DOCSLIB.ORG

Late-Life Mental Health

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Late-Life Mental Health QuarterlyThe Winter 2012 RESEARCH NEWS 2 RESEARCH DISCOVERIES IN THE NEWS 5 INTERVIEW WITH A RESEARCHER Eric R. Kandel, M.D. 9 ASK THE RESEARCHER 10 FREQUENTLY ASKED QUESTIONS ON LATE-LIFE MENTAL HEALTH 21 GLOSSARY 22 NEW TREATMENTS/THERAPIES 24 MOMENTUM Events Calendar Save the Dates Healthy Minds Across America Symposia 32 MEET A DISTINGUISHED INVESTIGATOR Dilip V. Jeste, M.D. Page 5 FEATURE 13 A FAMILY STORY FOCUS The Lottmann Family: Late-Onset Mental Illness on Unravels a Family’s Life LATE-LIFE 17 NARSAD GRANTS ON LATE-LIFE MENTAL HEALTH MENTAL HEALTH Scientific Council “The Brain & Behavior Research Foundation Scientific Council has grown to include 132 volunteer members, each of whom bring special skills and unique knowledge bases that cover every aspect of brain and behavior research. The reach of the Brain & Behavior Research Foundation support extends to the world's leading medical research and care facilities. Our effort knows no borders. The impact of our effort is not only in the development of promising scientists, but also in the focus it brings to the challenge and urgent need of bringing hope and better lives to all those living with mental illness.” Herbert Pardes, M.D. President, Scientific Counci President & CEO, NewYork-Presbyterian Hospital President Herbert Pardes, M.D. Vice President Emeritus Floyd E. Bloom, M.D. George K. Aghajanian, M.D. Jay Adam Gingrich, M.D., Ph.D. Ronald McKay, Ph.D. Schahram Akbarian, M.D., Ph.D. David Goldman, M.D., Ph.D. James H. Meador-Woodruff, M.D. Huda Akil, Ph.D. Frederick K. Goodwin, M.D. Herbert Y. Meltzer, M.D. Susan G. Amara, Ph.D. Anthony A. Grace, Ph.D. Karoly Mirnics, M.D. Stewart A. Anderson, M.D. Paul Greengard, Ph.D. Bita Moghaddam, Ph.D. Nancy C. Andreasen, M.D., Ph.D. Suzanne N. Haber, Ph.D. Dennis L. Murphy, M.D. Amy F.T. Arnsten, Ph.D. Philip D. Harvey, Ph.D. Charles B. Nemeroff, M.D., Ph.D. Jay M. Baraban, M.D., Ph.D. Stephan Heckers, M.D. Eric J. Nestler, M.D., Ph.D. Jack D. Barchas, M.D. René Hen, Ph.D. Andrew A. Nierenberg, M.D. Samuel H. Barondes, M.D. Fritz A. Henn, M.D., Ph.D. Patricio O'Donnell, M.D., Ph.D. Francine Mary Benes, M.D., Ph.D. Robert M.A. Hirschfeld, M.D. Steven M. Paul, M.D. Wade H. Berrettini, M.D., Ph.D. Steven E. Hyman, M.D. Godfrey D. Pearlson, M.D. Randy D. Blakely, Ph.D. Robert B. Innis, M.D., Ph.D. Daniel S. Pine, M.D. Pierre Blier, M.D., Ph.D. Jonathan A. Javitch, M.D., Ph.D. Robert M. Post, M.D. Robert W. Buchanan, M.D. Daniel C. Javitt, M.D., Ph.D. James B. Potash, M.D., M.P.H. Peter F. Buckley, M.D. Lewis L. Judd, M.D. Steven G. Potkin, M.D. William E. Bunney, Jr., M.D. Peter W. Kalivas, Ph.D. Pasko Rakic, M.D., Ph.D. Joseph D. Buxbaum, Ph.D. Eric R. Kandel, M.D. Judith L. Rapoport, M.D. William F. Byerley, M.D. Richard S.E. Keefe, Ph.D. Perry F. Renshaw, M.D., Ph.D., M.B.A. Marc G. Caron, Ph.D. Samuel J. Keith, M.D. Kerry J. Ressler, M.D., Ph.D. William T. Carpenter, Jr., M.D. Martin B. Keller, M.D. Carolyn B. Robinowitz, M.D. Cameron S. Carter, M.D. John R. Kelsoe, M.D. Bryan