Implications of Cytochrome P450 Interactions When Prescribing Medication for Hypertension
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Calcium Channel Blocker As a Drug Candidate for the Treatment of Generalised Epilepsies
UNIVERSITAT DE BARCELONA Faculty of Pharmacy and Food Sciences Calcium channel blocker as a drug candidate for the treatment of generalised epilepsies Final degree project Author: Janire Sanz Sevilla Bachelor's degree in Pharmacy Primary field: Organic Chemistry, Pharmacology and Therapeutics Secondary field: Physiology, Pathophysiology and Molecular Biology March 2019 This work is licensed under a Creative Commons license ABBREVIATIONS AED antiepileptic drug AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ANNA-1 antineuronal nuclear antibody 1 BBB blood-brain barrier Bn benzyl BnBr benzyl bromide BnNCO benzyl isocyanate Boc tert-butoxycarbonyl Bu4NBr tetrabutylammonium bromide Ca+2 calcium ion CACNA1 calcium channel voltage-dependent gene cAMP cyclic adenosine monophosphate CCB calcium channel blocker cGMP cyclic guanosine monophosphate CH3CN acetonitrile Cl- chlorine ion Cmax maximum concentration CMV cytomegalovirus CTScan computed axial tomography DCM dichloromethane DIPEA N,N-diisopropylethylamine DMF dimethylformamide DMPK drug metabolism and pharmacokinetics DNET dysembryoplastic neuroepithelial tumours EEG electroencephalogram EPSP excitatory post-synaptic potential FDA food and drug administration Fe iron FLIPR fluorescence imaging plate reader fMRI functional magnetic resonance imaging GABA γ-amino-α-hydroxybutyric acid GAD65 glutamic acid decarboxylase 65 GAERS generalised absence epilepsy rat of Strasbourg GluR5 kainate receptor GTC generalised tonic-clonic H+ hydrogen ion H2 hydrogen H2O dihydrogen dioxide (water) -
Accupril® (Quinapril Hydrochloride Tablets)
Accupril® (Quinapril Hydrochloride Tablets) WARNING: FETAL TOXICITY When pregnancy is detected, discontinue ACCUPRIL as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See Warnings: Fetal Toxicity DESCRIPTION ACCUPRIL® (quinapril hydrochloride) is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat. Quinapril hydrochloride is chemically described as [3S-[2[R*(R*)], 3R*]]-2-[2-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5 •HCl and its structural formula is: Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents. ACCUPRIL tablets contain 5 mg, 10 mg, 20 mg, or 40 mg of quinapril for oral administration. Each tablet also contains candelilla wax, crospovidone, gelatin, lactose, magnesium carbonate, magnesium stearate, synthetic red iron oxide, and titanium dioxide. CLINICAL PHARMACOLOGY Mechanism of Action: Quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation. Quinapril inhibits the elevation in blood pressure caused by intravenously administered angiotensin I, but has no effect on the pressor response to angiotensin II, norepinephrine or epinephrine. Angiotensin II also stimulates the secretion of aldosterone from the adrenal cortex, thereby facilitating renal sodium and fluid reabsorption. -
Quinapril Tablets USP8289921/0720Frx Only
QUINAPRIL- quinapril tablet American Health Packaging ---------- Quinapril Tablets USP 8289921/0720F Rx only WARNING: FETAL TOXICITY When pregnancy is detected, discontinue quinapril tablets as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS: Fetal Toxicity DESCRIPTION Quinapril hydrochloride is the hydrochloride salt of quinapril, the ethyl ester of a non- sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat. Quinapril hydrochloride is chemically described as [3S-[2[R*(R*)], 3R*]]-2-[2-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C 25H 30N 2O 5•HCl and its structural formula is: Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents. Quinapril tablets USP contain 5 mg (equivalent to 5.416 mg Quinapril Hydrochloride), 10 mg (equivalent to 10.832 mg Quinapril Hydrochloride), 20 mg (equivalent to 21.664 mg Quinapril Hydrochloride), or 40 mg (equivalent to 43.328 mg Quinapril Hydrochloride) of quinapril for oral administration. Each film-coated tablet also contains crospovidone, iron oxide yellow, lecithin, magnesium carbonate, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol, povidone, talc, titanium dioxide and xanthan gum. CLINICAL PHARMACOLOGY Mechanism of Action Quinapril is deesterified to the principal metabolite, quinaprilat, which is an inhibitor of ACE activity in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor, angiotensin II. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation. -
