Supplementary Table 7. aPCP PPI network details for significantly changed , as identified in 3.2, underlying each of the five functional domains. The network nodes represent each significant , followed by the list of interactors. Note that identifiers were converted to names to facilitate PPI database queries.

Functional Domain Node Interactors Development and Ap2a1 Grin2b differentiation Eps15 Sgip1 Dlg4 Atp6v1a Snap25 Ywhab Ywhae Development and Sirt2 Ripk3 differentiation Cdc20 Fzr1 Ripk1 Dlg4 Ywhae Development and Cnp Cask differentiation Grid2 Gria2 Ywhaz Dlg4 Ybx3 Ywhab Ywhae Development and Rab10 Clstn1 differentiation Hmga2 Ccdc64b Ywhae Development and Rab35 Hmga2 differentiation Ywhaz Ywhae Development and Mbp Clstn1 differentiation Kcnma1 Grin2b Ywhae Development and H3f3a Zfp819 differentiation Ss18 Hspa8 Hist1h4a Rbmxl2 Ubc Rps27a Uba52 Ubb Rgs9 Daxx Atrx Dnajc9 Dnmt3a Hira Dhx9 Smarca5 Rbbp4 Ssrp1 Rbbp7 H2afz Asf1a Atp5b Asf1b Nasp Supt16h Parp1 Ubr7 Hsp90ab1 Mcm7 Macf1 Hat1 Hist1h2aa Hist1h2bm Mcm2 Mcm6 Desi1 Ezh2 Hsd3b4 Ywhaz Hsd3b7 Ywhae Development and Vdac3 Dlg4 differentiation Fbp1 Hsd3b4 Ywhab Ywhae Development and Rab13 Ccdc64b differentiation Grb2 Development and Arrb1 Mdm2 differentiation Son Top2a Nfe2l2 Matn2 Hnrnpa1 Vim Dnajb6 Cd164 Bmpr2 Gnpat Hax1 Rtn3 Cd247 Ywhae Development and Psmd3 Hmga2 differentiation Psmd4 Rpgrip1l Development and Slc25a12 Ywhaz differentiation Nphp4 Grin2b Dlg4 Ywhab Ywhae Development and Dnm1 Pfn2 differentiation Bin1 Amph Cltc Kcnma1 Dnm1 Pxn Itsn1 Grb2 Syn1 Lrrk2 Grin1 Atp6v1a Ywhaz Grin2b Dlg4 Ap2a2 Pacsin1 Prnp Vamp2 Bsn Ywhab Ywhae Development and Gphn Pin1 differentiation Ywhaz Glrb Pgls Ywhab Ywhae Development and Ina Grin1 differentiation Atp6v1a Kcnma1 Grin2b Dlg4 Ywhab Ywhae Development and Hspa8 Ckb differentiation Klc1 Rnf2 Irs1 Nphp1 Iqcb1 Bag5 Invs Mks1 Nphp3 Cep290 Ahi1 Hist1h3a Hist1h3b Ywhaz Nphp4 Kcnma1 Dlg4 Rpgrip1l Sult2b1 Ilk Ftl1 H3f3a Ezh2 Hsd3b7 Pgls Hsd3b4 Ywhab Ywhae Development and Vdac2 Bak1 differentiation Invs Ywhaz Grin2b Dlg4 Fbp1 Ywhah Hsd3b4 Ywhab Ywhae Development and Atp6v0a1 Psen1 differentiation Syp Clstn1 Ywhab Ywhae Intracellular signalling and Sirt2 Ripk3 regulation Cdc20 Fzr1 Ripk1 Dlg4 Ywhae Intracellular signalling and Cnp Cask regulation Grid2 Gria2 Ywhaz Dlg4 Ybx3 Ywhab Ywhae Intracellular signalling and Rab10 Clstn1 regulation Hmga2 Ccdc64b Ywhae Intracellular signalling and Rab35 Hmga2 regulation Ywhaz Ywhae Intracellular signalling and Mbp Clstn1 regulation Kcnma1 Grin2b Ywhae Intracellular signalling and H3f3a