The Historical Development of Obstetric Anesthesia and Its Contributions to Perinatology
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Review Article The Historical Development of Obstetric Anesthesia and Its Contributions to Perinatology Matthew L. Edwards, AB1 Anwar D. Jackson, MD2 1 School of Medicine, University of Texas Medical Branch at Galveston, Address for correspondence Matthew L. Edwards, AB, 301 University Galveston, Texas Boulevard, University of Texas Medical Branch at Galveston, School of 2 Department of Obstetrics and Gynecology, Michigan State University Medicine, Galveston, TX 77555 (e-mail: [email protected]). College of Human Medicine, Hurley Medical Center, Flint, Michigan Am J Perinatol Abstract Scottish obstetrician James Young Simpson first introduced the use of ether and Keywords chloroform anesthesia for labor in 1847, just 1 year after William Morton’s first ► obstetric anesthesia successful public demonstration of ether anesthesia at the Massachusetts General ► perinatology Hospital. The contemporaneous development of surgical anesthesia and obstetrics ► drugs enabled obstetric anesthesia to address the pain of childbirth. Shortly after its ► placental transport introduction, obstetricians raised concerns regarding placental transport, or the idea ► Virginia Apgar that drugs not only crossed the placenta, but exerted detrimental effects on the ► James Young Simpson neonate. The development of regional anesthesia and clinical work in obstetric ► history anesthesia and perinatology addressed issues of the safety of the neonate, enabling ► regional anesthesia obstetric anesthesia to safely and dramatically reduce the pain of childbirth. ► twilight sleep It is remarkable that Boston dentist William T. G. Morton Obstetric Anesthesia and Concepts of (1819–1868) gave the first successful public demonstration of Placental Transport ether anesthesia at the Massachusetts General Hospital in 1846, several centuries after the discovery of ether. Certainly, At a time when 6 out of every 100 British mothers died during ether and other anesthetic agents have expanded the bound- childbirth, and even more suffered complications from the aries of surgery, aided the process of childbirth, and codified event, the development of obstetrics promised to increase the Downloaded by: Cornell. Copyrighted material. the medical treatment of pain. By 1847, just 1 year after safety of women and children during the perinatal period.4 Morton’ssuccessfuldemonstration,Scottishobstetrician Relatedly, James Young Simpson believed that mitigating the James Young Simpson (1811–1870) first introduced the use pain of childbirth was necessary for improving its safety.5 One of ether and chloroform anesthesia for labor.1–3 of Simpson’speersdescribedhimashavingthe“head of Jove” This article reviews the history of obstetric anesthesia and the and the “body of Bacchus,” while others described him as social responses to the management of pain during childbirth. gregarious and charming.6 Although these characteristics no Drawing on the historical and medical literatures between the doubt enabled him to advocate for the use of anesthesia mid-19th and 20th centuries, we discuss the major agents, during labor, the public had other reasons to adopt the use achievements and figures in obstetric anesthesia. Of particular of gases in labor. importance to perinatology, we also discuss the effect of the Feminism emerged during the mid-19th century and development of ideas about drugs in general (and anesthetics in many of its proponents believed that the pain of repetitive particular) on the neonate, ideas which arose among obstetri- childbirth was largely responsible for propagating the cians around 1880. Clinical work with the neonate came rather oppression of women.6,7 Leading feminists shared Simpson’s late in the history of obstetric anesthesia, in part from the work of desire for medical advancement and transmogrified it into anesthesiologist Virginia Apgar (1909–1974). the quest for female empowerment.1 While early recipients of received Copyright © by Thieme Medical DOI http://dx.doi.org/ May 10, 2016 Publishers, Inc., 333 Seventh Avenue, 10.1055/s-0036-1585409. accepted after revision New York, NY 10001, USA. ISSN 0735-1631. June 5, 2016 Tel: +1(212) 584-4662. History of Obstetric Anesthesia Edwards et al. ether and chloroform included Emma Darwin (1808–1896) in 1834. Conversely, W. S. Savory found that strychnine (the wife of Charles Darwin [1809–1882]) and Queen Victoria injected into the fetal dogs’ circulation subsequently caused (1819–1901),8 these agents were generally out of reach for the mothers to convulse. In 1850, obstetrician C. C. Hüter the average laboring woman. Cognizant of this disparity, devised a chemical test that identified chloroform in neonatal philanthropists helped establish the