Use of Pipamperone and an SNDRI, SNRI Or SSRI for the Treatment Of

Total Page:16

File Type:pdf, Size:1020Kb

Use of Pipamperone and an SNDRI, SNRI Or SSRI for the Treatment Of (19) & (11) EP 1 541 197 B8 (12) CORRECTED EUROPEAN PATENT SPECIFICATION (15) Correction information: (51) Int Cl.: Corrected version no 1 (W1 B1) A61K 31/343 (2006.01) A61K 31/4545 (2006.01) Corrections, see A61P 25/22 (2006.01) A61P 25/24 (2006.01) Bibliography INID code(s) 56 (48) Corrigendum issued on: 10.06.2009 Bulletin 2009/24 (45) Date of publication and mention of the grant of the patent: 18.03.2009 Bulletin 2009/12 (21) Application number: 04025035.9 (22) Date of filing: 21.10.2004 (54) Use of pipamperone and an SNDRI, SNRI or SSRI for the treatment of mood or anxiety disorders Verwendung von Pipamperon und einem SNDRI, SNRI oder SSRI zur Behandlung von Stimmungs- oder Angststörungen Utilisation de pipamperone et d’un SNDRI, SNRI ou SSRI pour le traitement des troubles de l’humeur ou anxieux (84) Designated Contracting States: • VOLMAT R ET AL: "The treatment of depressions AT BE BG CH CY CZ DE DK EE ES FI FR GB GR by Cledial. Evolution and clinical state and HU IE IT LI LU MC NL PL PT RO SE SI SK TR handwriting" PSYCHOLOGIE MEDICALE 1986 FRANCE, vol. 18, no. 10, 1986, pages 1615-1622, (30) Priority: 02.12.2003 EP 03447279 XP009028776 05.01.2004 EP 04447001 • SQUELART P ET AL: "Pipamperone (Dipiperon), 18.03.2004 EP 04447066 a useful sedative neuroleptic drug in troublesome chronic psychotic patients." ACTA (43) Date of publication of application: PSYCHIATRICA BELGICA. BELGIUM 1977 MAR- 15.06.2005 Bulletin 2005/24 APR, vol. 77, no. 2, March 1977 (1977-03), pages 284-293, XP009028314 ISSN: 0300-8967 (73) Proprietor: PharmaNeuroBoost N.V. • KOCH H J ET AL: "Successful therapy of tardive 3570 Alken (BE) dyskinesia in a 71-year-old woman with a combination of tetrabenazine, olanzapine and (72) Inventor: Buntinx, Erik tiapride." INTERNATIONAL JOURNAL OF 3750 Alken (BE) CLINICAL PRACTICE. ENGLAND MAR 2003, vol. 57, no. 2, March 2003 (2003-03), pages 147-149, (74) Representative: De Clercq, Ann G. Y. et al XP009030046 ISSN: 1368-5031 De Clercq, Brants & Partners c.v. • DIEBOLD K. ET AL: "Are psychoactive-drug- Edgard Gevaertdreef 10a induced changes in plasma lipid and lipoprotein 9830 Sint-Martens-Latem (BE) levels of significance for clinical remission in psychiatric disorders?." (56) References cited: PHARMACOPSYCHIATRY, (1998) 31/2 (60-67)., WO-A-98/43646 DE-A- 4 039 631 1998, XP009029360 US-A- 5 762 960 Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). EP 1 541 197 B8 Printed by Jouve, 75001 PARIS (FR) (Cont. next page) EP 1 541 197 B8 • PERUGI G ET AL: "EFFECTIVENESS OF • ENGELBORGHS S ET AL: "AMINO ACIDS AND ADJUNCTIVE GABAPENTIN IN RESISTANT BIOGENIC AMINES IN CEREBROSPINAL FLUID BIPOLAR DISORDER: IS IT DUE TO ANXIOUS- OF PATIENTS WITH PARKINSON’S DISEASE" ALCOHOL ABUSE COMORBIDITY?" JOURNAL NEUROCHEMICAL RESEARCH, PLENUM OF CLINICAL PSYCHOPHARMACOLOGY, PRESS, NEW YORK, US, vol. 28, no. 8, August WILLIAMS AND WILKINS, US, vol. 22, no. 6, 2002, 2003 (2003-08), pages 1145-1150, XP009031514 pages 584-591, XP009029358 ISSN: 0271-0749 ISSN: 0364-3190 • ADLER L ET AL: "PRAXIS DER STATIONAEREN • DATABASE EMBASE [Online] ELSEVIER AKUTBEHANDLUNG VON MANIEN SCIENCE PUBLISHERS, AMSTERDAM, NL; 1999, RETROSPEKTIVE ETCHEPAREBORDA M C: "Neurocognitive and VERGLEICHSUNTERSUCHUNG AN JE 100 pharmacological approach to specific learning PATIENTEN ZWEIER PSYCHIATRISCHER disorders" XP002312308 Database accession no. ZENTREN PRACTICE OF IN-PATIENT ACUTE EMB-2000050033 & REVISTA DE NEUROLOGIA TREATMENT OF MANIAS" FORTSCHRITTE DER 1999 SPAIN, vol. 28, no. SUPPL. 2, 1999, pages NEUROLOGIE PSYCHIATRIE, STUTTGART, DE, S81-S93, ISSN: 0210-0010 vol. 62, no. 12, 1994, pages 479-488, XP009029389 • WIRZ-JUSTICE A ET AL: "HALOPERIDOL ISSN: 0720-4299 DISRUPTS, CLOZAPINE REINSTATES THE • ANSOMS C ET AL: "Sleep disorders in patients CIRCADIAN REST-ACTIVITY CYCLE IN A with severe mental depression: double-blind PATIENT WITH EARLY-ONSET ALZHEIMER placebo-controlled evaluation of the value of DISEASE" ALZHEIMER DISEASE AND pipamperone (Dipiperon)." ACTA ASSOCIATED DISORDERS, RAVEN PRESS, NEW PSYCHIATRICA SCANDINAVICA. FEB 1977, vol. YORK, NY, US, vol. 14, no. 4, 2000, pages 212-215, 55, no. 2, February 1977 (1977-02), pages 116-122, XP009029353 ISSN: 0893-0341 XP009041169 ISSN: 0001-690X • FAHS H ET AL: "THYMOREGULATEURS DANS • LEYSEN J E ET AL: "RECEPTOR INTERACTI0NS L’AGITATION ET LES TROUBLES DU OF NEW ANTIPSYCHOTICS: RELATION TO COMPORTEMENT CHEZ LE SUJET DEMENT A PHARMACODYNAMIC AND CLINICAL EFFECTS" PROPOS DE HUIT CAS ANTICONVULSIVANTS INTERNATIONAL JOURNAL OF PSYCHIATRY IN AND AGGRESSIVE BEHAVIORS IN CLINICAL PRACTICE, MARTIN DUNITZ, ALZHEIMER’S DISEASE. EIGHT CASES LONDON, GB, vol. 2, no. 1, 1998, pages S03-S17, REPORTS" ENCEPHALE, PARIS, FR, vol. 25, no. XP001009585 ISSN: 1365-1501 2, 1999, pages 169-174, XP009039295 ISSN: • DATABASE BIOSIS [Online] BIOSCIENCES 0013-7006 INFORMATION SERVICE, PHILADELPHIA, PA, • GRÖZINGER M ET AL: "Melperone is an inhibitor US; 1996, SCHOTTE A ET AL: "Risperidone of the CYP2D6 catalyzed O-demethylation of compared with new and reference antipsychotic venlafaxine." PHARMACOPSYCHIATRY. drugs: In vitro and in vivo receptor binding" GERMANY JAN 2003, vol. 36, no. 1, January 2003 XP002290498 Database accession no. (2003-01), pages 3-6, XP009029363 ISSN: PREV199698829913 & 0176-3679 PSYCHOPHARMACOLOGY, vol. 124, no. 1-2, • WERTH ESTHER ET AL: "Decline in long-term 1996, pages 57-73, ISSN: 0033-3158 circadian rest-activity cycle organization in a • VANHOENACKER P ET AL: "EFFICIENT patient with dementia." JOURNAL OF GERIATRIC EXPRESSION OF THE HUMAN DOPAMINE D4.2 PSYCHIATRY AND NEUROLOGY. 2002 SPRING, RECEPTOR: POSITIVE INFLUENCE OF vol. 15, no. 1, April 2002 (2002-04), pages 55-59, PIPAMPERONE ON EXPRESSION LEVELS" XP009042127 ISSN: 0891-9887 ABSTRACTS OF THE SOCIETY FOR • STAHL STEPHEN M ET AL: "Examination of NEUROSCIENCE, SOCIETY FOR nighttime sleep-related problems during double- NEUROSCIENCE, WASHINGTON, DC, US, vol. 26, blind, placebo-controlled trials of galantamine in no. 1/2, 2000, page 1, XP001181469 ISSN: patients with Alzheimer’s disease." CURRENT 0190-5295 MEDICAL RESEARCH AND OPINION. APR 2004, • VIJVER VAN DE D A M C ET AL: vol. 20, no. 4, April 2004 (2004-04), pages 517-524, "ANTIPSYCHOTICS AND PARKINSON’S XP009041652 ISSN: 0300-7995 DISEASE: ASSOCIATION WITH DISEASE AND • DATABASE BIOSIS [Online] BIOSCIENCES DRUG CHOICE DURING THE FIRST 5 YEARS OF INFORMATION SERVICE, PHILADELPHIA, PA, ANTIPARKINSONIAN DRUG TREATMENT" US; 1995, MELTZER HERBERT Y ET AL: "Plasma EUROPEAN JOURNAL OF CLINICAL clozapine levels and the treatment of L-DOPA- PHARMACOLOGY, SPRINGER VERLAG, DE, vol. induced psychosis in Parkinson’s disease. A 58, no. 7, 2002, pages 157-161, XP009033980 high potency effect of clozapine" XP002290499 ISSN: 0031-6970 Database accession no. PREV199598192811 & NEUROPSYCHOPHARMACOLOGY, vol. 12, no. 1, 1995, pages 39-45, ISSN: 0893-133X 2 (Cont. next page) EP 1 541 197 B8 • MUENCHAU A ET AL: "PHARMACOLOGICAL • "Pipamperone dichlorhydrate"[Online] 2000, TREATMENT OF PARKINSON’S DISEASE" pages 1-4, Retrieved from the Internet: URL:http: POSTGRADUATE MEDICAL JOURNAL, //www.biam2.org/www/Sub2783.html> [retrieved MCMILLAN PRESS, BASINGSTOKE, GB, vol. 76, on 2007] no. 900, October 2000 (2000-10), pages 602-610, • ’Médicaments psychotropes: posologies chez XP009034316 ISSN: 0032-5473 l’enfant et l’adolescent’, [Online] 2001, pages 1 - • FALTRACO F ET AL: "AKTUELLE 3 Retrieved from the Internet: <URL:http: THERAPIEMOEGLICHKEITEN DER ALZHEIMER //www.adiph.org/pic/pedia-neurole ptiques.pdf> DEMENZ CURRENT THERAPEUTICAL [retrieved on 2007-00-00] STRATEGIES IN DEMENTIA" NEUROLOGIE UND • HEISER P.; REMSCHMIDT H.: ’SELECTIVE REHABILITATION, BONN, DE, vol. 9, no. 1, 2003, SEROTONIN REUPTAKE INHIBITORS AND pages 15-22, XP009041267 ISSN: 0947-2177 NEWER ANTIDEPRESSIVE SUBSTANCES IN • MONTGOMERY S.A.; ANDERSEN H.F.: CHILD AND ADOLESCENT PSYCHIATRY. DIE ’Escitalopram versus venlafaxine XR in the SELEKTIVEN SEROTONIN- treatment of depression’ INTERNATIONAL WIEDERAUFNAHMEHEMMER UND DIE CLINICAL PHARMACOLOGY vol. 21, no. 5, 2006, NEUEREN ANTIDEPRESSIVA-SUBSTANZEN IN pages 297 - 309 DER KINDER- UND JUGENDPSYCHIATRIE’ • KHAN ARIF; WARNER HEATHER A.; BROWN ZEITSCHRIFT FUER KINDER- UND WALTER A.: ’Symptom reduction and suicide risk JUGENDPSYCHIATRIE UNDPSYCHOTHERAPIE in patients treated with placebo in antidepressant vol. 30, no. 3, 2002, pages 173 - 183, XP009076880 clinical trials: An analysis of the Food and Drug • CARLIER P.R. ET AL: ’Synthesis of a Potent Wide- Administration database’ ARCHIVES OF Spectrum Serotonin-, Norepinephrine-, GENERAL PSYCHIATRY vol. 57, no. 4, 2000, Dopamine-Reuptake Inhibitor (SNDRI) and a pages 311 - 317 Species-Selective Dopamine-Reuptake Inhibitor • MOORE NICHOLAS; VERDOUX HÉLÈNE; Based on the Gamma-Amino Alcohol Functional FANTINO BRUNO: ’Prospective, multicentre, Group’ BIOORGANIC & MEDICINAL CHEMISTRY randomized, double-blind study of the efficacy of LETTERS vol. 8, no. 5, 1998, pages 487 - 492 escitalopram versus citalopram in outpatient • MAINA GIUSEPPE ET AL: ’ANTIPSYCHOTIC treatment of major depressive disorder’ AUGMENTATION FOR TREATMENT RESISTANT INTERNATIONAL CLINICAL OBSESSIVE-COMPULSIVE DISORDER: WHAT IF PSYCHOPHARMACOLOGY
Recommended publications
  • Dipiperon®) Is a Mild to Moderately Potent Butyrophenone Neuroleptic and Is Used in the Treatment of Psychosis and Severe Agitation
