ITRACONAZOLE If you are taking anti-ulcer drugs that What ADVERSE EFFECTS can this can decrease the acidity of the stomach drug cause? What should you do

[ranitidine (Zantac ), famotidine about them? Other names: Sporanox  (Pepcid ), pantoprazole (Pantoloc ),

lansoprazole (Prevacid ), omeprazole Nausea, vomiting, diarrhea, WHY is this drug prescribed? (Losec ), rabeprazole (Pariet ), headache, and dizziness commonly

 occur and should go away as your body Itraconazole is an antifungal drug. It is esomeprazole (Nexium )], absorption adjusts to the drug. If they become used to treat fungal infections in the may be improved by taking itraconazole bothersome, call your doctor or mouth (like thrush), the esophagus, the capsules with a carbonated cola drink pharmacist. genital tract (like a yeast infection) and or cranberry juice. other areas. It may also be used to Itraconazole may cause increases in prevent cryptococcal meningitis (brain Your dosage is: various tests measuring liver fungal infection) or other types of fungal function . These changes serve as a infections from recurring. 100 mg capsule signal to watch for liver damage. If you

experience unusual fatigue, yellowing HOW should this drug be taken? ____capsule(s) (____mg) ____time(s) a day of eyes and skin, nausea, vomiting, Itraconazole is available in 100 mg dark urine, or pale stool , call your capsules and a 10 mg / mL oral or doctor or pharmacist. Itraconazole may suspension. cause the potassium in your body to 10 mg / mL oral solution drop. This may cause unusual The dose of itraconazole will depend on tiredness or weakness in limbs . If the type of infection that is being treated. ____mL (____mg) ____ time(s) a day you experience these symptoms, call It is usually given once or twice daily. Swish in the mouth then swallow your doctor or pharmacist. An allergic reaction to itraconazole is possible but Itraconazole capsules should be taken Take itraconazole for the duration of time rare. Symptoms of an allergic reaction immediately after a full meal. it is prescribed. If you stop it earlier, your include fever, skin rash or itching . Itraconazole oral solution should be infection may come back. If the infection Call your doctor or pharmacist if these taken without food. Avoid taking an worsens or persists, consult your doctor. occur. antacid (Maalox , Tums , etc) or didanosine (Videx ) at the same time as What should you do if you FORGET a What other PRECAUTIONS should the itraconazole capsules , since an acid dose? you follow while using this drug? environment in the stomach is necessary for itraconazole to be well absorbed. If If you miss a dose of itraconazole, take Certain drugs can increase or decrease you need to take antacids or didanosine it as soon as possible. However, if it is the effect of itraconazole. Also, itraconazole might influence the effect (Videx ), it should be taken at least 1 time for your next dose, do not double of other drugs you are taking. Inform hour before or 2 hours after the the dose, just carry on with your regular your doctor and pharmacist of all itraconazole capsules. schedule. prescribed and non-prescribed drugs this drug. Please discuss this with your you are taking. As well, you should doctor or pharmacist if this is a concern. inform them of natural products you are taking. If you wish to start a new drug or How should this drug be STORED? natural product, please consult with your pharmacist before doing so. Itraconazole capsules and oral solution should be stored at room temperature in ITRACONAZOLE You should NOT take the following a cool (15-25 °C) dry place, protected drugs if your doctor has prescribed from light and well out of the reach of itraconazole : children. Ensure that the drug has not expired by checking the expiry date Astemizole (Hismanal ) (“EXP”) shown on the outside of the Cisapride (Prepulsid ) package. MEDICATION Dofetilide Eletriptan Do not store in your bathroom or Ergot alkaloids such as kitchen, as heat and moisture may FACT SHEET dihydroergotamine, ergometrine cause the drug to be less active. (ergonovine), ergotamine and methylergometrine If you have any questions or concerns (methylergonovine) about this drug or if you are Levomethadyl experiencing adverse effects, please Lovastatin (Mevacor ) discuss them with your pharmacist, Oral Midazolam (Versed ) doctor or nurse. Nisoldipine Pimozide (Orap ) Write questions or concerns down to Quinidine (Biquin Durules ) ensure they are addressed. Terfenadine (Seldane ) Simvastatin (Zocor ) The following pharmacist is available to Triazolam (Halcion ) answer questions:

Women of childbearing potential should Pharmacist: ______take itraconazole ONLY if they are using Telephone: ______an effective form of birth control Reference: Product monograph Sporanox  (itraconazole). (condom, birth control pill). Toronto, ON, Canada: Janssen-Ortho Inc, 2008. Prepared by the Ontario HIV Pharmacy Professional Specialty Group, 2003. Updated 2009. Itraconazole should not be used in pregnant women. Also, breastfeeding is Additional medication fact sheets and updates may be found at: www.hivclinic.ca NOT recommended while you are taking