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Human T-Lymphotropic Virus Type 1: Technical Report February 2020
TECHNICAL REPORT HUMAN T-LYMPHOTROPIC VIRUS TYPE 1: TECHNICAL REPORT FEBRUARY 2020 HUMAN T-LYMPHOTROPIC VIRUS TYPE 1: TECHNICAL REPORT FEBRUARY 2020 Human T-lymphotropic virus type 1: technical report ISBN 978-92-4-002022-1 (electronic version) ISBN 978-92-4-002023-8 (print version) © World Health Organization 2021 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization (http://www.wipo.int/amc/en/mediation/rules/). Suggested citation. Human T-lymphotropic virus type 1: technical report. Geneva: World Health Organization; 2021. -
Speakers' Biographies 4Th Annual Short Course in Medical Virology Of
Speakers’ Biographies 4th Annual Short Course in Medical Virology of the GVN Clement A. Adebamowo, BM, ChB, ScD, FWACS, FACS. As a member of the Population Sciences Program of the Cancer Center and a cancer epidemiologist, I conduct research on the epidemiology of cancer. At this time, I am the PI of the NIH funded African Collaborative Center for Microbiome and Genomics Research (ACCME) which is one of the NIH/Wellcome Trust funded Human Heredity and Health in Africa (H3Africa) initiative on genomics research and education in Africa. ACCME’s current project is enrolling 10,000 women in Nigeria and Zambia and following them up every 6 months for research focused on integrative epidemiology of persistent high risk HPV infection, host germline and somatic genomics and epigenomics, and vaginal microenvironment (cytokines and microbiome) and risk of cervical cancer. As part of this project, I established a comprehensive genomics laboratory in Nigeria including facilities for epigenetics and next generation sequencing using Illumina NextSeq500. The genomics lab is linked to an NIH funded biorepository at IHVN. I also direct the Fogarty funded West African Bioethics Training program which has provided medium term training leading to Certificates in Research Ethics for 842 biomedical researchers, Masters’ degree in Bioethics to 34 individuals and Online WAB-CITI Training program to 6115 participants in West Africa. In Baltimore, I am working with colleagues at the University of Maryland Greenebaum Cancer Center and University of Maryland College Park to develop a research program on cancer disparities among Africans in Africa, recent African immigrants to the United States and African Americans in order to better understand the role of genetics, environment cultural and socio- economic factors in cancer prevention, treatment seeking behavior and outcomes. -
GVN Overview | 3 the GENESIS of the GVN the Concept of a Global Virus Network (GVN) Began Back in the 1980’S When Dr
Overview of the Global Virus Network We represent centers of excellence for research in virology from across the globe. Our work is dedicated to understanding, preventing and eradicating viral disease threats to mankind. Today, we affirm the need for new programs to coordinate, support and promote research that bridges the gap between virus surveillance and public health implementation. We gather in Washington, D.C. to support goals and ideals of the Global Virus Network, a new approach to fostering true collaboration among all regions and all peoples of the world. Seeking to improve the immediate responses to emerging viral threats, train future generations of virologists, and advise governments or non-governmental organizations on viral disease threats and their control, the Global Virus Network fills a critical need in international health for today and into the future. GVN declaration of support was signed March 3, 2011, Washington, D.C. www.gvn.org “The 1918-1919 influenza pandemic killed more people in absolute numbers than any other disease outbreak in history. A contemporary estimate put the death toll at 21 million, a figure that persists in the media today, but understates the real number. Epidemiologists and scientists have revised that figure several times since then. Each and every revision has been upward. Frank Macfarlane Burnet, who won his Nobel prize for immunology but who spent most of his life studying influenza, estimated the death toll as probably 50 million, and possibly as high as 100 million. A 2002 epidemiologic study also estimates the deaths at between 50 and 100 million (Johnson and Mueller, 2002). -
Vaccine Hesitancy