    Pipamperone and increased appetite/weight Introduction Pipamperone (Dipiperon®) is a mild to moderately potent butyrophenone neuroleptic and is used in the treatment of psychosis and severe agitation. It is a 5-HT(2) receptor antagonist and demonstrates weak affinity for alpha1-adrenergic and D2-receptors. Pipamperone has not been associated with anticholinergic effects. Pipamperone has been approved for the Dutch market since 1968[1]. Weight gain is a well-known side-effect of antipsychotics, alone or part of a metabolic syndrome. Weight gain, diabetes, dyslipidemia, diabetic ketoacidosis, and cardiovascular disease constitute a metabolic syndrome usually associated with second-generation antipsychotics, presenting with comparable frequency in first-generation antipsychotics. The mechanism by which these symptoms are produced is not entirely clear. There is some evidence for both increased appetite and altered metabolic control with these drugs. Patient-related factors include pre-existing metabolic issues. Those who are obese, diabetic or prediabetic, or have high-risk lipid profiles are more likely to experience problems with these medications than other patients. Increased susceptibility for metabolic side effects in patients with some of the disorders they are treated for, particularly schizophrenia, may also play a role [2]. Reports Between April 1989 and April 2017 Lareb received 12 reports of weight increased and/or increased appetite associated with the use of pipamperone. Table 1. Cases of pipamperone and increased weight/appetite
    [Show full text]
  • Mrna Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases Upon Antidepressant Treatment
    International Journal of Molecular Sciences Article mRNA Expression of SMPD1 Encoding Acid Sphingomyelinase Decreases upon Antidepressant Treatment Cosima Rhein 1,2,* , Iulia Zoicas 1 , Lena M. Marx 1, Stefanie Zeitler 1, Tobias Hepp 2,3, Claudia von Zimmermann 1, Christiane Mühle 1 , Tanja Richter-Schmidinger 1, Bernd Lenz 1,4 , Yesim Erim 2, Martin Reichel 1,† , Erich Gulbins 5 and Johannes Kornhuber 1 1 Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Schwabachanlage 6, D-91054 Erlangen, Germany; [email protected] (I.Z.); [email protected] (L.M.M.); [email protected] (S.Z.); [email protected] (C.v.Z.); [email protected] (C.M.); [email protected] (T.R.-S.); [email protected] (B.L.); [email protected] (M.R.); [email protected] (J.K.) 2 Department of Psychosomatic Medicine and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-91054 Erlangen, Germany; [email protected] (T.H.); [email protected] (Y.E.) 3 Institute of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-91054 Erlangen, Germany 4 Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, D-68159 Mannheim, Germany 5 Department of Molecular Biology, University Hospital, University of Duisburg-Essen, D-45147 Essen, Germany; [email protected] * Correspondence: [email protected]; Tel.: +49-9131-85-44542 Citation: Rhein, C.; Zoicas, I.; Marx, † Current address: Department of Nephrology and Medical Intensive Care, Charité—Universitätsmedizin L.M.; Zeitler, S.; Hepp, T.; von Berlin, Berlin, Germany.
