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Drug Administration Routes - Summary
Only Use L6. DrugCourse Administration & Transport 207 by Fluid Motion 243/CENG April 19, 2018 NANO Only Use Course 207 243/CENG Part I: Drug Administration NANO Routes of Drug Administration Only Topical: local effect, substanceUse is applied directly where its action is desired. EnteralCourse: systemic effect, substance is 207given via the gastrointestinal (GI) tract. Parenteral: systemic effect, substance is given by routes other than the gastrointestinal (GI) tract. 243/CENG NANO Topical Drug Delivery Epicutaneous – directly onto the surface of the skin Only allergy testing local anesthesia… Use Eye drops antibiotics for conjunctivitis … Course Inhalational207 asthma medications acute infection in upper airway … 243/CENG Intranasal route decongestant nasal sprays … NANO Enteral Drug Delivery Any form of administration that involves any part of the gastrointestinalOnly tract Use Course 207 Oral: Rectal: Gastric feeding tube: many drugs as tablets, various drugs in many drugs, enteral capsules, drops… suppository or enema nutrition… form… 243/CENG NANO Parenteral Drug Delivery Intravenous: into a vein (many drugs, total parenteral nutrition…) Only Intramuscular: into a muscle (many vaccines, antibiotics…) Use Subcutaneous: under the skin (insulin…) Intraarterial: into an artery (vasodilator drugs in the treatment of vasospasm…) Course Intradermal: into the skin itself (skin testing some allergens, tattoos…) 207 Transdermal: diffusion through the intact skin (transdermal opioid patches in pain management, nicotine patches for treatment -
Frequently Asked Questions (Faqs)
Frequently Asked Questions (FAQs) What is hyperbaric oxygen therapy? Commonly referred to as HBOT, hyperbaric oxygen therapy enhances the body’s natural healing process by delivering oxygen under pressure, which increases the oxygen content in the blood, plasma, cerebral spinal fluid, and other body tissues. There are two basic types of HBOT—hard HBOT and mild HBOT. With hard HBOT, treatments are delivered in a hard-sided chamber typically at pressures greater than 1.5 ATA and using 100% oxygen. 100% oxygen is extremely flammable; therefore, hard HBOT involves managing the risk of explosion. Another concern with hard HBOT is oxygen toxicity. While hard HBOT with 100% oxygen results in greater oxygen saturation in the tissues, many conditions respond better to mild HBOT. In clinical trials to date, there has been virtually no difference in clinical outcome between mild HBOT and hard HBOT. Mild HBOT refers to hyperbaric oxygen therapy at lower pressures, typically 1.5 ATA or below, and the use of an oxygen concentrator delivering 90-95% oxygen inside a portable soft-sided chamber. Mild HBOT has no known safety risks with fire or toxicity, and it is substantially less expensive. Our facility provides concentrated oxygen (90-95%) at 1.3 ATA—(Mild HBOT)a highly effective combination clinically, and without the risk of oxygen toxicity or explosion, as 100% oxygen is avoided. How should I expect mild HBOT to feel? You will be seated or lying down inside the chamber, relaxing comfortably in your own clothing, as you breathe concentrated oxygen (90-95% O2) through a facemask. -
Stratus 5 Oxygen Concentrator User Manual
USER MANUAL OXYGEN CONCENTRATOR CE 0123 v2.1 STR1005 User Manual Symbol Key MARK DEFINITION II Power on Power off Follow Instruction for Use No smoking Caution, consult accompanying documents. Class Ⅱ (Double Insulated) Type BF Applied Part CE certification mark 0123 AC Power Stacking Limit by Number This Way Up Fragile, handle with care Keep dry Temperature limit No open flames IIPP2211 IP21 Drip Proof Equipment Consult instructions for use Stand-by Warning, electricity 2 v2.1 STR1005 User Manual 3 v2.1 STR1005 User Manual SPECIAL NOTES • Please read this manual carefully before using this product and save it for future reference. • If you need assistance with this manual, Please contact your local DME or home health provider • The Stratus 5 is a prescription device. Use only the liter setting prescribed for you. • It is always recommended for critically ill patients to have a backup oxygen source in case of malfunction. • If patient experiences an adverse reaction contact physician or call 911 immediately. • In case of machine malfunction, contact the home medical equipment provider; do not attempt to disassemble the Stratus 5. • The Stratus 5 is not intended as life support, it is for supplemental oxygen use only. Patients with special needs may be unable to understand the alarm features and should be well supervised while using an oxygen concentrator. • The Stratus 5 is for single patient use. • Do not adjust the flowmeter float beyond the red line position. Long-term use out of range will reduce the efficiency of the oxygen generator. SAFETY NOTICE Please read the following information carefully before Operating the oxygen concentrator Warning Special attention should be paid to reducing the risk of fire when using oxygen therapy. -
