T cell receptor signaling pathway all genes sink node genes ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ●● ● ● ●● ● ● ● ●●● ●● ● ● ● ● ● ●●● ● ●●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ●●● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ●● ● ● ● ● ● ●● ● ● ● ● ●● ● ● ● ● ● ● ● ● ●● ●● ● ● ● ● ● ● ● ●● ● ● ● ● ● ● ● ● ● ● ● ● ●● ● ● ●● ●●● ● ● ● ● ● ● ● ● ●● ● ● ● ●● ● ● ●● ● ● ●● ● ● ● ● ● ● ● ●●●●●● ●●● ● ● ● ● ● ● maximum = 4 maximum = 3 2 1 s>
10 0 0 10 log −1 −2 group 1 group 2 group 3 group 4 group 5 group 6 group 7 group 8 T_cell_receptor_signaling_pathway genes with data PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway sink nodes PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway group 1 PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway group 2 PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway group 3 PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway group 4 PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway group 5 PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway group 6 PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway group 7 PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B T_cell_receptor_signaling_pathway group 8 PDCD1 CTLA4 PTPN6 PTPRC CD4 LCK CBLB CD3E FYN DLG1 CD3G CD247 ZAP70 MAPK14 CD247 CD3D CD3E LCP2 NCK1 PAK4 GRAP2 LAT VAV3 RHOA ITK GRB2 PLCG1 PPP3CA NFATC1 IL2 IL4 IL5 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK1 FOS IL10 IFNG CSF2 TNF CDK4 MAP3K7 MAP2K7 MAPK9 NFKB1 PRKCQ CARD11 CD40LG BCL10 IKBKB NFKBIA MALT1 IKBKG CHUK ICOS PIK3CA AKT3 MAP3K8 MAP3K14 CD28 PDPK1 GRB2 GSK3B