Zfp819 regulation Ss18 Hspa8 Hist1h4a Rbmxl2 Ubc Rps27a Uba52 Ubb Rgs9 Daxx Atrx Dnajc9 Dnmt3a Hira Dhx9 Smarca5 Rbbp4 Ssrp1 Rbbp7 H2afz Asf1a Atp5b Asf1b Nasp Supt16h Parp1 Ubr7 Hsp90ab1 Mcm7 Macf1 Hat1 Hist1h2aa Hist1h2bm Mcm2 Mcm6 Desi1 Ezh2 Hsd3b4 Ywhaz Hsd3b7 Ywhae Intracellular signalling and Vdac3 Dlg4 regulation Fbp1 Hsd3b4 Ywhab Ywhae Intracellular signalling and Rab13 Ccdc64b regulation Grb2 Intracellular signalling and Arrb1 Mdm2 regulation Son Top2a Nfe2l2 Matn2 Hnrnpa1 Vim Dnajb6 Cd164 Bmpr2 Gnpat Hax1 Rtn3 Cd247 Ywhae Intracellular signalling and Gphn Pin1 regulation Ywhaz Glrb Pgls Ywhab Ywhae Intracellular signalling and Ap2a1 Grin2b regulation Eps15 Sgip1 Dlg4 Atp6v1a Snap25 Ywhab Ywhae Intracellular signalling and Atp6v0a1 Psen1 regulation Syp Clstn1 Ywhab Ywhae Intracellular signalling and Dnm1 Pfn2 regulation Bin1 Amph Cltc Kcnma1 Dnm1 Pxn Itsn1 Grb2 Syn1 Lrrk2 Grin1 Atp6v1a Ywhaz Grin2b Dlg4 Ap2a2 Pacsin1 Prnp Vamp2 Bsn Ywhab Ywhae Intracellular signalling and Rab3c Rpgrip1l regulation Intracellular signalling and Slc25a12 Ywhaz regulation Nphp4 Grin2b Dlg4 Ywhab Ywhae Intracellular signalling and Stx1a Syt2 regulation Snap25 Stxbp1 Vamp2 Kcnma1 Rusc1 Lrrk2 Htt Nsf Chga Grin1 Grin2b Ywhab Cltc Ywhae Intracellular signalling and Uqcrc1 Cyc1 regulation Neurl1 Kcnma1 Dlg4 Ywhaz Hsd3b4 Ywhab Ywhae Intracellular signalling and Vdac2 Bak1 regulation Invs Ywhaz Grin2b Dlg4 Fbp1 Ywhah Hsd3b4 Ywhab Ywhae Intracellular signalling and Basp1 Dlg4 regulation Ywhah Ywhab Ywhae Intracellular signalling and Ina Grin1 regulation Atp6v1a Kcnma1 Grin2b Dlg4 Ywhab Ywhae Intracellular signalling and Psmd3 Hmga2 regulation Psmd4 Rpgrip1l Intracellular signalling and Hspa8 Ckb regulation Klc1 Rnf2 Irs1 Nphp1 Iqcb1 Bag5 Invs Mks1 Nphp3 Cep290 Ahi1 Hist1h3a Hist1h3b Ywhaz Nphp4 Kcnma1 Dlg4 Rpgrip1l Sult2b1 Ilk Ftl1 H3f3a Ezh2 Hsd3b7 Pgls Hsd3b4 Ywhab Ywhae Intracellular signalling and Pdxk Kcnma1 regulation Dlg4 Pgls Ywhae Intracellular transport and Sirt2 Ripk3 organization Cdc20 Fzr1 Ripk1 Dlg4 Ywhae Intracellular transport and Cnp Cask organization Grid2 Gria2 Ywhaz Dlg4 Ybx3 Ywhab Ywhae Intracellular transport and Rab10 Clstn1 organization Hmga2 Ccdc64b Ywhae Intracellular transport and Rab35 Hmga2 organization Ywhaz Ywhae Intracellular transport and Mbp Clstn1 organization Kcnma1 Grin2b Ywhae Intracellular transport and H3f3a Zfp819 organization Ss18 Hspa8 Hist1h4a Rbmxl2 Ubc Rps27a Uba52 Ubb Rgs9 Daxx Atrx Dnajc9 Dnmt3a Hira Dhx9 Smarca5 Rbbp4 Ssrp1 Rbbp7 H2afz Asf1a Atp5b Asf1b Nasp Supt16h Parp1 Ubr7 Hsp90ab1 Mcm7 