Aeromedical Factors
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Hypoxia Signaling in Cardiovascular Diseases
DOI: 10.5772/intechopen.80456 ProvisionalChapter chapter 3 Hypoxia Signaling in Cardiovascular Diseases NehaNeha Gupta Gupta and Mohammad Zahid AshrafZahid Ashraf Additional information is available at the end of the chapter http://dx.doi.org/10.5772/intechopen.80456 Abstract Cardiovascular diseases such as stroke, coronary artery disease, and thrombosis remain a global health burden. Understanding the mechanism of these diseases paves the way for development of prophylactics/therapeutics. It is well known at cellular levels; the patho- physiology of most of the cardiovascular disease involves a complicated yet coordinated signaling networks triggered in response to either cellular or tissue levels of hypoxic milieu. Information related to types of hypoxia and signaling mechanism associated to such complications if complied and presented in a comprehensive manner shall prove relevant in proposing common therapeutic targets for wide array of cardiovascular com- plications. The relative functional roles of hypoxia-triggered signaling pathways are also an area of current research. Based upon these facts, this chapter discusses the types of hypoxia and role of hypoxia-mediated signaling pathways in various types of commonly occurring cardiovascular disorders. Keywords: hypoxia, signaling, cardiovascular disorders, thrombosis, therapeutics 1. Introduction Oxygen concentration below the tissue specific physiological levels is termed as ‘Hypoxia’. Depending upon the cause of oxygen scarcity, hypoxia can be classified into Hypoxic hypoxia (occurs due to deficiency in oxygen exchange in lungs or arises due to reduced partial pres- sure of oxygen in air), Anemic hypoxia (arises when the transport of oxygen is affected), stagnant hypoxia (due to delayed blood renewal, or insufficient blood flow) or histotoxic hypoxia (body is not able to use the available oxygen) [1]. -
Asphyxia Neonatorum
CLINICAL REVIEW Asphyxia Neonatorum Raul C. Banagale, MD, and Steven M. Donn, MD Ann Arbor, Michigan Various biochemical and structural changes affecting the newborn’s well being develop as a result of perinatal asphyxia. Central nervous system ab normalities are frequent complications with high mortality and morbidity. Cardiac compromise may lead to dysrhythmias and cardiogenic shock. Coagulopathy in the form of disseminated intravascular coagulation or mas sive pulmonary hemorrhage are potentially lethal complications. Necrotizing enterocolitis, acute renal failure, and endocrine problems affecting fluid elec trolyte balance are likely to occur. Even the adrenal glands and pancreas are vulnerable to perinatal oxygen deprivation. The best form of management appears to be anticipation, early identification, and prevention of potential obstetrical-neonatal problems. Every effort should be made to carry out ef fective resuscitation measures on the depressed infant at the time of delivery. erinatal asphyxia produces a wide diversity of in molecules brought into the alveoli inadequately com Pjury in the newborn. Severe birth asphyxia, evi pensate for the uptake by the blood, causing decreases denced by Apgar scores of three or less at one minute, in alveolar oxygen pressure (P02), arterial P02 (Pa02) develops not only in the preterm but also in the term and arterial oxygen saturation. Correspondingly, arte and post-term infant. The knowledge encompassing rial carbon dioxide pressure (PaC02) rises because the the causes, detection, diagnosis, and management of insufficient ventilation cannot expel the volume of the clinical entities resulting from perinatal oxygen carbon dioxide that is added to the alveoli by the pul deprivation has been further enriched by investigators monary capillary blood. -
Chapter 23 ENVIRONMENTAL EXTREMES: ALTERNOBARIC