    [Show full text]
  • A Long Term Clinical Diagnostic-Therapeutic
    Psychiatria Danubina, 2013; Vol. 25, Suppl. 2, pp 190–193 Conference paper © Medicinska naklada - Zagreb, Croatia A LONG TERM CLINICAL DIAGNOSTIC-THERAPEUTIC EVALUATION OF 30 CASE REPORTS OF BIPOLAR SPECTRUM MIXED STATES Giuseppe Tavormina "Psychiatric Studies Center" (Cen.Stu.Psi.), Provaglio d'Iseo (BS), Italy SUMMARY The aim of this study is to show how managing long term patients who are diagnosed as having bipolar disorder with an affective mixed states can cause them to achieve a high level of recovery from the illness and quality of life. This study observed all consecutive new patients who were seen in a private psychiatry practice during the years 2008-2009- 2010 who had a diagnosis within the mixed states sub-group (Irritable Cyclothymia, Mixed Disphoria and Agitated Depression)Thirty patients were selected who presented with a score of less than 40 on the Global Assessment Scale (GAS). They were reassessed by readministering the GAS scale after six months and after two years treatment. The final results demonstrate an improvement of the mood of the patients and their increasing quality of life.Almost all reached a value on the GAS scale of between 60 and 80 after six months, and between 90 and 100 scores after two years. Key words: bipolar spectrum disorders – mixed states – long time treatment * * * * * BACKGROUND and in Agitated Depression. The main symptoms present are the following: The aim of this study is to show how to manage long overlapping depressed mood and irritability; time patients with serious mixed states bipolar disorders high internal and muscular tension; by describing 30 cases reports, and demonstrating that reduced ability to concentrate and mental over- they can achieve a high level of recovery from the activity; illness and improvement in the quality of life.
    [Show full text]
  • The Effects of Antipsychotic Treatment on Metabolic Function: a Systematic Review and Network Meta-Analysis
    The effects of antipsychotic treatment on metabolic function: a systematic review and network meta-analysis Toby Pillinger, Robert McCutcheon, Luke Vano, Katherine Beck, Guy Hindley, Atheeshaan Arumuham, Yuya Mizuno, Sridhar Natesan, Orestis Efthimiou, Andrea Cipriani, Oliver Howes ****PROTOCOL**** Review questions 1. What is the magnitude of metabolic dysregulation (defined as alterations in fasting glucose, total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglyceride levels) and alterations in body weight and body mass index associated with short-term (‘acute’) antipsychotic treatment in individuals with schizophrenia? 2. Does baseline physiology (e.g. body weight) and demographics (e.g. age) of patients predict magnitude of antipsychotic-associated metabolic dysregulation? 3. Are alterations in metabolic parameters over time associated with alterations in degree of psychopathology? 1 Searches We plan to search EMBASE, PsycINFO, and MEDLINE from inception using the following terms: 1 (Acepromazine or Acetophenazine or Amisulpride or Aripiprazole or Asenapine or Benperidol or Blonanserin or Bromperidol or Butaperazine or Carpipramine or Chlorproethazine or Chlorpromazine or Chlorprothixene or Clocapramine or Clopenthixol or Clopentixol or Clothiapine or Clotiapine or Clozapine or Cyamemazine or Cyamepromazine or Dixyrazine or Droperidol or Fluanisone or Flupehenazine or Flupenthixol or Flupentixol or Fluphenazine or Fluspirilen or Fluspirilene or Haloperidol or Iloperidone
    [Show full text]
  • Revision of Precautions Asenapine Maleate, Aripiprazole, Olanzapine
    Published by Translated by Ministry of Health, Labour and Welfare Pharmaceuticals and Medical Devices Agency This English version is intended to be a reference material to provide convenience for users. In the event of inconsistency between the Japanese original and this English translation, the former shall prevail. Revision of Precautions Asenapine maleate, aripiprazole, olanzapine, quetiapine fumarate, clocapramine hydrochloride hydrate, chlorpromazine hydrochloride, chlorpromazine hydrochloride/promethazine hydrochloride/phenobarbital, chlorpromazine phenolphthalinate, spiperone, zotepine, timiperone, haloperidol, paliperidone, pipamperone hydrochloride, fluphenazine decanoate, fluphenazine maleate, brexpiprazole, prochlorperazine maleate, prochlorperazine