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Central Annals of Medicinal Chemistry and Research Bringing Excellence in Open Access

Editorial *Corresponding author Prakash Prajapat, Department of Chemistry, Ganpat University, Mehsana-384012, Gujarat, India, Tel: Synthetic and Medicinal 917891554090; Email: Submitted: 09 December 2017 Chemistry in Drug Discovery: Accepted: 11 December 2017 Published: 12 December 2017 Needs for Today ISSN: 2378-9336 Copyright Prakash Prajapat1*, Hasit Vaghani1, Shikha Agarwal2, and © 2017 Prajapat et al. 2 GLTalesara OPEN ACCESS 1Department of Chemistry, Ganpat University, India 2Department of Chemistry, MLS University, India

EDITORIAL Synthetic organic and medicinal chemistry (Figure 1) is arguably reorienting the field of drug discovery in the same way as one century ago the field of organic chemistry. The area of synthesizing new drugs, their designing, development and application is the most focused and challenging task for the researchers [1]. Drug discovery needs to basic study into the medicinal and chemical nature of the diseased state. For this, specialists from various fields including organic, medicinal chemists and academic researchers are needed. Synthesis of newer organic molecules with more favorable therapeutic properties and their conversion to derivatives which show optimum medicinal activity and synthesize the novel molecule Figure 1 or drug by combining different heterocyclic rings and the Relation between Synthetic Organic and Medicinal chemistry. synthetic pathway followed, should be economic, safer, less time etc.consuming in order to prepare combinational molecule and also viz.better creation against lethal diseases like malaria, TB, cancer [2,3]. Furthermore, a minor change in chemical structure change in stereochemistry, geometry, functionaletc group, removal of groups, derivative information, oxidation, reduction, hydrogenation, chelate formation, salt formation may modify its medicinal activity. The effect of substitution is also of great significance in deciding medicinal activityetc of a drug. Similarly, drug activity depends upon physical and molecule structure, isosterism, solubility, partition coefficients . The current methods aid and expand experimental approaches to drug design, but are still often not accurate enough to replace experimental methods. Therefore, there is an ongoing and pressing need for improved methodology, and Figure 2 tremendous development efforts are ongoing in the synthetic organic chemistry [4]. Hence, the drug discovery (Figure 2) Drug discovery cycle. of well-organized synthetic approaches allowing rapid access to miscellaneous series of molecular hybrids must be further investigated by chemist and researchers. Thus, today needs to impetus for discovery of novel chemical reactions, due to the develop new rapid, convenient, selective, clean synthetic routes valueACKNOWLEDGEMENTS implicit in providing a molecule for study [5,6]. (greener approach) and new information, newer scaffolds in chemical encyclopedia and idea about reaction mechanism which helps the drug discovery in medicinal chemistry. Finally, I thankful to chemistry staff members of the Mehesana Urban medicinal active molecular hybrids will continue to give strong Institute of Sciences, Ganpat University, Gujarat for support. Cite this article: Prajapat P, Vaghani H, Agarwal S, Talesara GL (2017) Synthetic and Medicinal Chemistry in Drug Discovery: Needs for Today. Ann Med Chem Res 3(1): 1021. Prajapat et al. (2017) Email:

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Central Bringing Excellence in Open Access REFERENCES 3. Gervais B. An overview of molecular hybrids in drug discovery. Expert Opin on Drug Discov. 2016; 11: 281-305. 1. Perez-Nueno V. Towards the integration of Quantitative and Pharmacology into Drug Discovery: a systems level understanding 4. Shivaputra AP. Role of Medicinal Chemist in the Modern Drug of therapeutic and toxic effects of drugs. Curr Pharm Des. 2016; 22: Discovery and Development. Organic Chem Curr Res. 2012; 1: 3. 6881-6884. 5. David PR. The critical role of organic chemistry in drug discovery. ACS 2. Patel HM, Noolvi MN, Sharma P, Jaiswal V, Bansal S, Lohan S, et Chem Neurosci. 2016; 7: 1315-1316. al. Quantitative structure–activity relationship (QSAR) studies as 6. Jean YT, Pablo C. Synthetic biology for pharmaceutical drug discovery. strategic approach in drug discovery. Med Chem Res. 2014; 23: 4991- Drug Des Devel Ther. 2015; 9: 6285-6302. 5007.

Cite this article Prajapat P, Vaghani H, Agarwal S, Talesara GL (2017) Synthetic and Medicinal Chemistry in Drug Discovery: Needs for Today. Ann Med Chem Res 3(1): 1021.

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