L. Roth, M.D., Ph.D. BJ Casey, Ph.D. Kenneth S. Kendler, M.D. John L. R. Rubenstein, M.D., Ph.D. Dennis S. Charney, M.D. James L. Kennedy, M.D. Elaine Sanders-Bush, Ph.D. Bruce M. Cohen, M.D., Ph.D. Robert M. Kessler, M.D. Akira Sawa, M.D., Ph.D. Jonathan D. Cohen, M.D., Ph.D. Kenneth K. Kidd, Ph.D. Alan F. Schatzberg, M.D. Richard Coppola, D.Sc. Mary-Claire King, Ph.D. Nina R. Schooler, Ph.D. Joseph T. Coyle, M.D. Rachel G. Klein, Ph.D. Robert Schwarcz, Ph.D. Jacqueline N. Crawley, Ph.D. John H. Krystal, M.D. Philip Seeman, M.D., Ph.D. Karl Deisseroth, M.D., Ph.D. James F. Leckman, M.D. Solomon H. Snyder, M.D., D.Sc., J. Raymond DePaulo, Jr., M.D. Ellen Leibenluft, M.D. D.Phil. (Hon. Causa) Ariel Y. Deutch, Ph.D. Robert H. Lenox, M.D. John S. Strauss, M.D. Wayne C. Drevets, M.D. David A. Lewis, M.D. John David Sweatt, Ph.D. Ronald S. Duman, Ph.D. Jeffrey A. Lieberman, M.D. John A. Talbott, M.D. Jan A. Fawcett, M.D. Irwin Lucki, Ph.D. Carol A. Tamminga, M.D. Stan B. Floresco, Ph.D. Robert C. Malenka, M.D., Ph.D. Laurence H. Tecott, M.D., Ph.D. Judith M. Ford, Ph.D. Anil K. Malhotra, M.D. Ming T. Tsuang, M.D., Ph.D., D.Sc. Alan Frazer, Ph.D. Husseini K. Manji, M.D., FRCPC Leslie G. Ungerleider, Ph.D. Robert R. Freedman, M.D. J. John Mann, M.D. Rita J. Valentino, Ph.D. Fred H. Gage, Ph.D. John S. March, M.D., M.P.H. Nora D. Volkow, M.D. Aurelio Galli, Ph.D. Helen S. Mayberg, M.D. Karen Dineen Wagner, M.D., Ph.D. Mark S. George, M.D. Robert W. McCarley, M.D. Daniel R. Weinberger, M.D. Elliot S. Gershon, M.D. Bruce S. McEwen, Ph.D. Jon-Kar Zubieta, M.D., Ph.D. Mark A. Geyer, Ph.D. Paul R. McHugh, M.D. Board of Directors OFFICERS Chairman Dear Friends, Stephen A. Lieber President and CEO This is a very special year for us at the Brain & Behavior Benita Shobe Research Foundation as we begin our 25th year of awarding NARSAD Grants leading to advances and breakthroughs Vice President in scientific research. NARSAD was formed with a vision of Suzanne Golden transforming brain and behavior research through drama- Secretary tically accelerated investments to better understand the John B. Hollister causes of mental illness, develop better treatments and improve lives. Since that time more than 4,000 NARSAD Grants have been funded—with almost $300 Treasurer Arthur Radin, CPA million of donor contributions—to scientists around the world. This investment has shaped the psychiatric field and enabled countless discoveries that are paving the road to curing the diseases of the brain. DIRECTORS Anne E. Abramson We open this issue of The Quarterly with highlights of some of the most recent Mark H. Alcott, Esq. Bonnie D. Hammerschlag discoveries in 2011. They reflect the breadth of the research we fund, across mental George B. Handran, Esq. illnesses and across research disciplines. We then turn to our theme of ‘late-life Ken Harrison mental health’ with a profile interview of Nobel Prizewinner Eric R. Kandel, M.D., Milton Maltz longtime Brain & Behavior Research Foundation Scientific Council Member and Marc R. Rappaport Barbara K. Streicker three-time NARSAD Distinguished Investigator Grantee. He speaks of the aging