mesilate, Pharmaceuticals and Medical Devices Agency Office of Safety I 3-3-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-0013 Japan E-mail: [email protected] Published by Translated by Ministry of Health, Labour and Welfare Pharmaceuticals and Medical Devices Agency This English version is intended to be a reference material to provide convenience for users. In the event of inconsistency between the Japanese original and this English translation, the former shall prevail. propericiazine, bromperidol, perphenazine, perphenazine hydrochloride, perphenazine fendizoate, perphenazine maleate, perospirone hydrochloride hydrate, mosapramine hydrochloride, risperidone (oral drug), levomepromazine hydrochloride, levomepromazine maleate March 27, 2018 Non-proprietary name Asenapine maleate,
    [Show full text]
  • Potential Drug-Drug Interactions and Adverse Drug Reactions Associated with Hydroxychloroquine
    Original Article Potential Drug-drug Interactions and Adverse Drug Reactions Associated with Hydroxychloroquine Arjun Singh1, Richa Chaudhary1, Prayas Verma2, Nilanchal Trivedi3,*, Md. Shamim4 1Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, INDIA. 2Teerthanker Mahaveer Dental College and Research Centre, TMU Moradabad, Uttar Pradesh, INDIA. 3Department of Pharmacology, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, INDIA. 4LCP College of Pharmacy Baghpat, Abdul Kalam Technical University (AKTU), Uttar Pradesh, INDIA. ABSTRACT Introduction: COVID-19 is a pandemic disaster and a health emergency of prime focus for all the world economies. Various prophylactic treatments are considered to combat the disease. Hydroxychloroquine drug is one such option that is given much attention as an armor against SARS COV-2 pandemic. Evaluation and assessment of drug interactions and ADRs is required from ethical concern to justify the use of HCQ on such large scale. Methods: We have performed an analysis of HCQ drug interactions on Micromedex®. We have reviewed literature of HCQ pharmacokinetic properties, ADRs/ ADEs and toxicities associated with the use of HCQ drug on PubMed, Google Scholar and CDC database. Results: There are around 180 drug interactions possible with HCQ. Out of them 13 are of contraindicated severity level and other 165 are of major severity and 2 of them are moderately severe. Most of the interactions are coupled with QT prolonging agents (170), Cardiac arrhythmias is possible with the concomitant use of at least 2 drugs, 4 drugs leads to Torsade de points. System organ level ADRs are also evaluated along with various precautions, warnings and contraindications.
    [Show full text]
  • Antipsychotics and the Risk of Sudden Cardiac Death
    ORIGINAL INVESTIGATION Antipsychotics and the Risk of Sudden Cardiac Death Sabine M. J. M. Straus, MD; Gyse`le S. Bleumink, MD; Jeanne P. Dieleman, PhD; Johan van der Lei, MD, PhD; Geert W. ‘t Jong, PhD; J. Herre Kingma, MD, PhD; Miriam C. J. M. Sturkenboom, PhD; Bruno H. C. Stricker, PhD Background: Antipsychotics have been associated with Results: The study population comprised 554 cases of prolongation of the corrected QT interval and sudden car- sudden cardiac death. Current use of antipsychotics was diac death. Only a few epidemiological studies have in- associated with a 3-fold increase in risk of sudden car- vestigated this association. We performed a case- diac death. The risk of sudden cardiac death was high- control study to investigate the association between use est among those using butyrophenone antipsychotics, of antipsychotics and sudden cardiac death in a well- those with a defined daily dose equivalent of more than defined community-dwelling population. 0.5 and short-term (Յ90 days) users. The association with current antipsychotic use was higher for witnessed cases Methods: We performed a population-based case-control (n=334) than for unwitnessed cases. study in the Integrated Primary Care Information (IPCI) project, a longitudinal observational database with com- Conclusions: Current use of antipsychotics in a gen- plete medical records from 150 general practitioners. All eral population is associated with an increased risk of sud- instances of death between January 1, 1995, and April 1, den cardiac death, even at a low dose and for indica- 2001, were reviewed. Sudden cardiac death was classified tions other than schizophrenia.