Environmental Extremes: Alternobaric Chapter 23 ENVIRONMENTAL EXTREMES: ALTERNOBARIC RICHARD A. SCHEURING, DO, MS*; WILLIAM RAINEY JOHNSON, MD†; GEOFFREY E. CIARLONE, PhD‡; DAVID KEYSER, PhD§; NAILI CHEN, DO, MPH, MASc¥; and FRANCIS G. O’CONNOR, MD, MPH¶ INTRODUCTION DEFINITIONS MILITARY HISTORY AND EPIDEMIOLOGY Altitude Aviation Undersea Operations MILITARY APPLIED PHYSIOLOGY Altitude Aviation Undersea Operations HUMAN PERFORMANCE OPTIMIZATION STRATEGIES FOR EXTREME ENVIRONMENTS Altitude Aviation Undersea Operations ONLINE RESOURCES FOR ALTERNOBARIC ENVIRONMENTS SUMMARY *Colonel, Medical Corps, US Army Reserve; Associate Professor, Military and Emergency Medicine, Uniformed Services University of the Health Sci- ences, Bethesda, Maryland †Lieutenant, Medical Corps, US Navy; Undersea Medical Officer, Undersea Medicine Department, Naval Medical Research Center, Silver Spring, Maryland ‡Lieutenant, Medical Service Corps, US Navy; Research Physiologist, Undersea Medicine Department, Naval Medical Research Center, Silver Spring, Maryland §Program Director, Traumatic Injury Research Program; Assistant Professor, Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland ¥Colonel, Medical Corps, US Air Force; Assistant Professor, Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland ¶Colonel (Retired), Medical Corps, US Army; Professor and former Department Chair, Military and Emergency Medicine, Uniformed Services University of the Health Sciences, -
Pulmonary Barotrauma During Hypoxia in a Diver While Underwater
POLISH HYPERBARIC RESEARCH 2(71)2020 Journal of Polish Hyperbaric Medicine and Technology Society PULMONARY BAROTRAUMA DURING HYPOXIA IN A DIVER WHILE UNDERWATER Brunon Kierznikowicz, Władysław Wolański, Romuald Olszański Institute of Maritime and Tropical Medicine of the Military Medical Academy, Gdynia, Poland ABSTRACT The article describes a diver performing a dive at small depths in a dry suit, breathing from a single-stage apparatus placed on his back. As a result of training deficiencies, the diver began breathing from inside the suit, which led to hypoxia and subsequent uncontrolled ascent. Upon returning to the surface, the diver developed neurological symptoms based on which a diagnosis of pulmonary barotrauma was made. The diver was successfully treated with therapeutic recompression-decompression. Keywords: diving, accident, hypoxia, pulmonary barotrauma. ARTICLE INFO PolHypRes 2020 Vol. 71 Issue 2 pp. 45 – 50 ISSN: 1734-7009 eISSN: 2084-0535 Casuistic (case description) article DOI: 10.2478/phr-2020-0009 Pages: 6, figures: 0, tables: 1 Originally published in the Naval Health Service Yearbook 1977-1978 page www of the periodical: www.phr.net.pl Acceptance for print in PHR: 27.10.2019 r. Publisher Polish Hyperbaric Medicine and Technology Society 2020 Vol. 71 Issue 2 INTRODUCTION that he suddenly experienced an "impact" from an increased amount of air flowing into his lungs during In recent years, we can observe a continuous inhalation. Fearing a lung injury, he immediately pulled the dynamic development of diving technology. At the same mouthpiece out of his mouth and started breathing air time, the spectrum of works carried out by scuba divers for from inside the suit for about 2 minutes. -
BTS Guideline for Oxygen Use in Adults in Healthcare and Emergency
BTS guideline BTS guideline for oxygen use in adults in healthcare Thorax: first published as 10.1136/thoraxjnl-2016-209729 on 15 May 2017. Downloaded from and emergency settings BRO’Driscoll,1,2 L S Howard,3 J Earis,4 V Mak,5 on behalf of the British Thoracic Society Emergency Oxygen Guideline Group ▸ Additional material is EXECUTIVE SUMMARY OF THE GUIDELINE appropriate oxygen therapy can be started in the published online only. To view Philosophy of the guideline event of unexpected clinical deterioration with please visit the journal online ▸ (http://dx.doi.org/10.1136/ Oxygen is a treatment for hypoxaemia, not hypoxaemia and also to ensure that the oxim- thoraxjnl-2016-209729). breathlessness. Oxygen has not been proven to etry section of the early warning score (EWS) 1 have any consistent effect on the sensation of can be scored appropriately. Respiratory Medicine, Salford ▸ Royal Foundation NHS Trust, breathlessness in non-hypoxaemic patients. The target saturation should be written (or Salford, UK ▸ The essence of this guideline can be summarised ringed) on the drug chart or entered in an elec- 2Manchester Academic Health simply as a requirement for oxygen to be prescribed tronic prescribing system (guidance on figure 1 Sciences Centre (MAHSC), according to a target saturation range and for those (chart 1)). Manchester, UK 3Hammersmith Hospital, who administer oxygen therapy to monitor the Imperial College Healthcare patient and keep within the target saturation range. 