Current- and Varifold-Based Registration of Lung Vessel and Airway Trees Yue Pan, Gary E. Christensen, Oguz C. Durumeric, Sarah E. Gerard, Joseph M. Reinhardt The University of Iowa, IA 52242 {yue-pan-1, gary-christensen, oguz-durumeric, sarah-gerard, joe-reinhardt}@uiowa.edu Geoffrey D. Hugo Virginia Commonwealth University, Richmond, VA 23298
[email protected] Abstract 1. Introduction Registration of lung CT images is important for many radiation oncology applications including assessing and Registering lung CT images is an important problem adapting to anatomical changes, accumulating radiation for many applications including tracking lung motion over dose for planning or assessment, and managing respiratory the breathing cycle, tracking anatomical and function motion. For example, variation in the anatomy during radio- changes over time, and detecting abnormal mechanical therapy introduces uncertainty between the planned and de- properties of the lung. This paper compares and con- livered radiation dose and may impact the appropriateness trasts current- and varifold-based diffeomorphic image of the originally-designed treatment plan. Frequent imaging registration approaches for registering tree-like structures during radiotherapy accompanied by accurate longitudinal of the lung. In these approaches, curve-like structures image registration facilitates measurement of such variation in the lung—for example, the skeletons of vessels and and its effect on the treatment plan. The cumulative dose airways segmentation—are represented by currents or to the target and normal tissue can be assessed by mapping varifolds in the dual space of a Reproducing Kernel Hilbert delivered dose to a common reference anatomy and com- Space (RKHS). Current and varifold representations are paring to the prescribed dose.