Medicinal Chemistry Groups a History by John L

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E N O A E S S S L T A E A C R C I N S M S E E H C C TI N O CA April 2009 Vol. LXXXVII, No. 8 N • AMERI Monthly Meeting Esselen Award Meeting at Harvard Awarded to Dr. Chad R. Mirkin, Northwestern University 13th Weinberg Memorial Lecture Dr. Lee J. Helman speaks at the Dana-Farber Cancer Institute Science Club for Girls By Mindy Levine ACS and NESACS Medicinal Chemistry Groups A History by John L. Neumeyer The Division of Medicinal Chemistry (1909-2009) and The Medicinal Chemistry Group, NESACS (1964-2009)

Two significant anniversaries in 2009 maceutical formulations, the division E. Ullget as the Program Chair. Sym- deserve attention, the centennial changed its name in 1920 to The Divi- posia have subsequently been held reg- anniversary of the founding of the sion of Medicinal Products. In 1928 ularly on alternate even-numbered Division of Medicinal Chemistry of there was a final change of name made years, always on a university campus. the American Chemical Society (ACS) to The Division of Medicinal Chem- In 1968, the symposium assumed an and the 45th anniversary of the Medic- istry with the stated goals being international flavor, meeting at Laval inal Chemistry Group of the Northeast- “…stimulation of progress in medici- University, Quebec, Canada, under ern Section of the ACS. nal chemistry research.” The term joint sponsorship with the newly Medicinal Chemistry replaced the less formed Medicinal Chemistry Division The Division of Medicinal Chem- precise one, pharmaceutical chemistry, of the Chemical Society of Canada. A istry since medicinal chemists were prima- second joint symposium with this At a meeting of the Pharmaceutical rily employed in the pharmaceutical group was held at the University of Science Section of theACS held in industry and were recognized by the Toronto in 1982, at which time Bengt Detroit in October of 1909, a group of scientific community as practitioners L. Samuelsson from the Karolinska 35 chemists petitioned the ACS coun- of a unique type of chemistry, some- Institute in Sweden was awarded the cil to change the section’s status and times related to, but nevertheless sepa- Medicinal Chemistry Award. Later name to The Division of Pharmaceu- rate and distinct from organic that year, Professor Samuelsson was tical Chemistry. The new division chemistry, biochemistry, and pharma- awarded the Nobel Prize in Medicine. was chaired by Alviso Burdett Stevens ceutical chemistry (pharmacy). Since its earliest existence, the division of the University of Michigan and The first National Medicinal recognized that an English language Benjamin L. Murray of Merck & Co., Chemistry Symposium (sponsored by journal dedicated exclusively to medic- who served as Secretary. As the inter- the Division) was held in 1948 at the inal chemistry research would be most ests of its membership gradually University of Michigan with F.F. desirable. It was not until 1959 that changed from drug analysis and phar- Bliche as the General Chair and Glenn continued on page 8

2 The Nucleus April 2009 The Northeastern Section of the American Chemical Society, Inc. Contents Office: Marilou Cashman, 23 Cottage St., Natick, MA 01360. 1-800-872-2054 The Division of Medicinal Chemistry (1909-2009) and (Voice or FAX) or 508-653-6329. e-mail: mcash0953(at)aol.com The Medicinal Chemistry Group, NESACS (1964-2009) 2 Any Section business may be conducted ______via the business office above. By John L. Neumeyer NESACS Homepage: http://www.NESACS.org Science Club for Girls 4 David Cunningham, Webmaster ______ACS Hotline, Washington, D.C.: By Mindy Levine 1-800-227-5558 Officers 2009 Monthly Meeting 5 Chair: ______Dr. E. Joseph Billo Esselen Award Meeting at the Harvard Faculty Club 13 Shattuck Street Awarded to Dr. Chad A. Mirkin, Northwestern University Natick, MA 01760 508-653-3074, joseph.billo(at)verizon.net The 13th Annual Weinberg Memorial Lecture 6 Chair-Elect: ______John McKew Dr. Lee J. Helman, National Cancer Institute to speak at Dana-Farber Cancer Wyeth Research Institute. Title: “Targeting the IGF signal in sarcomas: past, present 200 Cambridge Park Drive Cambridge, MA 02140 and future” Immediate Past Chair: YCC Announcements 7 Marietta Schwartz ______Chemistry Department, UMass-Boston Northeast Student Career Fair and Research Conference; Boston, MA 02125 617-287-6146; marietta.schwartz(at)umb.edu Attention all Northeastern Section Beer Brewers! Secretary: Course Announcement 9 Michael Singer ______Sigma-Aldrich Two Hands-On Short Courses for Advanced Microsoft Excel Users 3 Strathmore Rd., Natick, MA 01360 508-651-8151X291; msinger(at)sial.com Taught by Dr. E. Joseph Billo at the Courtyard-Marriott, Natick, MA Treasurer: Advances in Chemical Sciences Symposium 13 James Piper ______19 Mill Rd., Harvard, MA 01451 978-456-3155, piper28(at)attglobal.net Program Announcement, April 10, 2009. To be held in conjunction Auditor: with the Robert B. Woodward Symposium at the Royal Sonesta, Cambridge, MA Anthony Rosner Cover: Archivist: The 2009 Gustavus Esselen Prize Winner, Dr. Chad A. Mirkin of North- Myron S. Simon western University (Photo courtesy of Dr. Mirkin) 20 Somerset Rd. Newton, MA 02465; 617-332-5273 Deadlines: Romysimon(at)mindspring.com Summer 2009 Issue: June 16, 2009 Trustees: September 2009 Issue: July 14, 2009 Joseph A. Lima, Esther A. H. Hopkins, Michael E. Strem Councilors Alternate Councilors Term Ends 12/31/2009 Catherine Costello Julia H.Miwa Patricia Mabrouk Alfred Viola Michaeline F. Chen Jerry P. Jasinski Dorothy J. Phillips Eva B. Chenail Amy Tapper Marietta Schwartz The Nucleus is published monthly, except June and August, by the Northeastern Section of the American Term Ends 12/31/2010 Chemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Text Thomas R. Gilbert Timothy B. Frigo must be received by the editor six weeks before the date of issue. Pamela Nagafuji Mark Froimowitz Robert Lichter David Cunningham Editor: Michael P. Filosa, Ph.D., ZINK Imaging, Inc., 16 Crosby Drive, Building 4G, Michael Singer Mukund Chorghade Bedford, MA 01730 Email: Michael.filosa(at)zink.com; Tel: 508-843-9070 Term Ends 12/31/2011 Associate Editors: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 617-332-5273 Doris I. Lewis C. Jaworek-Lopes Sheila E Rodman, Konarka Technologies, Inc., 116 John St. Suite 12, Lowell, Mary Burgess Patrick M. Gordon MA 01852 email:srodman(at)konarka.com tel 978-569-1414 Morton Z. Hoffman Lawrence Scott Assistant Editors: Stefan G. Koenig, Mindy Levine Michael P. Filosa Donald Rickter Kathi Brown Liming Shao Board of Publications: David Cunningham (Chair), Mary Mahaney, Vivian K. Walworth Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, Tel: 978-456-8622 All Chairs of standing Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050, Committees, the editor Tel: 781-837-0424 of THE NUCLEUS, and Contributing Editors: Morton Hoffman, Feature Editor; Dennis Sardella, Book Reviews the Trustees of Section Calendar Coordinator: Sheila Rodman, email: srodman(at)konarka.com Funds are members of the Board of Directors. Any Photographers: Morton Z. Hoffman and James Phillips Councilor of the American Chemical Society Proofreaders: Donald O. Rickter, Vivian K. Walworth, Mindy Levine residing within the section area is an ex officio Webmaster: David Cunningham, webmaster(at)nesacs.org member of the Board of Directors. Copyright 2008, Northeastern Section of the American Chemical Society, Inc. The Nucleus April 2009 3 Science Club for Girls Corporate Patrons ($2000+) Abbott Bioresearch By Mindy Levine Genzyme Lyophilization Service of New England It is 2:30 p.m. on a Thursday afternoon the ocean?” The group leader, a college Merck at the Cambridgeport Elementary student volunteer, patiently fielded National ACS School in Cambridge, Mass., and the their questions. “Oil comes out of Novartis final bell has rung. Students exit from rocks at the very bottom of the ocean,” Pfizer all doors, heading to after-school pro- she replied. She reminded them that, Schering Corporation grams and activities. For a group of “science is about asking questions you Sepracor elementary school girls, their school don’t know the answer to.” Serono Reproductive Institute day will not end until 3:45 pm, after Vertex Pharmaceuticals they have met in their weekly Science History of the Organization Wyeth Pharmaceuticals Club for Girls. Science Club for Girls was started in Patrons ($1000-$1999) This particular Thursday is the 1994 by a group of parents who Aptuit first day of Science Club for Girls at formed a Gender Issues in Education Astra-Zeneca R&D Boston the Cambridgeport School, and the stu- Committee at the King Open School in Broad Institute dents have many questions. “Can we Cambridge to address discrepancies in Creagen Biosciences make ice cream like we did last time?” the science education of girls and boys Estate of Wallace Gleekman one fourth grader requested. A kinder- in elementary school. Fifteen years Irix Pharmaceuticals garten student asked, “Why is Science later, the program provides free after- Millennium Pharmaceuticals Club for Girls only for girls? Why is school and weekend science clubs for PCI Synthesis there no Science Club for Boys?” 400 girls in grades K-12. Connie Shasun USA Another student replied, “We love to Chow, who has been the executive Sirtris Pharmaceuticals learn so that girls can be smarter than director of Science Club for Girls for Strem Chemicals boys.” the past two and half years, has over- ZINK Imaging In the fifth and sixth grade room, seen a substantial expansion of the pro- Ziopharm Oncology, Inc. the girls were learning about the ocean. gram. During Dr. Chow’s tenure, new Donors ($300-$999) “How deep is the ocean?” asked one clubs have been started in Lawrence, Cambridge-Major Laboratories student. “Does oil really come out of Boston and Framingham. The number Medicilon Inc Occidental Organix Peptech Corp Royal Society of Chemistry SAFC Pharma SAPA-NE

