SP) provides a treatment manual for CRAFT, an outgrowth of CRA. The manual outlines seven treatment sessions and describes the theoretical framework for the intervention. Cognitive Behavioral Therapy (CBT) Resources Academy of is a group of mental health professionals practicing CBT. The website provides multiple resources for both administrators and clients, training, and certification for CBT administrators. It also offers assistance with program implementation.

Beck Academy offers training and certification for CBT administrators (i.e., professionals, educators, graduate students). The website includes online training courses, in-person workshops, newsletters, and other resources. It also offers assistance with program implementation and utilizing supervisors and consultants.

SAMHSA Website provides CBT guidelines, training manuals, toolkits, workbooks, and training modules. It also includes resources for implementing CBT with specific populations and for specific applications (e.g., substance use disorders, management, mental health issues). Resources are also available in multiple languages like Spanish and Chinese.

CBT4CBT is a self-guided, web-based program with various online modules. The program can be accessed through provider or client log-in (paid access). The website also has an additional CBT toolkit available for purchase.

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 27 Reference List

1 McKetin, R., Lubman, D. I., Najman, J. M., Dawe, 10 Olmstead, T. A., Ostrow, C. D., & Carroll, K. M. S., Butterworth, P., & Baker, A. L. (2014). Does (2010). Cost-effectiveness of computer-assisted methamphetamine use increase violent behaviour? training in cognitive-behavioral therapy as an Evidence from a prospective longitudinal study. adjunct to standard care for addiction. Drug and Addiction, 109(5), 798-806. Alcohol Dependence, 110(3), 200-207. 2 Wise, R. A. (2008). Dopamine and reward: The 11 Hedman, E., Ljótsson, B., & Lindefors, N. (2012). anhedonia hypothesis 30 years on. Cognitive behavior therapy via the Internet: A systematic Research, 14(2-3), 169-183. review of applications, clinical efficacy and cost– 3 Childress, A. R., Mozley, P. D., McElgin, W., effectiveness. Expert Review of Pharmacoeconomics & Fitzgerald, J., Reivich, M., & O’brien, C. P. (1999) . Outcomes Research, 12(6), 745-764. Limbic activation during cue-induced cocaine craving. 12 Ghitza, U. E., Epstein, D. H., Schmittner, J., American Journal of Psychiatry, 156(1), 11-18. Vahabzadeh, M., Lin, J. L., & Preston, K. L. (2007). 4 Rawson, R. A., Gonzales, R., & Brethen, P. (2002). Randomized trial of prize-based reinforcement Treatment of methamphetamine use disorders: An density for simultaneous abstinence from cocaine update. Journal of Substance Abuse Treatment, and heroin. Journal of Consulting and Clinical 23(2), 145-150. Psychology, 75(5), 765-774. 13 5 Center for Substance Abuse Treatment. (1999). Center for Substance Abuse Treatment. (2009). Enhancing motivation for change in substance abuse Implementing change in substance abuse treatment treatment. Rockville, MD: Substance Abuse and programs. Rockville, MD: Substance Abuse and Mental Health Administration. Mental Health Administration. 14 6 Keith, R. E., Crosson, J. C., O’Malley, A. S., Cromp, Schwalbe, C. S., Oh, H. Y., & Zweben, A. (2014). D., & Taylor, E. F. (2017). Using the Consolidated Sustaining motivational interviewing: A meta‐analysis Framework for Implementation Research (CFIR) of training studies. Addiction, 109(8), 1287-1294. to produce actionable findings: A rapid-cycle 15 Kauth, M. R., Sullivan, G., Blevins, D., Cully, J. evaluation approach to improving implementation. A., Landes, R. D., Said, Q., & Teasdale, A. (2010). Implementation Science, 12(1), 15. Employing external facilitation to implement 7 Hirchak, K. A., Leickly, E., Herron, J., et al. (2018). cognitive behavioral therapy in VA clinics: A pilot Focus groups to increase the cultural acceptability study. Implementation Science, 5(1), 75. of a contingency management intervention for 16 Olmstead, T., Carroll, K. M., Canning-Ball, M., & American Indian and Alaska Native Communities. Martino, S. (2011). Cost and cost-effectiveness of Journal of Substance Abuse Treatment, 90, 57-63. three strategies for training clinicians in motivational 8 Secades‐Villa, R., Sánchez‐Hervás, E., Zacarés‐ interviewing. Drug and Alcohol Dependence, 116(1- Romaguera, F., García‐Rodríguez, O., Santonja‐ 3), 195-202. Gómez, F. J., & García‐Fernández, G. (2011). 17 Novak, R. M., Metch, B., Buchbinder, S., et al. Community Reinforcement Approach (CRA) for (2013). Risk behavior among women enrolled in a cocaine dependence in the Spanish public health randomized controlled efficacy trial of an adenoviral system: 1 year outcome. Drug & Alcohol Review, vector to prevent HIV acquisition: The Step 30(6), 606-612. Study. AIDS, 27(11), 1763. 9 Carroll, K. M. (2014). Lost in ? Moving 18 Riley, E. D., Cohen, J., Knight, K. R., Decker, contingency management and cognitive behavioral A., Marson, K., & Shumway, M. (2014). Recent therapy into clinical practice. Annals of the New York violence in a community-based sample of homeless Academy of , 1327(1), 94-111. and unstably housed women with high levels of psychiatric . American Journal of Public Health, 104(9), 1657-1663.