WHY CHILDREN WORKSHOP ON IMMUNIZATIONS ARE NOT VACCINATED? VACCINE HESITANCY José Esparza MD, PhD - Adjunct Professor, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA - Robert Koch Fellow, Robert Koch Institute, Berlin, Germany - Senior Advisor, Global Virus Network, Baltimore, MD, USA. Formerly: - Bill & Melinda Gates Foundation, Seattle, WA, USA - World Health Organization, Geneva, Switzerland The value of vaccination “The impact of vaccination on the health of the world’s people is hard to exaggerate. With the exception of safe water, no other modality has had such a major effect on mortality reduction and population growth” Stanley Plotkin (2013) VACCINES VAILABLE TO PROTECT AGAINST MORE DISEASES (US) BASIC VACCINES RECOMMENDED BY WHO For all: BCG, hepatitis B, polio, DTP, Hib, Pneumococcal (conjugated), rotavirus, measles, rubella, HPV. For certain regions: Japanese encephalitis, yellow fever, tick-borne encephalitis. For some high-risk populations: typhoid, cholera, meningococcal, hepatitis A, rabies. For certain immunization programs: mumps, influenza Vaccines save millions of lives annually, worldwide WHAT THE WORLD HAS ACHIEVED: 40 YEARS OF INCREASING REACH OF BASIC VACCINES “Bill Gates Chart” 17 M GAVI 5.6 M 4.2 M Today (ca 2015): <5% of children in GAVI countries fully immunised with the 11 WHO- recommended vaccines Seth Berkley (GAVI) The goal: 50% of children in GAVI countries fully immunised by 2020 Seth Berkley (GAVI) The current world immunization efforts are achieving: • Equity between high and low-income countries • Bringing the power of vaccines to even the world’s poorest countries • Reducing morbidity and mortality in developing countries • Eliminating and eradicating disease WHY CHILDREN ARE NOT VACCINATED? •Vaccines are not available •Deficient health care systems •Poverty •Vaccine hesitancy (reticencia a la vacunacion) VACCINE HESITANCE: WHO DEFINITION “Vaccine hesitancy refers to delay in acceptance or refusal of vaccines despite availability of vaccination services. -
Clinical Scholars Visit Amish Research Clinic in Lancaster County, PA by Patrick Brunner, MD Dr
Spring 2018 Center for Clinical and Translational Science e- e-NewsletterNewsletter Center News James Krueger and Marina Caskey, Representing the Nussenzweig Lab Team, Honored at Translational Science 2018 Meeting By Hospital Leadership which fulfill the translation research Dr. James Krueger received paradigm of going from bench to the Association for Clinical and bedside, have been recognized by this Translational Science (ACTS) most prestigious national recognition. Distinguished Investigator Award for his It is well deserved!” Upon receiving the groundbreaking research on psoriasis at award, Dr. Krueger noted, “This award the Translational Science 2018 meeting would not have been possible without attended by more than 1,100 people in the support of many others associated Washington, DC in April. His research with the Rockefeller CTSA enterprise: has led to a fundamental change in my lab members, the nursing staff, the paradigm for understanding the all other support departments and, pathophysiology of the disorder, and of course, hundreds of patients who this in turn has led to the development directly tested progressively better drugs of a series of novel medications that that are now used to so effectively treat precisely modulate the immune system psoriasis.” and dramatically improve the therapy of the disorder. Each year, Clinical Research Forum sponsors a competition to identify Dr. Caskey Receiving “Top Ten” Award from the “Top Ten” Clinical Research Drs. Harry Selker and Herb Pardes studies reported in the previous year. commented that “The study reflects the The competition is intense and so it very best in translational science: the is a true tribute to the novelty and careful analysis of patient phenotypes; importance of the study led by Dr. -
Marburg Virus Outbreak in 1967
Stigmatized by viral infection Stephan Becker, Philipps-Universität, Marburg, Germany Not many in the general public understand how viruses infect humans or what can be done to prevent their spread. When viral infections spread quickly and result in an outbreak, the psychological effects can surpass the physical as communities deal with treating patients and preventing further occurrences. This can be particularly acute in populations that are unfamiliar with a disease or in situations that lack a carefully planned and engaging communications strategy. Doctor Stephan Becker is a professor at the Institute for Virology, Philipps-Universität in Marburg, Germany and a member of the Global Virus Network’s (GVN) German consortium. He underscores the need for enhanced communication strategies in dealing with viral diseases. As a young virologist, when he had just begun working on his Postdoctoral degree at the Institute of Virology in Marburg, he had the chance to visit two survivors of the Marburg virus outbreak in 1967. “The couple vividly remembered their experiences during this time, when the whole city of Marburg was in the grip of the exotic virus. Although the totality of infected patients was only 32, in the first days of the Marburg outbreak, citizens were very scared, and everybody expected to be the next victim. This had negative consequences for Marburg virus patients who experienced rejections from neighbors and friends. Some nurses, out of fear of becoming infected, refused to enter patients’ rooms, leaving food at the door. Nobody wanted to let their children play with healthy children of Marburg virus patients. Even twenty years later, when sharing their story, the couple was upset and traumatized from the ensuing chaos following the Marburg outbreak.” The Marburg virus was named after the German town where it was first identified in 1967. -
