Journal Thoracic of Disease Vol 6, No 12 December 2014 ISSN 2072-1439 JJOURNALOURNAL ofof TTHORACICHORACIC DDISEASEISEASE www.jthoracdis.com Volume 6 Number 12 December 2014 Pages 1654-1891; E246-E312 December Pages 6 Number 1654-1891; Volume 12 2014 Published by The Official Publication of Indexed in THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY PubMed, SCI Aims and Scope Guangzhou office: The Journal of Thoracic Disease (JTD, J Thorac Dis, pISSN: Guangqiao Zeng, MD 2072-1439; eISSN: 2077-6624) was founded in Dec 2009, Guangzhou Institute of Respiratory Disease & The First indexed in Pubmed/Pubmed Central in Dec 2011, and Affiliated Hospital of Guangzhou Medical University. Science Citation Index (SCI) on Feb 4, 2013. It is published No. 151, Yanjiang Rd, Guangzhou 510120, China. quarterly (Dec 2009- Dec 2011), bimonthly (Jan 2012- Dec 2013), and monthly (Jan 2014-), and openly distributed Email: [email protected] worldwide. JTD publishes manuscripts that describe new www.jthoracdis.com findings in the field to provide current, practical information on the diagnosis and treatment of conditions related to Note to NIH Grantees thoracic disease (lung disease, cardiac disease, breast disease Pursuant to NIH mandate, Pioneer Bioscience Publishing and esophagus disease). Original articles are considered Company will post the accepted version of contributions authored most important and will be processed for rapid review by by NIH grant-holders to PubMed Central upon acceptance. This the members of Editorial Board. Clinical trial notes, Cancer accepted version will be made publicly available 2 months after genetics reports, Epidemiology notes and Technical notes are publication. For further information, see www.thepbpc.org also published. Case reports implying new findings that have significant clinical impact are carefully processed for possible Conflict of Interest Policy for Editors publication. 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Endorsed by: (See P1762 in this issue). v International COPD Coalition (ICC) For submission instructions, subscription and all other Editorial Correspondence information visit www.jthoracdis.com HK office: Daoyuan Wang. © 2014 Pioneer Bioscience Publishing Company Pioneer Bioscience Publishing Company Room 604, 6/F Hollywood Center, 77-91 Queen’s road, Sheung Wan, Hong Kong. Editor-in-Chief Executive Editor-in-Chief Executive Editor-in-Chief Nanshan Zhong, MD Jianxing He, MD, FACS (Cardiovascular Surgery) Academician, Chinese Academy of Engineering. The First Affiliated Hospital of Guangzhou Tristan D. Yan, BSc, MBBS, MS, MD, PhD Guangzhou Institute of Respiratory Disease, Medical University, Guangzhou, China Department of Cardiothoracic Surgery, Royal Guangzhou, China Prince Alfred Hospital, University of Sydney, Sydney, Australia; The Collaborative Research Deputy Editors-in-Chief (CORE) Group, Sydney, Australia Jin-Shing Chen, MD, PhD Lawrence Grouse, MD, PhD Taipei, Taiwan Gig Harbor, USA Rongchang Chen, MD, PhD Shahzad G. Raja, MBBS, MRCSEd, FRCSEd Guangzhou , China (C-Th) Editorial Co-Directors & Executive Editors Yi-Jen Chen, MD, PhD London, United Kingdom Guangqiao Zeng, MD Duarte, USA Gaetano Rocco, MD, FRCS (Ed), FETCS, Guangzhou, China Kwun Fong, MBBS (Lon), FRACP, PhD FCCP Daoyuan Wang, MD Brisbane, Australia Naples, Italy Guangzhou, China Associate Editors Statistical Editors Hatem A Azim Jr, MD Paul Zarogoulidis, MD, PhD Jiqian Fang, PhD Brussels, Belgium Thessaloniki , Greece Guangzhou, China Kazuaki Takabe, MD, PhD, FACS Junya Zhu, MS, MA Baoliang Zhong, MD, PhD Richmond, United States Baltimore, United States Hong Kong, China Gary Y. Yang, MD Loma Linda, United States Section Editor (Surgical Video) Section Editor Section Editor Yaxing Shen, MD (Systematic Review and Meta-analysis) (Cancer Registry, Prevention and Control) Shanghai, China Zhi-De Hu, M.M Jinan, China Wanqing Chen, MD Wan-Jie Gu, MSc Nanning, China Beijing, China Zhi-Rui Zhou, MD Changchun, China Editorial Board Cesare Gridelli, MD Lunxu Liu, MD FCSHK, FHKAM (Surgery), FCCP Peter J Barnes, DM, DSc, FRCP, Tomas Gudbjartsson, MD, PhD Hui-Wen Lo, PhD Charles B. Simone, II, MD FCCP, FMedSci, FRS Henrik Jessen Hansen, MD Kevin W. Lobdell, MD Yong Song, MD, PhD J. Patrick