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 28 19 O’Brien, P., Crable, E., Fullerton, C., & Hughey, L. (2019). Best practices and barriers to engaging people with substance use disorders in treatment. Washington, DC: U.S. Department of Health and Human Services. 20 SAMHSA-HRSA Center for Integrated Health . (n.d.). Standard framework for levels of integrated healthcare. Retrieved June 6, 2020, from https://www.thenationalcouncil.org/integrated- health-coe/resources/ 21 Bernal, G., Jiménez-Chafey, M. I., & Domenech Rodríguez, M. M. (2009). Cultural adaptation of treatments: A resource for considering culture in evidence-based practice. Professional Psychology: Research and Practice, 40(4), 361. 22 Barrera Jr, M., Castro, F. G., Strycker, L. A., & Toobert, D. J. (2013). Cultural adaptations of behavioral health interventions: A progress report. Journal of Consulting and Clinical Psychology, 81(2), 196. 23 Venner, K. L., Feldstein, S. W., & Tafoya, N. (2006). Native American motivational interviewing: Weaving Native American and western practices. Washington, DC: National Institute on and . 24 Tomlin, K., Walker, R., Grover, J., Arquette, W., & Stewart, P. (2014). Motivational interviewing: Enhancing motivation for change--A learner’s manual for the American Indian/Alaska Native counselor. Rockville, MD: Substance Abuse and Mental Health Services Administration.

Treatment of Stimulant Use Disorders Guidance for Selecting and Implementing Evidence-based Practices 29 CHAPTER 4

Examples of Stimulant Use Treatment Programs

This chapter highlights three community examples of Although the programs highlighted below are population program models providing treatment services and support specific, the practices they implement have strong to people with a stimulant use disorder and documents how evidence, target a range of stimulants, and can successfully each uses one or more of the practices with strong evidence serve a wide range of geographically, racially, and detailed in Chapter 2: ethnically diverse populations. These programs are meant • Motivational Interviewing to be implementation examples and have not been subject • Contingency Management to rigorous evaluation. • Community Reinforcement Approach To be included in this chapter, programs had to: • Cognitive Behavioral Therapy • Implement one or more of the practices The chapter describes how each program has implemented identified in Chapter 2 these practices as part of a comprehensive strategy to • Be replicable (well-defined with guidance address the needs of their populations. materials or a manual) • Have research to support their impact on Programs should implement practices with fidelity to stimulant use evaluated models. Fidelity is the degree to which a • Provide appropriate and effective interventions program delivers a practice as intended and must be for varied stimulant types, geographic areas, maintained for desired therapy outcomes. However, many practice settings, and diverse populations programs adapt chosen practices to better serve their clients. As practitioners modify these practices to address the needs and constraints of their population, budget, setting, and other local factors, they should adhere to the practice’s foundational principles.

The three programs in this chapter were identified through an environmental and in consultation with experts. At this time, each of the programs predominantly serves a distinct population, namely people experiencing homelessness, members of a federally recognized tribe, and gay and bisexual men who have sex with men (MSM).