of girls participating in the program has increased by approximately 30%. Organizational Structure The girls meet at various locations in the Boston area once per week after school. The club is divided by grade, with approximately 8 to 12 students per grade. Each club is led by a mentor-scientist, typically a graduate student or college student majoring in the sciences. There are junior assistants (JAs) as well, who are students in grades 8-12 who help the mentor-scientists with that day’s curriculum. The junior assistants receive separate career guidance and counseling, in which female scientists come to discuss the continued on page 10

4 The Nucleus April 2009 Monthly Meeting Biography Dr. Chad A. Mirkin is the Director of The 896th Meeting of the Northeastern Section of the American the International Institute for Nan- Chemical Society otechnology, the George B. Rathmann Professor of Chemistry, Professor of Esselen Award Meeting Medicine, and Professor of Materials Thursday, April 16, 2009 Science and Engineering. Professor Mirkin is a chemist and Harvard University, Cambridge, MA a world renowned nanoscience expert, Harvard Faculty Club, 20 Quincy Street who is known for his development of 5:30 pm Social Hour nanoparticle-based biodetection schemes, the invention of Dip-Pen 6:30 pm Dinner Nanolithography, and contributions to 8:15 pm Award Meeting, Mallinckrodt Building, 12 Oxford Street supramolecular chemistry. He is the Pfizer Lecture Hall (MB23), Ground Floor author of over 360 manuscripts and over 350 patents and applications, Dr. E. Joseph Billo, NESACS Chair, presiding and the founder of two companies, Welcome and History of the Esselen Award- Dr. John L. Neumeyer, Nano sphere and NanoInk, which are Chair, Esselen Award Committee commercializing nanotechnology appli- Introduction of the Award Recipient - Dr. Charles Lieber, Mark cations in the life science and semicon- Hyman Professor of Chemistry, Harvard University ductor industries. At present, he is listed as one of the top 10 most cited Presentation of the Award - Gustavus J. Esselen, IV chemists in the world, and is the top Nanostructures in Chemistry, Biology and Medicine: Realized most cited nanomedicine researcher in Promise and Future Prospects - Dr. Chad A. Mirkin, Director of the world. the International Institute for Nanotechnology, George B. Rathman Dr. Mirkin has been recognized Professor of Chemistry, Professor of Biomedical Engineering, Pro- for his accomplishments with over 50 fessor of Biological and Chemical Engineering, Professor of Medi- national and international Awards. cine and Professor of Materials Science and Engineering, These include the Havinga Medal, Gus- Northwestern University, Evanston, Illinois tavus John Esselen Award, Biomedical Dinner reservations should be made no later than noon, Friday, April 10. Engineering Society’s Distinguished Please call or fax Marilou Cashman at (800) 872-2054 or e-mail at Achievement Award, Department of MCash0953(at)aol.com. Reservations not cancelled at least 24 hours in Defense NSSEFF Award, Pittsburgh advance must be paid. Members, $30.00; Non-members, $35; Retirees, $20; Analytical Chemistry Award, ACS Students, $10. Inorganic Nanoscience Award, iCON THE PUBLIC IS INVITED Innovator of the Year Award, a NIH Anyone who needs special services or transportation, please call Marilou Cash- Director’s Pioneer Award, the Colle- man a few days in advance so that suitable arrangements can be made. giate Inventors Award, National Inven- Free Parking in the Broadway Street Garage (3rd level or higher), enter from tors Hall of Fame (2002, 2004), an Cambridge Street via Felton Street. Directions to the Harvard Faculty Club can Honorary Doctorate Degree from N be found at http://www.hfc.harvard.edu/ . Dickinson College, the Pennsylvania continued on page 11

