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Evaluation of the Influence of Ultrasound and Supercritical Fluids in Processes of Polyphenolic Compounds Extraction from Agroindustrial Wastes

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Evaluation of the Influence of Ultrasound and Supercritical Fluids in Processes of Polyphenolic Compounds Extraction from Agroindustrial Wastes Evaluation of the influence of ultrasound and supercritical fluids in processes of polyphenolic compounds extraction from agroindustrial wastes Ashley Sthefanía Caballero Galván Universidad Nacional de Colombia sede Manizales Facultad de Ingeniería y Arquitectura, Departamento de Ingeniería Química Manizales, Colombia 2017 2 Evaluation of the influence of ultrasound and supercritical fluids in processes of polyphenolic compounds extraction from agroindustrial wastes Ashley Sthefanía Caballero Galván Thesis submitted in partial fulfillment of the requirements for the degree of: Master in Engineering – Chemical Engineering Advisor: Ph.D., M.Sc, Chemical Engineer Carlos Ariel Cardona Alzate Research line: Chemical and Biotechnological Processes Engineering Research group: Chemical, Catalytic and Biotechnological Processes Universidad Nacional de Colombia sede Manizales Facultad de Ingeniería y Arquitectura, Departamento de Ingeniería Química Manizales, Colombia 2017 3 Evaluación de la influencia del ultrasonido y fluidos supercríticos en procesos de extracción de compuestos polifenólicos a partir de residuos agroindustriales Ashley Sthefanía Caballero Galván Tesis presentada como requisito parcial para optar al título de: Magister en Ingeniería – Ingeniería Química Director: Ph.D., M.Sc, Ingeniero químico Carlos Ariel Cardona Alzate Línea de Investigación: Ingeniería de Procesos Químicos y Biotecnológicos Grupo de Investigación: Procesos Químicos, Catalíticos y Biotecnológicos Universidad Nacional de Colombia sede Manizales Facultad de Ingeniería y Arquitectura, Departamento de Ingeniería Química Manizales, Colombia 2017 4 “A Dios por su grandes bendiciones, a mis padres por su amor incondicional, a mis hermanos y seres queridos por la ayuda y comprensión” “Comienzo de la sabiduría: Adquiere la sabiduría; cueste lo que te cueste, Adquiere la inteligencia, tenla en gran estima y ella te exaltará; ella será tu honor, si la abrazas.” Proverbios 4: 7-8 5 Acknowledgements In first instance, I would like to thank my parents for the unconditional support they have always given me. For not leaving me alone, for showing me his unconditional love, for their words of encouragement, for their trust in me, for their effort, dedication and patience to give me a better future, full of dreams to fulfill and goals to achieve. Because they always teach me that education never ends, that life is a constant learning and unlearning. Where the experiences and things made with the heart that truly stop learning and change the way of thinking, doing and especially being. Likewise, i want to thank my brothers for their daily support, for understand my emotions changes, since the immense joys for some achievement obtained, even the slightest sadness for some frustration, knowing always give me words of encouragement to go ahead and never give up. Because I have always been told that dreams must be bigger and stronger than anything else. I also want to thank a Sergio, a special person who encouraged me, accompany me every day and motivate me to be better. To my advisor Carlos Ariel Cardona, who has been my reference figure, for his confidence, for guiding me, for transmitting his knowledge and making me participate in great experiences and learning throughout these years of research. Thanks to your ongoing collaboration. I also want to thank my friends Daissy, and Felipe whose were an unconditional help throughout my work. Additionally, to my colleagues Juan Camilo, Jhonny, Daniela, Yessica, Mariana, Estefanny, Sebastián, Carro, Jimmy, Juan José, Sara, Christian, for their great collaboration. Thanks to their help and company everything was easier.The Universidad Nacional de Colombia sede Manizales is a great university to which I owe everything I know and who saw me grow as a person and as a professional. To the Information System of the University of Colombia and to the Directorate of Research (DIMA) for the financial support throughout the masters. To the University of Athens and the University of Jaen, for giving me knowledge and collaboration. 6 List of Publicacions Research Papers 1. Published and accepted Hector Forero, Ashley Caballero, Blanca García, Agustín Castro, Alvaro Gómez, Yuri Pisarenko, Carlos Cardona, “Comparison of Thermodynamic Models for Topological Analysis of mixtures”, ISSN: 1390-1869. Revista de la Facultad de Ciencias Químicas, vol. 15, pp. 14- 24, May-September. 2016. Daissy Lorena Restrepo S., Ashley Sthefanía Caballero G., Christian David Botero G., Carlos Ariel Cardona A., “Energetic, techno-economic and environmental analysis of a biorefinery from sugarcane bagasse of different scales”. International Journal of Thermal and Environmental Engineering. Status: Accepted. 