Online Copy-Legends of the Botswana HIV Response Clendar
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QA& Raabya Rossenkhan Kathleen Wirth
H A I spotlisummer g ht 2015 HARVARD T.H. CHAN SCHOOL OF PUBLIC HEALTH AIDS INITIATIVE THE YOUNG INVESTIGATORS ISSUE Raabya Rossenkhan The Will to Make It Work Raabya Rossenkhan was always interested in science, so majoring in biology at the University of Botswana (UB) was an obvious choice. When she was offered a scholarship to continue her education, she saw the need to study HIV/AIDS. The year was 2003. In Botswana, the HIV prevalence among pregnant women was almost 40%. Kathleen Wirth “A lot of people were dying at the time. I Max had friends whose parents were dying. There In Search of the Purposeful was a lot of stigma associated with HIV. You Essex would hear stories, but nobody ever directly Growing up, Kathleen Wirth knew she wanted Q spoke about it,” said Raabya. She wanted to & to see the world outside of her small hometown A help end the crisis that was devastating her of Irmo, South Carolina. She felt she didn’t country. quite fit in. Her mother’s family had fled The Importance of Being from Cuba in 1960. Her grandfather, who’d There was just one problem. When Raabya and Having a Mentor been a respected doctor in Havana, worked indicated that she wanted to conduct HIV/ as a hospital janitor until he could qualify AIDS research, the UB Biological Sciences Max Essex is the Lasker Professor to practice medicine in America. Though Department said it would be difficult. For of Health Sciences at Harvard she got into minor trouble, it wasn’t enough the Master’s programs, there was either a food University and the Chair of the to keep Kathleen from becoming her high (continues on page 2) Harvard AIDS Initiative and the school valedictorian. -
Mo Ibrahim Foundation Announces No Winner of 2019 Ibrahim Prize for Achievement in African Leadership
Mo Ibrahim Foundation announces no winner of 2019 Ibrahim Prize for Achievement in African Leadership LONDON, 5 March 2020 – Today, the Mo Ibrahim Foundation announces that there is no winner of the 2019 Ibrahim Prize for Achievement in African Leadership. This decision has been made following deliberations by the independent Prize Committee. Announcing the decision, Prize Committee Chair Festus Mogae commented: “The Ibrahim Prize recognises truly exceptional leadership in Africa, celebrating role models for the continent. It is awarded to individuals who have, through the outstanding governance of their country, brought peace, stability and prosperity to their people. Based on these rigorous criteria, the Prize Committee could not award the Prize in 2019.” Commenting on the decision, Mo Ibrahim, Chairman of the Mo Ibrahim Foundation said: “Africa is facing some of the toughest challenges in the world – ranging from those connected to population growth, and economic development, to environmental impact. We need leaders who can govern democratically and translate these challenges into opportunities. With two-thirds of our citizens now living in better-governed countries than ten years ago, we are making progress. I am optimistic that we will have the opportunity to award this Prize to a worthy candidate soon.” Contacts For more information, please contact: Zainab Umar, [email protected], +44 (0) 20 7535 5068 MIF media team, [email protected], +44 (0) 20 7554 1743 Join the discussion online using the hashtag -
The Transnational Legal Process of Global Health Jurisprudence: HIV and the Law in Indonesia
The Transnational Legal Process of Global Health Jurisprudence: HIV and the Law in Indonesia Siradj Okta A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Washington 2020 Reading Committee: Walter J. Walsh, Chair Rachel A. Cichowski Dongsheng Zang Aaron Katz Program Authorized to Offer Degree: Law © Copyright 2020 Siradj Okta University of Washington Abstract The Transnational Legal Process of Global Health Jurisprudence: HIV and the Law in Indonesia Siradj Okta Chair of the Supervisory Committee: Walter J. Walsh School of Law As one of the most pressing global health priorities, HIV disruption requires effective transnational work. There is growing confidence among experts about ending AIDS by 2030. In Indonesia, a country with one of Asia’s fastest-growing HIV epidemics, the law is instrumental to achieve that goal. Nonetheless, national laws and policies that undermine HIV prevention are continuously being adopted or preserved. This suggests that the presence of global health jurisprudence does not necessarily lead to national legal processes to enable HIV prevention policies. This situation raises the central question of whether the perpetuation of national legal barriers to HIV prevention is associated with Indonesia’s internalization of global health jurisprudence. This study uses Professor Harold Koh’s transnational legal process theory to examine the transfer of global health jurisprudence by looking at Indonesia’s interaction at the global level, interpretation of norms, and domestic internalization thereof. As a multi-method study with an inductive reasoning approach, this research utilizes a qualitative data analysis of international organizations’ laws and policies, public/private institutions’ policies, international treaties, Indonesian laws, and relevant public records. -