National Birthday Trust cord blood. in 1928. The trust was an organization dedicated to making Nearly a quarter-century passed before the issue of placen- anesthesia available to every laboring woman in the British tal transport was resumed in 1876, however, when the Swiss Isles.1 By the turn of the 20th century, ether and chloroform obstetrician Paul Zweifel (1848–1927) demonstrated that were ubiquitous in childbirth on both sides of the Atlantic chloroform used in labor accumulated significantly in the fetal Ocean, and James Simpson was regarded in Europe as one of blood and urine.1,7,8 This third-generation physician who the era’smostinfluential physicians.6 pioneered the study of fetal-placental metabolism found a While Simpson gained fame and notoriety in the eyes of synthetic reducing agent in the urine of infants whose mothers the British public, his medical contemporaries in Europe and were treated with chloroform anesthesia for labor.1,9 Zweifel North America approached ether and chloroform with heavy believed that this metabolic “reaction resembled that pro- skepticism.6,8 Many British obstetricians argued that ether, a duced by glucose1” and hypothesized that chloroform altered volatile gas whose medical applications had only been dem- the fetal metabolism of carbohydrates.1 Using placental tissue, onstrated months before Simpson used it in childbirth, had he determined that the substance was not glucose, but rather unproven safety and efficacy in labor. The British medical chloroform.1 Fellow physicians and scientists questioned the establishment feared ether and chloroform not only significance of his study, however, arguing that the chloroform increased the risk of hemorrhage and infection, but also present in placental tissue might represent “contamination by had detrimental effects on the newborn.8 These criticisms maternal blood adherent to the placental membranes.”1 Zwei- were among the earliest expressing concerns about the fel used the same chemical reaction to demonstrate chloro- placental transport of drugs from mother to fetus. form in the umbilical artery and neonatal urine.1,9 His findings Some physicians feared that a drug strong enough to definitively proved that ether and chloroform quickly crossed sedate an adult would have even greater effects on neonates. the placenta. To be sure, Zweifel only demonstrated placental Simpson himself had experienced the potency of chloroform, transport; he did not test for the amount of drug that was and it was only after this experience that he became con- transported, or its effects on the neonate. vinced of chloroform’sanestheticsuperiorityandintroduced Issues of placental transport were not the only challenges it into his obstetric practice.5 Without extensive data, how- to obstetric anesthesia during Simpson’stime.Whenanes- ever, fears regarding the effects of chloroform on neonates thesia began to shape obstetrics in the mid-19th century, were nothing more than unproven suspicions. As the use of religious opposition became a formidable challenge.10 Resis- ether and chloroform became more widespread in labor, the tance became so strong that Simpson and another London complications of their use also became better known. John obstetrician Protheroe Smith (1809–1889), had to address the Snow (1813–1858), a British general practitioner who anes- issue of religion and obstetric anesthesia in publications by thetized Queen Victoria during the birth of her eighth child, arguing that the scriptural text “in sorrow thou shalt bring also expressed concerns about ether and chloroform.8 Snow forth children” was not congruent with the idea of intended Downloaded by: Cornell. Copyrighted material. noticed that neonates born to mothers who had received suffering of women during childbirth, and that moreover, the ether in labor came out with respiratory depression and pain experienced during childbirth could be directly decreased motor activity.8,9 Snow also smelled ether on the explained by anatomy and science rather than punishment breath of these neonates,8 thus supporting the idea of intra- from God.1 Simpson’s1847publicationcoincidedwithQueen uterine transport of the drug. Victoria’swillingnesstohaveetherasamedicalanestheticin In spite of mounting evidence about ether and chloro- her two subsequent births.1 form’seffectsonnewborns,ferventproponentsoflabor analgesia continued to dismiss their colleagues’ clinical find- 1 The Emergence of Twilight Sleep and ings. Walter Channing (1786–1876), a Harvard professor and Regional Anesthesia obstetrician, was one such proponent. A leading physician who cofounded the predecessor of the Brigham and Women’s Simpson was not indifferent to the effects of ether and Hospital in Boston, MA, Channing asserted that ether did not chloroform on newborns. He died in 1870, six years before cross the placenta.8