Treatment of Stimulant Use Disorders Examples of Stimulant Use Treatment Programs 30 Homeless Person Health Project (HPHP) County Health Services Agency (Santa Cruz County, CA) www.santacruzhealth.org

The HPHP primary care facility provides CM as an optional component of the Medication-Assisted Treatment Practice implemented by program (MAT) Program. The CM program was initially introduced Contingency Management as a 12-week pilot to address the needs of polydrug Setting users and former users who were struggling with methamphetamine. MAT patients who have positive urine Outpatient; Organization is a full-service, primary drug screens, with exception of and THC, care center serving the needs of homeless and low-income populations in Santa Cruz County. are eligible for the program and can opt-in by signing a patient agreement form during intake. Population of Focus

The program employs the “fishbowl” method of CM. People experiencing homelessness receiving MAT for stimulant use. Typical clients are males, Participants with negative weekly or biweekly urine samples Caucasians, with ages ranging from 20 to 60 years. are eligible for one to three weekly drawings. Drawings offer $5 to $50 gift cards, or positive affirmations, and occur Program Duration during the program’s group psychotherapy sessions provided One session is considered 12 weeks. as a part of the MAT program. Related Resources The program was initially launched in early 2019 at a Center for Care Innovations Webinar on clinic run by the Health Services Agency of the County Contingency Management: https://www. of Santa Cruz and is led by the MAT clinic nurse. The careinnovations.org/resources/webinar- program has since expanded to the Agency’s two other contingency-management/ clinics. It began with 20 to 25 participants and a total project budget of about $750 for a 12-week session.

Model Features and Elements • CM Patient Agreement to facilitate voluntary enrollment and ensure patient understanding of the program. • Active outreach by program staff in their community to build rapport with people experiencing homelessness and make their transition into the program easier. • Weekly or biweekly urine drug screens. • Weekly “fishbowl” drawings for $5 to $50 gift cards and positive affirmations for clients with negative urine drug screens. • Weekly group psychoeducation sessions using a variety of manualized programs, such as “Seeking Safety,” an evidence-based, present- focused counseling model to help people attain safety from trauma and substance use. • Twelve-week cycles with the option to continue to a new cycle depending on stage of recovery.

Treatment of Stimulant Use Disorders Examples of Stimulant Use Treatment Programs 31 Findings and Outcomes Lessons Learned • Data before and after treatment indicated an • Use grants to obtain resources needed to increase in negative urine drug screens, from 41.6 implement the program. Nonprofit clinics and percent at baseline to 72 percent at week 48. programs can also ask for donations. • Less frequent use documented through client • Start small. Implementation of CM can vary self-report. with every program. Adaptation of CM runs • Increased client attendance. the risk of diminishing the efficacy of the • Patient empowerment evidenced by optimistic intervention. When possible adhere as closely attitudes about sobriety (e.g., client reactions as possible to established guidelines. When such as “I’ll get it next time” at not receiving a implemented in an integrated primary care gift card). setting, consider including stimulant data in • Positive patient engagement with the program electronic medical records of the client. (e.g., excitement about sessions, clapping to support peers when drawing from the lottery).

Treatment of Stimulant Use Disorders Examples of Stimulant Use Treatment Programs 32 Rosebud Sioux Tribe Alcohol and Drug Treatment Program, Methamphetamine Rehabilitation Program

The Rosebud Sioux Tribe Alcohol and Drug Treatment Program’s Methamphetamine Rehabilitation Program Practice implemented by program (MRP) is based on the Seven Direction Model developed The Spirit of Motivational Interviewing by Ed Parsells, in consultation with cultural and spiritual Setting leaders, and uses the underlying principles of MI. In-patient services on the Rosebud Sioux Tribe Program staff are trained in and use MI principles during Reservation in South Dakota. Staff include therapeutic sessions with clients. Staff adopt a non-directive counselors, treatment technicians, case style of interaction, allow the client to challenge them, managers, and , all of whom are ask questions that engage clients, and encourage clients to enrolled tribal members. examine and assess their own behaviors. Staff practice the Population of Focus MI technique of empathy while working with clients. Members of any federally recognized tribe. The Lakota Seven Direction Model is based on the belief that spirituality is the foundation for recovery. It relies Program Duration heavily on the concept of conscience and the role it plays Seven weeks of Lakota Seven Direction Model. in stimulant misuse treatment. The program runs for seven The program recommends two seven-week cycles. weeks, with each week focusing on a specific aspect of addiction, a particular Lakota value, and a positive Related Resources behavior. For example, during the third week, the program Trainer’s Guide: http://www.oneskycenter.org/ focuses on the physical aspect of the addiction and wp-content/uploads/2014/03/ encourages the Lakota value of and bravery. The AmericanIndianTrainersGuideto behavior emphasized during this week is “facing .” MotivationalInterviewing.pdf