Robert S. Warshaw, Esq. brain, emphasizing its plasticity and capacity to continually learn and adapt, and expresses the critical importance of the Foundation’s support of the field. PRESIDENT EMERITA We visit the personal story of Janet Larsen, who shares the journey of her father’s Constance E. Lieber mental illness and how its late onset was handled more than 40 years ago. With her story, we can appreciate the advances made in understanding mental illnesses, the DIRECTORS EMERITI development of diagnostic tools and the improved treatments available today. Hal B. Hollister It also reminds us of the progress being made in dealing with these illnesses as Patsy Hollister Tamar Maltz diseases of the brain, akin to the many diseases of the body. With increased Jeanne P. Robertson knowledge, the stigma of mental illness, too familiar to too many families, is slowly Shari Staglin being chipped away. The In ‘Meet a Distinguished Investigator’, Dr. Dilip V. Jeste, one of the world’s foremost Quarterly experts on geriatric psychiatry, shares his perspective. He explains what drew him to the field, highlights the key challenges of late-life mental health and expresses his CREDITS: deep wish for the full recognition in society that those in late life (with or without Writers: mental illness) are invaluable resources in their wealth of experience and wisdom. Judith N. Schwartz Peter Tarr, Ph.D. Throughout 2012 we will share more about our 25-years of unparalleled contribu- Editors: tions and commitment to the field of brain and behavior research. We count on you Laura C. Wells to join our Campaign for Productive Lives with your recommitment to, once again, Vice President, Marketing and Communications accelerate the momentum, build upon the substantial foundation made to date and support the brilliant minds working to improve the lives of all those suffering. Dianne Ackerman Associate Director, Communications and Public Relations Thank you for continuing the journey with us. The momentum is great and there is so much work yet to be done. Layout/Design: Lorraine Divone Production and Art Director Yours sincerely, On the Cover: Eric R. Kandel, M.D. Nobel Prizewinner, Brain & Behavior Research Benita Shobe Foundation Scientific Council Member President & CEO www.bbrfoundation.org 1 Research Discoveries in the News A Sampling of NARSAD Grants at Work: Visit our website to read more: Highlights from 2011 bbrfoundation.org Next Generation Therapies: Diagnostic Tools / Basic Research: Schizophrenia Early Intervention: Depression Schizophrenia and Bipolar Scientific Council Aaron T. Beck, M.D., and colleagues Andrea Danese, M.D., Ph.D., Jonathan Mill, Ph.D., and colleagues Member (SC) demonstrate that cognitive behavioral and colleagues discover that people demonstrate that potentially reversible therapy (CBT) can successfully treat the mistreated in childhood are twice as epigenetic changes play Distinguished ‘negative’ symptoms of schizophrenia, likely to suffer depression a key role in mental Investigator (DI) such as emotional flatness, listlessness and respond poorly to illness in the first and isolation.
