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Human Circadian Rhythms Melatonin Administration in the Early Evening

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SUGGESTED READINGS DELAYED SLEEP-WAKE Engaging in social activities in the evening can be Boivin DB and Boudreau P, Impacts of shift work on PHASE DISORDER (DSWPD) problematic and sleep restriction tends to be worse on sleep and circadian rhythms, Pathologie Biologie, 2014, weekend days. When patients with ASWPD go to bed 62:292-301. Delayed sleep-wake phase disorder (DSWPD) is the Boivin DB and Boudreau P. Les rythmes circadiens et most frequent intrinsic circadian rhythm disorder and earlier, according to their natural sleep tendency, sleep l’insomnie-Une approche pour intégrer la barrière du quality and duration are generally normal. temps. Insomnie-Conférences scientifiques, Société affect about 0.13% - 3.1% of the adult population with Canadienne du Sommeil (SCS), 2014, 2(4). an increased prevalence of 7-16% in young adults and Familial ASWPD, which causes extreme “morning lark” Cermakian N and Boivin DB. A molecular perspective of tendencies in whole families, seems to be related to a human circadian rhythm disorders. Brain Res Rev 2003: adolescents. 42 (3): 204-220. DSWPD is characterized by a delay in the main sleep clock gene mutation, supporting the idea that some sleep Czeisler, C.A., O.M. Buxton, and S.B. Khalsa, The human episode and an inability to fall asleep or wake up at the disorders have a genetic basis. The treatment of choice circadian timing system and sleep-wake regulation, in Principles and Practice of Sleep Medicine, M. Kryger, desired times. Patients naturally fall asleep abnormally for ASWPD is exposure to bright light for 1-2 hours in T. Roth, and W.C. Dement, Editors. 2005, Elsevier: late around 03:00 to 06:00 and wake up around 10:00 the evening and shielding from early morning light. Philadelphia. to 15:00. When they sleep at their natural times, sleep Arendt, J., Managing jet lag: Some of the problems and possible new solutions. Sleep Med Rev, 2009. 13(4): p. quality, sleep stage distribution, and sleep duration are Human 249-56. normal. NON-24-HOUR SLEEP-WAKE SYNDROME Reid, K.J. and P.C. Zee, Circadian rhythm disorders. However, when sleep is planned earlier, at more socially Circadian Semin Neurol, 2009. 29(4): p. 393- 405. Non-24-hour sleep-wake disorder results from a Wittmann, M., et al., Social jetlag: misalignment of acceptable times (e.g. 23:00), a significant increase in biological and social time. Chronobiol Int, 2006. 23(1): sleep latency and wake time during the first part of the failure of the endogenous circadian system to entrain Rhythms p. 497-509. night is observed. to the environmental 24-hour day. ADDITIONAL PATIENT BROCHURES BY SLEEP EXPERTS Excessive sleepiness is generally experienced in Patients with non-24-hour sleep-wake syndrome the morning and difficulties awakening at socially have sleep onset times that tend to be delayed by 1-2 INTRODUCTION • Dental Appliances • Obstructive Sleep Apnea acceptable times are reported. As a result, a significant hours from one day to the next. The condition may • Sleep in Aging • Patient Guide to Sleep proportion of DSWPD patients report disrupted work go unrecognized for several years. In the disturbed Studies • Sleep Bruxism or social functioning. The treatment of choice for periods, the patient suffers from severe sleep-onset • Positional Therapy for • Drowsy Driving insomnia and difficulty awakening in the morning. Obstructive Sleep Apnea DSWPD is exposure to bright light for 1-2 hours in This condition is more common in blind patients, 50% ENTRAINMENT OF HUMAN • Insomnia • Children the morning, shielding from light in the evening, and • Human Circadian Rhythms melatonin administration in the early evening. of whom lack photic entrainment the 24-hour day. It is CIRCADIAN RHYTHMS • Restless Legs Syndrome rare in sighted individuals and usually associated with • Strategies for Night Shift • Sleep and Post- Traumatic Workers Stress Disorder other neurological or psychiatric conditions. • Narcolepsy and Cataplexy • Normal Sleep A combined approach with phototherapy in the morning, shelding from light in the evening, and • Dreams and Nightmares CIRCADIAN MODULATION OF melatonin administration in the evening is suggested SLEEP AND WAKING to treat this condition. Please note that the content of these brochures are copyrighted by Canadian Sleep Society, unless otherwise indicated. Rev 15/05/2020 CONCLUSION “HEALTHY SLEEP FOR HEALTHY CANADIANS” Most behavioural and physiological functions vary CIRCADIAN RHYTHM The Canadian Sleep Society is a national organization committed to across the day. Most of them are generated by an SLEEP-WAKE DISORDERS improving sleep for all Canadians through: support for research, promotion of high quality clinical care, education of