The program is often credited for taking the abstract Manual for Counselors in Native American concepts of spirituality and conscience and applying them Communities: https://www.integration.samhsa.gov/ in the Seven Direction Model. MRP empowers people to clinical-practice/ Native_American_MI_Manual.pdf engage in the process of recovery from addiction. Staff promote physical, mental, spiritual, and emotional wellness. Goals for the first cycle: Model Features and Elements Goal I: Learn the Seven Directions, Seven Life Powers, • Two seven-week cycles focus on different and Seven Lakota Values curriculum. The first cycle is more didactic Goal II: Develop healthy and values and and helps clients work through their cognitive resolve internal conflict impairment brought on by stimulant use. The second cycle adds a Rational Emotive Therapy Goals for the second cycle: 1 beyond the didactic strategy. Goal I: Reinforce positive changes and healthy communication skills Rational emotive behavior therapy is an active- Goal II: Prevent relapse and increase efficacy directive, philosophically and empirically-based psychotherapy with the aim of resolving emotional • “Talking circle” (a practice for expression of and behavioral problems and disturbances and thoughts and feelings in the context of complete helping people happier and more fulfilling lives.1 by participants) and sweat lodge ceremonies practiced weekly.

Treatment of Stimulant Use Disorders Examples of Stimulant Use Treatment Programs 33 • Daily, half-hour morning sessions where “The Rosebud Sioux Tribe Meth Rehabilitation Program clients share their thoughts and insights. Staff not only taught me about my addiction and why I use client sharing to determine progress. could not stop using meth, it also taught me how to • Partnership with cultural, spiritual, and live a spiritually, mentally, emotionally and physically religious leaders within and outside the fulfilling life. I no longer need to look outside myself for community, who are invited to address clients validation.” during their recovery process. • Weekly, 45- to 60-minute equine therapy “… MRP gave me the opportunity to take a good hard sessions that emphasize Lakota culture and look at reality. In treatment I was able to find my true values. Patterns of self-defeating thoughts, self. I was able to see all the wrongs I did to others and beliefs, and behaviors identified during the myself. Finding spirituality helped change my life. The equine therapy activities are processed in group RST MRP equipped me with the tools to stay sober and in therapy immediately following the activity. recovery… I will continue to work my recovery program using the tools and skills taught at the RST MRP.”

Lessons Learned Court-mandated clients complete the entire program. Self-referred clients typically terminate the program prematurely after about two to three weeks. They may need extra encouragement around that time to continue the program. Once the self-referred clients stay in the program through the first cycle of seven weeks, they tend to continue and complete the program.

Findings and Outcomes Sixty-six percent of clients from Quarter 1 in 2016 completed the program, while spending an average of 145 days in therapy. Qualitative data collected from the clients highlighted the positive outcomes of the program. In the actual words of two clients:

Treatment of Stimulant Use Disorders Examples of Stimulant Use Treatment Programs 34 Crystal Clear Project (Methamphetamine) Mount Sinai West Hospital (New York, NY) https://www.mountsinai.org/locations/addiction-institute/services/outpatient

The Crystal Clear Project (Methamphetamine) is designed to address the needs of gay and bisexual men who have Practice implemented by program sex with men (MSM) who misuse methamphetamines. Motivational Interviewing and Cognitive The program provides an accepting and culturally sensitive Behavioral Therapy for environment where clients are encouraged to engage in Setting open conversation about alcohol and drug use, sexual behaviors and intimacy, and how experiences related to Outpatient; Sessions occur at Mount Sinai West homophobia and sexual orientation may have contributed Hospital in New York City. to their drug use. The program’s goals are to reduce Population of Focus methamphetamine use and . Gay and bisexual men who have sex with men.

