Heat Awareness Information
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Metabolomic Profiling Identifies a Novel Mechanism for Heat Stroke‑Related Acute Kidney Injury
MOLECULAR MEDICINE REPORTS 23: 241, 2021 Metabolomic profiling identifies a novel mechanism for heat stroke‑related acute kidney injury LING XUE1*, WENLI GUO2*, LI LI2, SANTAO OU2, TINGTING ZHU2, LIANG CAI3, WENFEI DING2 and WEIHUA WU2 Departments of 1Urology and 2Nephrology, Sichuan Clinical Research Center for Nephropathy, The Affiliated Hospital of Southwest Medical University;3 Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China Received April 13, 2020; Accepted August 20, 2020 DOI: 10.3892/mmr.2021.11880 Abstract. Heat stroke can induce a systemic inflammatory factor mitochondria‑associated 2 (Aifm2), high‑mobility group response, which may lead to multi‑organ dysfunction including box 1 (HMGB1) and receptor for advanced glycosylation end acute kidney injury (AKI) and electrolyte disturbances. To products (RAGE). Liquid chromatography‑mass spectrometry investigate the pathogenesis of heat stroke (HS)‑related AKI, analysis was conducted to find differential metabolites and a mouse model of HS was induced by increasing the animal's signaling pathways. The HS mouse model was built success‑ core temperature to 41˚C. Blood samples obtained from the fully, with significantly increased creatinine levels detected tail vein were used to measure plasma glucose and creati‑ in the serum of HS mice compared with controls, whereas nine levels. Micro‑positron emission tomography‑computed micro‑PET/CT revealed active metabolism in the whole tomography (micro‑PET/CT), H&E staining and trans‑ body of HS mice. H&E and TUNEL staining revealed that mission electron microscopy were conducted to examine the kidneys of HS mice exhibited signs of hemorrhage and metabolic and morphological changes in the mouse kidneys. -
Prevention and Management of Heat-Related Illness
PREVENTION AND MANAGEMENT OF HEAT-RELATED ILLNESS Federal Bureau of Prisons Clinical Guidance DECEMBER 2017 Federal Bureau of Prisons (BOP) Clinical Guidance is made available to the public for informational purposes only. The BOP does not warrant this guidance for any other purpose, and assumes no responsibility for any injury or damage resulting from the reliance thereof. Proper medical practice necessitates that all cases are evaluated on an individual basis and that treatment decisions are patient- specific. Consult the BOP Health Management Resources Web page to determine the date of the most recent update to this document: http://www.bop.gov/resources/health_care_mngmt.jsp Federal Bureau of Prisons Prevention and Management of Heat-Related Illness Clinical Guidance December 2017 TABLE OF CONTENTS 1. PURPOSE AND OVERVIEW ......................................................................................................................1 2. PATHOPHYSIOLOGY...............................................................................................................................1 3. RISK FACTORS FOR HRI ........................................................................................................................2 4. SYMPTOMS AND SIGNS ..........................................................................................................................3 5. EVALUATION.........................................................................................................................................5 6. TREATMENT..........................................................................................................................................6 -
A Web Survey to Evaluate the Thermal Stress Associated with Personal Protective Equipment Among Healthcare Workers During the COVID-19 Pandemic in Italy †
International Journal of Environmental Research and Public Health Article A Web Survey to Evaluate the Thermal Stress Associated with Personal Protective Equipment among Healthcare Workers during the COVID-19 Pandemic in Italy † Alessandro Messeri 1,2,* , Michela Bonafede 3 , Emma Pietrafesa 3, Iole Pinto 4, Francesca de’Donato 5, Alfonso Crisci 1, Jason Kai Wei Lee 6,7,8,9,10,11 , Alessandro Marinaccio 3 , Miriam Levi 12 , Marco Morabito 1,2 and on behalf of the WORKLIMATE Collaborative Group ‡ 1 Institute of Bioeconomy, National Research Council (IBE-CNR), 50019 Florence, Italy; [email protected] (A.C.); [email protected] (M.M.) 2 Centre of Bioclimatology, University of Florence (UNIFI), 50144 Florence, Italy 3 Occupational and Environmental Medicine, Epidemiology and Hygiene Department, Italian Workers’ Compensation Authority (INAIL), 00143 Rome, Italy; [email protected] (M.B.); [email protected] (E.P.); [email protected] (A.M.) 4 Physical Agents Sector, Regional