interesting and technologically useful unusual distance-dependent plasmonic Abstract because they can have properties that properties, catalytic activity, coopera- are markedly different from molecular tive binding, and a resistance to nucle- Nanostructures in Chemistry, analogues and their bulk counterparts. ase degradation— properties which Biology, and Medicine: In biology and medicine, these funda- make them extremely useful as probes Realized Promise and Future mental property differences make cer- in molecular diagnostic assays, as tain nanostructures attractive as intracellular gene regulation agents, Prospects diagnostic labels and therapeutic and as siRNA delivery vehicles. The Over the past decade, the world has agents. For example, over the past fundamental origins of these properties witnessed an explosion of interest in decade we have developed synthetic will be addressed as well as the the development of methods for syn- methods for preparing polyvalent prospect for using such structures for thesizing functional nanostructures. oligonucleotide gold nanoparticle con- developing several useful tools in N Nanostructures are both fundamentally jugates. These structures exhibit chemistry, biology, and medicine. The Nucleus April 2009 5 Biography The 13th Annual Weinberg Memorial Lecture

Lee J. Helman, M.D. Scientific Director for Clinical Research Center for Cancer Research National Cancer Institute “Targeting the IGF signal in sarcomas: past, present and future” Tuesday, April 7th, 2009 4:00 pm – 5:00 pm Lee J. Helman received his M.D. from Dana 1620 Conference Room the University of Maryland School of Dana-Farber Cancer Institute Medicine magna cum laude in 1980 and was elected to Alpha Omega Alpha. He completed his internship activation. In addition, ongoing studies and residency in Internal Medicine at Abstract suggest a role for the adaptor signaling Barnes Hospital Washington Univer- molecule CRKL in RMS cell survival. sity, where he also served as Chief Targeting the IGF signal in Given previous demonstrations of Resident. He began his fellowship sarcomas: Past, Present, and the activity of human antibodies (hAb) training at the National Cancer Insti- Future to IGFIR against ES in Phase I studies, tute in 1983, where he has remained. we developed an international Phase II Dr. Helman is the Scientific Director My laboratory has been examining the study in collaboration with the Sar- for Clinical Research and a Deputy role of growth factors in pediatric sarcoma Alliance for Research through Director in the Center for Cancer comas for over 20 years. Advances in Collaboration (SARC) to examine the Research, National Cancer Institute. basic science, which have depended on efficacy of one of these hAb (Roche) He is a Professor of Pediatrics and the work of many laboratories, are against sarcomas. Patients being Oncology at the Johns Hopkins Uni- leading us to the development of novel enrolled in this study include those versity. He was elected to the Ameri- treatments for sarcomas. with treatment-refractory ES, RMS, can Society for Clinical Investigation We and others have demonstrated osteosarcoma, synovial sarcoma, and a and the American Association of that insulin-like growth factor (IGF)-II variety of other sarcoma types. We Physicians and is a founding member is over-expressed in rhabdomyosarco- have observed clear responses to and past president of the Connective mas (RMS), where it functions as an IGFIR hAb treatment in ES and RMS; Tissue Oncology Society. He serves autocrine growth factor. Its anti-apop- however, responses are sporadic and on the Board of Directors of and is a totic activity is mediated by the activa- may be transient. We are currently Clinical Advisor to The Children’s Inn tion of mTOR signaling. We have also working to identify determinants of at NIH and is a past member of the shown that a loss of imprinting of the response to IGFIR blockade in the Board of Governors of the Clinical IGFII ligand is present in both RMS clinic. In vitro and in vivo models sug- Center at NIH. He is a past member of and Ewing’s sarcomas (ES). We have gest that the antiproliferative activity the Board of Directors of the American found that blocking mTOR signaling of these antibodies is correlated with Society of Clinical Oncology, currently restores apoptosis capacity even in the IGIFR levels, sensitivity is correlated serves on the Science Education Com- presence of IGF signaling. Similarly, directly with inhibition of Akt activa- mittee of the American Association of we and others have found that mTOR tion, and loss of response to IGFIR Cancer Research, and is on the Scien- blockade activates Akt through a loss blockade is associated with re-activa- tific Advisory Committee of the Chil- of feedback inhibition of IGF signal- tion of Akt. We have also found that, in continued on page 7 ing, and that this Akt activation can be some cell lines and human tumors, the abrogated by blocking the IGFI Recep- overexpression of BCL-2 inhibits laboratory findings, we are planning tor (IGFIR). This suggested to us the apoptosis independent of IGF signal- clinical trials of IGFIR blockade in potential utility of combining mTOR ing, which suggests the need for dual combination with other interventions, N plus IGIFR inhibition to inhibit this Akt inhibition. Based on these clinical and such as mTOR inhibition. 6 The Nucleus April 2009 Attention all Northeastern YCC Announcements Registration is Ongoing for the Northeast Student Section Beer Chemistry Two-Day Symposium The Northeastern Section YCC (www.nsycc.org) encourages all chemistry Brewers undergraduate and graduate students and post-doctoral fellows to register online of our upcoming Career Fair and Research Conference. This year, the Start Brewing! event will be held May 1-2, 2009, and will culminate in the election for our The First Annual NSYCC BrewHaHa 2009-2010 YCC executive committee. th will take place on June 13 ! As we We are pleased to announce that: mentioned in the January 2009 • The Career Fair will be held on Friday, May 1st at the Brookline Holiday Inn Nucleus, we’re calling on the home- brewers and beer-aficionados among • Historically, eight to twelve companies have attended the Career Fair us to show their stuff. This will be an • There will be social events on Friday after the Career Fair outdoor (weather permitting) social • The Research Conference will be held on Saturday, May 2nd event where brewers and non-brewers • Gregory C. Fu (MIT) will be the keynote speaker for the Chemistry will be welcome. This event is hosted Research Conference by the NSYCC, BUT ALL AMATEUR • Thanks to our sponsors, nearly $2000 in awards were given for excellent SCIENTIST-BREWERS ARE WEL- presentations in 2008 COME! • A limited number of travel grants will be awarded to students inside and Details on the upcoming NSYCC outside the section BrewHaHa will be online as soon as they are available. Registration to • Applicants must register for (and attend) both events to be eligible for (and attend will be 5 dollars, and registra- receive) the travel grants tion to compete in the brewing compe- Please see our website for details and rules regarding registration for the two- tition will be 25 dollars, with monetary day symposium and application for travel grants. For specific questions, prizes awarded to up to four (4) top please contact Lee Johnson (leland.johnson(at)nsycc.org). competitors. To register, please contact leland.johnson(at)nsycc.org. Our policy, like the American Chemical Soci- Seeking Corporate Sponsors and Vendors for the ety’s policy, is that if you choose to Northeast Student Chemistry Two-Day Symposium drink alcohol, please do so responsi- N The Northeastern Section YCC (www.nsycc.org) is asking our hiring man- bly! agers from all chemical industries to join us for our sixth annual Northeast Weinberg Biography Student Chemistry Career Fair on Friday, May 1, 2009. This year we are also asking regional sales representatives and managers from suppliers of labora- Continued from page 6 tory equipment and consumables to join us for the Northeast Student Chem- dren’s Oncology Group. Dr. Helman is istry Research Conference on Saturday May 2, 2009. This two-day an associate editor for the journal Can- symposium will provide contact with career-seeking students from across the cer Research, a Senior Editor for Clini- Northeastern Section, and will provide a great opportunity to collect resumés cal Cancer Research, and on the and introduce laboratory products to this same audience. For an information editorial board of the Journal of Clini- sheet, please contact Lee Johnson (leland.johnson(at)nsycc.org) or Lynell cal Oncology. Skewis (lynell.skewis(at)nsycc.org). We look forward to helping you with His lab currently has three major your hiring and sales objectives for 2009! themes related to the biology and treatment of pediatric sarcomas: (1) the role of insulin-like growth factors on the biology of these tumors; (2) identifica- tion of the molecular mechanisms of The NESACS website metastases using animal models of Updated frequently • Late-breaking news • position postings spontaneously metastatic tumors; (3) Back issues of the Nucleus archived • Career-related Links • Awards and Scholarships translation of these findings into treatments to improve the outcome of N WWW.NESACS.org patients with pediatric sarcomas.

