GBE Migration-Selection Balance Drives Genetic Differentiation in Genes Associated with High-Altitude Function in the Speckled Teal (Anas flavirostris) in the Andes Downloaded from https://academic.oup.com/gbe/article-abstract/10/1/14/4685994 by University of Texas at El Paso user on 18 January 2019 Allie M. Graham1,*, Philip Lavretsky2, Violeta Munoz-Fuentes~ 3,4,AndyJ.Green4,RobertE.Wilson5,and Kevin G. McCracken1,5,6,7 1Department of Biology, University of Miami 2Department of Biological Sciences, University of Texas El Paso 3European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom 4Estacion Biologica de Donana,~ EBD-CSIC, Sevilla, Spain 5Institute of Arctic Biology and University of Alaska Museum, University of Alaska, Fairbanks 6Rosenstiel School of Marine and Atmospheric Sciences, University of Miami 7John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine *Corresponding author: E-mail:
[email protected]. Accepted: November 30, 2017 Data deposition: DNA sequence GenBank accession information is available in supplementary table S2, Supplementary Material online. Parsed Illumina reads for the RAD-Seq data sets are already available through NCBI short read archive (SRA PRJEB11624). Abstract Local adaptation frequently occurs across populations as a result of migration-selection balance between divergent selective pressures and gene flow associated with life in heterogeneous landscapes. Studying the effects of selection and gene flow on the adaptation process can be achieved in systems that have recently colonized extreme environments. This study utilizes an endemic South American duck species, the speckled teal (Anas flavirostris), which has both high- and low-altitude populations.