Load more

Recommended publications
  • Unrestricted Immigration and the Foreign Dominance Of
    Unrestricted Immigration and the Foreign Dominance of United States Nobel Prize Winners in Science: Irrefutable Data and Exemplary Family Narratives—Backup Data and Information Andrew A. Beveridge, Queens and Graduate Center CUNY and Social Explorer, Inc. Lynn Caporale, Strategic Scientific Advisor and Author The following slides were presented at the recent meeting of the American Association for the Advancement of Science. This project and paper is an outgrowth of that session, and will combine qualitative data on Nobel Prize Winners family histories along with analyses of the pattern of Nobel Winners. The first set of slides show some of the patterns so far found, and will be augmented for the formal paper. The second set of slides shows some examples of the Nobel families. The authors a developing a systematic data base of Nobel Winners (mainly US), their careers and their family histories. This turned out to be much more challenging than expected, since many winners do not emphasize their family origins in their own biographies or autobiographies or other commentary. Dr. Caporale has reached out to some laureates or their families to elicit that information. We plan to systematically compare the laureates to the population in the US at large, including immigrants and non‐immigrants at various periods. Outline of Presentation • A preliminary examination of the 609 Nobel Prize Winners, 291 of whom were at an American Institution when they received the Nobel in physics, chemistry or physiology and medicine • Will look at patterns of
    [Show full text]
  • Advertising (PDF)
    Neuroscience 2013 SEE YOU IN San Diego November 9 – 13, 2013 Join the Society for Neuroscience Are you an SfN member? Join now and save on annual meeting registration. You’ll also enjoy these member-only benefits: • Abstract submission — only SfN members can submit abstracts for the annual meeting • Lower registration rates and more housing choices for the annual meeting • The Journal of Neuroscience — access The Journal online and receive a discounted subscription on the print version • Free essential color charges for The Journal of Neuroscience manuscripts, when first and last authors are members • Free online access to the European Journal of Neuroscience • Premium services on NeuroJobs, SfN’s online career resource • Member newsletters, including Neuroscience Quarterly and Nexus If you are not a member or let your membership lapse, there’s never been a better time to join or renew. Visit www.sfn.org/joinnow and start receiving your member benefits today. www.sfn.org/joinnow membership_full_page_ad.indd 1 1/25/10 2:27:58 PM The #1 Cited Journal in Neuroscience* Read The Journal of Neuroscience every week to keep up on what’s happening in the field. s4HENUMBERONECITEDJOURNAL INNEUROSCIENCE s4HEMOSTNEUROSCIENCEARTICLES PUBLISHEDEACHYEARNEARLY in 2011 s )MPACTFACTOR s 0UBLISHEDTIMESAYEAR ,EARNMOREABOUTMEMBERAND INSTITUTIONALSUBSCRIPTIONSAT *.EUROSCIORGSUBSCRIPTIONS *ISI Journal Citation Reports, 2011 The Journal of Neuroscience 4HE/FlCIAL*OURNALOFTHE3OCIETYFOR.EUROSCIENCE THE HISTORY OF NEUROSCIENCE IN AUTOBIOGRAPHY THE LIVES AND DISCOVERIES OF EMINENT SENIOR NEUROSCIENTISTS CAPTURED IN AUTOBIOGRAPHICAL BOOKS AND VIDEOS The History of Neuroscience in Autobiography Series Edited by Larry R. Squire Outstanding neuroscientists tell the stories of their scientific work in this fascinating series of autobiographical essays.