The Nucleus April 2009 7 Medicinal Chemistry publication of Annual Reports in Award. In 2006 the division estab- Medicinal Chemistry which first lished the Division of Medicinal Continued from page 2 appeared in 1966 due in large measure Chemistry Hall of Fame to honor all the first edition of the Journal of to the efforts of its first editor-in-chief, the above mentioned recipients, as well Medicinal and Pharmaceutical Chem- C. K. Cain. These reports, which as members selected annually by the istry, edited by Arnold H. Becket (The appear annually and are written by Executive Committee from nomina- Chelsea College of Science and Tech- investigators primarily from the phar- tions submitted by its membership. nology, London) and Alfred Burger maceutical industry who are active in The roster of members of the Hall of (The University of Virginia) was pub- research and discoveries related to Fame is listed below and includes lished. This new journal appeared six drug research, is recognized as the Nobel Laureates, Bengt Samuelsson times yearly. In 1962, The Journal of most significant publication of its kind. and George Hitchings, who won Nobel Medicinal and Pharmaceutical Chem- Annual Reports in Medicinal Chem- Prizes in Physiology and Medicine, istry became one of the official publi- istry has published 43 volumes as of respectively. Edward E. Smissman, for cations of the ACS with Alfred Burger 2008 and continues to be a unique whom the Briston-Myers-Squibb as the sole editor. One year later, the resource for the medicinal chemistry Smissman Award was named after his name of the journal was changed to community. It is sponsored by the untimely death in 1974, was inducted The Journal of Medicinal Chemistry. Division and paid for by the Division into the Hall of Fame posthumously in Phillip S. Portoghese (University of membership from annual dues. 2008. Minnesota) succeeded Professor In 1966, The Division of Medici- In 2006, the Division of Medicinal Burger as Editor in 1972. Today, nal Chemistry, established two awards Chemistry held the distinction of being under the editorship of Professor Por- to recognize outstanding contributions the second largest special interest divi- toghese for the past 37 years, The to medicinal chemistry. The first award sion in the ACS with a membership of Journal of Medicinal Chemistry is uni- was presented to Professor Bernard over 10,500, which includes members versally recognized as the premier Baker at the Biennial Medicinal Chem- from many foreign countries. publication in medicinal chemistry istry Symposium held at Indiana Uni- research in the world. versity. Other divisional awards The Medicinal Chemistry Group of Consistent with the activities of subsequently established include the the Northeastern Section of the ACS other special interest divisions of the Bristol-Myers-Squibb Smissman In 1963 several chemists working in ACS and related scientific societies, Award, The Glaxo-Smith-Kline Alfred Arthur D. Little’s (ADL) Chemical the divisional membership favored the Burger Award, and the E. B. Hershberg continued on page 12

8 The Nucleus April 2009 The NESACS Committee on Continuing Education is pleased to sponsor two Two-Day Short Courses, designed to improve the skills and marketability of practicing B.S., M.S., and Ph.D. chemists, at a registration fee about one-third of that charged at National ACS Meetings

Two Hands-On Short Courses for Advanced Microsoft Excel® Users

PLACE: Courtyard by Marriott, 342 Speen St., Natick, MA INSTRUCTOR: E. Joseph Billo

Dr. Billo is the author of Excel® for Chemists, 2nd Ed., and Excel® for Scientists and Engineers: Numerical Methods, both published by J. Wiley and Sons. He has taught these courses to over 2,000 scientists at locations including ACS National Meetings, Amoco, Bayer, Chevron, Hercules, Kodak, Genzyme, National Cancer Institute, NIST, PITTCON, Proctor & Gamble, Shell, Texaco, Unilever, and numerous others.

® Advanced Excel for Scientists and Engineers Ways to apply Excel to scientific problems. DATES and TIME: Thursday, April 23 & Friday, April 24, 2009; 8:30 a.m. – 4:00 p.m. You'll learn how to: • produce professional-quality spreadsheets and charts. • create links between documents. • use Excel's lookup functions to obtain data from tables. • set up Excel to perform iterative calculations automatically. • use Excel's built-in functions to perform interpolation, multiple linear regression, and more. • use Excel's Solver to perform nonlinear least squares curve fitting. • record simple macros to automate routine spreadsheet tasks. • plus many shortcuts and tips to speed up your work.

® Excel Visual Basic Macros for Scientists An introduction to Visual Basic for Applications programming.