2. Submitted and review Ashley Sthefanía Caballero G., Daissy Lorena Restrepo S., Mariana Ortíz S., Carlos Ariel Cardona, “Determination of extraction kinetics of bioactive compounds from spent coffee grounds (Coffea arábica)”. Waste & Biomass Valorization. Status: Submitted. Angela Idarraga, Ashley Sthefanía Caballero G., Carlos Ariel Cardona A. “Preliminary analysis of the concept of biorefinery from exotic fruits: Naiku case”. International Journal of Fruit Science. Status: Submitted. Jimmy Anderson Martinez R., Ashley Sthefanía Caballero G., Daissy Lorena Restrepo S., Carlos Ariel Cardona A. “Techno-economic and environmental evaluation for the biogas 7 production from banana peel in a biorefinery concept (Musa paradisiaca)”. Environmental Science & Pollution Research. Status: Submitted. Ashley Sthefanía Caballero G., Daissy Lorena Restrepo S., Carlos Ariel Cardona A.”Analysis of biorefineries for value-added products from naranjilla peel (Solanum quitoense): Colombian case”. Status: Revision. Ashley Sthefanía Caballero G., Juan Miguel Romero G., Eulogio Castro G., Carlos Ariel Cardona A. “Effect of supercritical fluid extraction in obtaining polyphenolic compounds from olive waste”. Status: Revision. Ashley Sthefanía Caballero G., Carlos Ariel Cardona Á. “Analysis of polyphenolic compounds extraction from spent coffee grounds”. Status: Revision. Ashley Sthefanía Caballero G., Daissy Lorena Restrepo S., Jhonny Alejandro Poveda, Carlos Ariel Cardona A. “Evaluation of biorefineries schemes from spent coffee grounds”. Status: Revision. Ashley Sthefanía Caballero G., Juan José Caballero G., Carlos Ariel Cardona Alzate. “Analysis of polyphenolic compounds through of supercritical fluid extraction: spent coffee grounds case”. Status: Revision. Ashley Sthefanía Caballero G., Carlos Ariel Cardona Alzate. “Influence of non-conventional technologies in obtaining bioactive compounds from purple passion fruit”. Status: Revision. Ashley Sthefanía Caballero G., Carlos Ariel Cardona Alzate. “Application of supercritical fluids in the bioactive compounds extraction from coffee cut-stems”. Status: Revision. 8 Ashley Sthefanía Caballero G., Paula Marín Valencia, Carlos Ariel Cardona A. “Solvent extraction of antioxidants from coffee cut-stems”. Status: Revision. Ashley Sthefanía Caballero G., Daissy Lorena Restrepo S., Jhonny Alejandro Poveda, Carlos Ariel Cardona A.*. “Analysis of pre-feasibility in the integration of products from coffee cut- stems” Status: Revision. Ashley Sthefanía Caballero G., Sara Piedrahita, Carlos Ariel Cardona Alzate. "Comparison of polyphenolic compounds extraction through conventional and non-conventional technologies: sweet granadilla case” Status: Revision. Ashley Sthefanía Caballero G., Daissy Lorena Restrepo S., Juan José Caballero G., Carlos Ariel Cardona Á. “Analysis of polyphenolic compounds obtained from extraction technologies: naranjilla peel case”. Status: Revision. Ashley Sthefanía Caballero G., Carlos Ariel Cardona Á. “Polyphenolic compounds from spent coffee grounds through ultrasound assisted extraction”. Status: Revision. Ashley Sthefanía Caballero G., Daissy Lorena Restrepo S., Jhonny Alejandro Poveda G., Carlos Ariel Cardona Alzate “Added value of the coffee cut-stems through the extraction of polyphenolics compounds by ultrasound assisted extraction”. Status: Revision. Ashley Sthefanía Caballero-Galván, Daissy Lorena Restrepo-Serna, Carlos Ariel Cardona- Álzate. “Prefeasibility analysis in obtaining antioxidants from tree tomato peel”. Status: Revision. Ashley Sthefanía Caballero G., Carlos Ariel Cardona Á. “Comparison of extraction technologies for obtaining polyphenolic compounds: tree tomato peel case”. Status: Revision. 9 Ashley Sthefanía Caballero G., Carlos Ariel Cardona Á. “Analysis of conventional and non- conventional technologies in the production of polyphenolic compounds from Passiflora edulis”. Status: Revision. Carlos A. García, Estefanny Carmona, Ashley Sthefanía Caballero, Jimmy A. Martinez, Juan Camilo Solarte-Toro, Carlos A. Cardona. “Fermentative production of ethanol using Pinus patula as raw material: Economic and energetic assessment”. Status: Revision. Carlos a. García, Jimmy A. Martinez, Juan Camilo Solarte-Toro, Ashley Sthefanía Caballero, Estefanny Carmona, Carlos A. Cardona. “Effect of the alkaline pretreatment of Pinus patula in the production and economic profitability of biomethane through anaerobic digestion” Status: Revision. Josué Enríquez Obandoa, Ashley Sthefanía Caballero G., Clarisse Nobreb, José Teixeira, Carlos Ariel Cardona Alzate. “Evaluation of the prefeasibility of fructooligosaccharides production from sucrose through Aureo-basidium pullulans”. Status: Revision. Daissy Lorena Restrepo S., Ashley Sthefanía Caballero G., Carlos Ariel Cardona Alzate, “Evaluation of the pre-feasibility
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