    [Show full text]
  • Eric Kandel Form in Which This Information Is Stored
    RESEARCH I NEWS pendent, this system would be expected to [2] HEEsch and J E Bums. Distance estimation work quite well, since the new recruit bees by foraging honeybees, The Journal ofExperi­ mental Biology, Vo1.199, pp. 155-162, 1996. tend to take the same route as the experi­ [3] M V Srinivasan, S W Zhang, M Lehrer, and T enced scout bee. What dOJhe ants do when S Collett, Honeybee Navigation en route to they cover similarly several kilometres on the goal: Visual flight control and odometry, foot to look for food? Preliminary evidence The Journal ofExperimental Biology, Vol. 199, pp. 237-244, 1996. indicates that they don't use an odometer but [4] M V Srinivasan, S W Zhang, M Altwein, and instead might count steps! J Tautz, Honeybee Navigation: Nature and Calibration of the Odometer, Science, Vol. Suggested Reading 287, pp. 851-853, 1996. [1] Karl von Frisch, The dance language and OT­ Moushumi Sen Sarma, Centre for Ecological Sci­ ientation of bees, Harvard Univ. Press, Cam­ ences, Indian Institute of Science, Bangalore 560012, bridge, MA, USA, 1993. India. Email: [email protected] Learning from a Sea Snail: modify future behaviour, then memory is the Eric Kandel form in which this information is stored. Together, they represent one of the most valuable and powerful adaptations ever to Rohini Balakrishnan have evolved in nervous systems, for they In the year 2000, Eric Kandel shared the allow the future to access the past, conferring Nobel Prize in Physiology and Medicinel flexibility to behaviour and improving the with two other neurobiologists: Arvid chances of survival in unpredictable, rapidly Carlsson and Paul Greengard.
    [Show full text]
  • The Brain That Changes Itself
    The Brain That Changes Itself Stories of Personal Triumph from the Frontiers of Brain Science NORMAN DOIDGE, M.D. For Eugene L. Goldberg, M.D., because you said you might like to read it Contents 1 A Woman Perpetually Falling . Rescued by the Man Who Discovered the Plasticity of Our Senses 2 Building Herself a Better Brain A Woman Labeled "Retarded" Discovers How to Heal Herself 3 Redesigning the Brain A Scientist Changes Brains to Sharpen Perception and Memory, Increase Speed of Thought, and Heal Learning Problems 4 Acquiring Tastes and Loves What Neuroplasticity Teaches Us About Sexual Attraction and Love 5 Midnight Resurrections Stroke Victims Learn to Move and Speak Again 6 Brain Lock Unlocked Using Plasticity to Stop Worries, OPsessions, Compulsions, and Bad Habits 7 Pain The Dark Side of Plasticity 8 Imagination How Thinking Makes It So 9 Turning Our Ghosts into Ancestors Psychoanalysis as a Neuroplastic Therapy 10 Rejuvenation The Discovery of the Neuronal Stem Cell and Lessons for Preserving Our Brains 11 More than the Sum of Her Parts A Woman Shows Us How Radically Plastic the Brain Can Be Appendix 1 The Culturally Modified Brain Appendix 2 Plasticity and the Idea of Progress Note to the Reader All the names of people who have undergone neuroplastic transformations are real, except in the few places indicated, and in the cases of children and their families. The Notes and References section at the end of the book includes comments on both the chapters and the appendices. Preface This book is about the revolutionary discovery that the human brain can change itself, as told through the stories of the scientists, doctors, and patients who have together brought about these astonishing transformations.
    [Show full text]
  • Message from the Chairman
    Abstract1 6/01/09 8:36 Page 1 Abstract1 6/01/09 8:36 Page 2 MESSAGE FROM THE CHAIRMAN Recent years have been marked by unprecedented growth and development in the life sciences in areas such as gene sequencing, protein interactions and molecular biology. Research conducted during the last decade has resulted in important technological and conceptual advances, along with the development of treatments and early stage cures for diseases like cancer or neurodegenerative diseases. The full sequencing of the human genome, and of a growing number of other living organisms, has heralded a new era in molecular biology and genetics for human medicine. Although these discoveries have opened an unprecedented path toward medical advances, they have also revealed that organic, physiological and genetic mechanisms are far more complex than initially believed. I am therefore particularly honoured that such an impressive panel of scientists agreed to gather together at Ipsen’s new corporate headquarters to lecture on the challenging and exciting perspectives of medical innovation. Jean-Luc Bélingard, Chairman and CEO of the Ipsen Group Abstract1 6/01/09 8:36 Page 3 Professor at the Collège de France and the Institut Pasteur, he is a member of the French Académie des Sciences, the National Academy of Sciences US, the Institute of Medicine of the NAS. He discovered the allostery of proteins and isolated the nicotinic receptor of acetylcholine. Past president of the Comité National d’Ethique, he is the president of the Commission des dations, and the Jean-Pierre Changeux laureate of many scientific prizes: Chairperson médaille d’or du CNRS, Balzan prize, Louis-Jeantet Prize, Biotechnology Study Center of the New York University school of Medicine award, Jean-Louis Signoret Prize of la Fondation Ipsen, the National Academy of Sciences award in neurociences (2007).