DATES and TIME: Thursday, May 21 & Friday, May 22, 2009, 8:30 AM – 4:00 PM You'll learn how to: • record simple macros to automate routine spreadsheet tasks. • write VBA procedures to carry out complex, repetitive calculations automatically. • create user-defined mathematical functions. • create macros to produce customized reports from Excel databases. • manipulate arrays and matrices. • create custom menu commands or toolbar buttons. For further information contact Prof. Billo at: (508) 653-3074 or [email protected] Attendees should have some familiarity with Excel® in order to benefit from these courses. Participants should bring a laptop computer with Excel and CD-ROM drive. 110V outlets will be provided for power supplies. ------PRE-REGISTRATION REQUIRED There will be a limited number of $400 scholarships for unemployed ACS members. Registration Fee* Advanced Excel Excel® Visual Basic Both courses Received by April 10 after April 10 May 11 after May 11 April 10 after April 10 ACS Members $500 $595 $500 $595 $750 $845 Non - ACS Members $600 $695 $600 $695 $900 $995 Graduate Students $250 $345 $250 $345 $375 $470 Undergrad. Students $125 $220 $125 $220 $185 $280 *Includes a copy of Excel* for Chemists, 2/e, value $74.50) ------REGISTRATION FORM Please check: ! Advanced Excel (April 23-24) ! VBA Macros (May 21-22) ! Both courses

Name ______I am: ! ACS Member ! Grad. Student ! Undergrad.

Mailing ______I use: ! PC ! Mac ! Excel 2003 ! Excel 2007 Address ______Tel: ______e-mail: ______Amount enclosed: $______

Mail with remittance to: Marilou Cashman, 23 Cottage Street, Natick, MA 01760. e-mail: [email protected]

Please make check payable to NESACS (Sorry, no P.O.'s or credit cards.)

The Nucleus April 2009 9 Science Club for Girls ing, the girls moved into the hands-on ticipants are girls of color. Many of the experiment for the day - building a students are from lower income house- Continued from page 4 load tester out of straws, cupcake hold- holds. Furthermore, more than half of details involved in a career in science. ers, and paper clips. At the conclusion the JAs will be the first generation in The JAs also attend field trips to see of the experiment, the girls competed their families to go to college. Dr. how science can be applied to their to see how many Skittles their load Chow spoke about one former JA from daily lives. Past trips included the Art testers could hold before the testers a single-parent home. “I think her Restoration Department at the Museum collapsed. The girls’ prize? They could mother’s ambition for her was to grad- of Fine Arts and the New England eat all of the Skittles held by their load uate from high school and work in a Culinary Institute. tester. At 3:45 p.m., when parents and local retail store,” Dr. Chow said. “She The curriculum for the students older siblings began arriving to take went to Oxford.” varies substantially by grade. Dr. the girls home, the students pleaded for The mentor-scientists, said Dr. Chow described the curriculum as “just one more minute,” as they Chow, play an invaluable role. “One of “hands on,” and designed to show the patiently added Skittles, one at a time, the reasons that we call them ‘mentor students that science is fun, and that to their newly constructed load testers. scientists’ is [because of] the idea that “there are everyday things they could these mentors are interested in the Goals and Philosophy use to explore scientific phenomenon.” growth and development of these For example, in the fourth grade One of the key goals of the organiza- girls.” The girls “know that someone classroom at Cambridgeport, the group tion, said Dr. Chow, is to make sure else has a stake in them. Knowing that leader informed the students that the “that science is accessible and avail- they have a support system in the topic for the semester would be engi- able to as many as possible.” world…gives them confidence.” neering. “What is engineering?” Ms. “What we are trying to say is that Naomi Jiang, a mentor-scientist Kareen Wilkinson, the Cambridge Pro- science is for everyone,” Dr. Chow who is an undergraduate student at gram Manager of Science Club for said. “Science is not only performed in MIT studying biology, said she devel- Girls, asked. The replies came quickly. highly sophisticated environments… ops a relationship with the girls. “I “Engineering is something you do and There are people like you, there are think it is really good to have programs it helps the world.” “[Engineers] take women like you, who are doing sci- like these where you introduce younger stuff apart and then put it back ence.” children to a field that they may not together.” “Design cars.” “Help Science Club for Girls focuses have thought about going into,” Ms. NASA.” particularly on students from underrep- Jiang said. The program allowed her to After the discussion of engineer- resented groups. Over 75% of the par- “expose [students to science] and have them start thinking about science at a younger age.” Ms. Jiang, who has been a mentor-scientist for two semesters, said she has been amazed at the students’ enthusiasm. “I am surprised by how much second graders know…you say one thing and they can relate it to so many examples.” Plans for Future Growth Science Club for Girls is funded entirely by donations from founda- tions, private companies and individu- als. To date, Dr. Chow said, the organization has not needed to turn away interested participants. However, further expansion of the program would require increased funding. In the future, Dr. Chow said, she would like to collaborate with additional community centers, schools, and universities to bring the program to more girls. “There are not enough of these programs around,” Dr. Chow stated. “We would love to grow a movement whereby college students, university continued on page 11