    [Show full text]
  • Patent Application Publication ( 10 ) Pub . No . : US 2019 / 0192440 A1
    US 20190192440A1 (19 ) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0192440 A1 LI (43 ) Pub . Date : Jun . 27 , 2019 ( 54 ) ORAL DRUG DOSAGE FORM COMPRISING Publication Classification DRUG IN THE FORM OF NANOPARTICLES (51 ) Int . CI. A61K 9 / 20 (2006 .01 ) ( 71 ) Applicant: Triastek , Inc. , Nanjing ( CN ) A61K 9 /00 ( 2006 . 01) A61K 31/ 192 ( 2006 .01 ) (72 ) Inventor : Xiaoling LI , Dublin , CA (US ) A61K 9 / 24 ( 2006 .01 ) ( 52 ) U . S . CI. ( 21 ) Appl. No. : 16 /289 ,499 CPC . .. .. A61K 9 /2031 (2013 . 01 ) ; A61K 9 /0065 ( 22 ) Filed : Feb . 28 , 2019 (2013 .01 ) ; A61K 9 / 209 ( 2013 .01 ) ; A61K 9 /2027 ( 2013 .01 ) ; A61K 31/ 192 ( 2013. 01 ) ; Related U . S . Application Data A61K 9 /2072 ( 2013 .01 ) (63 ) Continuation of application No. 16 /028 ,305 , filed on Jul. 5 , 2018 , now Pat . No . 10 , 258 ,575 , which is a (57 ) ABSTRACT continuation of application No . 15 / 173 ,596 , filed on The present disclosure provides a stable solid pharmaceuti Jun . 3 , 2016 . cal dosage form for oral administration . The dosage form (60 ) Provisional application No . 62 /313 ,092 , filed on Mar. includes a substrate that forms at least one compartment and 24 , 2016 , provisional application No . 62 / 296 , 087 , a drug content loaded into the compartment. The dosage filed on Feb . 17 , 2016 , provisional application No . form is so designed that the active pharmaceutical ingredient 62 / 170, 645 , filed on Jun . 3 , 2015 . of the drug content is released in a controlled manner. Patent Application Publication Jun . 27 , 2019 Sheet 1 of 20 US 2019 /0192440 A1 FIG .
    [Show full text]
  • Pipamperone and Delirium: a Preliminary Evaluation of Its Effectiveness in the Management of Delirium and Its Subtypes
    Original article | Published 24 July 2017 | doi:10.4414/smw.2017.14471 Cite this as: Swiss Med Wkly. 2017;147:w14471 Pipamperone and delirium: a preliminary evaluation of its effectiveness in the management of delirium and its subtypes Boettger Soenkea, Knoepfel Silvanaa, Schubert Mariabd, Garcia Nuñez Davidc, Plichta Michael Martine, Klaghofer Richarda, Jenewein Josefa a Department of Psychiatry and Psychotherapy, University of Zurich, University Hospital Zurich, Switzerland b Centre of Clinical Nursing Science, University of Zurich, University Hospital Zurich, Switzerland c University Basel, University Hospital Basel, Switzerland d Directorate of Nursing/MTT, Inselspital, University Hospital Bern, Switzerland e Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany Summary Key words: haloperidol, pipamperone, antipsychotics, delirium, subtypes, effectiveness INTRODUCTION: Delirium has been recognised as an underdiagnosed and undermanaged syndrome with sub- Introduction stantial prevalence rates and potentially deleterious con- sequences in the medically ill population. Despite its fre- Delirium is a neuropsychiatric syndrome characterised by quent administration in the management of delirium, the an abrupt onset and fluctuating disturbances in conscious- effectiveness of pipamperone has not yet been evaluated. ness and cognition, as well as a range of noncognitive domains including disturbances in motor behaviour, emo- METHODS: In this retrospective, descriptive cohort study tionality and sleep-wake cycle, caused by an underlying of 192 patients, pipamperone as monotherapy and as an aetiology [1, 2]. adjunct to haloperidol, haloperidol alone, or atypical an- Delirium is a common occurrence over the course of hos- tipsychotics were compared with respect to their effective- pitalisation, depending, among other factors, on the age ness in the management of delirium and its subtypes over and gender of the patient, previous episodes of delirium, the course of 20 days.
    [Show full text]
  • Use of Pipamperone and a D2-Receptor Antagonist Or
    (19) & (11) EP 1 708 790 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 31/4545 (2006.01) A61K 31/00 (2006.01) 21.04.2010 Bulletin 2010/16 A61K 31/519 (2006.01) A61K 31/343 (2006.01) A61P 25/18 (2006.01) (21) Application number: 04801138.1 (86) International application number: (22) Date of filing: 02.12.2004 PCT/BE2004/000172 (87) International publication number: WO 2005/053796 (16.06.2005 Gazette 2005/24) (54) USE OF PIPAMPERONE AND A D2-RECEPTOR ANTAGONIST OR A SEROTONIN/DOPAMIN ANTAGONIST FOR THE TREATMENT OF PSYCHOTIC DISORDERS VERWENDUNG VON PIPAMPERON UND EINEM D2-REZEPTOR ANTAGONISTEN ODER EINEM SEROTONIN/DOPAMIN ANTAGONISTEN ZUR BEHANDLUNG VON PSYCHOTISCHEN STÖRUNGEN UTILISATION DE PIPAMPERONE ET D’UN ANTAGONISTE DES RECEPTEURS D2 OU D’UN ANTAGONISTE A LA DOPAMINE ET A LA SEROTONINE POUR LE TRAITEMENT DE TROUBLES PSYCHOTIQUES (84) Designated Contracting States: (74) Representative: De Clercq, Ann G. Y. et al AT BE BG CH CY CZ DE DK EE ES FI FR GB GR De Clercq, Brants & Partners c.v. HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR Edgard Gevaertdreef 10a Designated Extension States: 9830 Sint-Martens-Latem (BE) AL BA HR LV MK YU (56) References cited: (30) Priority: 02.12.2003 US 725965 WO-A-98/43646 WO-A-02/051833 02.12.2003 CA 2451798 DE-A- 4 039 631 US-A- 5 762 960 02.12.2003 EP 03447279 05.01.2004 EP 04447001 • VOLMAT R ET AL: "The treatment of depressions 06.01.2004 US 752423 by Cledial.