    [Show full text]
  • Download Ps Nobel Prizes for Site BEE 11.18.16 Revised 11.30.17.Pdf
    Nobel Laureates at the College of Physicians and Surgeons For years, College of Physicians and Surgeons alumni, faculty, and researchers have led groundbreaking clinical and basic scientific studies that have transformed our understanding of human biology and advanced the practice of medicine. On many occasions, this work has been honored with the Nobel Prize. The scope of research led by P&S Nobel laureates is tremendous. Although most of our prizewinners were honored for work in physiology or medicine, a few also received the prize for chemistry. Their research has fundamentally shaped the course of numerous fields, including cardiology, neuroscience, genetics, pharmaceutical development, and more. Our Nobel laureates include: André Cournand and Dickinson Richards (P&S’23), whose work at P&S on cardiac catheterization—a method of inserting a tiny tube into the heart—provided the basis for open-heart surgery and interventional cardiology Baruch Blumberg (P&S’51), who discovered the hepatitis B virus and helped develop a test and a vaccine for the virus Joshua Lederberg, a Columbia College and P&S graduate student who showed that bacteria can exchange genes when they reproduce, creating a way to model and study genetics in higher organisms Harold Varmus (P&S’66), who demonstrated how genes in normal human and animal cells can mutate to cause cancer, leading to a new generation of research on the genetic origins of cancer Eric Kandel, current University Professor, who showed how memories are stored in nerve cells, greatly enhancing
    [Show full text]
  • Making Your Mind: Molecules, Motion, and Memory Lecture One – Mapping Memory in the Brain Eric R
    Making Your Mind: Molecules, Motion, and Memory Lecture One – Mapping Memory in the Brain Eric R. Kandel, M.D. 1. Start of Lecture I (0:15) [ANNOUNCER:] From the Howard Hughes Medical Institute. The 2008 Holiday Lectures on Science. This year's lectures, "Making Your Mind: Molecules, Motion, and Memory," will be given by Dr. Eric Kandel, Howard Hughes Medical Institute investigator at Columbia University, and Dr. Thomas Jessell, Howard Hughes Medical Institute investigator also at Columbia University. The first lecture is titled "Mapping Memory in the Brain." And now to introduce our program, the President of the Howard Hughes Medical Institute, Dr. Thomas Cech. 2. Welcome by HHMI President Dr. Thomas Cech (1:08) [DR. CECH] Welcome to the Howard Hughes Medical Institute and the 2008 Holiday Lectures on Science. The Institute initiated this series in 1993. In 1995 I had the pleasure of coming here and delivering the lectures on catalytic RNA, and since I've been President of the Institute it's been a great pleasure to be involved in choosing 18 terrific scientists to talk to students here in the auditorium. The Holiday Lectures are one of more than 30 research and education programs of the Institute and please visit our website www.hhmi.org to learn more about all of our activities. This lecture series focuses on the most complex organ in our body and arguably the one that most is responsible for making us human. Clearly without this organ you wouldn't be able to find this auditorium, and even if you got here you wouldn't understand a word that was being said.
