(12) United States Patent (10) Patent No.: US 9.486,408 B2 Edelson Et Al
USOO9486408B2 (12) United States Patent (10) Patent No.: US 9.486,408 B2 Edelson et al. (45) Date of Patent: Nov. 8, 2016 (54) BOTULINUM NANOEMULSIONS 5,851,452 A 12/1998 Vallet Mas et al. 5,858.410 A 1/1999 Muller et al. (71) Applicant: UNIVERSITY OF 5,925,341 A 7/1999 Cervantes et al. MASSACHUSETTS LOWELL, 5,932,562 A 8/1999 Ostlund, Jr. Lowell, MA (US) 5,994.414 A 11/1999 Franco et al. 6,007,856 A 12/1999 Cox et al. 6,039,936 A 3/2000 Restle et al. (72) Inventors: Jonathan Edelson, Scarsdale, NY 6,165,500 A 12/2000 Cevc (US); Robert Nicolosi, Nashua, NH 6,224,853 B1 5, 2001 Steel et al. (US) 6,265,180 B1 7/2001 Zuelli et al. 6,274,150 B1 8/2001 Simonnet et al. (73) Assignee: University of Massachusetts Lowell, 6,312,708 B1 1 1/2001 Donovan Lowell, MA (US) 6,358,917 B1 3/2002 Carruthers et al. 6,387.411 B2 5, 2002 Bruce et al. (*) Notice: Subject to any disclaimer, the term of this 6,429,189 B1 8, 2002 Borodic patent is extended or adjusted under 35 6,558,941 B2 5/2003 Zuelli et al. U.S.C. 154(b) by 372 days. 6,573.241 B1 6/2003 Bigalke et al. 6,589,588 B1 7/2003 Wester et al. (21) Appl. No.: 13/647,759 6,623,780 B1 9, 2003 Stevens et al. 6,632.440 B1 10/2003 Quinn et al.
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