TERF2 monoclonal antibody, clone complex. This is present at 4A794.15 in of the , is a second negative regulator of length and plays a key Catalog Number: MAB0074 role in the protective activity of telomeres. While having similar telomere binding activity and domain Regulatory Status: For research use only (RUO) organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by Product Description: Mouse monoclonal antibody RefSeq] raised against full length recombinant TERF2. References: Clone Name: 4A794.15 1. Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation. Muramatsu Y, Tahara H, Immunogen: Recombinant protein corresponding to full Ono T, Tsuruo T, Seimiya H. Exp Cell Res. 2008 Mar length human TERF2. 10;314(5):1115-24. Epub 2007 Dec 14. 2. The telomeric protein TRF2 is critical for the protection Host: Mouse of A549 cells from both telomere erosion and DNA double-strand breaks driven by salvicine. Zhang YW, Reactivity: Deer,Human,Mouse,Rat Zhang ZX, Miao ZH, Ding J. Mol Pharmacol. 2008 Applications: ELISA, Flow Cyt, ICC, IF, IHC-Fr, IHC-P, Mar;73(3):824-32. Epub 2007 Nov 19. IP 3. FLASH is required for histone transcription and (See our web site product page for detailed applications S-phase progression. Barcaroli D, Bongiorno-Borbone L, information) Terrinoni A, Hofmann TG, Rossi M, Knight RA, Matera AG, Melino G, De Laurenzi V. Proc Natl Acad Sci U S A. Protocols: See our web site at 2006 Oct 3;103(40):14808-12. Epub 2006 Sep 26. http://www.abnova.com/support/protocols.asp or product page for detailed protocols

Form: Liquid

Isotype: IgG1

Recommend Usage: The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS (0.05% BSA, 0.05% sodium azide)

Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.

Entrez GeneID: 7014

Gene Symbol: TERF2

Gene Alias: TRBF2, TRF2

Gene Summary: This gene encodes a telomere specific protein, TERF2, which is a component of the telomere

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