Henry Ford Health System Henry Ford Health System Scholarly Commons Case Reports Medical Education Research Forum 2020 5-2020 Paradoxical Psoriatic Arthritis with the Initiation of Brodalumab and Guselkumab Reem Kashlan Henry Ford Health System,
[email protected] Kristin Slater Henry Ford Health System Francisca Kartono Henry Ford Health System Follow this and additional works at: https://scholarlycommons.henryford.com/merf2020caserpt Recommended Citation Kashlan, Reem; Slater, Kristin; and Kartono, Francisca, "Paradoxical Psoriatic Arthritis with the Initiation of Brodalumab and Guselkumab" (2020). Case Reports. 68. https://scholarlycommons.henryford.com/merf2020caserpt/68 This Poster is brought to you for free and open access by the Medical Education Research Forum 2020 at Henry Ford Health System Scholarly Commons. It has been accepted for inclusion in Case Reports by an authorized administrator of Henry Ford Health System Scholarly Commons. Paradoxical Psoriatic Arthritis with the Initiation of Brodalumab and Guselkumab Reem Kashlan MPH, Kristin Slater MS, Francisca Kartono DO Henry Ford Health System, Detroit, Michigan Background Timeline Discussion • Paradoxical reactions have been described in the literature Paradoxical plaque psoriasis reactions have been reported with for biologics such as anti-tumor Necrosis Factor Alpha the usage of biologics, primarily with the use of anti-TNF One week later, Patient Agents, ustekinumab, secukinumab, ixekizumab1 agents. Brodalumab, a human monoclonal antibody against Patient prescribed Siliq 210 called with joint pain after starting Siliq. Severe pain interleukin-17 receptor A (IL17RA), has been proven to be mg/1.5mL subcutanous • It has been hypothesized that paradoxical reactions occur injection over the weekend in knees effective against psoriasis and psoriatic arthritis.1 A newer and shoulders.