MAP Preauthorization List EFF: 8/1/2017 (Updated 8/24/17)
MAP Preauthorization List EFF: 8/1/2017 (Updated 8/24/17) CPT, HCPCS Description Comment or Revenue Code Revenue Codes 0100 All inclusive room and board plus ancillary 0101 All inclusive room and board 0110 Room and Board Private (one bed) 0111 Room and Board Private (one bed) - Medical/Surgical/GYN 0113 Room and Board Private (one bed) - Pediatric 0117 Room and Board Private (one bed) - Oncology 0118 Room and Board Private (one bed) - Rehab 0119 Room and Board Private (one bed) - Other 0121 Room and Board Semiprivate (two beds) - Medical/Surgical/GYN 0123 Room and Board Semiprivate (two beds) - Pediatric 0127 Room and Board Semiprivate (two beds) - Oncology 0128 Level 1 Rehab 0129 Level 2 Rehab - acute complex 0130 Room & Board - Three and Four Beds General Classification 0131 Room & Board - Three and Four Beds Medical/Surgical/Gyn 0133 Room & Board - Three and Four Beds Pediatric 0137 Room & Board - Three and Four Beds Oncology 0138 Room & Board - Three and Four Beds Rehabilitation 0139 Room & Board - Three and Four Beds Other 0140 Room & Board - Deluxe Private General Classification 0141 Room & Board - Deluxe Private Medical/Surgical/Gyn 0143 Room & Board - Deluxe Private Pediatric 0147 Room & Board - Deluxe Private Oncology 0148 Room & Board - Deluxe Private Rehabilitation 0149 Room & Board - Deluxe Private Other 0150 Room & Board - Ward General Classification 0151 Room & Board - Ward Medical/Surgical/Gyn 0153 Room & Board - Ward Pediatric 0157 Room & Board - Ward Oncology 0158 Room & Board - Ward Rehabilitation 0159 Room & Board - -
Effects of Intraoperative Insufflation with Warmed, Humidified CO2 During Abdominal Surgery: a Review
Annals of Original Article Coloproctology Ann Coloproctol 2018;34(3):125-137 pISSN 2287-9714 eISSN 2287-9722 https://doi.org/10.3393/ac.2017.09.26 www.coloproctol.org Effects of Intraoperative Insufflation With Warmed, Humidified CO2 during Abdominal Surgery: A Review Ju Yong Cheong1,2, Anil Keshava1, Paul Witting2, Christopher John Young1 1Colorectal Surgical Department, Concord Repatriation General Hospital, Sydney Medical School, The University of Sydney, Sydney; 2Discipline of Pathology, Charles Perkins Centre, Sydney Medical School, The University of Sydney, Sydney, Australia Purpose: During a laparotomy, the peritoneum is exposed to the cold, dry ambient air of the operating room (20°C, 0%– 5% relative humidity). The aim of this review is to determine whether the use of humidified and/or warmed CO2 in the intraperitoneal environment during open or laparoscopic operations influences postoperative outcomes. Methods: A review was performed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The PubMed, OVID MEDLINE, Cochrane Central Register of Controlled Trials and Embase databases were searched for articles published between 1980 and 2016 (October). Comparative studies on humans or nonhuman animals that involved randomized controlled trials (RCTs) or prospective cohort studies were included. Both laparotomy and laparoscopic studies were included. The primary outcomes identified were peritoneal inflammation, core body temperature, and postoperative pain. Results: The literature search identified 37 articles for analysis, including 30 RCTs, 7 prospective cohort studies, 23 human studies, and 14 animal studies. Four studies found that compared with warmed/humidified CO2, cold, dry CO2 resulted in significant peritoneal injury, with greater lymphocytic infiltration, higher proinflammatory cytokine levels and peritoneal adhesion formation. -
West Virginia Nerve Injury Slides
