Campos et al. Int J Transplant Res Med 2017, 3:024 Volume 3 | Issue 1 International Journal of Transplantation Research and Medicine Case Report: Open Access Case Report and Review of the Literature: Resolution of Lithium-Induced Nephrogenic Diabetes Insipidus with Pre- Emptive Living Related Kidney Transplantation for End- Stage Renal Disease B Daniel Campos1*, Natalia Velez-Ramos1, Stephanie M Smith2, Colin Lenihan2 and Marc L Melcher2 1Department of Surgery, University of Puerto Rico, USA 2Division of Abdominal Transplantation, Stanford University, USA *Corresponding author: B Daniel Campos, MD, Department of Surgery, Auxilio Mutuo Hospital, Transplant Center, University of Puerto Rico, PO BOX 191227, USA, Tel: 787-505-5074, Fax: 787-771-7416, E-mail:
[email protected] Abstract Introduction Long-term lithium therapy is known to cause renal dysfunc- Following lethal cases of lithium intoxication in the tion, including nephrogenic diabetes insipidus (nDI) and 1950s, lithium was removed from the market as a table salt chronic tubulointerstitial nephropathy, which may progress substitute. However, to this day, it continues to be widely to end-stage renal disease (ESRD) in approximately 1% of used in the treatment of bipolar disorder and refractory patients. We report a case of resolution of lithium-induced nDI following living related kidney transplantation for ESRD unipolar major depression [1]. As a monovalent cation, secondary to chronic lithium toxicity. A 63-year-old male pre- lithium is freely filtered through the glomeruli, and up sented with ESRD and a 22-year history of severe nDI fol- to 80% of the filtered load is reabsorbed, mostly in the lowing 11 years of oral lithium treatment for bipolar disorder.