Rates and Patterns of Indels in HIV-1 Gp120 Within and Among Hosts
Western University Scholarship@Western Electronic Thesis and Dissertation Repository 8-19-2020 1:00 PM Rates and patterns of indels in HIV-1 gp120 within and among hosts John Lawrence Palmer, The University of Western Ontario Supervisor: Poon, Art F.Y., The University of Western Ontario A thesis submitted in partial fulfillment of the equirr ements for the Master of Science degree in Pathology and Laboratory Medicine © John Lawrence Palmer 2020 Follow this and additional works at: https://ir.lib.uwo.ca/etd Part of the Molecular Genetics Commons Recommended Citation Palmer, John Lawrence, "Rates and patterns of indels in HIV-1 gp120 within and among hosts" (2020). Electronic Thesis and Dissertation Repository. 7308. https://ir.lib.uwo.ca/etd/7308 This Dissertation/Thesis is brought to you for free and open access by Scholarship@Western. It has been accepted for inclusion in Electronic Thesis and Dissertation Repository by an authorized administrator of Scholarship@Western. For more information, please contact [email protected]. Abstract Insertions and deletions (indels) in the HIV-1 gp120 variable loops modulate sensitivity to neutralizing antibodies and are therefore implicated in HIV-1 immune escape. However, the rates and characteristics of variable loop indels have not been investigated within hosts. Here, I report a within-host phylogenetic analysis of gp120 variable loop indels, with mentions to my preceding study on these indels among hosts. We processed longitudinally-sampled gp120 sequences collected from a public database (n = 11,265) and the Novitsky Lab (n=2,541). I generated time-scaled within-host phylogenies using BEAST, extracted indels by reconstructing ancestral sequences in Historian, and esti- mated variable loop indel rates by applying a Poisson-based model to indel counts and time data. -
His Excellency Festus Gontebanye Mogae Was Born on 21St August
of the First Chancellor of Amref International University HIS EXCELLENCY MR. F.G. MOGAE FORMER PRESIDENT OF THE REPUBLIC OF BOTSWANA is Excellency Festus Gontebanye Mogae was born on 21st August, 1939 at Serowe in the Central District of Botswana. He attended various educational institutions before Hhis graduation at Moeng College, an institution built in the 1930s and 1940s through community efforts in the then British protectorate of Bechuanaland. He thereafter attended the Universities of Oxford and Sussex in the United Kingdom where he trained as an Economist. He started his career in Botswana as a Planning Officer progressing to become Director of Economic Affairs, and Permanent Secretary, Ministry of Finance and Development Planning. He then proceeded to become an Alternate Governor for Botswana before later serving in Washington as an Alternate and Executive Director, International Monetary Fund (IMF) for Anglophone Africa and the International Bank for Reconstruction and Development. He then came back to Botswana to take up the position of Governor of the Bank of Botswana and later Permanent Secretary to the President, Secretary to the Cabinet and Supervisor of Elections. He was appointed Minister of Finance and Development Planning in 1989, Vice President in 1992 before his election as the Third President of the Republic of Botswana In 1998. Health service provision was a key priority for President Mogae’s tenure from 1998-2008. Among his achievements, he rolled out a grassroots focused health system strengthening programme that ensured that citizens, even in the remotest part of the Botswana had access to a health centre in their community. -
Annual Report
Extending the Frontiers of Science and Health: Research, Care, and Prevention in Action 2010 ANNUAL REPORT Wei Huang, PhD, Assistant Professor, Division of Basic Science and Vaccine Development, Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine 2 CONTENTS Director’s Message....................................................... 5&7 Our Mission .......................................................................9 IHV Leadership ................................................................10 About IHV ........................................................................11 Division of Basic Science and Vaccine Development ......13 Division of Clinical Care and Research ...........................18 Division of Epidemiology and Prevention ......................22 Financials and Related Charts .........................................26 IHV Board Memberships .................................................27 Photo above: Maria Salvato, PhD, Professor, Division of Basic Science and Vaccine Development, Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine and Igor Lukashevich, MD, PhD, Associate Professor, Division of Basic Science and Vaccine Development, Institute of Human Virology and Department of Medicine, University of Maryland School of Medicine 3 4 DIRECtor’S MESSAGE The Institute of Human Virology (IHV) at the University of Maryland School of Medicine had a prosperous and eventful year in FY10. In the Basic Science and Vaccine Development Division led by Dr. George Lewis and me, IHV’s preventative HIV vaccine candidate research continued to make progress with our colleague Dr. Tony DeVico through funding by the Bill and Melinda Gates Foundation and the National Institutes of Health. The next phase of funding would include researching the vaccine candidate through clinical trials next year. Also in the BSVD Division, IHV researchers including Dr. David Pauza continued to study the rise of HIV-related cancers as a growing Robert C. -