All program staff are trained in motivational interviewing Program Duration and adhere to its principles in their daily interactions with clients. Staff also employ Dialectical Behavior Therapy There is no prescribed length for the program. Typically, clients stay in the program for anywhere and “Getting Off,” an adaptation of Cognitive Behavioral from a few months to over a year. Length is Therapy (CBT) focused on the needs of MSM. determined by the needs of each client. Each client’s treatment is tailored to his individual needs Related Resources and considers the severity of his use and the amount of Getting Off Manual: structure he needs and is willing to accept. The program offers both day and evening sessions and clients can attend http://uclacbam.org/wp-content/uploads/2018/04/ as few as one session or as many as five sessions per week. Getting_Off_Behavioral_Treatment_Manual.pdf

Model Features/Elements Dialectical Behavior Therapy: • Team of practitioners include a family https://www.ncbi.nlm.nih.gov/pmc/articles/ therapist, addiction pharmacologist, social PMC2963469/ worker, and psychiatrist. • Holistic and culturally sensitive approach addresses stressors related to sexual orientation. • Reduction in severity of methamphetamine use • Individual evaluations conducted according to (including lower use, as well as abstinence). state regulations and by a psychiatrist. • Reduction in risky sexual behaviors. • One to five weekly sessions offered. Sessions are individual or in a group, driven by the needs Lessons Learned and capacities of each client. • The program is exploring the potential of hiring • Self-help sessions, based on principles of Alcoholics peer counselors on staff. Anonymous, are available but not required. • The program requires staff that are LGBTQ • Both unstructured (open process) and friendly and open to discussing these issues. structured (following a manualized therapy) • Conducting trainings and providing ongoing sessions are offered. supervision can be helpful to raise comfort level of the staff, thereby increasing program success. Findings and Outcomes • The program directly addresses clients’ sexual The program has not had funding to conduct an official behaviors. Crystal methamphetamine is often program evaluation. Outcomes reported by program staff tied to sexual behaviors, so it is important to include: address these behaviors during therapy.

Treatment of Stimulant Use Disorders Examples of Stimulant Use Treatment Programs 35 Reference List

1 Ellis, A. (1995). Rational emotive behavior therapy. Current , 5, 162-196.

Treatment of Stimulant Use Disorders Examples of Stimulant Use Treatment Programs 36 CHAPTER 5

Resources for Evaluation and Quality Improvement

Evaluating a practice or program answers critical Evaluation data provide information on what did and questions. Evaluation can provide information about how did not work. For example, initial information collected well a practice has been implemented, and what is and is from clients provides baseline data that can be compared not working in a program. Evaluation can also show how with data collected at the end of a program. This allows a program or practice benefits clients. This can be helpful program managers, clinicians, and other providers to assess in securing funding by providing evidence of program changes or improvements in client attitudes and behaviors. effectiveness. In addition, stakeholders can use information gathered via evaluation to encourage implementation of that practice in other programs or communities.

This chapter provides an overview of approaches to evaluate implementation and results of practices to treat stimulant use disorders. The chapter also includes information on implementing a continuous quality improvement (CQI) process. U.S. Department of Health and Human Services (HHS) defines CQI as, “the systematic process of identifying, describing, and analyzing strengths and problems and then testing, implementing, learning from, and revising solutions.” CQI is an essential process for successfully implementing a practice. Finally, the chapter concludes with specific evaluation resources, including potential outcomes to track. Type of Evaluations and Study Designs Although often overlooked, evaluation is an integral part Salabarría-Peña, Y., Apt, B.S., Walsh, C.M. (2007). Practical use of program of the implementation process and should be planned evaluation among sexually transmitted disease (STD) programs. Centers for from the start. Programs should consider assessing the Disease Control and Prevention. https://www.cdc.gov/std/program/pupestd/ extent to which a practice can be evaluated in a reliable types%20of%20evaluation.pdf and credible fashion.

Treatment of Stimulant Use Disorders Resources for Evaluation and Quality Improvement 37 Evaluation is typically conducted before a practice is one client (outcome and impact evaluations). All four implemented to determine its feasibility (formative types of evaluations are necessary to be able to make evaluation), during implementation (process evaluation), judgments about an intervention’s effectiveness on and after the intervention has been delivered to at least reducing stimulant misuse.

CONTINUOUS QUALITY IMPROVEMENT (CQI) What is CQI?

CQI involves a systematic process of assessing program or practice implementation and short-term outcomes and then involving program staff in identifying and implementing improvements in service delivery and organizational systems to achieve better treatment outcomes. CQI helps assess fidelity, the degree to which a program delivers a practice as intended.

CQI differs from process evaluation in that it involves quick assessments of program performance, timely identification of problems and potential solutions, and implementation of small improvements to enhance treatment quality. CQI is usually conducted by internal staff. Process evaluation involves longer-term assessments and is best conducted by an external evaluator.