Public Health Laboratory, 53100 Siena, Italy; [email protected] 5 Department of Epidemiology Lazio Regional Health Service, ASL ROMA 1, 00147 Rome, Italy; [email protected] 6 Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore; [email protected] 7 Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Citation: Messeri, A.; Bonafede, M.; Singapore S117593, Singapore 8 Pietrafesa, E.; Pinto, I.; de’Donato, F.; Global Asia Institute, National University of Singapore, Singapore S119076, Singapore 9 Crisci, A.; Lee, J.K.W.; Marinaccio, A.; N.1 Institute for Health, National University of Singapore, Singapore S117456, Singapore 10 Institute for Digital Medicine, National University of Singapore, Singapore S117456, Singapore Levi, M.; Morabito, M. -
Basal Digital Thermometer How to Use Instructions for Use 1
BASAL DIGITAL THERMOMETER HOW TO USE INSTRUCTIONS FOR USE 1. The probe is folded into the body of the thermometer for storage. Unfold the probe and Please read thoroughly before using KD-2160 disinfect with rubbing alcohol before using. FEATURES 2. Press and release the on/off button. The display will read or 3. Next the display will show L°F or L°C with the °F or °C flashing. This basal digital thermometer is intended to measure the human body temperature for 4. Place the probe under the tongue as described and shown below. women. It’s precise digital display is for using in a household environment. 5. Once the degree sign °F (°C) on the display has stopped flashing, the measured temperature is indicated. 1. Oral temperature measurement in approximately 30 seconds with proper use. 2. 40 sets of memories. Recall all memories using NFC (Near Field Communication) or the 6. The unit will automatically turn off in approx. 3 minutes. However, to prolong battery life, headset jack adaptor on your mobile device. it is best to turn off the thermometer by pressing the ON/OFF button once the 3. Very sensitive unit, easy to read digital LCD (liquid crystal display). temperature has been noted. 4. Compact, accurate and durable LSI (large scale integration) unit. 5. If the thermometer is inadvertently left on after temperature stabilization, it will automatically ORAL USE shut off after approximately 3 minutes. Place the probe well under the patient's tongue with the probe 6. Small, light weight unit with “store-away” probe and a handy carry case. -
Calcitonin Receptors Are Ancient Modulators for Rhythms of Preferential Temperature in Insects and Body Temperature in Mammals
Downloaded from genesdev.cshlp.org on October 7, 2021 - Published by Cold Spring Harbor Laboratory Press Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals Tadahiro Goda,1,5 Masao Doi,2,5 Yujiro Umezaki,1 Iori Murai,2 Hiroyuki Shimatani,2 Michelle L. Chu,1 Victoria H. Nguyen,1 Hitoshi Okamura,2 and Fumika N. Hamada1,3,4,6 1Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA; 2Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; 3Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA; 4Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila. DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms. -
Heat Stress and PPE During COVID-19: Impact on Health Care Workers’ Performance, Safety and Well-Being in NHS Settings
medRxiv preprint doi: https://doi.org/10.1101/2020.09.22.20198820; this version posted September 23, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Heat Stress and PPE during COVID-19: Impact on health care workers’ performance, safety and well-being in NHS settings. Sarah L Davey1*., Ben J Lee1., Timothy Robbins2,3., Harpal Randeva2, C. Doug Thake1. 1 Occupational and Environmental Physiology Group, Centre for Sport, Exercise and Life Sciences, (CSELS), Faculty of Health and Life Sciences, Coventry University, Coventry, United Kingdom. 2 University Hospitals Coventry & Warwickshire NHS Trust, Coventry, United Kingdom. 3 Institute of Digital Healthcare, WMG, University of Warwick, Coventry, United Kingdom Corresponding author: Sarah Davey E-mail: [email protected] Key words: PERSONAL PROTECTIVE EQUIPEMENT; HEAT STRESS; HEALTH CARE WORERS, SARS-COV-2 (COVID-19); EXTREME ENVIRONMENTS; HEAT-RELATED ILLNESS. NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. 1 medRxiv preprint doi: https://doi.org/10.1101/2020.09.22.20198820; this version posted September 23, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Abstract Background: The impermeable nature of PPE worn by health care workers (HCWs) during the SARS-CoV-2 (COVID-19) pandemic can potentiate heat stress which may negatively impact the performance, safety and well-being of HCWs. -
Rethinking the Normal Human Body Temperature