10 The Nucleus April 2009 P. 2, COL 1, PARA 2, LINE 10: ADD COMMA AT END COL 3, LINE 13: ADD COMMA AFTER ?1982? LAST LINE: CHANGE ?WHEN? TO ?THAT? PAGE 3 ? IN THE ?COVER?PARAGRAPH, SHOULD Mirkin Biography Harvard University E. Bright Wilson BE A LOWER CASE C IN Prize, the BF Goodrich Collegiate New Members Continued from page 5 ?COURTESY? Inventors Award, the Camille Dreyfus P. 5, COL 3, PARA 2, LINES 10-11: NANO-, SPHERE State University Outstanding Science Teacher-Scholar Award, the Alfred P. Invitation to attend a meeting Alumni Award, the ACS Nobel Laure- Sloan Foundation Award, the DuPont You are cordially invited to attend one P. 6, COL 3, 2ND LINE ABOVE ?CONTINUED?? ADD ate Signature Award for Graduate Edu- Young Professor Award, the NSF of our upcoming Section meetings as a COMMA AFTER ?RESEARCH? guest of the Section at the social hour cation in Chemistry, a Dickinson Young Investigator Award, the Naval P. 7, COL 1, PARA 3, LINE 4: INSERT COMMA AFTER College Metzger-Conway Fellowship, Young Investigator Award, the Beck- and dinner preceding the meeting. the 2003 Raymond and Beverly Sack- man Young Investigator Award, and Please call Marilou Cashman at ?RESEARCH? ler Prize in the Physical Sciences, the the Camille and Henry Dreyfus Foun- 800-872-2054, 508-653-6329 or: BOX, LINE 4: REPLACE ?FOR? WITH ?OF? Feynman Prize in Nanotechnology, the dation New Faculty Award. He is a Mcash(at)aol.com by noon of the first LAST PARA, LINE 8: REPLACE ?RESUME? Thursday of the month, letting her Leo Hendrick Baekeland Award, Member of the National Academy of N WITH ?RESUMé? Crain’s Chicago Business “40 under 40 Engineering and a Fellow of the Amer- know that you are a new member. Award,” the Discover 2000 Award for ican Association for the Advancement P. 8. COL 2, PARA 1,LINE 2: ADD COMMA AFTER Technological Innovation, I-Street of Science. ence, Plasmonics. He is the founding ?CHEMISTRY? Magazine’s Top 5 List for Leading Dr. Mirkin has served on the Edi- editor of the journal Small, one of the COL 3, PARA 1,LINE 4: ADD COMMA AFTER Academics in Technology, the Materials torial Advisory Boards of over twenty premier international nanotechnology ?RECIPIENTS? Research Society Young Investigator scholarly journals. At present he is a journals, and he has coauthored two Award, the ACS Award in Pure Chem- member of the Editorial Advisory best-selling books on nanobiotechnol- LINE 9: DELETE ?TWO? istry, the PLU Fresenius Award, the Boards of Accounts of Chemical ogy. Dr. Mirkin holds a B.S. degree LINE 12: ADD COMMA AFTER Research, Advanced Materials, Ange- from Dickinson College (1986, elected ?SUISSMAN? wandte Chemie, BioMacromolecules, into Phi Beta Kappa) and a Ph.D. Science Club for Girls Macromolecular Bioscience, SEN- degree in chemistry from the Pennsyl- PARA 2, LINE 5: ADD COMMA AFTER Continued from page 10 SORS, Encyclopedia of Nanoscience vania State University (1989). He was 10,500 and Nanotechnology, Chemistry-A an NSF Postdoctoral Fellow at the professors and women who are work- LINE 6: REPLACE ?MOST? WITH European Journal, Chemistry & Biol- Massachusetts Institute of Technology ing in companies all feel like they can ?MANY? ogy Nanotechnology Law & Business, prior to becoming a chemistry profes- take our program and start their own The Scientist, Journal of Materials sor at Northwestern University in P.10, COL 2, PARA 1, LINE 10: REPLACE ?PM? WITH branch.” In this way, she will be able to N Chemistry, and Journal of Cluster Sci- 1991. ?P.M.? ensure that girls who are underserved continue to have opportunities like par- COL 3, PARA 1, LINE 5: REPLACE ?FAMILY? ticipating in Science Club for Girls. WITH ?FAMILIES? Dr. Chow concluded with a FOOTER: ADD ?CONTINUED ON P. 11? broader view of the culture of science and its attitude toward women and P. 11, COL 1, PARA 4, LINE 5: ADD COMMA AFTER other underrepresented groups. “Orga- ?PROGRAM? nizations like Science Club for Girls P. 12, COL 3, PARA 1, LINE 4: ADD COMMA AFTER are doing our part to broaden the ?ORGANIZATIONS? understanding of science and to get girls interested in science. At the end LINE 6: ADD APOSTROPHE ?CHIL- of the day, it is institutions that must DREN?S? actually change their culture to really LINE 16: ADD COMMA AFTER make it welcoming for everyone.” ?MASSACHUSETTS? For more information about Sci- ence Club for Girls, visit their website LINE 24: ADD COMMA AFTER at www.scienceclubforgirls.org, where ?NY? you can see videos of the girls, read LINE 28: REPLACE ?WAS? WITH more about the history of the program, and find ways to donate time and/or ?IS? N money to the organization. LINE 34: ADD COMMA AFTER ?COMPANIES? LINE 41: ADD COMMA AFTER ??MENTS?

The Nucleus April 2009 11 Medicinal Chemistry Sciences Section discussed the possi- of the ACS. At that time there were bility of starting a medicinal chemistry only two pharmaceutical companies in Continued from page 8 group within the Northeastern Section the area, Astra and the Kendall Com- pany, but many prestigious research organizations, such as Boston Univer- AmericanAmerican Chemical Chemical Society Society Division Division of Medicinalof Medicinal Chemistry Chemistry Hall of Fame sity Medical School, Harvard Medical Hall of Fame School, Children’s Hospital, Massachu- 1966 Bernard R. Baker 1989 Lester A. Mitscher setts General Hospital, Tufts Medical 1968 Sydney Archer 1990 Philip S.Portoghese, Arnold Brossi School, The Worcester Foundation, 1970 James M. Sprague 1991 George deStevens and two colleges of pharmacy with 1972 George Hitchings 1992 Daniel H. Rich medicinal chemistry departments 1974 Josef Fried 1993 Leroy B. Townsend, Arthur A. Patchett (Massachusetts College of Pharmacy 1975 Corwin Hansch 1994 Laurence H. Hurley and Northeastern University). The 1976 Bernard Belleau 1995 Paul A. Anderson first meeting of the Medicinal Chem- 1977 Alfred Burger 1996 Kenner C. Rice istry Group of the Northeastern Sec- 1978 Leo Sternbach 1997 Joseph G. Cannon, Simon F. Campbell tion was held on November 17, 1964 at 1979 Everett L. May 1998 John G. Topliss, Monroe E. Wall ADL in Cambridge, Massachusetts, and 1980 C. Robin Ganellin, Tsung Ying Shen 1999 John J. Baldwin John L. Neumeyer, then at ADL, was 1981 Adrian Albert 2001 Iwao Ojima elected the first and founding chair- 1982 Bengt L. Samuelsson, David W. Cushman, 2002 F. Ivy Carroll Miguel A. Ondetti man. The late Gloria Lyle, then at the 1983 Hameo Umezawa 2003 Ronald T. Borchardt, A.K. Ganguly University of New Hampshire, served 1984 Paul A. Janssen 2004 Christopher Lipinski, William J. Greenlee as the first secretary. Louis Harris, 1985 E. J. Ariens 2006 George A. Ellestad, Joel R. Huff, Gary L. then a Senior Research Biologist in Grunewald, William F. Michne Pharmacology at Sterling Winthrop 1986 Ralph F. Hirschmann, John A. Montgomery 2007 Burton G. Christensen, James K. Coward, Robert Research Institute, Rensselaer, NY, Vince spoke at the first meeting on Pain, 1987 Robert H. Abeles 2008 Magid Abou,Gharbia, Raymond E. Counsell, Analgesia and Addiction – A Pharma- Bruce E. Maryanoff, Duane D. Miller, John L. cological and Medicinal Chemical Neumeyer, Edward E. Smissman Approach to the Problem. It is most 1988 Garland R. Marshall, Roland K. Robins gratifying that the Medicinal Chem- istry Group flourished over the years and continues to attract new members. In the 1990s many biotech and major pharmaceutical companies, as well as numerous start-up companies, have chosen to locate their research facilities in the Boston-Cambridge area. This influx of pharma research is no doubt due to the presence of four medical schools, excellent academic institutions with strong chemistry departments, and two colleges of pharmacy. The ongoing expansion of these biotech and pharmaceutical companies should bode well for the continued via- bility of the Medicinal Chemistry Group in the Northeastern Section for many years to come. John L. Neumeyer Distinguished Professor of Medicinal Chemistry and Chemistry, emeritus, Northeastern University, Director of Medicinal Chemistry Program, McLean Hospital, Harvard Medical School, Belmont, MA. N [email protected]