3 Oxygen administration NHS Trust, London, UK ▸ The guideline recommends aiming to achieve ▸ Oxygen should be administered by staff who are 4 University of Liverpool, normal or near-normal oxygen saturation for all trained in oxygen administration. -
Thermoregulatory Correlates of Nausea in Rats and Musk Shrews
www.impactjournals.com/oncotarget/ Oncotarget, Vol. 5, No. 6 Thermoregulatory correlates of nausea in rats and musk shrews Sukonthar Ngampramuan1, Matteo Cerri2, Flavia Del Vecchio2, Joshua J. Corrigan3, Amornrat Kamphee1, Alexander S. Dragic3, John A. Rudd4, Andrej A. Romanovsky3, and Eugene Nalivaiko5 1 Research Center for Neuroscience and Institute of Molecular Bioscience, Mahidol University, Bangkok, Thailand; 2 Department of Biomedical and Motor Sciences, University of Bologna, Bologna, Italy; 3 FeverLab, Trauma Research, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, USA; 4 School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China; 5 School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia. Correspondence to: Eugene Nalivaiko, email: [email protected] Correspondence to: Andrej A. Romanovsky, email: [email protected] Keywords: nausea, chemotherapy, temperature, hypothermia. Received: December 21, 2013 Accepted: February 21, 2014 Published: February 22 2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT: Nausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is limited, and their efficacy is questionable. Currently, the development of new compounds with anti-nausea activity is hampered by the lack of physiological correlates of nausea. Physiological correlates are needed because common laboratory rodents lack the vomiting reflex. Furthermore, nausea does not always lead to vomiting. Here, we report the results of studies conducted in four research centers to investigate whether nausea is associated with any specific thermoregulatory symptoms. -
Medical Aspects of Harsh Environments, Volume 2, Chapter
Medical Aspects of Harsh Environments, Volume 2 Chapter 32 PRESSURE CHANGES AND HYPOXIA IN AVIATION R. M. HARDING, BSC, MB BS, PHD* INTRODUCTION THE ATMOSPHERE Structure Composition THE PHYSIOLOGICAL CONSEQUENCES OF RAPID ASCENT TO ALTITUDE Hypoxia Hyperventilation Barotrauma: The Direct Effects of Pressure Change Altitude Decompression Sickness LIFE-SUPPORT SYSTEMS FOR FLIGHT AT HIGH ALTITUDE Cabin Pressurization Systems Loss of Cabin Pressurization Personal Oxygen Equipment SUMMARY *Principal Consultant, Biodynamic Research Corporation, 9901 IH-10 West, Suite 1000, San Antonio, Texas 78230; formerly, Royal Air Force Consultant in Aviation Medicine and Head of Aircrew Systems Division, Department of Aeromedicine and Neuroscience of the UK Centre for Human Science, Farnborough, Hampshire, United Kingdom 984 Pressure Changes and Hypoxia in Aviation INTRODUCTION The physiological consequences of rapid ascent and life-support engineers has established reliable to high altitude are a core problem in the field of techniques for safe flight at high altitudes, as demon- aerospace medicine. Those who live and work in strated by current atmospheric flight in all its forms, mountain terrain experience a limited range of al- military and civilian, from balloon flights to sail planes titudes and have time to adapt to the hypoxia ex- to supersonic aircraft and spacecraft. Although reli- perienced at high terrestrial elevations. In contrast, able cabin pressurization and oxygen delivery systems flyers may be exposed to abrupt changes in baro- have greatly reduced incidents and accidents due to metric pressure and to acute, life-threatening hy- hypoxia in flight, constant vigilance is required for poxia (see also Chapter 28, Introduction to Special their prevention. -
Gas Exchange in the Prone Posture