Macf1 Hat1 Hist1h2aa Hist1h2bm Mcm2 Mcm6 Desi1 Ezh2 Hsd3b4 Ywhaz Hsd3b7 Ywhae Intracellular transport and Vdac3 Dlg4 organization Fbp1 Hsd3b4 Ywhab Ywhae Intracellular transport and Rab13 Ccdc64b organization Grb2 Intracellular transport and Arrb1 Mdm2 organization Son Top2a Nfe2l2 Matn2 Hnrnpa1 Vim Dnajb6 Cd164 Bmpr2 Gnpat Hax1 Rtn3 Cd247 Ywhae Intracellular transport and Psmd3 Hmga2 organization Psmd4 Rpgrip1l Intracellular transport and Rab3c Rpgrip1l organization Intracellular transport and Stx1a Syt2 organization Snap25 Stxbp1 Vamp2 Kcnma1 Rusc1 Lrrk2 Htt Nsf Chga Grin1 Grin2b Ywhab Cltc Ywhae Intracellular transport and Basp1 Dlg4 organization Ywhah Ywhab Ywhae Intracellular transport and Ap2a1 Grin2b organization Eps15 Sgip1 Dlg4 Atp6v1a Snap25 Ywhab Ywhae Intracellular transport and Hspa8 Ckb organization Klc1 Rnf2 Irs1 Nphp1 Iqcb1 Bag5 Invs Mks1 Nphp3 Cep290 Ahi1 Hist1h3a Hist1h3b Ywhaz Nphp4 Kcnma1 Dlg4 Rpgrip1l Sult2b1 Ilk Ftl1 H3f3a Ezh2 Hsd3b7 Pgls Hsd3b4 Ywhab Ywhae Intracellular transport and Atp6v0a1 Psen1 organization Syp Clstn1 Ywhab Ywhae Biosynthetic processes and Ina Grin1 energy metabolism Atp6v1a Kcnma1 Grin2b Dlg4 Ywhab Ywhae Biosynthetic processes and Sirt2 Ripk3 energy metabolism Cdc20 Fzr1 Ripk1 Dlg4 Ywhae Biosynthetic processes and Cnp Cask energy metabolism Grid2 Gria2 Ywhaz Dlg4 Ybx3 Ywhab Ywhae Biosynthetic processes and Rab10 Clstn1 energy metabolism Hmga2 Ccdc64b Ywhae Biosynthetic processes and Rab35 Hmga2 energy metabolism Ywhaz Ywhae Biosynthetic processes and Mbp Clstn1 energy metabolism Kcnma1 Grin2b Ywhae Biosynthetic processes and H3f3a Zfp819 energy metabolism Ss18 Hspa8 Hist1h4a Rbmxl2 Ubc Rps27a Uba52 Ubb Rgs9 Daxx Atrx Dnajc9 Dnmt3a Hira Dhx9 Smarca5 Rbbp4 Ssrp1 Rbbp7 H2afz Asf1a Atp5b Asf1b Nasp Supt16h Parp1 Ubr7 Hsp90ab1 Mcm7 Macf1 Hat1 Hist1h2aa Hist1h2bm Mcm2 Mcm6 Desi1 Ezh2 Hsd3b4 Ywhaz Hsd3b7 Ywhae Biosynthetic processes and Vdac3 Dlg4 energy metabolism Fbp1 Hsd3b4 Ywhab Ywhae Biosynthetic processes and Rab13 Ccdc64b energy metabolism Grb2 Biosynthetic processes and Arrb1 Mdm2 energy metabolism Son Top2a Nfe2l2 Matn2 Hnrnpa1 Vim Dnajb6 Cd164 Bmpr2 Gnpat Hax1 Rtn3 Cd247 Ywhae Biosynthetic processes and Pdhb Prkce energy metabolism Ywhaz Kcnma1 Dlg4 Ezh2 Ywhah Hsd3b4 Ywhab Ywhae Biosynthetic processes and Slc25a12 Ywhaz energy metabolism Nphp4 Grin2b Dlg4 Ywhab Ywhae Biosynthetic processes and Uqcrc1 Cyc1 energy metabolism Neurl1 Kcnma1 Dlg4 Ywhaz Hsd3b4 Ywhab Ywhae Biosynthetic processes and Vdac2 Bak1 energy metabolism Invs Ywhaz Grin2b Dlg4 Fbp1 Ywhah Hsd3b4 Ywhab