    [Show full text]
  • Samuel H. Barondes 1
    EDITORIAL ADVISORY COMMITTEE Giovanni Berlucchi Mary B. Bunge Robert E. Burke Larry E Cahill Stanley Finger Bernice Grafstein Russell A. Johnson Ronald W. Oppenheim Thomas A. Woolsey (Chairperson) The History of Neuroscience in" Autob~ograp" by VOLUME 5 Edited by Larry R. Squire AMSTERDAM 9BOSTON 9HEIDELBERG 9LONDON NEW YORK 9OXFORD ~ PARIS 9SAN DIEGO SAN FRANCISCO 9SINGAPORE 9SYDNEY 9TOKYO ELSEVIER Academic Press is an imprint of Elsevier Elsevier Academic Press 30 Corporate Drive, Suite 400, Burlington, Massachusetts 01803, USA 525 B Street, Suite 1900, San Diego, California 92101-4495, USA 84 Theobald's Road, London WC1X 8RR, UK This book is printed on acid-free paper. O Copyright 92006 by the Society for Neuroscience. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, E-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting "Support & Contact" then "Copyright and Permission" and then "Obtaining Permissions." Library of Congress Catalog Card Number: 2003 111249 British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library ISBN 13:978-0-12-370514-3 ISBN 10:0-12-370514-2 For all information on all Elsevier Academic Press publications visit our Web site at www.books.elsevier.com Printed in the United States of America 06 07 08 09 10 11 9 8 7 6 5 4 3 2 1 Working together to grow libraries in developing countries www.elsevier.com ] ww.bookaid.org ] www.sabre.org ER BOOK AID ,~StbFC" " " =LSEVI lnt .....
    [Show full text]
  • In Search of Memory
    In Search of Memory (The emergence of a new science of mind) Eric R. Kandel (Book review by Carles Sierra. Published in AI Journal 2010, vol 174) This book is a passionate praise of scientific inquiry. The initial biography of the author, from a childhood in nazi-occupied Vienna to a youth of liberal education in the USA, set the character of Eric Kandel as a determined person. His family escaped, when he was 9 years old, the nazi prosecution of Jews in 1939. The book accounts for his personal biography at large put in the context of the research of his time and his contribution to neurosciences. He accounts also for the results of many other European researchers that unfortunately had to leave their countries during WWII. The book is hard to put down, Kandel masters scientific writing and gives a clear and chronological history of the fascinating discoveries of the neurosciences in the twentieth century, The book also accounts for the personal quest of the author to find the ultimate biological explanation of human behaviour, that is, how learning processes and memory are sustained by neurological mechanisms, electrical, chemical and genetic. Memory is the essence of all of us. When we lose our memory we fade away. As Kandel puts it: ‘we are who we are because of what we learn and what we remember.’ The book is organised along three different types of content. On the one hand the personal biography of the author that allows the reader to enjoy the motives, illusions and emotions of a researcher, a detailed explanation of research findings that introduce the reader to the big names in neuroscience during the nineteenth and twentieth centuries, and a chronological description of the research focus of Eric Kandel.
    [Show full text]
  • OPINION When All the Giants Are Gone
    The Journal of Undergraduate Neuroscience Education (JUNE), Fall 2015, 14(1):E1-E2 OPINION When All the Giants Are Gone Ian A. Harrington Department of Psychology and Program in Neuroscience, Augustana College, Rock Island, IL 61201. It is one of the most often repeated aphorisms in the productive, respected, and even celebrated scientists to history of science: “If I have seen further it is by standing come, but will they be equal to the measure of the giants on the shoulders of giants.” Although this form of the who came before? Inspired by Thomas Kuhn (1996), I aphorism can be attributed to Sir Isaac Newton, the actual propose that what leads to the establishment of a giant is sentiment can be traced at least to the Middle Ages, radical change or, in Kuhn’s words, scientific revolution. A suggesting that Newton was standing on others’ shoulders fledgling science, as neuroscience was in the 1950s and not only in his science but in his reflections upon science 60s, is all revolution. For example, Hodgkin and Huxley’s (Merton, 1993). This opinion piece is about the giants of characterization of action potential propagation (1952), neuroscience and was motivated by three things. The first Levi-Montalcini’s work with nerve growth factor (Levi- was my reading of Michael Gazzaniga’s recent memoir, Montalcini and Angeletti, 1968), Hubel and Wiesel’s Tales from Both Sides of the Brain: A Life in Neuroscience studies in the physiology of the visual cortex (1962), Sperry (2014). I was amazed by the scope of the scientific life it and Gazzaniga’s research with split brain patients described.