A Global Early Warning System for Pandemics Mobilizing Surveillance for Emerging Pathogens
A Global Early Warning System for Pandemics Mobilizing Surveillance for Emerging Pathogens ESTHER KROFAH, CARLY GASCA, AND ANNA DEGARMO About the Milken Institute The Milken Institute is a nonprofit, nonpartisan think tank. For the past three decades, the Milken Institute has served as a catalyst for practical, scalable solutions to global challenges by connecting human, financial, and educational resources to those who need them. Guided by a conviction that the best ideas, under-resourced, cannot succeed, we conduct research and analysis and convene top experts, innovators, and influencers from different backgrounds and competing viewpoints. We leverage this expertise and insight to construct programs and policy initiatives. These activities are designed to help people build meaningful lives in which they can experience health and well-being, pursue effective education and gainful employment, and access the resources required to create ever-expanding opportunities for themselves and their broader communities. About FasterCures FasterCures, a center of the Milken Institute, is working to build a system that is effective, efficient, and driven by a clear vision: patient needs above all else. We believe that transformative and lifesaving science should be fully realized and deliver better treatments to the people who need them. ©2021 Milken Institute This work is made available under the terms of the Creative Commons Attribution-NonCommercial- NoDerivs 3.0 Unported License, available at creativecommons.org/licenses/by-nc-nd/3.0/. CONTENTS -
Report on Global Surveillance of Epidemic-Prone Infectious Diseases, 2000
Pan American Health Organization Regional Office of the World Health Organization PAHO/DPC/CD-V/243/03 Original: English Report: Workshop on Dengue Burden Studies (Washington, DC, 5-7 November 2002) Convened by The Pan American Health Organization The Rockefeller Foundation The Pediatric Dengue Vaccine Initiative Executive Summary Background Dengue fever (DF) and dengue hemorrhagic fever (DHF) are caused by the mosquito borne virus, dengue virus, of which there are four antigenically distinct serotypes. It is estimated that annually these viruses cause at least 20 million infections worldwide leading to some 24,000 deaths (WHO, http://www.who.int/health_topics/dengue/en/ ). The alarming rise in dengue hemorrhagic fever in the world today is illustrated most starkly by the chart below which represents data from the World Health Organization (WHO) showing the rise of DHF cases over the last four decades. Indeed the first two years of the new millennium has seen outbreak after outbreak of DHF not only in Southeast Asia where DHF has been seen for half a century, but also in many countries of South and Central America. REPORTED CASES OF DHF 600 ds 500 housan t 400 n d i e 300 200 r report e 100 numb 0 1955-1959 1960-1069 1970-1979 1980-1989 1990-1998 Source: WHO; adapted from http://www.who.int/health_topics/dengue/en/ While there is no doubt that severe dengue is spreading from countries in Southeast Asia to countries in the Pacific and in the Americas, there is also no doubt that many international efforts into the development of dengue vaccines have led to a number of promising vaccine candidates which may offer some solutions to the control of this disease. -
Meeting-Report-The-10Th-International-Global-Virus-Network-Meeting.Pdf
Antiviral Research 163 (2019) 140–148 Contents lists available at ScienceDirect Antiviral Research journal homepage: www.elsevier.com/locate/antiviral 2018 international meeting of the Global Virus Network T Christian Brechota, Juliet Bryantb, Hubert Endtzc, Robert F. Garryd, Diane E. Griffine, ∗ Sharon R. Lewinf, Natalia Mercera, Albert Osterhausg, Valentina Picotb, Anders Vahlnea,h, , Georges M.G.M. Verjansi,k, Scott Weaverj a The Global Virus Network, Baltimore, MD, USA b Mérieux Foundation, Lyon, France c Mérieux Foundation and the Erasmus University in Rotterdam, the Netherlands d Tulane University, New Orleans, LA, USA e Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA f The Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, and Department of Infectious Diseases, Alfred Health and Monash University, Australia g The University of Veterinary Medicine Hannover, Germany h Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden i Department of Viroscience, Erasmus MC, Rotterdam, the Netherlands j The University of Texas Medical Branch at Galveston, USA k TiHo-RIZ, Hannover, Germany ABSTRACT The Global Virus Network (GVN) was established in 2011 to strengthen research and responses to emerging viral causes of human disease and to prepare against new viral pandemics. There are now 45 GVN Centers of Excellence and 7 Affiliate laboratories in 29 countries. The 10th International GVN meeting was held from November 28–30, 2018 in Veyrier du Lac, France and was co-hosted by the two GVN Centers of Excellence, the Mérieux Foundation and the University of Veterinary Medicine Hannover (TiHo). The theme of this 10th International GVN meeting was “Eradication and control of (re-) emerging viruses”. -