RESPIRATORY CARE Paper in Press. Published on May 30, 2017 as DOI: 10.4187/respcare.05512 Gas Exchange in the Prone Posture Nicholas J Johnson MD, Andrew M Luks MD, and Robb W Glenny MD Introduction Overview of Gas Exchange Lung Structure Normal Exchange of Oxygen and Carbon Dioxide Abnormal Exchange of Oxygen and Carbon Dioxide Gas Exchange in the Prone Posture Under Normal Conditions Spatial Distribution of Ventilation Spatial Distribution of Perfusion Ventilation and Perfusion Matching Mechanisms by Which the Prone Posture Improves Gas Exchange in Animal Models of ARDS Additional Physiologic Effects of the Prone Posture Clinical Trials Summary The prone posture is known to have numerous effects on gas exchange, both under normal condi- tions and in patients with ARDS. Clinical studies have consistently demonstrated improvements in oxygenation, and a multi-center randomized trial found that, when implemented within 48 h of moderate-to-severe ARDS, placing subjects in the prone posture decreased mortality. Improve- ments in gas exchange occur via several mechanisms: alterations in the distribution of alveolar ventilation, redistribution of blood flow, improved matching of local ventilation and perfusion, and reduction in regions of low ventilation/perfusion ratios. Ventilation heterogeneity is reduced in the prone posture due to more uniform alveolar size secondary to a more uniform vertical pleural pressure gradient. The prone posture results in more uniform pulmonary blood flow when com- pared with the supine posture, due to an anatomical bias for greater blood flow to dorsal lung regions. Because both ventilation and perfusion heterogeneity decrease in the prone posture, gas exchange improves. -
Some Major Points on the Causes of Hypoxia [Pdf]
Some major points on the causes of Hypoxia, the Effects of Hyperventilation and Breath Holding Times Source Kings College London tutorials: http://www.kcl.ac.uk/teares/gktvc/vc/dental/year1/lectures/rbmsmajorpoints/hypoxiaandhyperventilation.htm The causes of hypoxia Cells use oxygen to obtain their energy and may not function adequately if their supply of oxygen is impeded; this is called hypoxia which is a contraction of hypo-oxia or low level of oxygen. Many cells can respire anaerobically but the cells in the brain cannot and they need a constant supply of oxygen. A shortage of oxygen in the brain progressively produces inappropriate behaviour, unconsciousness and death which can occur within a few minutes if the brain is completely deprived of oxygen. There are many ways in which hypoxia can be produced but they can be divided into 4 types, each of which has fairly similar effects, because of the way the body works. This handout will be mainly concerned with the causes of hypoxia and will consider the effects only briefly; a later handout will go further into the effects. Please note that the space devoted to each cause in this handout reflects the number of words needed to explain it, not its importance. Hypoxic hypoxia This unfortunately named form of hypoxia occurs when the arterial partial pressure of oxygen (PaO2) is reduced so that the blood leaves the lungs without its haemoglobin being fully saturated. Hypoxic hypoxia can be produced in many ways: if there is a low partial pressure of oxygen in the inspired air, as at high altitudes, the PAO2 and the PaO2 will fall. -
Bluemagazine Caribbeanexplor
38 SABA KITTS /ST. LUXURY LIVEABOARD Caribbean Explorer II The liveaboard experience is luxurious and focused on one thing—maximum diving pleasure. Hard-core divers who don’t mind interacting with a small group out at sea for a week, would love this excursion. By SOLOMON BAKSH Tent Reef is probably the most striking reef in Saba with vibrant sponges, enormous gorgonians and teeming with fish life 39 THE Boat at. Dive. Sleep…well, sleeping my shoes into. That was the last I saw of crew members on board: Tim Heaton, is optional. It’s a liveaboard them until seven days later. Captain, USA; Chris Johnson, Engineer, lifestyle—getting up from your I was the first guest to arrive on board USA; Nichol Schilling, Purser, Germany; Ebed every