The Network for Improvement of Addiction Treatment (NIATx), a project originally funded by SAMHSA’s Center for Substance Abuse Treatment (CSAT), offers tools to conduct CQI and improve services in treatment settings. NIATx is based on the foundational principle of aiming to accomplish program improvement through not one big change, but through a series of smaller changes, tested and implemented one at a time, that in the end have a cumulative effect.

Why use CQI?

CQI takes a broader look at the systems in which programs or practices operate. Because of the pivotal role it plays in performance management, organizations implementing new clinical practices or programs for treating stimulant use disorders are encouraged to implement CQI procedures.

What are the steps involved in CQI? Although steps in the CQI process may vary based on objectives, typical CQI steps are:

• Identify a program or practice issue needing improvement and a target improvement goal • Analyze the issue and its root causes • Develop an action plan to correct the root causes of the problem, including specific actions to be taken • Implement the actions in the action plan • Review the results to confirm that the issue and its root causes have been addressed and short-term and long-term treatment outcomes have improved • Repeat these steps to identify and address other issues as they arise

New Jersey Department of Children and Families (n.d.) CQI Framework. https://www.nj.gov/dcf/about/divisions/opma/CQI%20framework.pdf Office of (n.d.). Continuous Quality Improvement. https://www.hhs.gov/ash/oah/sites/default/files/cqi-intro.pdf Center for Health Enhancement Systems Studies, University of Wisconsin (n.d.) NIATx program https://www.niatx.net/what-is-niatx/

Treatment of Stimulant Use Disorders Resources for Evaluation and Quality Improvement 38 Data collected as a part of any of the four evaluations are who deliver treatment using the new practice to obtain either quantitative or qualitative. their perspective on facilitators and challenges, or barriers, to practice implementation. Qualitative data can provide Quantitative data are those collected in a numerical complementary context to quantitative data. form which can be put into categories, or in rank order, or measured in units of measurement. These data can be processed by mathematical or statistical analysis. Types Outcomes of quantitative data collection can include close-ended One of the final important but often challenging steps survey questions and polling responses. in the process of implementing practices is to determine whether they have yielded desired outcomes. An outcome Qualitative data, on the other hand, are any non- is the change a program to accomplish through the numeric, text-based information such as verbal, visual, implementation of a practice. or written data. These types of data provide information about the acceptability of an intervention and the Below is a list of potential outcomes and illustrative challenges recipients of the intervention face. Examples outcome indicators and data sources that may be used to of qualitative data collection methods include interviews, evaluate practices to reduce stimulant use disorders. Many focus groups, observations, gathering data from of these short- and intermediate-term outcomes may be documents and images, and case studies. tracked at baseline and throughout the practice or program duration through an electronic health record. Longer-term One benefit of qualitative research is that it enables outcomes may be obtained from administrative and survey program managers, clinicians, and providers to learn from data. clients and to obtain the perspective of those with lived experiences. It also can involve collecting data from staff

Outcome Illustrative Indicators Illustrative Data Sources Process outcomes Treatment retention Number of treatment sessions attended Attendance/administrative data Treatment engagement Extent of client engagement in the treatment Self-report Short-term outcomes Reduced immediate use of Amount of use Stimulant-negative urine drug stimulants Frequency of use screens Number of days/weeks without use Self-report Longest duration of confirmed stimulant abstinence Total abstinence Reduced craving of craving Self-report (e.g., Addiction Severity Index Scale) Standardized scales (e.g., Brief Substance Craving Scale) Long-term individual- and population-level outcomes and impacts Long-term abstinence Prevalence of continued abstinence and/or Self-report relapse Readmission to treatment Reduced prevalence of Prevalence of stimulant use Large scale national surveys stimulant use Reduction in co-occurring Prevalence of hospitalizations for mental health Hospitals and medical facilities’ mental health issues in issues related to substance use disorders administrative data individuals with substance use disorders Reduction in substance use- Rates of substance use-related arrests Justice system administrative data related crime

