Cytokine/Chemokine Release Patterns and Transcriptomic
International Journal of Molecular Sciences Article Cytokine/Chemokine Release Patterns and Transcriptomic Profiles of LPS/IFNγ-Activated Human Macrophages Differentiated with Heat-Killed Mycobacterium obuense, M-CSF, or GM-CSF Samer Bazzi 1,*, Emale El-Darzi 2, Tina McDowell 3, Helmout Modjtahedi 4 , Satvinder Mudan 5, Marcel Achkar 6, Charles Akle 5 , Humam Kadara 3 and Georges M. Bahr 2 1 Division of Biology and Environmental Science, Faculty of Arts and Sciences, University of Balamand, 33 Amioun, Al Kurah 100, Lebanon 2 Department of Biomedical Sciences, Faculty of Medicine and Medical Sciences, University of Balamand, 33 Amioun, Al Kurah 100, Lebanon; emaledarzi@gmail.com (E.E.-D.); georges.bahr@balamand.edu.lb (G.M.B.) 3 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; CLMcDowell@mdanderson.org (T.M.); HKadara@mdanderson.org (H.K.) 4 School of Life Sciences, Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Surrey KT1 2EE, UK; H.Modjtahedi@kingston.ac.uk 5 The London Clinic, 20 Devonshire Pl, London W1G 6BW, UK; mudans@aol.com (S.M.); cakle@me.com (C.A.) 6 Clinical Laboratory, Nini Hospital, Tripoli 1434, Lebanon; marcel.achkar@hopitalnini.com Citation: Bazzi, S.; El-Darzi, E.; * Correspondence: samer.bazzi@balamand.edu.lb; Tel.: +961-6-930250 (ext. 3832) McDowell, T.; Modjtahedi, H.; Mudan, S.; Achkar, M.; Akle, C.; Abstract: Macrophages (M's) are instrumental regulators of the immune response whereby they Kadara, H.; Bahr, G.M. acquire diverse functional phenotypes following their exposure to microenvironmental cues that Cytokine/Chemokine Release govern their differentiation from monocytes and their activation.
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