Overview of the Global Virus Network
Overview of the Global Virus Network We represent centers of excellence for research in medical virology from across the globe. Our work is dedicated to understanding, preventing and eradicating viral disease threats to mankind. Today, we affirm the need for new programs to coordinate, support and promote research that bridges the gap between virus surveillance and public health implementation. We gather in Washington, D.C. to support goals and ideals of the Global Virus Network, a new approach to fostering true collaboration among all regions and all peoples of the world. Seeking to improve the immediate responses to emerging viral threats, train future generations of medical virologists, and advise governments or non-governmental organizations on viral disease threats and their control, the Global Virus Network fills a critical need in international health for today and into the future. GVN declaration of support was signed March 3, 2011, Washington, D.C. www.gvn.org “The 1918-1919 influenza pandemic killed more people in absolute numbers than any other disease outbreak in history. A contemporary estimate put the death toll at 21 million, a figure that persists in the media today, but understates the real number. Epidemiologists and scientists have revised that figure several times since then. Each and every revision has been upward. Frank Macfarlane Burnet, who won his Nobel prize for immunology but who spent most of his life studying influenza, estimated the death toll as probably 50 million, and possibly as high as 100 million. A 2002 epidemiologic study also estimates the deaths at between 50 and 100 million (Johnson and Mueller, 2002). -
V21 MTG 0033 List of Particip
THE FIRST WHO INTEGRATED MEETING ON DEVELOPMENT AND CLINICAL TRIALS OF INFLUENZA VACCINES THAT INDUCE BROADLY PROTECTIVE AND LONG-LASTING IMMUNE RESPONSES Baptist University, Hong Kong 24 – 26 January 2013 LIST OF PARTICIPANTS Dr Akira Ainai, Emeritus Member, National Institute of Infectious Diseases, Tokyo, Japan Dr Christopher Ambrose, Senior Director, Medical Affairs, MedImmune, Gaithersburg, United States of America Professor Filippo Ansaldi, Health Sciences, University of Genoa and Hygiene Unit, Genoa, Italy Dr Robert L. Atmar, Associate Professor, Department of Medicine and Molecular Virology & Microbiology, Baylor College of Medicine, Houston, United States of America Dr Emma Ball, CSL Limited A.C.N., Parkville, Victoria, Australia Dr Pamuk Bilsel, FluGen Inc., Madison, United States of America Mr Albert Chan, President, Hong Kong Baptist University, Hong Kong, China Dr Paul Chan, Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China Dr Marta Coehlo Nunes, Respiratory and Meningeal Pathogens Research Unit, Wits University, Johannesburg, South Africa Dr Ben Cowling, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China Dr Manon Cox, President and CEO, Protein Sciences Corporation, Meridien, United States of America Professor Rebecca Cox, Influenza Centre, The Gade Institute, University of Bergen, Bergen, 5021 Norway Dr Giuseppe Del Giudice, Global Head Translation Medicine, Novartis Vaccines and Diagnostics S.p.A, Divisione Biologici -
A Letter from the GVN Scientific Director and Chair, Scientific Leadership Board
A Letter from the GVN Scientific Director and Chair, Scientific Leadership Board When the Global Virus Network (GVN) was founded in 2011, our mandate was to safeguard mankind from a potential catastrophic and devastating pandemic virus. To accomplish this, we assembled a network of experts from across the globe to share information, collaborate on research, train virologists, and encourage advocacy among government leaders, the private sector and the scientific community. Since then, we have made great strides in building this worldwide network and educating the next generation of virologists. One important headline is that we have a new leader. In October of 2017, GVN appointed Dr. Christian Bréchot as the next president of GVN. With his extraordinary experience and commitment, Dr. Bréchot is the perfect choice to lead us forward. He has spent his career working on some of the viruses that we are trying to vanquish. Most recently, he has served as president of the Institut Pasteur. Not only does Dr. Bréchot have extraordinary ability in public health and basic science virology, he is also an experienced administrator. His relentless dedication and boundless energy, as well as his breadth of international experience, will help enable GVN to realize its great potential. We are very pleased to have him. As we move forward, the GVN continues to focus on understanding and planning for viral epidemics. We’ve created several task forces to focus on specific viruses, including Zika and HTLV-1, and are closely watching developments related to MERS, Global Virus Network Virion Newsletter 1 Ebola, West Nile virus, polio, measles, and pandemic influenza.