12 The Nucleus April 2009 Third Annual Advances In Chemical Sciences Symposium sponsored by NESACS, IUPAC and RSC-US

Royal Sonesta Hotel, Cambridge, MA

9:00 a.m. April 10, 2009

This day long scientific conference will focus on Medicinal Chemistry Organic Synthesis Methodology

Eminent scientists from industry and academia will deliver plenary lectures. Confirmed Lecturers include:

Melanie Sanford, University of Michigan “Pd(II/IV)-Catalyzed Reactions in Organic Synthesis”

Alison Frontier, University of Rochester "New Twists on the Nazarov Cyclization”

Christopher Straub, Novartis Institutes for BioMedical Research “Sympathy for the Devil: Taking IAP Antagonists from Research to the Clinic”

Andreas Goutopoulos, EMD Serono "The Discovery of Novel Allosteric MEK Inhibitors as Potential Anticancer Agents"

Michael Barbachyn, AstraZeneca Pharmaceuticals "Challenges in the Discovery of New Antibacterial Agents"

Scott Snyder, Columbia University "Lessons in Chemoselectivity: Total Synthesis of Polyphenolic Natural Products"

The symposium will be followed by a networking reception and vendor exhibition

Symposium registration fee: $ 50.00 Vendors please contact the Organizing Committee Attendance is Limited – Advanced Registration is REQUIRED Please send your full contact information along with your check for $50 made payable to NESACS to Marilou Cashman Administrative Secretary, NESACS, 23 Cottage Street, Natick, MA 01760 For additional details, including sponsorship and exhibition opportunities contact any of the Organizing Committee:

[email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] [email protected] Gabriel.Martinez- m [email protected] [email protected] [email protected] [email protected] ! The Nucleus April 2009 13 BUSINESS DIRECTORY SERVICES SERVICES SERVICES

QXPHJDODEVFRP 3

14 The Nucleus April 2009 BUSINESS DIRECTORY SERVICES SERVICES CAREER SERVICES

Index of Advertisers Am. Instrument Exchange ...... 14 Arendt & Associates IP Group 14 Cambrex Corporation ...... 15 Columbia Analytical Services ...8 CreaGen Biosciences...... 12 Eastern Scientific Co...... 10 G. Finkenbeiner, Inc...... 14 Front Run OrganX, Inc...... 14 HT Laboratories, Inc...... 14 Huffman Laboratories, Inc...... 14 Mass-Vac, Inc...... 4 Micron Inc...... 14 Nacalai USA, Inc...... 2 New Era Enterprises, Inc...... 14 NuMega Resonance Labs ...... 14 Organix, Inc...... 14 PCI Synthesis...... 11 PolyOrg Inc...... 15 Robertson Microlit Labs...... 14 Waters Corporation...... 14

The Nucleus April 2009 15 April 1 April 16, Harvard, MA 01451 19 Mill Road Kyoung-Shin Choi, Purdue University Dr. Jay D. Keasling, University of California, Berkeley April 6 April 17, MIT, 6-120 “From Bugs to Biofuels” Andrew J. Phillips, University of Colorado Dr. Jay D. Keasling, University of California, 4:00 pm Boston College, Merkert 127 Brandeis University, Gerstenzang 122 Berkeley 4:00 pm Dr. Christopher Doona, Biosciences and Technology 3:45 pm “Synthetic Biology: a new discipline in Team, U.S. Army NSRDEC Lara Mahal, University of Texas at Austin April 6-7 biological engineering” “Comparing the Quasi-chemical and other models for MIT, 6-120 Boston College, Merkert 127 4:00 pm controlling foodborne microbes using novel 4:00 pm The Max Tishler Prize Lectures April 20 Tohru Fukuyama technolgies.“ Richard Saykally, University of California, Berkeley , University of Tokyo Michael Krische UMass Dartmouth, Building Group II, Room 115 “pH of the Liquid Water Surface: Selective Adsorption Harvard Univ., Pfizer Lecture Hall , University of Texas, Austin 4:00 pm of the Hydornium and Hydroxide” 4:00 pm both days Brandeis University, Gerstenzang 122 April 2 April 7 3:45 pm Harvard Univ., Pfizer Lecture Hall April 23 Thomas E. Mallouk, Pennsylvania State University 4:00 pm Prof. Jovica Badjic, Ohio State University “A Nanoscience Approach to Photocatalysis and Solar April 17, “Gated Molecular Baskets” Professor Scott Denmark, University of Cells” Dr. Jay D. Keasling, University of California, Berkeley Boston College, Merkert 130 Illinois, Urbana-Champaign Novartis Lecturer Harvard Univ. Pfizer Lecture Hall “Synthetic Biology: a new discipline in biological 4:00 pm, 4:00 pm engineering” Prof. Jacqueline Barton, California Institute of Boston College, Merkert 130 4:00 pm April 6 Boston College, Merkert 127 Technology Harry Atwater, California Institute of “DNA-Mediated Signaling of Damage and Technology Andrew J. Phillips, University of Colorado 4:00 pm Repair” “Plasmonic materials and structures for Brandeis University, Gerstenzang 122 April 20 Tufts Univ., Pearson Chemistry Building, computing and solar energy conversion” 3:45 pm Michael Krische, University of Texas, Austin Room P-106 at Harvard Univ., Pfizer Lecture Hall 4:00 pm

