bioRxiv preprint doi: https://doi.org/10.1101/115097; this version posted March 9, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Clinically Useful Brain Imaging for Neuropsychiatry: How Can We Get There? Michael P. Milham1,2, R. Cameron Craddock1,2 and Arno Klein1 1Center for the Developing Brain, Child Mind Institute, New York, NY 2Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, New York, NY Corresponding Author: Michael P. Milham, MD, PhD Phyllis Green and Randolph Cowen Scholar Child Mind Institute 445 Park Avenue New York, NY 10022
[email protected] bioRxiv preprint doi: https://doi.org/10.1101/115097; this version posted March 9, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Abstract Despite decades of research, visions of transforming neuropsychiatry through the development of brain imaging-based ‘growth charts’ or ‘lab tests’ have remained out of reach. In recent years, there is renewed enthusiasm about the prospect of achieving clinically useful tools capable of aiding the diagnosis and management of neuropsychiatric disorders. The present work explores the basis for this enthusiasm. We assert that there is no single advance that currently has the potential to drive the field of clinical brain imaging forward.