CART FREE HEALTHBEAT SIGNUP SHOP ▼ SIGN IN What can we help you 繠nd? HEART HEALTH MIND & MOOD PAIN STAYING CANCER DISEASES & MEN'S HEALTH WOMEN'S HEALTHY CONDITIONS HEALTH Normal Body Temperature : Rethinking the normal human body temperature The 98.6° F "normal" benchmark for body temperature comes to us from Dr. Carl Wunderlich, a 19th-century German physician who collected and analyzed over a million armpit temperatures for 25,000 patients. Some of Wunderlich's observations have stood up over time, but his de繠nition of normal has been debunked, says the April issue of the Harvard Health Letter {http://www.health.harvard.edu/newsletters/Harvard_Health_Letter.htm}. A study published years ago in the Journal of the American Medical Association found the average normal temperature for adults to be 98.2°, not 98.6°, and replaced the 100.4° fever mark with fever thresholds based on the time of day. Now, researchers at Winthrop University Hospital in Mineola, N.Y., have found support for another temperature truism doctors have long recognized: Older people have lower temperatures. In a study of 150 older people with an average age of about 81, they found that the average temperature never reached 98.6°. These 繠ndings suggest that even when older people are ill, their body temperature may not reach levels that people recognize as fever. On the other hand, body temperatures that are too low (about 95°) can also be a sign of illness. The bottom line is that individual variations in body temperature should be taken into account, reports the Harvard Health Letter. -
HHE Report No. HETA-2018-0154-3361, Evaluation of Rhabdomyolysis and Heat Stroke in Structural Firefighter Cadets
Evaluation of Rhabdomyolysis and Heat Stroke in Structural Firefighter Cadets HHE Report No. 2018-0154-3361 November 2019 Authors: Judith Eisenberg, MD, MS Jessica F. Li, MSPH Karl D. Feldmann, MS, CIH Desktop Publisher: Jennifer Tyrawski Editor: Cheryl Hamilton Logistics: Donnie Booher, Kevin Moore Medical Field Assistance: Nonita Dhirar Data Support: Hannah Echt Keywords: North American Industry Classification System (NAICS) 922160 (Fire Protection), Structural Firefighter Training, Structural Firefighter Cadet Course, Heat, Heat-Related Illness, Heat Stroke, Rhabdomyolysis, Texas Disclaimer The Health Hazard Evaluation Program investigates possible health hazards in the workplace under the authority of the Occupational Safety and Health Act of 1970 [29 USC 669a(6)]. The Health Hazard Evaluation Program also provides, upon request, technical assistance to federal, state, and local agencies to investigate occupational health hazards and to prevent occupational disease or injury. Regulations guiding the Program can be found in Title 42, Code of Federal Regulations, Part 85; Requests for Health Hazard Evaluations [42 CFR Part 85]. Availability of Report Copies of this report have been sent to the employer, employees, and union at the plant. The state and local health departments and the Occupational Safety and Health Administration Regional Office have also received a copy. This report is not copyrighted and may be freely reproduced. Recommended Citation NIOSH [2019]. Evaluation of rhabdomyolysis and heat stroke in structural firefighter cadets. By Eisenberg J, Li JF, Feldmann KD. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Hazard Evaluation Report 2018-0154-3361, https://www.cdc.gov/niosh/hhe/reports/pdfs/2018-0154-3361.pdf. -
Decreasing Human Body Temperature in the United States Since the Industrial Revolution
bioRxiv preprint doi: https://doi.org/10.1101/729913; this version posted August 8, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Decreasing human body temperature in the United States since the Industrial Revolution Myroslava Protsiv1, Catherine Ley1, Joanna Lankester2, Trevor Hastie3,4, Julie Parsonnet1,5,* Affiliations: 5 1Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305. 2 Division of Cardiovascular Medicine, Stanford University, School of Medicine CA 94305. 3Department of Statistics, Stanford University, Stanford, CA 94305. 4Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, 10 CA, 94305. 5Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, 94305 *Correspondence to: Julie Parsonnet, 300 Pasteur Dr., Lane L134, Stanford University, Stanford, CA 94305. [email protected]. bioRxiv preprint doi: https://doi.org/10.1101/729913; this version posted August 8, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 15 ABSTRACT In the US, the normal, oral temperature -
Occupational Exposure to Heat and Hot Environments