    [Show full text]
  • ILAE Historical Wall02.Indd 10 6/12/09 12:04:44 PM
    2000–2009 2001 2002 2003 2005 2006 2007 2008 Tim Hunt Robert Horvitz Sir Peter Mansfi eld Barry Marshall Craig Mello Oliver Smithies Luc Montagnier 2000 2000 2001 2002 2004 2005 2007 2008 Arvid Carlsson Eric Kandel Sir Paul Nurse John Sulston Richard Axel Robin Warren Mario Capecchi Harald zur Hauser Nobel Prizes 2000000 2001001 2002002 2003003 200404 2006006 2007007 2008008 Paul Greengard Leland Hartwell Sydney Brenner Paul Lauterbur Linda Buck Andrew Fire Sir Martin Evans Françoise Barré-Sinoussi in Medicine and Physiology 2000 1st Congress of the Latin American Region – in Santiago 2005 ILAE archives moved to Zurich to become publicly available 2000 Zonismide licensed for epilepsy in the US and indexed 2001 Epilepsia changes publishers – to Blackwell 2005 26th International Epilepsy Congress – 2001 Epilepsia introduces on–line submission and reviewing in Paris with 5060 delegates 2001 24th International Epilepsy Congress – in Buenos Aires 2005 Bangladesh, China, Costa Rica, Cyprus, Kazakhstan, Nicaragua, Pakistan, 2001 Launch of phase 2 of the Global Campaign Against Epilepsy Singapore and the United Arab Emirates join the ILAE in Geneva 2005 Epilepsy Atlas published under the auspices of the Global 2001 Albania, Armenia, Arzerbaijan, Estonia, Honduras, Jamaica, Campaign Against Epilepsy Kyrgyzstan, Iraq, Lebanon, Malta, Malaysia, Nepal , Paraguay, Philippines, Qatar, Senegal, Syria, South Korea and Zimbabwe 2006 1st regional vice–president is elected – from the Asian and join the ILAE, making a total of 81 chapters Oceanian Region
    [Show full text]
  • Jacsue Kehoe 320
    EDITORIAL ADVISORY COMMITTEE Marina Bentivoglio Larry F. Cahill Stanley Finger Duane E. Haines Louise H. Marshall Thomas A. Woolsey Larry R. Squire (Chairperson) The History of Neuroscience in Autobiography VOLUME 4 Edited by Larry R. Squire ELSEVIER ACADEMIC PRESS Amsterdam Boston Heidelberg London New York Oxford Paris San Diego San Francisco Singapore Sydney Tokyo This book is printed on acid-free paper. (~ Copyright 9 byThe Society for Neuroscience All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: [email protected]. You may also complete your request on-line via the Elsevier homepage (http://elsevier.com), by selecting "Customer Support" and then "Obtaining Permissions." Academic Press An imprint of Elsevier 525 B Street, Suite 1900, San Diego, California 92101-4495, USA http ://www.academicpress.com Academic Press 84 Theobald's Road, London WC 1X 8RR, UK http://www.academicpress.com Library of Congress Catalog Card Number: 2003 111249 International Standard Book Number: 0-12-660246-8 PRINTED IN THE UNITED STATES OF AMERICA 04 05 06 07 08 9 8 7 6 5 4 3 2 1 Contents Per Andersen 2 Mary Bartlett Bunge 40 Jan Bures 74 Jean Pierre G. Changeux 116 William Maxwell (Max) Cowan 144 John E. Dowling 210 Oleh Hornykiewicz 240 Andrew F.
    [Show full text]