Uva-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) Venous and arterial coronary artery bypass grafts in a pharmacological perspective Rinia-Feenstra, M. Publication date 2001 Link to publication Citation for published version (APA): Rinia-Feenstra, M. (2001). Venous and arterial coronary artery bypass grafts in a pharmacological perspective. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:04 Oct 2021 92 Saphenous vein harvesting techniques 15. Zerkowski H-R, Knocks M, Konerding MA, et al. Endothelial damage of the venous graft in CABG. Eur] Cardiothorac Surg 1993;7:376-82. 16. Dhein S, Reiß N, Gerwin R, et al. Endothelial function and contractility of human vena saphena magna prepared for aortocoronary bypass grafting. Thorac Cardiovasc Surg 1991;39:66-9. -
Drug and Medication Classification Schedule
KENTUCKY HORSE RACING COMMISSION UNIFORM DRUG, MEDICATION, AND SUBSTANCE CLASSIFICATION SCHEDULE KHRC 8-020-1 (11/2018) Class A drugs, medications, and substances are those (1) that have the highest potential to influence performance in the equine athlete, regardless of their approval by the United States Food and Drug Administration, or (2) that lack approval by the United States Food and Drug Administration but have pharmacologic effects similar to certain Class B drugs, medications, or substances that are approved by the United States Food and Drug Administration. Acecarbromal Bolasterone Cimaterol Divalproex Fluanisone Acetophenazine Boldione Citalopram Dixyrazine Fludiazepam Adinazolam Brimondine Cllibucaine Donepezil Flunitrazepam Alcuronium Bromazepam Clobazam Dopamine Fluopromazine Alfentanil Bromfenac Clocapramine Doxacurium Fluoresone Almotriptan Bromisovalum Clomethiazole Doxapram Fluoxetine Alphaprodine Bromocriptine Clomipramine Doxazosin Flupenthixol Alpidem Bromperidol Clonazepam Doxefazepam Flupirtine Alprazolam Brotizolam Clorazepate Doxepin Flurazepam Alprenolol Bufexamac Clormecaine Droperidol Fluspirilene Althesin Bupivacaine Clostebol Duloxetine Flutoprazepam Aminorex Buprenorphine Clothiapine Eletriptan Fluvoxamine Amisulpride Buspirone Clotiazepam Enalapril Formebolone Amitriptyline Bupropion Cloxazolam Enciprazine Fosinopril Amobarbital Butabartital Clozapine Endorphins Furzabol Amoxapine Butacaine Cobratoxin Enkephalins Galantamine Amperozide Butalbital Cocaine Ephedrine Gallamine Amphetamine Butanilicaine Codeine -
Interactions Between Antihypertensive Drugs and Food B
11. INTERACTIONS:01. Interacción 29/11/12 14:38 Página 1866 Nutr Hosp. 2012;27(5):1866-1875 ISSN 0212-1611 • CODEN NUHOEQ S.V.R. 318 Revisión Interactions between antihypertensive drugs and food B. Jáuregui-Garrido1 and I. Jáuregui-Lobera2 1Department of Cardiology. University Hospital Virgen del Rocío. Seville. Spain. 2Bromatology and Nutrition. Pablo de Olavide University. Seville. Spain. Abstract INTERACCIONES ENTRE FÁRMACOS ANTIHIPERTENSIVOS Y ALIMENTOS Objective: A drug interaction is defined as any alter- ation, pharmacokinetics and/or pharmacodynamics, Resumen produced by different substances, other drug treatments, dietary factors and habits such as drinking and smoking. Objetivo: la interacción de medicamentos se define como These interactions can affect the antihypertensive drugs, cualquier alteración, farmacocinética y/o farmacodiná- altering their therapeutic efficacy and causing toxic mica, producida por diferentes sustancias, otros tratamien- effects. The aim of this study was to conduct a review of tos, factores dietéticos y hábitos como beber y fumar. Estas available data about interactions between antihyperten- interacciones pueden afectar a los fármacos antihipertensi- sive agents and food. vos, alterando su eficacia terapéutica y causando efectos Methods: The purpose of this review was to report an tóxicos. El objetivo de este estudio fue realizar una revisión update of main findings with respect to the interactions de los datos disponibles acerca de las interacciones entre los between food and antihypertensive drugs -
Domperidone Packet
Domperidone IND Packet For Sponsors Treating Patients with Gastrointestinal Disorders Last Updated February 2, 2021 Page 1 1. Domperidone Background ...................................................................................................................................................... 3 2. Obtaining an IND..................................................................................................................................................................... 3 3. Application Process ................................................................................................................................................................. 3 Single Patient IND (SPI) .............................................................................................................................................................. 4 Intermediate Size Patient Population (multi-patient) IND ........................................................................................................... 4 4. Regulatory Responsibilities as a Sponsor ............................................................................................................................... 5 5. Ordering Domperidone........................................................................................................................................................... 5 6. Financial Responsibility ......................................................................................................................................................... -