Treatment of Stimulant Use Disorders Resources for Evaluation and Quality Improvement 39 Evaluation Resources Evaluating practice or program implementation Resources for evaluating programs and • A Framework for Program Evaluation from the practices in Native American communities Program Performance and Evaluation Office at • Children’s Bureau’s A Roadmap for CDC summarizes essential elements of program Collaborative and Effective Evaluation in evaluation. Tribal Communities provides Native American • Introduction to Program Evaluation for Public values and priorities, knowledge of which can Health Programs is a self-study guide from enhance between Tribal programs and their CDC that includes worksheets and checklists for evaluation partners and other stakeholders. implementing the steps in CDC’s Framework for • SAMHSA’s cultural card provides strategies to Program Evaluation. enhance while providing • CDC’s Evaluation Brief provides information services to American Indian and Alaska Native about document review and how it can be used communities. for program evaluation. • Native American Motivational Interviewing: • HHS’s Administration for Families and Children’s Weaving Native American and Western Practices webpage on evaluation provides multiple tools for is a manual for counselors in Native American prevention and treatment evaluation. communities. • SAMHSA’s Behavioral Health Services for Evaluating client- and population-level outcomes American Indians and Alaska Natives provides • National Science Foundation’s webpage on tips for providers to improve their cultural evaluation provides an overview of quantitative competence and provide culturally responsive, and qualitative data collection methods. engaging, holistic, trauma-informed services to • National Institute of Health’s webpage on American Indian and Alaska Native clients. evaluation provides information on engaging in • Children’s Bureau’s Creating a New Narrative: qualitative research methods. Collaborative and Effective Evaluation in Tribal Communities is a video that guides the Quality improvement and continuous performance monitoring development of culturally and scientifically rigorous evaluation. • Institute for Healthcare Improvement’s Quality • Native American Center for Excellence’s Steps Improvement Essentials Toolkit includes for Conducting Research and Evaluation in the tools and templates needed to launch a Native Communities explores the lessons and successful quality improvement project and challenges of research and evaluation in Native manage performance improvement. communities. • The Network for Improvement of Addiction Treatment (NIATx)’s model of process improvement specifically for behavioral health care settings to improve access to and retention in treatment.

Treatment of Stimulant Use Disorders Resources for Evaluation and Quality Improvement 40 Appendix 1: Acknowledgments

This publication was developed with a significant Contract Staff contribution from Thomas Freese, PhD and Rucha Margaret Gwaltney, MBA Abt Associates* Londhe, PhD. The guidance is based on the thoughtful input of SAMHSA staff and the Expert Panel on Philip Kim, MEd Abt Associates Treatment of Stimulant Use Disorders from October Rucha Londhe, PhD Abt Associates* 2019 through September 2020. A series of guide development meetings was held virtually over a period Sarah Steverman, PhD, MSW Abt Associates* of several months. Three expert panel meetings were Alec Wall, BS Abt Associates convened during this time. *Members of Guide Planning Team SAMHSA Staff Christine Cichetti National Mental Health and Substance Use Policy Laboratory Thomas Clarke, PhD National Mental Health and Substance Use Policy Laboratory Tanya Geiger, PhD, MPH National Mental Health and Substance Use Policy Laboratory* Donelle Johnson, PhD, MHSA National Mental Health and Substance Use Policy Laboratory* Carter Roeber, PhD National Mental Health and Substance Use Policy Laboratory* Onaje Salim, EdD Center for Substance Abuse Prevention*

Expert Panel Bradley Donohue, PhD University of Nevada Holly Echo-Hawk, MS Mental Health Consultant Molly Evans, MD, MPH Centers for Disease Control and Prevention (CDC) Daniel Foster, PsyD, MS Rosebud Health Service Thomas Freese, PhD University of California, Los Angeles Udi Ghitza, PhD National Institute on Drug Abuse (NIDA) Ted Hall, PharmD Indian Health Service (IHS) Ed Parsells Rosebud Sioux Tribe Meth/Opioid Treatment Program John Roll, PhD Washington State University

Treatment of Stimulant Use Disorders Appendix 1: Acknowledgments 41 Appendix 2: Evidence Review Methodology