professionals and the public, and ADVANCED SLEEP-WAKE endogenous circadian system and can be entrained advocacy for sleep and sleep disorders medicine. by environmental synchronizers such as the Diane B. Boivin, M.D, Ph.D., Professor, Director, PHASE DISORDER (ASWPD) Centre for Study and Treatment of Circadian Rhythms light-dark cycle. Douglas Mental Health University Institute For more information visit www.canadiansleepsociety.com or email [email protected] Advanced sleep-wake phase disorder (ASWPD) is less A complex interaction between homeostatic and Department of Psychiatry, McGill University prevalent than DSWPD with an estimated rate of 1% in circadian processes modulates the quality and www.canadiansleepsociety.com middle-aged individuals. It is considered a sleep-wake disorder in old age as sleep tends to stabilize at earlier duration of sleep and wake periods. An abrupt times-of-day with aging. of evening sleepiness, a need change in the timing of sleep relative to the environment Atlantic Sleep Centre to go to bed early around 18:00 to 21:00, early morning can lead to substantial disturbances of sleep and waking Saint John Regional Hospital awakenings around 02:00-05:00, and reduced total sleep like those observed in night shift work, jet lag, DSWPD, 506-648-6178 time. 5 ASWPD, and non-24-hour sleep-wake disorder. 6 Exposure to light can shift rhythms of the central clock The second process is called the circadian process The long-term safety of artificial light exposure must towards other internal time zones (called circadian and is controlled by the endogenous circadian system. be better documented. Exogenous melatonin is phases). The pattern of light exposure can be planned It modulates the strength of sleep propensity and known to have sleep-promoting and circadian phase to rapidly reset the timing of the circadian system varies as a function of time-of-day. Peak time of shifting effects. A few prior studies suggest the use of according to a phase response. sleep propensity occurs near the nadir of core body melatonin tablets or melatoninergic receptor agonists Exposure to light in the late evening/early night will temperature cycle, at the end of the night. can be beneficial for shift workers, although further delay rhythms to later times (akin to a westward An interaction between homeostatic and circadian large scale experimental testing is needed to support travel) whereas light exposure in the late night/early processes explains the drop in vigilance levels around their clinical efficacy. INTRODUCTION morning will advance rhythms to earlier times (akin 4:00-6:00 and 13:00-15:00 for an individual who Finally, interventions designed to correct the circadian to an eastward travel). Light intensity, its spectral normally sleeps from midnight to 8:00. misalignment might not be advisable or practical in Circadian rhythms are rhythms that last about 24 composition, and prior exposure to light, influence all types of shift work rosters. The strategic planning hours (from circad about and diem day). They have the resetting response of the circadian system. The of naps is considered efficient and safe in sustained been observed in a wide variety of physiological and central circadian clock is sensitive to low indoor room CIRCADIAN RHYTHMS operations, and should also be considered. behavioural functions when humans are isolated from light and integrates light information in such a way SLEEP-WAKE DISORDERS the periodic cycling of light and darkness for several that its effect can be sustained even when light is weeks indicating these rhythms are endogenous. intermittently interrupted by darkness. Light in the Circadian rhythm sleep-wake disorders form a Indeed, circadian rhythms are under the control of blue visible range of 440-480 nm induces larger phase distinct subgroup of sleep disorders, caused by a circadian system which is comprised of a master shifts than white light, although a switch of sensitivity misalignment between the patient’s natural sleep central clock located in the suprachiasmatic nucleus towards light in the green visible range of 555 nm requirements and that dictated by his professional (SCN) of the anterior hypothalamus and several occurs at lower irradiances. Melatonin has also been or social life. peripheral clocks located throughout the body and shown to reset human circadian rhythms. brain. Administration of melatonin in the evening and morning can advance and delay the endogenous Endogenous circadian rhythms are self-sustained JET LAG circadian rhythms, respectively. Other non-photic and generated by a set of clock genes involved Rapid travel across more than 2 time zones induces synchronizers such as exercise, meal and nap timing in negative and positive regulatory intracellular an abrupt desynchrony between circadian clocks and could entrain
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