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Mechanisms of Dna Repair and Mutagenesis PL9800397 Institute of Biochemistry and Biophysics Polish Academy of Sciences Abstracts of the Conference on: MECHANISMS OF DNA REPAIR AND MUTAGENESIS on the 100th Anniversary of the Discovery of Polonium and Radium Warsaw, October 8-11, 1997 ISBN 83-906782-6-8 Wydawca: Instytut Biochemii i Biofizyki Polskiej Akademii Nauk 02-106 Warszawa ill. Pawiriskiego 5a Warszawa 1997 Druk: AKCES Agencja Wydawnicza i Reklamowa tel.: 39-16-17 Cena: 6,90 zt Institute of Biochemistry and Biophysics Polish Academy of Sciences Abstracts of the Conference on: MECHANISMS OF DNA REPAIR AND MUTAGENESIS on the 100th Anniversary of The Discovery of Polonium and Radium Warsaw, October 8-11, 1997 Organizing Committee of the Conference: President: Barbara Tudek Vice-president: Irena Pietrzykowska Anna B^benek Zygmunt Ciesla Iwona Fijalkowska Maria-Anna Grajziewicz Elzbieta Grzesiuk Celina Janion Piotr Jonczyk Jarostaw Kusmierek JanilSZ Siedlecki (Institute of Oncology, Warsaw) Ewa &ledziewska-G6jska Honorary Committee of the Conference: Wtodzimierz Zagorski-Ostoja (Director of IBB PAS) David Shugar TadeUSZ Chojnacki (Secretary of Biological Sciences Dept, PAS) FikllS (Secretary of Committee of Biochemistry, PAS) Program The Program of the Conference on: MECHANISMS OF DNA REPAIR AND MUTAGENESIS on the 100th Anniversary of The Discovery of Polonium and Radium Warszawa, October 8-11, 1997 WEDNESDAY 8 OCTOBER 1997 930 j ooo OPENING CEREMONY Session I: Oxidative DNA Damage and its Genetic Consequences Chairperson: B. Singer 1000- 103 L. Ernster, Dept. of Biochemistry, Aarhenius Lab., University of Stockholm, Sweden Jwo different aspects of oxidative DNA damage: mitochondrial disorders and cancer chemotherapy" 1035 - 1105 S. Boiteux, Commissariat a L'Energie Atomique, Centre d'Etudes de Fonteney-aux-Roses, Fonteney-aux-Roses, France „ Repair of 8-Oxoguanine in eukaryotic cells: the Oggl enzymes" j j io _ j |40 ^ Collins, Rowett Research Institute, Aberdeen, Great Britain »Oxidative DNA damage in human cells: antioxidant protection and DNA repair" II45-1200 coffee break 1200 - 1230 R. Olinski, Dept. of Clinical Biochemistry, University of Medical Science, Bydgoszcz, Poland ..Oxidative DNA base modification as factors in carcinogenesis and AIDS" Program 1235 - 1255 B. Tudek, Institute of Biochemistry an Biophysics, PAS, Warsaw, Poland „ Formation of imidazole ring-opened purines in DNA and their biological consequences" U^-U00 lunch Chairperson: S. Boiteux 1405 - 1435 S. Loft, Dept. of Pharmacalogy, University of Copenhagen, Denmark „ Estimation ofoxidative DNA damage in man from urinary excretion of repair products" 14 -15 A. Barbin, unit of Enviromental Carcinogenesis, IARC, Lyon, France „ Formation of DNA etheno adducts in rodents and humans and their role in carcinogenesis" 15-15 I. Felzenszwalb, Universidade do Estado do Rio de Janeiro, Instituto de Biologia, Rio de Janeiro, Brazil „Hydrogen peroxide effects in Escherichia coli cells" 1550-1605 coffee break Chairperson: J. Drake 1605 - 1635 B. Bridges, University of Sussex, Brighton, Great Britain MOxidative DNA damage as a cause of spontaneous mutation in non-dividing cells" 1640 - 1710 R. C. von Borstel, University of Alberta, Edmonton, Canada „ Repair of radiation damage by DNA and deoxyribonucleosides" 1715 - 1745 D. Shugar, Institute of Biochemistry and Biophysics, PAS, Warsaw, Poland 18 30- departure to the welcome party 19oo_21oo WELCOME PARTY Program THURSDAY 9 OCTOBER 1997 SESSION II DNA Repair in Prokaryotes and Mechanisms of Mutagenesis Chairperson: J. T. Kusmierek 9-9 B. Singer, Donner Laboratory - LBL, University of California, Berkeley, USA „ Structure-function relationships in replication and repair of carcinogen-damaged DNA" 935 - 1005 J. W. Drake, NIEHS, Research Triangle Park, USA „Autonomous polymerase fidelity" 1010 - 1040 K. Bebenek, NIEHS, Research Triangle Park, USA „Structure and functions of DNA polymerases" 1045 - II10 I. Fijalkowska, Institute of Biochemistry and Biophysics, PAS, Warsaw, Poland ..Unequal fidelity of leading and lagging strand replication on E.coli chromosome" II15-II30 coffee break Chairperson: H. Hayatsu 1130 - 1200 R. M. Schaaper, NIEHS, Research Triangle Park, USA „ Mutagenesis and DNA replication fidelity in Escherichia coil" 1205 - 1235 R. P. Fuchs, Groupe de Cancerogenese et de Mutagenese, Moleculaire et Structural, I.B.M.C du CNRS, Starsbourg, France „Steps during translesion synthesis and replication blocking lesions" 1240 - 1310 R. T. Johnson, University of Cambridge, Cambridge, United Kingdom „Solutions to replication on damaged DNA templates" Program 1315 -1415 lunch Chairperson: T. Kunkel 1415 - 1445 C. Lawrence, University of Rochester, USA ,,DNA polymerase zeta and the control ofDNA damage induced