Ywhae Biosynthetic processes and Gphn Pin1 energy metabolism Ywhaz Glrb Pgls Ywhab Ywhae Biosynthetic processes and Pdxk Kcnma1 energy metabolism Dlg4 Pgls Ywhae Biosynthetic processes and Hspa8 Ckb energy metabolism Klc1 Rnf2 Irs1 Nphp1 Iqcb1 Bag5 Invs Mks1 Nphp3 Cep290 Ahi1 Hist1h3a Hist1h3b Ywhaz Nphp4 Kcnma1 Dlg4 Rpgrip1l Sult2b1 Ilk Ftl1 H3f3a Ezh2 Hsd3b7 Pgls Hsd3b4 Ywhab Ywhae Biosynthetic processes and Psmd3 Hmga2 energy metabolism Psmd4 Rpgrip1l Biosynthetic processes and Ap2a1 Grin2b energy metabolism Eps15 Sgip1 Dlg4 Atp6v1a Snap25 Ywhab Ywhae Biosynthetic processes and Basp1 Dlg4 energy metabolism Ywhah Ywhab Ywhae Nucleic acid metabolism Sirt2 Ripk3 and ATP/GTPase activity Cdc20 Fzr1 Ripk1 Dlg4 Ywhae Nucleic acid metabolism Cnp Cask and ATP/GTPase activity Grid2 Gria2 Ywhaz Dlg4 Ybx3 Ywhab Ywhae Nucleic acid metabolism Rab10 Clstn1 and ATP/GTPase activity Hmga2 Ccdc64b Ywhae Nucleic acid metabolism Rab35 Hmga2 and ATP/GTPase activity Ywhaz Ywhae Nucleic acid metabolism Mbp Clstn1 and ATP/GTPase activity Kcnma1 Grin2b Ywhae Nucleic acid metabolism H3f3a Zfp819 and ATP/GTPase activity Ss18 Hspa8 Hist1h4a Rbmxl2 Ubc Rps27a Uba52 Ubb Rgs9 Daxx Atrx Dnajc9 Dnmt3a Hira Dhx9 Smarca5 Rbbp4 Ssrp1 Rbbp7 H2afz Asf1a Atp5b Asf1b Nasp Supt16h Parp1 Ubr7 Hsp90ab1 Mcm7 Macf1 Hat1 Hist1h2aa Hist1h2bm Mcm2 Mcm6 Desi1 Ezh2 Hsd3b4 Ywhaz Hsd3b7 Ywhae Nucleic acid metabolism Vdac3 Dlg4 and ATP/GTPase activity Fbp1 Hsd3b4 Ywhab Ywhae Nucleic acid metabolism Rab13 Ccdc64b and ATP/GTPase activity Grb2 Nucleic acid metabolism Arrb1 Mdm2 and ATP/GTPase activity Son Top2a Nfe2l2 Matn2 Hnrnpa1 Vim Dnajb6 Cd164 Bmpr2 Gnpat Hax1 Rtn3 Cd247 Ywhae Nucleic acid metabolism Pdhb Prkce and ATP/GTPase activity Ywhaz Kcnma1 Dlg4 Ezh2 Ywhah Hsd3b4 Ywhab Ywhae Nucleic acid metabolism Slc25a12 Ywhaz and ATP/GTPase activity Nphp4 Grin2b Dlg4 Ywhab Ywhae Nucleic acid metabolism Uqcrc1 Cyc1 and ATP/GTPase activity Neurl1 Kcnma1 Dlg4 Ywhaz Hsd3b4 Ywhab Ywhae Nucleic acid metabolism Vdac2 Bak1 and ATP/GTPase activity Invs Ywhaz Grin2b Dlg4 Fbp1 Ywhah Hsd3b4 Ywhab Ywhae Nucleic acid metabolism Dnm1 Pfn2 and ATP/GTPase activity Bin1 Amph Cltc Kcnma1 Dnm1 Pxn Itsn1 Grb2 Syn1 Lrrk2 Grin1 Atp6v1a Ywhaz Grin2b Dlg4 Ap2a2 Pacsin1 Prnp Vamp2 Bsn Ywhab Ywhae Nucleic acid metabolism Basp1 Dlg4 and ATP/GTPase activity Ywhah Ywhab Ywhae Nucleic acid metabolism Hspa8 Ckb and ATP/GTPase activity Klc1 Rnf2 Irs1 Nphp1 Iqcb1 Bag5 Invs Mks1 Nphp3 Cep290 Ahi1 Hist1h3a Hist1h3b Ywhaz Nphp4 Kcnma1 Dlg4 Rpgrip1l Sult2b1 Ilk Ftl1 H3f3a Ezh2 Hsd3b7 Pgls Hsd3b4 Ywhab Ywhae