Inherited Coagulopathy: Commonly Affected Breeds

Handout Hematology Peer Reviewed

Michelle Fulks, DVM, & Virginia Sinnott, DVM, DACVECC Cape Cod Veterinary Specialists, Buzzards Bay, Massachusetts

Disorder Breed or Species PRIMARY HEMOSTASIS (petechiae, ecchymosis, epistaxis, hematuria, incisional bleeding) Thrombocytopenia Cyclic hematopoiesis Gray collie Inherited macrothrombocytopenia Cavalier King Charles spaniel, Chihuahua, English toy spaniel, Havanese, Parson Russell terrier, labradoodle, Labrador retriever, Maltese, poodle, shi tzu May-Hegglin anomaly Pug Thrombocytopathia (normal platelet count ) Chédiak-Higashi syndrome Persian cats Dense granule defects American cocker spaniel Glanzmann thrombasthenia Great Pyrenees, otterhound Scott syndrome German shepherd dog Signal transduction disorders Basset hound, spitz von Willebrand disease (vWD) type I Airedale terrier, Akita, dachshund, Doberman pinscher, crossbreed dogs, (variable severity ) German shepherd dog, golden retriever, greyhound, Irish wolfhound, Manchester terrier, Pembroke Welsh corgi, poodle, schnauzer, Shetland sheepdog vWD type II (moderate to severe bleeding ) German shorthaired pointer, German wirehaired pointer vWD type III (severe bleeding; may also cause Chesapeake Bay retriever, crossbreed cats, Dutch kooiker, Himalayan cats, factor VIII deficiency ) Scottish terrier, Shetland sheepdog SECONDARY HEMOSTASIS (hematomas, cavitary bleeding, bleeding with teething or spay) Factor I (fibrinogen) deficiency Bernese mountain dog, borzoi, Lhasa apso, vizsla Factor II (thrombin) deficiency Boxer, English cocker spaniel, otterhound Factor VII deficiency Alaskan malamute, beagle, boxer, bulldog, miniature schnauzer Factor X deficiency American cocker spaniel, crossbreed dogs, Parson Russell terrier Factor XI deficiency English springer spaniel, Great Pyrenees, Kerry blue terrier Hemophilia A (factor VIII deficiency) Collie, feline breeds (including crossbreeds), German shorthaired pointer, X-linked autosomal recessive disorder German wirehaired pointer, German shepherd dog, miniature poodle, predominantly affecting males numerous other canine breeds (including crossbreeds), Weimaraner Hemophilia B (factor IX deficiency) Alaskan malamute, Cairn terrier, cocker spaniel, coonhound, feline breeds X-linked autosomal recessive disorder (including crossbreeds), French bulldog, German shepherd, Labrador predominantly affecting males retriever, Old English sheepdog, numerous other canine breeds (including crossbreeds), Saint Bernard, Scottish terrier Vitamin K –dependent factor deficiency Devon Rex SECONDARY HEMOSTASIS (prolonged aPTT, no clinical bleeding) Factor XII deficiency Feline breeds, German shorthaired pointer, miniature poodle, standard poodle aPTT = activated partial thromboplastin time, vWD = von Willebrand disease

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November 2013 • clinician’s brief 85