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Bioorganic Chemistry 84 (2019) Ii-Xvi Bioorganic Chemistry 84 (2019) ii-xvi Contents lists available at ScienceDirect Bioorganic Chemistry journal homepage: www.elsevier.com/locate/bioorg Graphical Abstracts/Bioorganic Chemistry 84 (2019) ii-xvi REGULAR ARTICLES Synthesis and antioxidant activity of new lipophilic dihydropyridines Bioorganic Chemistry 84 (2019) pp. 1–16 Diego da Costa Cabreraa, Eduarda Santa-Helenab, Heloisa P. Leala, Renata Rodrigues de Mouraa, Luiz Eduardo Maia Neryb, Carla Amorim Neves Gonçalvesb, Dennis Russowskyc, ⁎ Marcelo G. Montes D'Ocaa, aKolbe Laboratory of Organic Synthesis, School of Chemistry and Food, Federal University of Rio Grande-FURG, Rio Grande, RS, Brazil bInstitute of Biological Sciences, Federal University of Rio Grande-FURG, Rio Grande, RS, Brazil cLaboratory of Organic Synthesis, Institute of Chemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil Anti-melanogenesis potential of a new series of Morita-Baylis-Hillman adducts in Bioorganic Chemistry 84 (2019) pp. 17–23 B16F10 melanoma cell line ⁎ Emna Ketataa, , Haitham Elleuchb, Aref Neifara,c, Wafa Mihoubia, Wajdi Ayadia, Naziha Marrakchid, Farhat Rezguib, Ali Gargouria aLaboratoire de Biotechnologie Moléculaire des Eucaryotes, Centre de Biotechnologie de Sfax, Université de Sfax, Tunisia bLaboratoire de Chimie Organique Structurale LR99ES14, Faculté des Sciences de Tunis, Université de Tunis El Manar, Campus Universitaire, 2092 Tunis, Tunisia cLaboratoire de Biodiversité et Biotechnologie Marine, Institut National des Sciences et Technologies de la Mer (INSTM) Sfax, Tunisia dLaboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunisia An alkali tolerant α-L-rhamnosidase from Fusarium moniliforme MTCC-2088 used in de- Bioorganic Chemistry 84 (2019) pp. 24–31 rhamnosylation of natural glycosides OH ⁎ HO Dhirendra Kumar, Sarita Yadav , Sudha Yadava, K.D.S. Yadav H Į-L- rhamnosidase Department of Chemistry, Deen Dayal Upadhyay Gorakhpur University, Gorakhpur 273009, UP, India Naringin Prunin L- rhamnose H Į-L- rhamnosidase HO L- rhamnose Quercetin glucoside Rutin Graphical Abstracts Immobilized Baliospermum montanum hydroxynitrile lyase catalyzed synthesis of Bioorganic Chemistry 84 (2019) pp. 32–40 chiral cyanohydrins OH ⁎ CN Nisha Jangir, Santosh Kumar Padhi OH CN Biocatalysis and Enzyme Engineering Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India OH CN CLEA OH (this study) CN O H Pure enzyme Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine Bioorganic Chemistry 84 (2019) pp. 41–50 oxidase and cholinesterase inhibitors ⁎ Fatih Toka, Bedia Koçyiğit-Kaymakçıoğlua, Begüm Nurpelin Sağlıkb,c, Serkan Leventb,c, Yusuf Özkayb,c, , Zafer Asım Kaplancıklıb aDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, İstanbul, Turkey bDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey cDoping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu Universty, Eskişehir, Turkey Design, synthesis and cytotoxicity of chimeric erlotinib- Bioorganic Chemistry 84 (2019) pp. 51–62 alkylphospholipid hybrids Md. Maqusood Alama,1, Ahmed H.E. Hassanb,c,1, Kun Won Leea, Min Chang Choa,JiSeulYanga, Jiho Songd, Kyung Hoon Mind, Jongki Hongb, ⁎ Dong-Hyun Kima, Yong Sup Leea,b,e, aDepartment of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea bDepartment of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea cDepartment of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt dDepartment of Pharmacy, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea eKHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea Switching of Trp-214 intrinsic rotamer population in human serum albumin: An insight Bioorganic Chemistry 84 (2019) pp. 63–75 into the aftermath of embracing therapeutic bioorganic luminophore azapodophyllotoxin into sudlow site I ⁎ Soham Mukherjeea, Kapil Ganorkara, Ajay Kumarb, Naina Sehraa, Sujit Kumar Ghosha, aDepartment of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra 440010, India bInternational Centre for Trans-disciplinary Research, School of Environmental Affairs, Universidad Metropolitana, PR 00928, United States iii Graphical Abstracts 1,4-Dihydroquinazolin-3(2H)-yl Bioorganic Chemistry 84 (2019) pp. 76–86 benzamide derivatives as anti- inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study ⁎ Asmaa Sakra,1, Hend Kothayera, ,1, Samy M. Ibrahima, Mohamed M. Barakaa, Samar Rezqb aDepartment of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt bDepartment of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt Repurposing approach identifies new treatment options for invasive fungal disease Bioorganic Chemistry 84 (2019) pp. 87–97 ⁎ Isis Regina Grenier Capocia, , Daniella Renata Fariaa, Karina Mayumi Sakitaa, Franciele Abigail Vilugron Rodrigues-Vendraminia, Patricia de Souza Bonfim-Mendonçaa, Tania Cristina Alexandrino Beckera, Érika Seki Kioshimaa, Terezinha Inez Estivalet Svidzinskia, Bernard Maigretb aDepartment of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil bLORIA, Lorraine University, Nancy, France Biological evaluation and structure activity relationship of 9-methyl-1-phenyl- Bioorganic Chemistry 84 (2019) pp. 98–105 9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents Penta Ashoka, Subhash Chandera,b, Terry K. Smithc, Rajnish Prakash Singhd, Prabhat Nath Jhad, ⁎ Murugesan Sankaranarayanana, aMedicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science Pilani, Pilani Campus, Pilani 333031, Rajasthan, India bSchool of Pharmacy, Maharaja Agrasen University, Atal ShikshaKunj, Solan, Himachal Pradesh 174103, India cSchools of Biology & Chemistry, BSRC, The University, St. Andrews, Fife Scotland. KY16 9ST, UK dDepartment of Biological Sciences, Birla Institute of Technology & Science Pilani, Pilani Campus, Pilani 333031, Rajasthan, India Heterocyclic cellular lipid peroxidation Bioorganic Chemistry 84 (2019) pp. 106–114 inhibitors inspired by the marine antioxidant barettin Christophe Labrièrea,1, Jeanette H. Andersenb, Marte Albrigtsenb, Jørn H. Hansena, ⁎ Johan Svensona,c, aDepartment of Chemistry, UiT The Arctic University of Norway, Breivika, N-9037 Tromsø, Norway bMarbio, The Norwegian College of Fishery Science, UiT The Arctic University of Norway, Breivika, N-9037 Tromsø, Norway cDepartment of Chemistry and Materials, RISE Research Institutes of Sweden, Box 857, SE-501 15 Borås, Sweden iv Graphical Abstracts Encapsulation of ciprofloxacin within modified xanthan gum- chitosan Bioorganic Chemistry 84 (2019) pp. 115–124 based hydrogel for drug delivery ⁎ Demiana H. Hanna , Gamal R. Saad Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt The first target specific, highly diastereoselective synthesis, design and characterization Bioorganic Chemistry 84 (2019) pp. 125–136 of pyranoquinolinyl acrylic acid diastereomers as potential α-glucosidase inhibitors ⁎ G. Lavanyaa, K. Venkatapathya, C.J. Magesha, , M. Ramanathanb, R. Jayasudhaa aPG& Research Department of Chemistry, Arignar Anna Govt Arts College, Cheyyar, Tamil Nadu, India bDepartment of Chemistry, National Taiwan University, Roosevelt Road, Taipei 10617, Taiwan Novel salicylamide derivatives as potent multifunctional agents for Bioorganic Chemistry 84 (2019) pp. 137–149 the treatment of Alzheimer's disease: Design, synthesis and biological evaluation Qing Songa,1, Yan Lia,1, Zhongcheng Caoa, Xiaoming Qianga, Zhenghuai Tanb, ⁎ Yong Denga, aDepartment of Medicinal Chemistry, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China bInstitute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, PR China 1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell Bioorganic Chemistry 84 (2019) pp. 150–163 growth and EGFR, Src, IL-6 and STAT3 activities ⁎ ⁎ Marwa Ali A. Fathia,1, Amer Ali Abd El-Hafeezb,c,d,1, , Dalia Abdelhamida, Samar H. Abbasa, , Monica M. Montanod, Mohamed Abdel-Aziza aMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt bPharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt cPharmacotherapy Department, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734- 8553, Japan dPharmacology Department, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA v Graphical Abstracts 1-(2-Hydroxy-5-((trimethylsilyl)ethynyl)phenyl)ethanone based α,β-unsaturated Bioorganic Chemistry 84 (2019) pp. 170–176 derivatives an alternate to non-sulfonamide carbonic anhydrase II inhibitors, synthesis via Sonogashira coupling, binding analysis, Lipinsk’s rule validation ⁎ ⁎ Jamaluddin Mahara,b, Aamer Saeeda, , Kevin D. Belfieldb, Fayaz Ali Larika, , Pervaiz Ali Channara, Mehar Ali
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