Anesthesia for Robotic Surgery: Is it a Different Ball Game? Michael A. Olympio, M.D. Professor of Anesthesiology Wake Forest University School of Medicine YES, it is… Access to, and monitoring the patient Combined Pneumoperitoneum and Trendelenburg – Type and amount of inflation gas – Pulmonary impairments – Hydrostatic gradients – Cardiovascular derangements – Circulation to the lower limb – Confounding obesity Anesthetic adjuncts and outcomes – Routine general anesthesia – General and regional? – Multimodal, narcotic-sparing, “ideal” anesthetic Olympio, MA. “Anesthetic Considerations for Robotic Urologic Surgery” In, Hemal AK, Menon M (eds.) Robotic Urologic Surgery. New York: Springer-Verlag, 2011. Photo of RALRP At the end of this lecture, the learner will explain or understand: – the physiological derangements associated with combined pneumoperitoneum and Trendelenburg posture – the relationships between, and significance of hydrostatic pressure, blood pressure measurement and the risks of organ hypo/hyper-perfusion – the reasons for choosing specific anesthetic management techniques and drugs. No disclosures. What you should know about your own surgical outcomes: operative time nausea and vomiting rates blood loss use of intermittent morbidity types and rates pneumatic serial compression (IPSC) length of stay and criteria for discharge desired extremes of TP mortality (if any and its desired intra-abdominal cause) inflation pressures (IAP) postoperative pain and and, type of inflation gas analgesic regimens Pre-Anesthetic -
I-Gel User Guide
User Guide i-gel® single use supraglottic airway Adult and paediatric sizes www.i-gel.com Contents 1.0 Introduction .................................................................................................................... 2 1.1 The i-gel design ..................................................................................................................................................2 1.2 Key components and their function .........................................................................................................3 1.2.1 Soft non-inflatable cuff ................................................................................................................4 1.2.2 Gastric channel .............................................................................................................................4 1.2.3 Epiglottic rest ................................................................................................................................4 1.2.4 Buccal cavity stabiliser ................................................................................................................4 1.2.5 15mm connector ..........................................................................................................................5 1.2.6 Important key points.....................................................................................................................5 2.0 Indications ..................................................................................................................... -
E-Cigarette Use in Patients Receiving Home Oxygen Therapy
FOCUSED REVIEW E-cigarette use in patients receiving home oxygen therapy Yves Lacasse MD MSc FRCP1,2, Martin Légaré MD FRCP3, François Maltais MD FRCP1,2 Y Lacasse, M Légaré, F Maltais. E-cigarette use in patients receiving La cigarette électronique chez les patients sous home oxygen therapy. Can Respir J 2015;22(2):83-85. oxygénothérapie à domicile Current smokers who are prescribed home oxygen may not benefit from the therapy. In addition to being an obvious fire hazard, there is some evi- Il se peut que les fumeurs qui se font prescrire une oxygénothérapie à domi- dence that the physiological mechanisms by which home oxygen is cile ne profitent pas de ce traitement. Sans compter que le tabagisme pose believed to operate are inhibited by smoking. Although their effectiveness un risque d’incendie évident, certaines données probantes indiquent qu’il is yet to be demonstrated, electronic cigarettes (e-cigarettes) are often inhibe les mécanismes physiologiques par lesquels l’oxygénothérapie à regarded as an aid to smoking cessation. However, several burn accidents domicile fonctionnerait. Même si son efficacité reste à démontrer, la ciga- in e-cigarette smokers receiving home oxygen therapy have also been rette électronique (vapoteuse) est souvent perçue comme une aide au reported, leading Health Canada to release a warning of fire risk to oxygen sevrage du tabagisme. Cependant, plusieurs incidents de brûlure chez des therapy patients from e-cigarettes. It is the authors’ position that patients vapoteurs sous oxygénothérapie à domicile ont été déclarés, ce qui a incité receiving oxygen should definitely not use e-cigarettes. -
Download the Evonik for More Information!