Criteria for a Recommended Standard Occupational Exposure to Heat and Hot Environments DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Cover photo by Thinkstock© Criteria for a Recommended Standard Occupational Exposure to Heat and Hot Environments Revised Criteria 2016 Brenda Jacklitsch, MS; W. Jon Williams, PhD; Kristin Musolin, DO, MS; Aitor Coca, PhD; Jung-Hyun Kim, PhD; Nina Turner, PhD DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention National Institute for Occupational Safety and Health This document is in the public domain and may be freely copied or reprinted. Disclaimer Mention of any company or product does not constitute endorsement by the National Institute for Occupational Safety and Health (NIOSH). In addition, citations of websites external to NIOSH do not constitute NIOSH endorsement of the sponsoring organizations or their programs or products. Furthermore, NIOSH is not responsible for the content of these websites. Ordering Information This document is in the public domain and may be freely copied or reprinted. To receive NIOSH documents or other information about occupational safety and health topics, contact NIOSH at Telephone: 1-800-CDC-INFO (1-800-232-4636) TTY: 1-888-232-6348 E-mail: [email protected] or visit the NIOSH website at www.cdc.gov/niosh. For a monthly update on news at NIOSH, subscribe to NIOSH eNews by visiting www.cdc.gov/ niosh/eNews. Suggested Citation NIOSH [2016]. NIOSH criteria for a recommended standard: occupational exposure to heat and hot environments. By Jacklitsch B, Williams WJ, Musolin K, Coca A, Kim J-H, Turner N. -
Diagnostic Value of Procalcitonin in Patients with Heat Stroke
Arch Microbiol Immunology 2020; 4 (1): 001-010 DOI: 10.26502/ami.93650040 Research Article Diagnostic Value of Procalcitonin in Patients with Heat Stroke Xuan Song1, Xinyan Liu1, Huairong Wang2, Xiuyan Guo2, Maopeng Yang1, Daqiang Yang1, Yahu Bai3, Nana Zhang1, Chunting Wang4* 1Department of Intensive Care Unit, DongE Hospital Affiliated to Shandong First Medical University, Liaocheng, China. 2Education Department, DongE Hospital Affiliated to Shandong First Medical University, Liaocheng, China. 3Emergency Department, DongE Hospital Affiliated to Shandong First Medical University, Liaocheng, China. 4Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China. *Corresponding Author: Chunting Wang, Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan, Shandong Province, China, 250021, Tel: +86-17806359196; E-mail: [email protected] Received: 13 January 2020; Accepted: 23 January 2020; Published: 03 February 2020 Citation: Xuan Song, Xinyan Liu, Huairong Wang, Xiuyan Guo, Maopeng Yang, Daqiang Yang, Yahu Bai, Nana Zhang, Chunting Wang. Diagnostic Value of Procalcitonin in Patients with Heat Stroke. Arch Microbiol Immunology 2020; 4 (1): 001-010. Abstract (APACHE II) score and Multiple Organ Dysfunction Background: Heat stroke is a life-threatening disease, Score (MODS) were calculated within the first 24 hours but there is currently no biomarker to accurately assess of admission to the ICU. The ability of PCT, APACHE prognosis. II score, and MODS score to predict prognosis was assessed using a receiver operating characteristic curve Objective: To study whether serum procalcitonin (PCT) (ROC) and area under the curve (AUC) analyses. is an effective biomarker for evaluating the prognosis Result: There was no statistical difference in the PCT for patients with heat stroke. -
Relationship Between MH Susceptibility and Heat Or Exercise Related Rhabdomyolysis Posted in 2017
Relationship Between MH Susceptibility and Heat or Exercise Related Rhabdomyolysis Posted in 2017 Topic What is the relationship between malignant hyperthermia susceptibility and heat or exercise related rhabdomyolysis? Supporting Evidence Background: There is a poorly-defined relationship between MH susceptibility and the development of a non-anesthetic MH-like illness during conditions of heat, exercise, stress, or viral illness.1,2 This non-anesthetic-induced MH-like condition may demonstrate many of the same clinical signs as anesthetic-induced MH including hyperthermia, muscle rigidity, rhabdomyolysis, and life-threatening hyperkalemia. Animal and anecdotal human data suggest that dantrolene is effective in ameliorating consequences of heat stroke. Many questions remain. In the absence of previous diagnostic testing, when should patients with a history of a non-anesthetic MH-like syndrome related to external conditions be considered to be at special risk for MH when they present for general anesthesia? When should these patients be referred for diagnostic testing for MH susceptibility? Are patients with a suspected or proven susceptibility to MH at greater than normal risk of developing a non-anesthetic MH-like syndrome during non-extreme levels of exercise or heat exposure? If so, should their lifestyles be altered to avoid those conditions? Should competitive athletics be avoided? Discussion: The relationship between MH and non-anesthetic MH-like illnesses has been confirmed by experimental human4 and animal5 studies as well as