Human Retroviruses in the Second Decade: a Personal Perspective
© 1995 Nature Publishing Group http://www.nature.com/naturemedicine • REVIEW Human retroviruses in the second decade: A personal perspective Human retroviruses have developed novel strategies for their propagation and survival. A consequence of their success has been the induction of an extraordinarily diverse set of human dlst!ases, including AIDS, cancers and neurological and Inflammatory disorders. Early research focused on their characterization, linkage to these dlst!ases, and the mechanisms Involved. Research should now aim at the eradication of human retroviruses and on treatment of infected people. Retroviruses are transmitted either geneti- .................... ···.. .... ·. ..... .. discovered". Though its characteristics are cally (endogenous form) or as infectious ROBERT C. GALLO strikingly similar to HTLV-1, HTLV-II is not agents (exogenous form)'·'. As do many so clearly linked to human disease. It is cu other animal species, humans have both forms ..... In general, rious that HTLV-11 is endemic in some American Indians and endogenous retroviruses are evolutionary relics of old infec more prevalent in drug addicts than HTLV-I"·'•. tions and are not known to cause disease. The DNA of many HIV-1 is also most prevalent in equatorial Africa, but in con species, including humans, harbours multiple copies of differ trast to HTLV the demography of the HIV epidemic is still in ent retroviral proviruses. The human endogenous proviral flux, and the virus is new to most of the world. The number of sequences are virtually all defective, and comprise about one infected people worldwide is now estimated to be about 17 mil percent of the human genome, though R. Kurth's group in lion and is predicted to reach 30 to SO million by the year 2000. -
History Botswana Was a British Protectorate from 1885 Until It
September 2000 History Botswana was a British Protectorate from 1885 until it achieved independence in 1966. Sir Seretse Khama was elected the country’s leader under the banner of the Botswana Democratic Party (BDP). He was succeeded in an orderly transition by Quett Ketemile Masire who retired in March 1998. The country’s current president is Festus Mogae. Most of Botswana's population is Tswana. Economy Botswana’s economic growth rate - averaging 7.3 percent between 1970 and 1995 - has been the highest in the developing world. The mining industry, particularly diamonds, currently contributes about 35 percent of Botswana’s GDP. At independence 32 years ago, mining contributed only 1 percent of GDP. Manufacturing, construction and agriculture each contribute about 3-6 percent of GDP, and there has been growth in financial, and government services in recent years. With a per capita GNP of US$3,600, Botswana is one of only a few African states classified as a lower middle-income country. The government has managed the country’s resources prudently and has kept its recurrent expenditure within its revenue, allowing for investment in human and physical capital. The government’s revenue from diamonds, as well as profits from large foreign exchange reserves of the Bank of Botswana, have largely cushioned Botswana from the recessions that have buffeted most countries in the region. Politics Botswana is a democratic republic with a 44 member national assembly, 40 of which are elected every five years on the basis of universal adult suffrage, and the other four members are appointed by the elected members of the assembly. -
Hypervariable Region 3 Residues of HIV Type 1 Gp120 Involved in CCR5 Coreceptor Utilization: Therapeutic and Prophylactic Implications
Proc. Natl. Acad. Sci. USA Vol. 96, pp. 4558–4562, April 1999 Medical Sciences Hypervariable region 3 residues of HIV type 1 gp120 involved in CCR5 coreceptor utilization: Therapeutic and prophylactic implications WEI-KUNG WANG,TIM DUDEK,MAX ESSEX, AND TUN-HOU LEE* Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA 02115 Communicated by Elkan R. Blout, Harvard Medical School, Cambridge, MA, February 17, 1999 (received for review November 2, 1998) ABSTRACT Crystallographic characterization of a ter- The coreceptor binding step of the HIV-1 life cycle is a nary complex containing a monomeric gp120 core, parts of potential target for therapeutic and prophylactic interventions. CD4, and a mAb, revealed a region that bridges the inner and To design intervention strategies targeting this critical step of outer domains of gp120. In a related genetic study, several HIV-1 entry requires knowing how V3 works in concert with residues conserved among primate lentiviruses were found to those residues in the bridging sheet to interact with CCR5, the play important roles in CC-chemokine receptor 5 (CCR5) chemokine coreceptor most often used by the so-called R5 coreceptor utilization, and all but one were mapped to the viruses of human and nonhuman primate lentiviruses (15, 16). bridging domain. To reconcile this finding with previous To that end, it is essential to provide a full account of V3 reports that the hypervariable region 3 (V3) of gp120 plays an residues involved in CCR5 utilization. In this study, we iden- important role in chemokine coreceptor utilization, elucidat- tified several V3 residues, both highly conserved and variable ing the roles of various V3 residues in this critical part of the ones, that were shown to play a role in CCR5 utilization. -