ADVANCED APPROACHES THE PRESCRIPTION CAN WE ACHIEVE FOR DELAYED-RELEASE ABUSE EPIDEMIC: EFFECTIVE ORAL P04 FORMULATIONS P18 DESIGNING A SOLUTION P32 DELIVERY OF VACCINES? NOVEL ORAL DELIVERY SYSTEMS 77 O 2017 • ISSUE N 2017 TH JULY 17 JULY Contents o TH ONdrugDelivery Issue N 77, July 17 , 2017 Advanced Approaches for Delayed-Release Formulations Maria Montero Mirabet, Senior Project Manager, NOVEL ORAL DELIVERY SYSTEMS Drug Delivery Services, Business Line Health Care, and 4 - 9 Brigitte Skalsky, Senior Director, Scientific Communication, This edition is one in the ONdrugDelivery series Business Line Health Care of publications from Frederick Furness Publishing. Evonik Nutrition & Care Each issue focuses on a specific topic within the field of drug delivery, and is supported by industry Technologies & Clinical Studies for the Oral Delivery of Calcitonin Nozer Mehta, Principal leaders in that field. Peptide Technologies James P Gilligan, Chief Scientific Officer 12 MONTH EDITORIAL CALENDAR 10 - 16 Tarsa Therapeutics Sep Wearable Injectors William Stern, Consultant Peptide Drug Development Oct Prefilled Syringes Nov Pulmonary & Nasal Delivery The Prescription Abuse Epidemic: Designing a Solution Dec Connecting Drug Delivery Aia Malik, Healthcare Product Manager, and 18 - 20 Gemma Budd, Director of Technologies and Strategy Jan ‘18 Ophthalmic Delivery Lucideon Feb Prefilled Syringes Mar Skin Drug Delivery: Targeting the End Goal: Opportunities & Innovations in Colonic Drug Delivery Dermal, Transdermal & Microneedles Sejal R Ranmal, Director -
Ozone in Medicine. the Low-Dose Ozone Concept and Its Basic Biochemical Mechanisms of Action in Chronic Inflammatory Diseases
International Journal of Molecular Sciences Article Ozone in Medicine. The Low-Dose Ozone Concept and Its Basic Biochemical Mechanisms of Action in Chronic Inflammatory Diseases Renate Viebahn-Haensler 1,*,† and Olga Sonia León Fernández 2,*,† 1 Medical Society for the Use of Ozone in Prevention and Therapy, Iffezheim, D-76473 Baden-Baden, Germany 2 Pharmacy and Food Institute, University of Havana, Coronela, Lisa, Havana 10 400, Cuba * Correspondence: [email protected] (R.V.-H.); [email protected] (O.S.L.F.) † Both authors contributed equally. Abstract: Low-dose ozone acts as a bioregulator in chronic inflammatory diseases, biochemically char- acterized by high oxidative stress and a blocked regulation. During systemic applications, “Ozone peroxides” are able to replace H2O2 in its specific function of regulation, restore redox signaling, and improve the antioxidant capacity. Two different mechanisms have to be understood. Firstly, there is the direct mechanism, used in topical treatments, mostly via radical reactions. In systemic treatments, the indirect, ionic mechanism is to be discussed: “ozone peroxide” will be directly reduced by the glutathione system, informing the nuclear factors to start the regulation. The GSH/GSSG balance outlines the ozone dose and concentration limiting factor. Antioxidants are regulated, and in the case of inflammatory diseases up-regulated; cytokines are modulated, here downregulated. Rheumatoid Citation: Viebahn-Haensler, R.; arthritis RA as a model for chronic inflammation: RA, in preclinical and clinical trials, reflects the León Fernández, O.S. Ozone in pharmacology of ozone in a typical manner: SOD (superoxide dismutase), CAT (catalase) and finally Medicine. The Low-Dose Ozone GSH (reduced glutathione) increase, followed by a significant reduction of oxidative stress. -
Cough Assist Machine" SW3 6NP UK Fax: 44 2073518911 Educational Aims E-Mail: [email protected]