The authors followed a rigorous, systematic evidence The studies identified in the literature search varied in review process in the development of this guide. This type and rigor, so the reviewers assessed them further for appendix provides an overview of the evidence review inclusion in the evidence review. To be eligible for review methodology used to identify the ratings for the practices and study rating, research studies had to: included in the guide; motivational interviewing, • Employ a randomized or quasi-experimental contingency management, community reinforcement design, or approach, and cognitive behavioral therapy. Reviewers, in • Be a single sample pre-post design or coordination with SAMHSA and experts, conducted a four an epidemiological study with a strong step process to select practices, identify related studies, counterfactual—a study that analyzes what review and rate studies, and identify practice ratings. would have happened in the absence of the intervention. Step 1: Practice Literature reviews, descriptive studies, implementation Selection studies, and meta-analyses were not included in the review, but were documented to provide context and The authors identified these four practices after a review identify implementation supports for the practices. of the literature and in consultation with experts. In an effort to include interventions that would be most Additionally, to be eligible for further review and rating, useful to those seeking to reduce stimulant use, eligible studies had to: practices were required to meet the following criteria for evidence review: • Be published or prepared in or after 2000 • Be publicly available peer-reviewed or research • Be clearly defined and replicable report • Address the target outcome of reducing • Be available in English stimulant misuse • Include at least one eligible outcome related to • Be currently in use reduced stimulant use • Have studies of their effectiveness • Have a comparison/control group that is • Have accessible implementation and fidelity treatment as usual or no/minimal intervention supports if using a randomized experimental or quasi- experimental designs At the conclusion of this step, SAMHSA and the guide’s Expert Panel reviewed the proposed practices identified by the authors and agreed on four for inclusion in the Step 3: Study Review evidence review and rating process. and Rating Next, trained reviewers assessed each study to ensure Step 2: Study the methodology was rigorous and therefore could Identification demonstrate causation between the practice and the identified outcomes. Reviewers reviewed and documented Once the practices were selected, the reviewers each study to ensure that: conducted a comprehensive review of published research on these practices to identify studies of the • Experimental and comparison groups were selected practices. This review only included studies statistically equivalent, with the only difference from eligible sources (i.e., peer reviewed journals and being that participants in the experimental government reports) that avoid clear conflicts of . group received the intervention and those in the The reviewers documented all potential studies identified comparison group received treatment as usual through the literature search. or no/minimal intervention

Treatment of Stimulant Use Disorders Appendix 2: Evidence Review Methodology 42 • For randomized experiments with high attrition Step 4: Practice Rating and for quasi-experimental designs, baseline equivalence was established between the After all studies for a practice were assessed for these treatment and comparison groups criteria, the reviewers gave each practice a rating • For randomized experiments, randomization based on the number of studies with strong, moderate, was not compromised. For example, ensuring or emerging support of causal impact. Causal impact is that reassignment of treatment status, usually evidence demonstrating that an intervention causes, or made to the distribution of background is responsible for, the outcome measured in the study’s variables between treatment and control groups, sample population. The practice was placed into one did not occur of the following categories based on the level of causal • Study did not have any confounding factors (factors that affect the outcome but are not evidence of its studies: accounted for by the study) • Strong Evidence: Causal impact demonstrated • Missing data were addressed appropriately by at least two randomized controlled trials, o Imputation based on surrounding cases was quasi-experimental designs, or epidemiological considered valid studies with a high or moderate rating. • Moderate Evidence: Causal impact o Complete case analysis was considered valid and accounted for as attrition demonstrated by at least one randomized controlled trial, quasi-experimental design, or Using model with dummy for missing as a o epidemiological study with a high or moderate covariate was considered valid rating. o Assuming all missing data points are either • Emerging Evidence: No study received a high positive or negative was not considered or a moderate rating. The practice may have valid been evaluated with less rigorous studies (e.g., o Regression-based imputation was consid- pre-post designs) that demonstrate an association ered valid, mean imputation was not consid- between the practice and positive outcomes, but ered valid. additional studies are needed to establish causal • Outcome measures were reliable, valid, and impact. collected consistently from all participants The four-step process described above resulted in • Valid statistical models were used to estimate identification and rating of four practices with strong impacts evidence for reducing stimulant use. The rating given • Practice demonstrated improved outcomes to each practice is intended to inform decision making related to stimulant use about adoption of new practices or clinical or system Based on the study design and these study characteristics, enhancements that will improve outcomes for individuals reviewers gave each study a rating for causal impact. with stimulant use disorders. Reviewers used the following scoring metric for each study based on the eight factors above to determine if a study is rated:

• High support of causal evidence • Moderate support of causal evidence • Low support of causal evidence Only randomized controlled trials, quasi-experimental designs, and epidemiological studies with a strong comparison were eligible to receive a high or moderate study rating.

Treatment of Stimulant Use Disorders Appendix 2: Evidence Review Methodology 43 Photos are for illustrative purposes only. Any person depicted in a photo is a model.

Publication No. PEP20-06-01-001

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