Compounds and Bulk Powders
UnitedHealthcare Pharmacy Clinical Pharmacy Programs Program Number 2021 P 1014-13 Program Prior Authorization/Notification Medication Compounds and Bulk Powders P&T Approval Date 1/2012, 02/2013, 04/2013, 07/2013, 10/2013, 11/2013, 2/2014, 4/2014, 10/2014, 4/2015, 7/2015, 4/2016, 10/2016, 10/2017, 10/2018, 10/2019, 5/2020, 1/2021 Effective Date 4/1/2021; Oxford only: 4/1/2021 1. Background: Compounded medications can provide a unique route of delivery for certain patient- specific conditions and administration requirements. Compounded medications should be produced for a single individual and not produced on a large scale. A dollar threshold may be used to identify compounds which require Notification and must meet the criteria below in order to be covered. Drugs included in the compound must be a covered product. Claims for patients under the age of 6 will process automatically for First-Lansoprazole, First-Omeprazole, and Omeprazole + Syrspend SF compounding kits. 2. Coverage Criteriaa: A. Authorization for compounds and bulk powders will be approved based on all of the following criteria (includes bulk powders requested as a single ingredient such as bulk powder formulations of cholestyramine or nystatin when the powder formulation requested is not the commercially available FDA approved product): 1. The requested drug component is a covered medication -AND- 2. The requested drug component is to be administered for an FDA-approved indication -AND- 3. If a drug included in the compound requires prior authorization and/or step therapy, all drug specific clinical criteria must also be met -AND- 4. -
Novel Effects of Mibefradil, an Anti-Cancer Drug, on White Adipocytes
Georgia State University ScholarWorks @ Georgia State University Biology Theses Department of Biology 8-8-2017 Novel Effects of Mibefradil, An Anti-Cancer Drug, on White Adipocytes Sonia Thompson Follow this and additional works at: https://scholarworks.gsu.edu/biology_theses Recommended Citation Thompson, Sonia, "Novel Effects of Mibefradil, An Anti-Cancer Drug, on White Adipocytes." Thesis, Georgia State University, 2017. https://scholarworks.gsu.edu/biology_theses/77 This Thesis is brought to you for free and open access by the Department of Biology at ScholarWorks @ Georgia State University. It has been accepted for inclusion in Biology Theses by an authorized administrator of ScholarWorks @ Georgia State University. For more information, please contact [email protected]. NOVEL EFFECTS OF MIBEFRADIL, AN ANTI-CANCER DRUG, ON WHITE ADIPOCYTES by SONIA JOSEPH Under the Direction of Vincent Rehder, PhD ABSTRACT The present study was undertaken to investigate the effects of the T-type calcium channel blocker, Mibefradil, on white adipocytes. Unexpected for a T-type channel blocker, Mibefradil was found to increase intracellular calcium levels, cause lipid droplet fusion, and result in cell death. Calcium imaging of white adipocytes showed an increase of calcium concentration by Mibefradil at concentrations ranging from10-50 µM. The elevation in calcium by Mibefradil was significantly reduced by pretreatment of cells with Thapsigargin, an endoplasmic reticulum (ER) specific Ca ATPase inhibitor. Additionally, lipid droplet fusion and cell death were also attenuated by Thapsigargin pretreatment in white adipocytes. We conclude that Mibefradil elevated intracellular calcium levels, induced lipid droplet fusion and cell death in white adipocytes via mobilizing intracellular calcium stores from the ER. -
A Multicentre Phase II Study of AZD1775 Plus Chemotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, Or Primary Peritoneal Cancer