Breathe review cough.qxd 21/05/2008 16:06 Page 2 Key points k Ineffective cough is a major cause of mortality and morbidity in patients with neuromuscular disease. k A normal cough requires the inspiratory muscles to inspire to up to 85–90% of total lung capacity followed by rapid closure of the glottis for ~0.2 s. Both glottic opening and contraction of abdominal and intercostal (expiratory) muscles, resulting in intrapleural pressures of >190 cmH2O and generating transient peak cough flows (PCF) of 360–1,200 L per min [1] complete the manoeuvre. k Cough assist techniques are used in patients who present with a weak cough. The goal of these techniques is to increase the expiratory airflow that occurs during a cough, by assist- ing inspiration and/or expiration, thus increasing cough efficacy. k When conventional cough assistance techniques become ineffective, a mechanical insufflator–exsufflator should be considered. Breathe review cough.qxd 21/05/2008 16:06 Page 3 The ERS designates this educational activity for a maximum of 1 CME credit. For information on how to earn CME credits, see page 375 How to use a mechanical M. Chatwin Sleep and Ventilation Unit insufflator–exsufflator Royal Brompton Hospital Sydney Street London "cough assist machine" SW3 6NP UK Fax: 44 2073518911 Educational aims E-mail: [email protected] k To raise awareness of how to use mechanical insufflator–exsufflators. k To discuss the use of mechanical insufflation–exsufflation compared with conventional airway clearance techniques. Support statement k To identify an escalation treatment protocol. M. Chatwin was funded by grants from the Jennifer Trust for Spinal Muscular Atrophy (UK) and Breas Summary Medical (Sweden) Effective cough is a protective mechanism against respiratory tract infections. -
An Introduction to Anaesthesia
What You Need to KNoW about An introduction to anaesthesia Introduction divided into three stages: induction, main- n Central neuraxial block, e.g. spinal or Anaesthetic experience in the undergradu- tenance and emergence. epidural (Figure 1 and Table 1). ate timetable is often very limited so it can In regional anaesthesia, nerve transmis- remain somewhat of a mysterious practice sion is blocked, and the patient may stay Components of a general well into specialist training. This introduc- awake or be sedated or anaesthetized dur- anaesthetic tion to the components of an anaesthetic ing a procedure. Techniques used include: A general anaesthetic always involves an will help readers to get more from clinical n Local anaesthetic field block hypnotic agent, usually an analgesic and attachments in surgery and anaesthetics or n Peripheral nerve block may also include muscle relaxation. The serve as an introduction to the topic for n Nerve plexus block combination is referred to as the ‘triad of novice or non-anaesthetists. anaesthesia’. Figure 1. Schematic vertical longitudinal section The relative importance of each com- Types and sites of anaesthesia of vertebral column and structures encountered ponent depends on surgical and patient The term anaesthesia comes from the when performing central neuraxial blocks. * factors: the intervention planned, site, Greek meaning loss of sensation. negative pressure space filled with fat and surgical access requirement and the Anaesthetic practice has evolved from a venous plexi. † extends to S2, containing degree of pain or stimulation anticipated. need for pain relief and altered conscious- arachnoid mater, CSF, pia mater, spinal cord The technique is tailored to the individu- ness to allow surgery.