Journal of International Society for Food Bioactives Nutraceuticals and Functional Foods Review J. Food Bioact. 2018;4:69–87 Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances Petras Rimantas Venskutonis* Department of Food Science and Technology, Kaunas University of Technology, Radvilėnų rd. 19, Kaunas, LT-50254, Lithuania *Corresponding author: Petras Rimantas Venskutonis, Department of Food Science and Technology, Kaunas University of Technology, Radvilėnų rd. 19, Kaunas, LT-50254, Lithuania. E-mail:
[email protected] DOI: 10.31665/JFB.2018.4163 Received: December 04, 2018; Revised received & accepted: December 23, 2018 Abbreviations: ABTS, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid; AChE, acethylcholinesterase; AMP, adenosine monophos- phate; BchE, butyrylcholinesterase; CPT-1, carnitine palmitoyl transferase; DPPH•, stable 2,2-diphenyl-1-picrylhydrazyl radical; DW, dry weight; eNOS, endothelial NO synthase; FRAP, ferric reducing antioxidant power; GAE, gallic acid equivalents; Gpx3, glutathione per- oxidase 3; HDLC, high density lipoprotein cholesterol; HFD, high-fat diet; HLF, hawthorn leaf flavonoids; ICAM-1, intercellular adhesion molecule; IL, interleukin; LDLC, low density lipoprotein cholesterols; LPS, lipopolysaccharide; MDA, malondialdehyde; NAFLD, non- alcoholic fatty liver disease; NO, nitric oxide; ORAC, oxygen radical absorbance capacity; PKC-α, protein kinase C α; PPARα, peroxisome proliferator activated receptor α; RAW264.7, murine macrophage cell line; RCT, reverse cholesterol transport; ROS, reactive oxygen spe- cies; SOD, superoxide dismutase; SREBP-1c, sterol regulatory element binding protein-1c; TBARS, thiobarbituric acid reactive substances; TC, total cholesterol; TE, trolox equivalents; TFC, total flavonoid content; TG, triacylglycerols; TNF-α, necrosis factor-α; TPC, total phe- nolic content; VLDLC, very low density lipoprotein cholesterol.