Bryn Mawr College Scholarship, Research, and Creative Work at Bryn Mawr College Biology Faculty Research and Scholarship Biology 2017 Asymmetric DNA methylation of CpG dyads is a feature of secondary DMRs associated with the Dlk1/Gtl2 imprinting cluster in mouse Megan Guntrum Ekaterina Vlasova Tamara L. Davis
[email protected] Let us know how access to this document benefits ouy . Follow this and additional works at: http://repository.brynmawr.edu/bio_pubs Part of the Biology Commons Custom Citation M. Guntrum, E. Vlasova and T.L. Davis 2017. "Asymmetric DNA methylation of CpG dyads is a feature of secondary DMRs associated with the Dlk1/Gtl2 imprinting cluster in mouse." Epigenetics & Chromatin 10:31. This paper is posted at Scholarship, Research, and Creative Work at Bryn Mawr College. http://repository.brynmawr.edu/bio_pubs/24 For more information, please contact
[email protected]. Guntrum et al. Epigenetics & Chromatin (2017) 10:31 DOI 10.1186/s13072-017-0138-0 Epigenetics & Chromatin RESEARCH Open Access Asymmetric DNA methylation of CpG dyads is a feature of secondary DMRs associated with the Dlk1/Gtl2 imprinting cluster in mouse Megan Guntrum, Ekaterina Vlasova and Tamara L. Davis* Abstract Background: Diferential DNA methylation plays a critical role in the regulation of imprinted genes. The diferentially methylated state of the imprinting control region is inherited via the gametes at fertilization, and is stably maintained in somatic cells throughout development, infuencing the expression of genes across the imprinting cluster. In con- trast, DNA methylation patterns are more labile at secondary diferentially methylated regions which are established at imprinted loci during post-implantation development.