April 6-7 Brandeis University, Gerstenzang 122 AMERICAN CHEMICAL 4:30 pm

U.S. POSTAGE PAID Prof. Mark D. Marshall, Amherst College NONPROFIT ORG. 3:45 pm NORTHEASTERN The Max Tishler Prize Lectures April 9 U. New Hampshire, Iddles, Room L103 SOCIETY Tohru Fukuyama, University of Tokyo April 23 SECTION Stuart Rice, University of Chicago 11:10 am Harvard Univ., Pfizer Lecture Hall Professor Scott Denmark, University of Illinois, Harvard Univ., Pfizer Lecture Hall M. Christina White, University of Illinois 4:00 pm both days Urbana-Champaign 4:00 pm Urbana-Champaign April 7 Novartis Lecturer Jovica Badjic, Ohio State MIT, 6-120 Boston College, Merkert 130 Prof. Jovica Badjic, Ohio State University U. New Hampshire, Iddles, Room L103 4:00 pm 4:00 pm “Gated Molecular Baskets” 11:10 am April 27 Harry Atwater, California Institute of Technology Boston College, Merkert 130 David E. Cane, Brown University Amos Smith, University of Pennsylvania “Plasmonic materials and structures for computing and 4:00 pm, MIT, 6-120 Harvard Univ., Pfizer Lecture Hall 4:00 PM solar energy conversion” Prof. Jacqueline Barton, California Institute of 4:00 pm Harvard Univ., Pfizer Lecture Hall Calendar April 28 Technology Apr 13 “DNA-Mediated Signaling of Damage and Repair” 4:00 pm Check the NESACS Homepage Prof. Uwe Bunz, Georgia Institute of Tufts Univ., Pearson Chemistry Building, Room P-106 Prof. Mark D. Marshall, Amherst College for late additions: Michael Green, Pennsylvania State Technology at U. New Hampshire, Iddles, Room L103 Brandeis University, Gerstenzang 122 “From Large Heteroacenes to Cruciform 4:30 pm 11:10 am http://www.NESACS.org 3:45 pm Fluorophores” April 14 Boston College, Merkert 130 4:00 pm April 9 M. Christina White, University of Illinois Urbana- Note also the Chemistry Department web Champaign Prof. Kelsey Cook, University of Tennessee Stuart Rice, University of Chicago pages for travel directions and updates. Prof. Tehshik Yoon, Univ. Wisconsin MIT, 6-120 These include: “Oxidative Functionalization Reactions of “Fourier Transformation of Mass Spectra – Harvard Univ., Pfizer Lecture Hall 4:00 pm Enhanced Information from Inexpensive 4:00 pm http://chemserv.bc.edu/seminar.html Oxaziridines” April 27 http://www.bu.edu/chemistry/events/ Boston College, Merkert 130 Spectra” Jovica Badjic, Ohio State http://www.chem.brandeis.edu/colloquium.shtml 4:00 pm Tufts Univ., Pearson Chemistry Building, U. New Hampshire, Iddles, Room L103 Amos Smith, University of Pennsylvania http://www-chem.harvard.edu/events/ Room P-106 11:10 am Harvard Univ., Pfizer Lecture Hall Prof. Samuel Kounaves, Tufts University 4:30 pm http://web.mit.edu/chemistry/ “The Saga of a Robotic Lab Assistant on Mars” David E. Cane, Brown University 4:00 PM Amos Smith www.chem.neu.edu/web/calendar/index.html Tufts Univ., Pearson Chemistry Building, , University of Pennsylvania MIT, 6-120 April 28 http://chem.tufts.edu/seminars.html [CHEM.] Room P-106 at 4:30 pm Brandeis University, Gerstenzang 122 4:00 pm Prof. Uwe Bunz, Georgia Institute of Technology http://ase.tufts.edu/chemical/seminar.htm April 15 3:45 pm Apr 13 “From Large Heteroacenes to Cruciform Fluorophores” [CHEM. ENGG.] Paul Hanson, Kansas University http://www.chem.umb.edu/ Dr. Jay D. Keasling, University of California, Michael Green, Pennsylvania State Boston College, Merkert 130 Organic Syntheses Seminar 4:00 pm www.umassd.edu/cas/chemistry/seminars.cfm Berkeley U. New Hampshire, Iddles, Room L103 Brandeis University, Gerstenzang 122 www.uml.edu/Dept/Chemistry/speakers.html Prof. Kelsey Cook, University of Tennessee “Engineering microbial metabolism for 11:10 AM 3:45 pm http://www.unh.edu/chemistry/seminars.html “Fourier Transformation of Mass Spectra – Enhanced production of anti-malarial drugs” April 29 April 14 April 1 Boston College, Merkert 127 4:00 pm Information from Inexpensive Spectra” Andrew Borovik Prof. Tehshik Yoon, Univ. Wisconsin April 15 , Univ. California, Irvine Tufts Univ., Pearson Chemistry Building, Room P-106 t Kyoung-Shin Choi, Purdue University , “Oxidative Functionalization Reactions of Oxaziridines” MIT 6-120 4:30 pm MIT, 6-120 Michael Green, Pennsylvania State University Boston College, Merkert 130 4:00 pm Amos Smith, University of Pennsylvania 4:00 pm Harvard Univ. Pfizer Lecture Hall 4:00 pm April 30 Brandeis University, Gerstenzang 122 Dr. Christopher Doona, Biosciences and 4:00 pm Prof. Samuel Kounaves, Tufts University 3:45 pm Technology Team, U.S. Army NSRDEC April 16, Tobin Marks, Northwestern University “The Saga of a Robotic Lab Assistant on Mars” Paul Hanson, Kansas University “Comparing the Quasi-chemical and other Harvard Univ., Pfizer Lecture Hall 4:00 pm Dr. Jay D. Keasling, University of California, Tufts Univ., Pearson Chemistry Building, Room P-106 Organic Syntheses Seminar models for controlling foodborne microbes Shannon S. Stahl, Univ. Wisconsin Berkeley at U. New Hampshire, Iddles, Room L103 using novel technolgies.“ MIT, 6-120 “From Bugs to Biofuels” 4:30 pm 11:10 AM UMass Dartmouth, Building Group II, 4:00 pm April 15 April 29 Room 115 Boston College, Merkert 127 4:00 pm Notices for The Nucleus Lara Mahal, University of Texas at Austin Dr. Jay D. Keasling, University of California, Berkeley 4:00 pm Calendar of Seminars Andrew Borovik, Univ. California, Irvine MIT, 6-120 “Engineering microbial metabolism for production of April 2 MIT, 6-120 4:00 pm should be sent to: anti-malarial drugs” Thomas E. Mallouk, Pennsylvania State 4:00 pm Richard Saykally, University of California, Boston College, Merkert 127 University Sheila E Rodman April 30 Berkeley 4:00 pm “A Nanoscience Approach to Photocatalysis and Konarka Technologies, Inc. “pH of the Liquid Water Surface: Selective April 15 Tobin Marks, Northwestern University Solar Cells” 116 John St. Suite 12 Adsorption of the Hydronium and Hydroxide” Michael Green, Pennsylvania State University Harvard Univ., Pfizer Lecture Hall Harvard Univ. Pfizer Lecture Hall Lowell, MA 01852 Harvard Univ., Pfizer Lecture Hall N Harvard Univ. Pfizer Lecture Hall 4:00 pm 4:00 pm email: srodman(at)konarka.com 4:00 pm 4:00 pm Shannon S. Stahl, Univ. Wisconsin MIT, 6-120 4:00 pm