Barron, MD Don Hayes, Jr, MD, MS, Med Jiade J. Lu, MD, MBA Joerg S. Steier, MD (D), PhD (UK) Luca Bertolaccini, MD, PhD Andrea Imperatori, MD Wei-Guo Ma, MD Xiaoning Sun, MD, PhD Alessandro Brunelli, MD Mary Sau Man Ip, MBBS(HK), Giovanni Mariscalco, MD, PhD Lijie Tan, MD, Vice Chief Peter Calverley, MD MD(HK), FRCP (London, Doug McEvoy, MBBC, FRACP Kosmas Tsakiridis, MD, PhD Weiguo Cao, MD Edinburgh, Glasgow), FHKCP, Walter McNicholas, MD, FRCPI, Kenneth WT Tsang, MD, FRCP Stephen D. Cassivi, MD, MSc, FHKAM, FAPSR, FCCP FRCPC, FCCP Mark I. van Berge Henegouwen, FRCSC, FACS Rihard S. Irwin, MD, Master FCCP Michael T. Milano, MD, PhD MD, PhD Mario Cazzola, MD Ki-Suck Jung, MD, PhD John D. Mitchell, MD Federico Venuta, MD Joe Y Chang, MD, PhD Markus Krane, MD Alyn H Morice, MD Ko Pen Wang, MD, FCCP Kian Fan Chung, MD, DSc, FRCP Alexander Sasha Krupnick, MD Akio Niimi, MD, PhD Qun Wang, MD, FRCS Henri G. Colt, MD, FCCP Hyun Koo Kim, MD, PhD Antonio Passaro, MD Yi-Xiang Wang, MD Thomas A. D’Amico, MD Anand Kumar, MD Georgios Plataniotis, MD, PhD Zheng Wang, MD Giovanni Dapri, MD, FACS, FASMBS Aseem Kumar, PhD David Price, M.B B.Chir, MA, Bryan A Whitson, MD, PhD Keertan Dheda, MBBcH, Y. C. Gary Lee, MBChB, PhD, DRCOG, FRCGP Yunlong Xia, MD, PhD FCP(SA), FCCP, PhD(Lond), FCCP, FRCP, FRACP Gui-bin Qiao, MD, PhD Jin Xu, MS FRCP(Lond) Mario Leoncini, MD Klaus F Rabe, MD, PhD Stephen C. Yang, MD Peter V. Dicpinigaitis, MD Hui Li, MD Dominik Rüttinger, MD, PhD, FACS Kazuhiro Yasufuku, MD, PhD Leonardo M. Fabbri Min Li, PhD, Professor Sundeep Salvi, MD, DNB, PhD, FCCP Xiuyi Zhi, MD Wentao Fang, MD Tianhong Li, MD, PhD Martin Schweiger, MD Ming Zhong, MD Yoshinosuke Fukuchi, MD, PhD Wenhua Liang, MD Suresh Senan, MRCP, FRCR, PhD Caicun Zhou, MD, PhD Diego Gonzalez-Rivas, MD, FECTS Yang Ling, MD Alan Dart Loon Sihoe, MBBChir, Qinghua Zhou, MD Dominique Gossot, MD Deruo Liu, MD MA (Cantab), FRCSEd (CTh), Zhi-hua Zhu, MD, PhD Journal Club Director Editorial Assistants Senior Editors Science Editors Executive Copyeditor Executive Typesetting Editor Bing Gu, MD Maria Karina, MD, PhD, Grace S. Li (Corresponding Melanie C. He Emily M. Shi Jian Li FRCP Editor) Tina C. Pei Parag Prakash Shah, PhD Eunice X. Xu Molly J. Wang Production Editor Elva S. Zheng Rui Wang Emily M. Shi Nancy Q. Zhong Table of Contents Editorial 1654 The next challenge for VATS lobectomy surgeons Antonio E. Martin-Ucar 1655 Spontaneous esophageal rupture as the underlying cause of pneumothorax: early recognition is crucial George Garas, Paul Zarogoulidis, Alkiviadis Efthymiou, Thanos Athanasiou, Kosmas Tsakiridis, Sofia Mpaka, Emmanouil Zacharakis 1659 Big data and clinical research: perspective from a clinician Zhongheng Zhang 1665 Endobronchial ultrasound-guided transbronchial needle aspiration: a maturing technique Jianjun Zhang, Yangang Ren Original Article 1668 The lung cancer epidemic in Spanish women: an analysis of mortality rates over a 37-year period Jose Luis López-Campos, Miguel Ruiz-Ramos, Carmen Calero 1674 Treatment of giant emphysamous bulla with endobronchial valves in patients with chronic obstructive pulmonary disease: a case series Qing Tian, Yang An, Bin-Bin Xiao, Liang-An Chen 1681 Effect of a neutrophil elastase inhibitor on ventilator-induced lung injury in rats Do-Hyung Kim, Jae Ho Chung, Bong Soo Son, Yeon Ji Kim, Sang Gwon Lee 1690 Cost and effectiveness of video-assisted thoracoscopic surgery for clinical stage I non-small cell lung cancer: a population-based analysis Hsin-Yuan Fang, Fei-Yuan Hsiao, Hsu-Chih Huang, Yu-Sen Lin, Chih-Yi Chen, Shwn-Huey Shieh, Pin-Ru Chen, Chein-Kuang Chen, Chun-Ru Chien 1697 Predictive risk factors for lymph node metastasis in patients with small size non-small cell lung cancer Feichao Bao, Ping Yuan, Xiaoshuai Yuan, Xiayi Lv, Zhitian Wang, Jian Hu 1704 The protective effects of glutamine in a rat model of ventilator-induced lung injury Chin-Ming Chen, Kuo-Chen Cheng, Chien-Feng Li, Haibo Zhang 1714 Lung cancer staging: the value of PET depends on the clinical setting Frank C. Detterbeck, Santiago Figueroa Almanzar 1724 Five-year epidemiological survey of valvular heart disease: changes in morbidity, etiological spectrum and management in a cardiovascular center of Southern China Fang-Zhou Liu,