day for a week with a the boat and was given the best location to Instructors Claire Keany, Scotland; Brett view of a breathtaking sunrise from your set up my gear—right next to the exit. Lockhoff, USA; Joe Lamontage, Canada. window, the ocean always in sight, a hot The person responsible for keeping all of us breakfast and another day of great diving. Amenities well fed was chef, Sarah Dauphinee, USA. It’s the nature of these trips that make The Caribbean Explorer II was well laid Every day was an epicurean delight with them so attractive. Plying the open ocean out. The upper deck housed the galley, air- Sarah serving up Mexican, Mediterranean, to different dive sites every day and over conditioned dining area and sun deck. Italian, Caribbean and BBQ dishes. -
Near Drowning
Near Drowning McHenry Western Lake County EMS Definition • Near drowning means the person almost died from not being able to breathe under water. Near Drownings • Defined as: Survival of Victim for more than 24* following submission in a fluid medium. • Leading cause of death in children 1-4 years of age. • Second leading cause of death in children 1-14 years of age. • 85 % are caused from falls into pools or natural bodies of water. • Male/Female ratio is 4-1 Near Drowning • Submersion injury occurs when a person is submerged in water, attempts to breathe, and either aspirates water (wet) or has laryngospasm (dry). Response • If a person has been rescued from a near drowning situation, quick first aid and medical attention are extremely important. Statistics • 6,000 to 8,000 people drown each year. Most of them are within a short distance of shore. • A person who is drowning can not shout for help. • Watch for uneven swimming motions that indicate swimmer is getting tired Statistics • Children can drown in only a few inches of water. • Suspect an accident if you see someone fully clothed • If the person is a cold water drowning, you may be able to revive them. Near Drowning Risk Factor by Age 600 500 400 300 Male Female 200 100 0 0-4 yr 5-9 yr 10-14 yr 15-19 Ref: Paul A. Checchia, MD - Loma Linda University Children’s Hospital Near Drowning • “Tragically 90% of all fatal submersion incidents occur within ten yards of safety.” Robinson, Ped Emer Care; 1987 Causes • Leaving small children unattended around bath tubs and pools • Drinking -
Effects of Smoking on Acute Hypobaric Hypoxia Tolerance
Ercan et al. Effects of Smoking on Hypoxia Tolerance ORI GI NAL AR TIC LE DOI: 10.4274/hamidiyemedj.galenos.2021.29291 Hamidiye Med J 2021;2(1):37-42 Effects of Smoking on Acute Hypobaric Hypoxia Tolerance Sigara Kullanımının Akut Hipobarik Hipoksi Toleransı Üzerine Etkisi Erdinç Ercan1, Menduh Şavaş İlbasmış2, Cantürk Taşçı3 1Health Science University, Department of Aerospace Medicine, Ankara, Turkey 2Yunus Emre State Hospital, Clinic of Hyperbaric Oxygen Therapy, Eskişehir, Turkey 3Health Science University, Department of Pulmonology, Ankara, Turkey Background: Smoking may impair oxygen transport ability of blood and airway destructions might be seen in long term smokers. After 1-3 cigarette smoking, it leads to a rise in carboxyhemoglobin level in blood, and it has a negative effect such as taking extra 5,000-8,000 feet altitude. Thus, it is thought that smoking before or in-flight may contribute to altitude hypoxia. The objective of this study was to evaluate the effects of smoking on acute hypobaric hypoxia tolerance at 30,000 ft. simulated altitude. Materials and Methods: This study was planned prospectively, and a standardized survey that consisted of smoking status and demographic characteristics of subjects was applied before the procedures. Aircrews are exposed to high altitude during “Hypobaric Hypoxia Training” in an altitude chamber. Pulse oximeter measurements were done to analyze oxygen saturations during different stages of the hypoxia trainings. T C Results: Seventy eight male healthy aircrews were included in this study. Twenty five (32.1%) of subjects stated that they were currently smoking (4.9±2.6 years). Hypoxic pulse oximeter mean values of the Nonsmoker Group were higher than those of the Smoker Group (p>0.05).