Saturday Is for Funerals: a Book Review by Martin Adams
Saturday is for funerals: A book review By Martin Adams According to the 2012 HIV/AIDS global fact sheet The final chapter – Government Action Makes a Difference: A .( www.kff.org), some 70% of those infected with HIV/AIDS live Nation Responds – describes what government and donors in Sub-Saharan Africa, which provides a home for some 12% of have done since 1996 to reduce fatalities and restore AIDS the world’s population. Further, 94% of the world’s children sufferers through drug therapy. Recent data offer promising who have HIV are estimated to live in SSA. Swaziland with signs that the national HIV/AIDS incidence (i.e. the rate of new 25.9% is believed to have the highest HIV prevalence in the infections per year) is declining in Botswana and to a lesser world. In Botswana in 2010, 24.8% of 15-49 year-olds were extent in countries in the region. But even in Botswana, in the found to be HIV positive. continuing absence of an effective vaccine, current rates of incidence will continue to increase the overall number Working on land matters in Africa, I have long been aware of infected. Even if death rates are reduced by 70-80% through the negative impact of AIDS on food security and on the un- effective treatment with ARVs, the rate of new infections certain tenure of widows and children. But, until recently, I would have to decrease by the same amount for HIV/AIDS had not really taken sufficient time to acquaint myself with the prevalence just to stay even. -
2012 Annual Report
INSTITUTE OF HUMAN VIROLOGY 725 West Lombard Street | Baltimore, Maryland 21201-1009 INSTITUTE OF HUMAN VIROLOGY 410.706.8614 | 410.706.1952 fax | www.ihv.org Forging Global Connections and Initiating Global Leadership 2012 ANNUAL REPORT The Institute of Human Virology is a center at the University of Maryland School of Medicine and is affiliated with the University of Maryland Medical Center. For more information call Nora Grannell 410.706.8614 or visit www.ihv.org Our Mission The Institute of Human Virology was established to create and develop a world-class center of excellence focusing on chronic viral diseases, especially HIV/AIDS, and virally-linked cancers. The IHV is dedicated to the discovery, research, treatment and prevention of these diseases. Its unique structure seeks to connect cohesive, multi-disciplinary research and clinical programs so that new treatments are streamlined from discovery to patient. The IHV serves patients locally and the scientific community globally. 2 Contents Director’s Message ........................................................................4-5 IHV Leadership ..................................................................................6 About IHV .........................................................................................7 Division of Basic Science and Vaccine Development ...................8-17 Division of Clinical Care and Research ......................................18-21 Division of Epidemiology and Prevention .................................22-26 Global Virus Network -
Quest for the AIDS Virus
Dr. Robert Gallo and Secretary Margaret Heckler hold a press confer- ence concerning the cause of AIDS, April 23, 1984. Bettmann / Contributor “Good afternoon, Ladies and Gentlemen. The probable cause of AIDS has been found…Today we add another miracle to the long honor roll of American medicine and science. Today’s discovery represents the triumph of science over a dreaded disease. Those who have disparaged this scientific search—those who said we weren’t doing enough—have not understood how sound, solid, significant medical research proceeds. From the first day that AIDS was identified in 1981, HHS scientists and their medical allies have never stopped searching for the answers to the AIDS mystery. Without a day of procrastination, the resources of the Public Health Service have been effectively mobilized.…Credit must go to our eminent Dr. Robert Gallo [AΩA, Sidney Kimmel Medical College, 1962], who directed the research that produced this discovery.” —Margaret Heckler, Secretary of Health and Human Services (HHS), April 23, 1984, Washington, DC Quest for the AIDS virus Harry W. Haverkos, M.D. Dr. Haverkos is Captain (retired), United States Public study among men in Atlanta, Los Angeles, New York City, Health Service; and Associate Professor, Preventive and San Francisco was conducted.1 Medicine and Biostatistics, Uniformed Services The study identified the two leading risk factors for University of the Health Sciences, Bethesda, Maryland. Kaposi’s sarcoma and/or Pneumocystis carinii pneumo- nia (PCP) as the lifetime number of sexual partners, and n July 1981, I entered the Epidemic Intelligence Service meeting partners in bathhouses.2,3 Those results suggested (EIS) of the Centers for Disease Control (CDC) and that a novel sexually transmitted agent was involved, and Iwas immediately recruited by James Curran, MD, retroviruses soon became a target for the search.