    [Show full text]
  • Concentrations of Antidepressants, Antipsychotics, and Benzodiazepines in Hair Samples from Postmortem Cases
    SN Comprehensive Clinical Medicine (2020) 2:284–300 https://doi.org/10.1007/s42399-020-00235-x MEDICINE Concentrations of Antidepressants, Antipsychotics, and Benzodiazepines in Hair Samples from Postmortem Cases Maximilian Methling1,2 & Franziska Krumbiegel1 & Ayesha Alameri1 & Sven Hartwig1 & Maria K. Parr2 & Michael Tsokos1 Accepted: 30 January 2020 /Published online: 10 February 2020 # The Author(s) 2020 Abstract Certain postmortem case constellations require intensive investigation of the pattern of drug use over a long period before death. Hair analysis of illicit drugs has been investigated intensively over past decades, but there is a lack of comprehensive data on hair concentrations for antidepressants, antipsychotics, and benzodiazepines. This study aimed to obtain data for these substances. A LC-MS/MS method was developed and validated for detection of 52 antidepressants, antipsychotics, benzodiazepines, and metabolites in hair. Hair samples from 442 postmortem cases at the Institute of Legal Medicine of the Charité-University Medicine Berlin were analyzed. Postmortem hair concentrations of 49 analytes were obtained in 420 of the cases. Hair sample segmentation was possible in 258 cases, and the segments were compared to see if the concentrations decreased or increased. Descriptive statistical data are presented for the segmented and non-segmented cases combined (n = 420) and only the segmented cases (n = 258). An overview of published data for the target substances in hair is given. Metabolite/parent drug ratios were investigated for 10 metabolite/parent drug pairs. Cases were identified that had positive findings in hair, blood, urine, and organ tissue. The comprehensive data on postmortem hair concentrations for antidepressants, antipsychotics, and benzodiazepines may help other investigators in their casework.
    [Show full text]
  • Low Dose Pipamperone in Treating Mood and Anxiety Disorders
    (19) & (11) EP 2 236 138 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 06.10.2010 Bulletin 2010/40 A61K 31/4545 (2006.01) A61K 45/06 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) (2006.01) (21) Application number: 09156752.9 A61K 31/343 (22) Date of filing: 30.03.2009 (84) Designated Contracting States: • van der Geest, Ronald AT BE BG CH CY CZ DE DK EE ES FI FR GB GR 4835 AA, Breda (BE) HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR (74) Representative: De Clercq, Ann G. Y. et al Designated Extension States: De Clercq & Partners cvba AL BA RS Edgard Gevaertdreef 10 a 9830 Sint-Martens-Latem (BE) (71) Applicant: PharmaNeuroBoost N.V. 3570 Alken (BE) Remarks: Claim .17-19,21-24ed to be abandoned due to non- (72) Inventors: payment of the claims fee (Rule 45(3) EPC). • Buntinx, Erik 3570, Alken (BE) (54) Low dose pipamperone in treating mood and anxiety disorders (57) The present invention relates to the use of combinations comprising pipamperone and an SSRI, SNDRI or SNRI and compositions comprising the same for the treatment of mood or anxiety disorders. EP 2 236 138 A1 Printed by Jouve, 75001 PARIS (FR) EP 2 236 138 A1 Description Field of the invention 5 [0001] The invention relates to the field of neuropsychiatry. More specifically, the invention relates to the use of pipamperone in augmenting and in a faster onset of serotonin re- uptake inhibitors, such as SSRIs, SNDRIs and SNRIs, in treating mood and anxiety disorders.
    [Show full text]