Clinical Study Protocol AstraZeneca AZD1775 - D6010C00004 Version 10, 05 September 2018 Clinical Study Protocol Drug Substance AZD1775 Study Code D6010C00004 Version 10 Date 05 September 2018 A Multicentre Phase II Study of AZD1775 plus Chemotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Sponsor: AstraZeneca AB, 151 85 Södertälje, Sweden. EudraCT: 2015-000886-30 CONFIDENTIAL AND PROPRIETARY 1 of 153 Clinical Study Protocol AstraZeneca AZD1775 - D6010C00004 Version 10, 05 September 2018 VERSION HISTORY Version 10.0, 05 September 2018 (Amendment 9) Changes to the protocol are summarised below: ! Specified that patients still receiving AZD1775 after the primary data cut-off will have a Final Protocol Visit (FPV) occurring at their next scheduled visit focused on capturing safety information. Following the FPV, patients may continue to receive treatment with AZD1775 ± chemotherapy as deemed appropriate by the Investigator (see Table 2, footnote ‘bb’, Table 3, footnote ‘cc’, and Section 4.4). The end-of-study treatment visit is not required for patients continuing treatment after the FPV. ! Amended Section 5.6 to add clarification about optional tumour biopsies. ! Clarified that blood samples and optional tumour biopsies for exploratory biomarker research will be collected at treatment discontinuation due to disease progression for subjects that continue taking AZD1775 ± chemotherapy after the FPV (see Section 5.6). ! Clarified how SAEs will be reported after the FPV (see Section 6.4.1 and Section 6.5). ! Clarified that after the FPV pregnancies will be monitored while patients are on treatment and for 30 days after their final dose of AZD1775 ±chemotherapy (Section 6.7). -
Effects of Intraoperative Angiotensin-Converting Enzyme Inhibition by Quinaprilat on Gastric Mucosal Blood Flow During Cardiopulmonary Bypass in Humans M
Effects of intraoperative angiotensin-converting enzyme inhibition ... 43 Applied Cardiopulmonary Pathophysiology 14: 43-50, 2010 Effects of intraoperative angiotensin-converting enzyme inhibition by quinaprilat on gastric mucosal blood flow during cardiopulmonary bypass in humans M. Müller1, M. Kwapisz1, S. Klemm1, H. Maxeiner1, H. Akintürk2, K. Valeske2 University Hospital Gießen and Marburg GmbH, Campus Gießen: 1Department of Anaes- thesiology, Intensive Care Medicine and Pain Therapy; 2Department of Cardiovascular Sur- gery Abstract Laser Doppler flow (LDF) assessment and regional carbon dioxide measurements by air tonom- etry were performed to estimate the changes in gastric mucosal blood flow after angiotensin- converting enzyme (ACE) inhibition in patients undergoing cardiopulmonary bypass (CPB). Patients scheduled for elective CABG were prospectively assigned to group A (quinaprilat 0.02 mg/kg, n = 10), group B (quinaprilat 0.04 mg/kg, n = 10), or group C (control, n = 10). Base- line values were measured after induction of anesthesia (T0) and repeated during steady state CPB (T1). Thereafter either quinaprilat, a non-sulphydryl ACE inhibitor, (group A and B) or saline solution (group C) were given as an intravenous bolus. The LDF measurements were per- formed after 5 (T2), 10 (T3), 15 (T4) minutes during CPB as well as 5 minutes after weaning off CPB (T5) and at the end of surgery (T6). The tonometric measurements were repeated at T4, T5 and T6. During hypothermic CPB LDF decreased in all groups. In group B only, LDF returned to base- line after application of quinaprilat. At the end of surgery (T6) LDF returned to baseline in group A and C, too. -
Cardiovascular Pharmacotherapy
Cardiovascular Pharmacotherapy APPENDICES Appendix 1: Eligibility Criteria PICOS Search Terms for Appendix 2: Process of Selecting Articles to be Reviewed Studies to be Evaluated for Inclusion in the Systematic Review Databases PubMed (1996 to search date) EMBASE (1947 to search date) Population - Adults Search Terms ([T lymphocytes AND regulatory] OR Treg - Acute coronary syndrome OR CD4+ OR CD25+ OR FOXP3) AND [acute - Atherosclerosis coronary syndrome OR Coronary Artery - Unstable angina Disease OR Atherosclerosis OR Myocardial - STEMI Infarction OR STEMI OR ST Elevation Myocardial Infarction OR NSTEMI OR Non-ST - NSTEMI Elevated Myocardial Infarction OR unstable - Coronary artery disease angina] AND [hydroxymethylglutaryl-CoA Intervention - 3-Hydroxy-3-methylglutaryl coenzyme A reductase Reductase Inhibitors OR HMGCOA reductase inhibitors OR atorvastatin OR fluvastatin OR inhibitors lovastatin OR pravastatin OR rosuvastatin OR - Atorvastatin simvastatin]) - Fluvastatin Search date 13 June 2017 - Pravastatin - Rosuvastatin Hits from the search (excluding 187 - Simvastatin repeats, n) - Lipitor Articles discarded after reviewing 182 - Lescol title and abstracts (n) - Lipostat Articles discarded after data 1 - Crestor retrieval (n) - Zocor Articles included (n) 4 Comparator - Placebo - Control Outcomes - CD4+CD25+FOXP3+ - Regulatory T-cells Study - Randomised controlled trial - Controlled clinical trial - Randomised Exclude (medications - Amprenavir - Amiodarone known to interact with - Atazanavir - Bezafibrate statins) - Bosentan - Cholestyramine