mutagenesis in eukaryotes" 1450 - 15 R. Devoret, Laboratoire Mutagenese et Cancerogenese, Institute Curie, Orsay, France ,, The mechanism of SOS mutagenesis involves dynamic interaction between recombination and mutagenesis proteins" 1525 - 1555 R. Woodgate, NICHD, NIH, Bethesda, USA ^Structural insights into the regulation of SOS-mutagenesis" 16°°-1615 coffee break Chairperson: Z. Ciesla 1615 - 1635 A. Bebenek, Institute of Biochemistry and Biophysics, PAS, Warsaw, Poland ,,A new gene in E.coli K12, isfA may be involved in down regulation of the SOS system" 1640 - 1700 I. Pietrzykowska, Institute of Biochemistry and Biophysics, PAS.Warsaw, Poland »Studies on UV-induced mutagenesis not related to DNA replication" 1705 - 1725 C. Janion, Institute of Biochemistry and Biophysics, PAS, Warsaw, Poland „ Effect ofTnlO on the survival and mutation frequency of halogen light-irradiated E.coli strain AB1157" 18'5 departure to the Theatre Program MUDAY 10 OCTOBER 1997 900 - 1300 Warsaw sightseeing or free time 1300-1400 lunch Chairperson: D. Shugar 14 -14 H. Hayatsu, Okayama University, Japan „ Mechanism of mutagenesis ofcytosine analogs" 1435 - 1505 Y. Pavlov, Dept. of Genetics and Breeding, Sankt-Petersburg State University, Sankt Petersburg, Russia ,,Mutagenic pathways of the base analog, 6-N-hydroxylaminopurine in bacteria and yeast" 15-15 J. T. KuSmierek, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland ,,Template-directed base pairing of 2-chlorodeoxyadenosine catalysed by AMV reverse transcriptase" 1535-1550 coffee break Session III sponsored by POLISH NETWORK of MBCM UNESCO and POLISCH ACADEMY OF SCIENCE DNA Repair in Eukaryotes and its Relation to Human Diseases Chairperson: A. Collins 1550 - 16 ° M. Z. Zdzienicka, Dept. of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Leiden, The Netherlands »Genetic basis of radiation sensitivity of mammalian cells" 1625 - 1655 T. Kunkel, NIEHS, Research Triangle Park, USA ,,Studies of eukaryotic DNA mismatch repair" 17-17 J. Jiricny, University of Zurich and The Paul Scherrer Institute, Switzerland ..Biochemistry of G/T mismatch repair in human cells" Program 1735 - 1805 B. Salles, IPBS, CNRS, Toulouse, France Mucleotide excision repair: in vitro analysis" 1810 - 1840 L. H. F. Mullenders, Dept. of Genetics, Radiation Genetics and Chemical Mutagenesis, Medical Genetics Centre, Netherlands „ Processing of structurally different lesions by nucieotide excision repair" 1900-2130 DINNER, Poster Session SATURDAY 11 OCTOBER 1997 Chairperson: M. Zdzienicka 900 . 930 G. Russev, Institutte of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria „ Assessing NER activity in different genome regions" 935 - 1005 M. Pirsel, Dept. of Molecular Genetics, Cancer Research Institute, Bratislava, Slovakia ,,DNA repair domains" 1010 - 1040 G. P. Margison, Dept. of Carcinogenesis, Peterson Institute for Cancer Research, Manchester, Great Britain ,,DNA alkylation damage, repair and clinical significance" 1045 - II15 K. Kleibl, Cancer Research Institute, Bratislava, Slovakia Jnactivation of alkyltransferase to enhance chemoterapy" II20-II35 coffee break Chairperson: L. H. F. Mullenders II35- 1205 T. R. O'Connor, National Medical Centre, City of Hope, USA „Repair of DNA alkylating agent damage in human cells" 1210 - 1240 F. Larminat, Laboratoire de Pharmacologie et de Toxicologie Foundamentales du CNRS, Toulouse, France ^Mammalian cellular responses to DNA cross-linking agents" Program 1245 - 1315 L. Daya-Grosjean, Institute sur le Cancer - IFC 1, Villejuif, France Jhe role ofp53 in DNA repair deficient syndromes hypersensitive to UV light" 1320-1430 lunch Chairperson: R. C. von Borstel 1430 . 1500 A. Larsen, Institut Gustave Roussy, LA147 CNRS, Villejuif, France „ Influence of the oncogene suppressor protein p53 on the sensitivity of tumor cells to DNA topoisomerase inhibitors" 15-15 R. Hancock, Laval University Cancer Research Center, Quebeck, Canada ,,Oncogenic transformation resulting from dysfunction of the DNA cleavage-religation reaction of topoisomerase II" 15 -16 M. Nivard, Dept. of Radiation Genetics and Chemical Mutagenesis, Leiden University, Leiden, The Netherlands „ The impact of DNA repair on chemically induced germ cell mutagenesis" 16-16 R. Stetina, Lab. of Developmental Toxicology, Institute of Experimental Medicine, Olesnice v Orlickych Horach, Czech Republic ,,DNA damage in lymphocytes and aortal endothelia of diabetic and cholesterol-fed rats" 1650 - 1715 CLOSING LECTURES Session I: Oxidative DNA Damage and its Genetic Consequences TWO DIFFERENT ASPECTS OF OXIDATIVE DNA DAMAGE: MITOCHONDRIAL DISORDERS AND CANCER CHEMOTHERAPY Lars Ernster Department of Biochemistry, Arrhenius Laboratories for Natural Sciences, Stockholm University, S-10691 Stockholm, Sweden. It is now
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